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1
المؤلفون: Phillip C.C. Liu, Peggy Scherle, Gregory Hollis, Reid Huber, Andrew P. Combs, Wenqing Yao, Chu-Biao Xue, Swamy Yeleswaram, Bruce Ruggeri, Richard Wynn, Maryanne Covington, Yanlong Li, Xin He, Christine Gardiner, Pramod Thekkat, Valerie Dostalik, Patricia Feldman, Darlise DiMatteo, Padmaja Polam, Nikoo Falahatpisheh, Robert Collins, Jun Li, Xuesong Mike Liu, Huiqing Liu, Ravi Jalluri, Margaret Favata, Paul Waeltz, Nina Zolotarjova, Alla Volgina, Xiaoming Wen, Mark Rupar, Sharon Diamond, Thomas Maduskuie, Richard Sparks, Timothy C. Burn, Matthew C. Stubbs
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2
المؤلفون: Phillip C.C. Liu, Peggy Scherle, Gregory Hollis, Reid Huber, Andrew P. Combs, Wenqing Yao, Chu-Biao Xue, Swamy Yeleswaram, Bruce Ruggeri, Richard Wynn, Maryanne Covington, Yanlong Li, Xin He, Christine Gardiner, Pramod Thekkat, Valerie Dostalik, Patricia Feldman, Darlise DiMatteo, Padmaja Polam, Nikoo Falahatpisheh, Robert Collins, Jun Li, Xuesong Mike Liu, Huiqing Liu, Ravi Jalluri, Margaret Favata, Paul Waeltz, Nina Zolotarjova, Alla Volgina, Xiaoming Wen, Mark Rupar, Sharon Diamond, Thomas Maduskuie, Richard Sparks, Timothy C. Burn, Matthew C. Stubbs
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3
المؤلفون: Reid Huber, Maryanne Covington, Xin He, Paul Waeltz, Valerie Dostalik, Yanlong Li, Nina Zolotarjova, Chu-Biao Xue, Matthew C. Stubbs, Jun Li, Huiqing Liu, Peggy Scherle, Timothy Burn, Sharon Diamond, Thomas Maduskuie, Wenqing Yao, Padmaja Polam, Richard B. Sparks, Christine Gardiner, Xuesong Mike Liu, Robert Collins, Nikoo Falahatpisheh, Andrew P. Combs, Phillip Liu, Margaret Favata, Gregory Hollis, Richard Wynn, Swamy Yeleswaram, Bruce Ruggeri, Alla Volgina, Ravi Kumar Jalluri, Pramod Thekkat, Darlise DiMatteo, Patricia Feldman, Mark Rupar, Xiaoming Wen
المصدر: Clinical Cancer Research. 25:300-311
مصطلحات موضوعية: STAT3 Transcription Factor, 0301 basic medicine, Cancer Research, BRD4, Cell Cycle Proteins, Fibroblast growth factor, Proto-Oncogene Proteins c-myc, BET inhibitor, Mice, 03 medical and health sciences, 0302 clinical medicine, In vivo, Cell Line, Tumor, Animals, Humans, Receptor, Fibroblast Growth Factor, Type 3, Organic Chemicals, STAT3, Receptor, Cell Proliferation, Janus Kinases, biology, Chemistry, Proteins, Histone-Lysine N-Methyltransferase, Receptors, Interleukin-6, Bromodomain, Gene Expression Regulation, Neoplastic, Repressor Proteins, 030104 developmental biology, Oncology, Fibroblast growth factor receptor, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Heterografts, Multiple Myeloma, Protein Binding, Signal Transduction, Transcription Factors
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4
المؤلفون: Andrew P Combs, Niu Shin, Laurine Galya, James Hall, Sharon Diamond, Kevin Baptiste, Jason Boer, Yan-ou Yang, Kevin J Bowman, Maryanne B Covington, Yanlong Li, Xin He, Daniel Levy, Brent D Douty, Padmaja Polam, David M Burns, Artem Shvartsbart, Eddy W Yue, Rick Sparks, Nikoo Falahatpisheh, Lixin Shao, Stacey Shepard, Andrew W Buesking
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5
المؤلفون: Brian M. Glass, Padmaja Polam, Tom Emm, Kevin Bowman, Jordan S. Fridman, Holly Koblish, Richard Wynn, Michael Hansbury, Yanlong Li, Eddy W. Yue, Brian Metcalf, Michael J. Bower, Min Wei, Richard B. Sparks, Peggy Scherle, Xiangdong Liu, Andrew P. Combs, Timothy Burn, Dilip P. Modi, Brian Wayland, Qian Wang, Lynn Leffet, Brent Douty, Wenyu Zhu, Amy Takvorian, Joseph Glenn
المصدر: ACS Medicinal Chemistry Letters
مصطلحات موضوعية: 0301 basic medicine, Letter, Organic Chemistry, data-centric medicinal chemistry, Pembrolizumab, Pharmacology, Furazan, Biochemistry, Small molecule, In vitro, Bioavailability, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, IDO1, chemistry, INCB24360, 030220 oncology & carcinogenesis, Drug Discovery, Epacadostat, Indoleamine 2,3-dioxygenase, immuno-oncology, Sulfamide, ADME
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6
المؤلفون: Swamy Yeleswaram, Thomas Maduskuie, Brian Wayland, Hao Feng, Patricia Feldman, Niu Shin, Yanlong Li, Chu-Biao Xue, Peggy Scherle, Song Mei, Kathy Wang, Maryanne Covington, Wenqing Yao, Padmaja Polam, Richard B. Sparks, Wenyu Zhu, Xin He, Sharon Diamond, Eddy W. Yue, Chunhong He, Brian Metcalf, Holly Koblish, Ke Zhang, Nikoo Falahatpisheh, Brent Douty, Leslie Hall, Yu Li, Andrew P. Combs, Joseph Glenn, Kamna Katiyar, Yun-Long Li
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Purine, Phosphoinositide 3-kinase, biology, 010405 organic chemistry, Organic Chemistry, Pharmacology, 01 natural sciences, Biochemistry, Duvelisib, Pyrazolopyrimidine, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, Pharmacokinetics, In vivo, Drug Discovery, biology.protein, Idelalisib, ADME
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7
المؤلفون: Qian Wang, Holly Koblish, Andrew P. Combs, Richard Wynn, Lynn Leffet, Robert C. Newton, Padmaja Polam, Kevin Bowman, Xiangdong Liu, Eddy W. Yue, Richard B. Sparks, Paul Waeltz, Peggy Scherle, Timothy Burn, Niu Shin, Gengjie Yang, Mark Rupar, Michael Hansbury, Jordan S. Fridman, Beth Thomas, Yanlong Li, Kathy Wang
المصدر: Blood. 115:3520-3530
مصطلحات موضوعية: Cellular immunity, T-Lymphocytes, medicine.medical_treatment, Immunology, Mice, Nude, Apoptosis, Biology, Biochemistry, Mice, chemistry.chemical_compound, Immune system, Neoplasms, medicine, Animals, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Enzyme Inhibitors, CD86, Immunity, Cellular, Mice, Inbred BALB C, Dose-Response Relationship, Drug, Cell growth, Dendritic Cells, Cell Biology, Hematology, Coculture Techniques, Tryptophan Oxygenase, In vitro, Cytokine, chemistry, Cancer research, B7-2 Antigen, Kynurenine, HeLa Cells
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8
المؤلفون: Erin McLaughlin, Richard Wynn, Brent Douty, Brian Wayland, Andrew P. Combs, Mary Becker-Pasha, Amy Takvorian, Brian M. Glass, Lucie Gonneville, Eddy W. Yue, Timothy Burn, Matthew L. Crawley, Richard B. Sparks, Gregory Hollis, Milton Hillman, Paul J. Ala, Padmaja Polam
المصدر: Journal of Biological Chemistry. 281:38013-38021
مصطلحات موضوعية: Models, Molecular, Benzimidazole, Protein Conformation, Stereochemistry, Static Electricity, In Vitro Techniques, Crystallography, X-Ray, Ring (chemistry), Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Catalytic Domain, Amide, Humans, Moiety, Enzyme Inhibitors, Molecular Biology, Protein Tyrosine Phosphatase, Non-Receptor Type 1, chemistry.chemical_classification, biology, Chemistry, Hydrogen bond, Aryl, Active site, Hydrogen Bonding, Cell Biology, Recombinant Proteins, Sulfonamide, Thiazoles, Drug Design, biology.protein, Protein Tyrosine Phosphatases
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9
المؤلفون: Brian Wayland, Brian M. Glass, Padmaja Polam, Wenyu Zhu, Amy Takvorian, Milton Hillman, Yanlong Li, Lucie Gonneville, Matthew L. Crawley, Brian Metcalf, Richard B. Sparks, Mary Becker-Pasha, Eddy W. Yue, Reid Huber, Laurine G. Galya, Erin McLaughlin, Dilip P. Modi, Richard Wynn, Brent Douty, Timothy Burn, Brian Reid, Michael J. Bower, Andrew P. Combs, Mei Li, Zelda Wasserman, Phillip Liu, Ronald M. Klabe, Min Wei, Karl F Blom, Paul J. Ala, James Russell Pruitt, Lori L. Bostrom, Gregory Hollis
المصدر: Journal of Medicinal Chemistry. 48:6544-6548
مصطلحات موضوعية: Models, Molecular, Molecular model, medicine.drug_class, Stereochemistry, In silico, Quantitative Structure-Activity Relationship, Peptide, Carboxamide, Protein tyrosine phosphatase, Crystallography, X-Ray, chemistry.chemical_compound, Drug Discovery, medicine, Peptide synthesis, Phosphotyrosine, Protein Tyrosine Phosphatase, Non-Receptor Type 1, chemistry.chemical_classification, biology, Molecular Mimicry, Stereoisomerism, Dipeptides, Thiazoles, Enzyme, chemistry, Biochemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Protein Tyrosine Phosphatases
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10
المؤلفون: Peggy Scherle, Timothy Burn, Reid Huber, Kris Vaddi, Beth Rumberger, Jun Li, Yu Li, Mark Rupar, Valerie Dostalik, Xiaoming Wen, Matthew C. Stubbs, Nikoo Falahatpisheh, Gregory Hollis, Margaret Favata, Xuesong M. Liu, Eian Caulder, Sybil O'Connor, Andrew P. Combs, Richard B. Sparks, Wenqing Yao, Padmaja Polam, Thomas Maduskuie, Phillip Liu
المصدر: Cancer Research. 75:692-692
مصطلحات موضوعية: Cancer Research, Oncogene, Chemistry, medicine.medical_treatment, JAK-STAT signaling pathway, In vitro, Bromodomain, Cytokine, Oncology, In vivo, Cancer research, medicine, BET Inhibitor INCB054329, Signal transduction
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11
المؤلفون: Gregory Hollis, Matthew C. Stubbs, Richard Wynn, Thomas Maduskuie, Reid Huber, Alla Volgina, Nina Zolotarjova, Richard B. Sparks, Sharon Diamond-Fosbenner, Maryanne Covington, Robert Collins, Margaret Favata, Phillip Liu, Yu Li, Darlise DiMatteo, Peggy Scherle, Timothy Burn, Nikoo Falahatpisheh, Kris Vaddi, Jun Li, Andrew P. Combs, Wenqing Yao, Padmaja Polam, Xuesong Mike Liu, Swamy Yeleswaram, Patricia Feldman, Xiaoming Wen
المصدر: Cancer Research. 75:3523-3523
مصطلحات موضوعية: Cancer Research, BRD4, business.industry, Promoter, Bromodomain, chemistry.chemical_compound, Oncology, chemistry, In vivo, Cell culture, Immunology, Cancer research, Medicine, BET Inhibitor INCB054329, Growth inhibition, business, Transcription factor
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12
المؤلفون: Padmaja Polam, Kris Vaddi, Reid Huber, Valerie Dostalik, Nikoo Falahatpisheh, Xuesong M. Liu, Thomas Maduskuie, Richard B. Sparks, Sybil O'Connor, Peggy Scherle, Gregory Hollis, Timothy Burn, Chu-Biao Xue, Andrew P. Combs, Eian Caulder, Phillip Liu, Xiaoming Wen, Taisheng Huang, Matthew C. Stubbs, Alla Vogina
المصدر: Cancer Research. 75:691-691
مصطلحات موضوعية: Melphalan, Cancer Research, business.industry, Bortezomib, Cell growth, Cereblon, medicine.disease, Oncology, In vivo, Cancer research, Medicine, BET Inhibitor INCB054329, business, Multiple myeloma, medicine.drug, Lenalidomide
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13
المؤلفون: Timothy Burn, Phillip C.C. Liu, Yanlong Li, Nancy J. Taylor, Matthew L. Crawley, Paul J. Ala, Erin McLaughlin, Wenyu Zhu, Amy Takvorian, Padmaja Polam, Andrew P. Combs, Min Wei, Lucie Gonneville, Richard Wynn, Richard B. Sparks
المصدر: Bioorganicmedicinal chemistry letters. 17(3)
مصطلحات موضوعية: Models, Molecular, Benzimidazole, Cell Membrane Permeability, Stereochemistry, Peptidomimetic, Clinical Biochemistry, Pharmaceutical Science, Protein tyrosine phosphatase, Tripeptide, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Humans, Benzothiazoles, Enzyme Inhibitors, Molecular Biology, Protein Tyrosine Phosphatase, Non-Receptor Type 1, biology, Organic Chemistry, Thiazoles, chemistry, Benzothiazole, Enzyme inhibitor, biology.protein, Molecular Medicine, Benzimidazoles, Caco-2 Cells, Protein Tyrosine Phosphatases, hormones, hormone substitutes, and hormone antagonists
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14
المؤلفون: Milton Hillman, Andrew P. Combs, Paul J. Ala, Ronald M. Klabe, Brian Wayland, Brent Douty, Michael J. Bower, Min Wei, Eddy W. Yue, Brian Reid, Mary Becker-Pasha, Gregory Hollis, Timothy Burn, Lucie Gonneville, Padmaja Polam, Richard Wynn, Zelda Wasserman
المصدر: The Journal of biological chemistry. 281(43)
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Protein Conformation, Phosphatase, Organophosphonates, Ring (chemistry), Crystallography, X-Ray, Biochemistry, Protein Structure, Secondary, Catalysis, Substrate Specificity, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Catalytic Domain, Hydrolase, Side chain, Escherichia coli, Moiety, Humans, Molecular Biology, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Binding Sites, Molecular Structure, Hydrogen bond, Hydrolysis, Molecular Mimicry, Water, Hydrogen Bonding, Cell Biology, Phosphonate, Protein Structure, Tertiary, Kinetics, Thiazoles, chemistry, Protein Tyrosine Phosphatases
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15
المؤلفون: Richard Wynn, Swamy Yeleswaram, Eddy W. Yue, Gregory Hollis, Nancy Taylor, Padmaja Polam, Paul J. Ala, Zelda Wasserman, Andrew P. Combs, Dawn Ellis, Richard B. Sparks, Wenyu Zhu, Amy Takvorian, Michael J. Bower, Brian M Reid, Phillip Liu, Lucie Gonneville, Timothy Burn, Min Wei, Erin McLaughlin, Mark Rupar, Thomas Emm, Brian Metcalf, Matthew L. Crawley, Dilip P. Modi, Yanlong Li, Brian M. Glass
المصدر: Journal of medicinal chemistry. 49(13)
مصطلحات موضوعية: Models, Molecular, Benzimidazole, Stereochemistry, Tripeptide, Protein tyrosine phosphatase, Crystallography, X-Ray, Cell Line, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Humans, Phosphorylation, Phosphotyrosine, chemistry.chemical_classification, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Sulfonamides, biology, Molecular Structure, Aryl, Molecular Mimicry, Stereoisomerism, Receptor, Insulin, Sulfonamide, Thiazoles, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Benzimidazoles, Protein Tyrosine Phosphatases, Oligopeptides, Proto-Oncogene Proteins c-akt, hormones, hormone substitutes, and hormone antagonists