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المصدر: European Journal of Pharmaceutical Sciences
مصطلحات موضوعية: Tubular reabsorption, BCRP, breast cancer resistance protein, Metabolic Clearance Rate, TSA, tubular surface area, Freab, fraction of the drug reabsorbed in the renal tubule, CD, collecting duct, PT, proximal tubule, RMSE, root mean squared error, Models, Biological, Article, IVIVE, in vitro–in vivo extrapolation, TFR, tubular flow rate, Renal excretion clearance, P-gp, P-glycoprotein, Humans, AUC, area under the plasma concentration-time profile, fu,p, fraction of drug unbound in plasma, DT, distal tubule, OCT, organic cation transporter, Clinical Trials as Topic, LoH, loop of Henle, GFR, glomerular filtration rate, CLR, renal excretion clearance, Cp, plasma concentration, CLR, filt, renal filtration clearance, OATP, organic anion-transporting peptides, gmfe, geometric mean fold error, OCTN, organic cation/l-carnitine transporter, Renal Elimination, Kidney Tubules, CLR, int,reab, intrinsic permeability clearance in renal tubule, Papp, apparent permeability, Pharmaceutical Preparations, PBPK, physiologically-based pharmacokinetic, CLR,sec, renal secretion clearance, In vitro–in vivo extrapolation, OAT, organic anion transporter, Freab’, intermediate model parameter, representing the fraction of the equilibrium reached between unbound drug concentration in the plasma and urine, MRP, multidrug resistance protein, LogD, octanol-buffer distribution coefficient, Glomerular Filtration Rate, MATE, multidrug and toxin extrusion protein