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1Academic Journal
المؤلفون: Farber, Charles R, Chitwood, James, Lee, Sang-Nam, Verdugo, Ricardo A, Islas-Trejo, Alma, Rincon, Gonzalo, Lindberg, Iris, Medrano, Juan F
المصدر: BMC Genomic Data. 9(1)
مصطلحات موضوعية: Biological Sciences, Genetics, Biotechnology, Human Genome, 2.1 Biological and endogenous factors, Aetiology, Animals, Body Weight, Gene Expression Profiling, Gene Expression Regulation, Enzymologic, Mice, Mice, Congenic, Neuroendocrine Secretory Protein 7B2, Oligonucleotide Array Sequence Analysis, Polymerase Chain Reaction, Promoter Regions, Genetic, Proprotein Convertase 2, Quantitative Trait Loci, Sequence Analysis, DNA, Up-Regulation, Genetics & Heredity
وصف الملف: application/pdf
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2Academic Journal
المؤلفون: Remes, Satu Maria, Leijon, Helena, Vesterinen, Tiina, Louhimo, Johanna, Pulkkinen, Ville, Ezer, Sini, Kere, Juha, Haglund, Caj, Arola, Johanna
المساهمون: HUSLAB, Department of Pathology, Helsinki University Hospital Area, University of Helsinki, Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE, HUS Abdominal Center, Department of Surgery, HUS Heart and Lung Center, Biosciences, Clinicum, Keuhkosairauksien yksikkö, STEMM - Stem Cells and Metabolism Research Program, Research Programs Unit, Juha Kere / Principal Investigator, Medicum, II kirurgian klinikka, CAN-PRO - Translational Cancer Medicine Program, Faculty of Medicine
مصطلحات موضوعية: Neuroendocrine tumors, primary origin, PCSK2, immunohistochemistry, CHROMOGRANIN-A, HUMAN TISSUES, PROTEIN 7B2, PC2, CONVERTASE-2, STANDARDS, MEDICINE, MARKERS, CELLS, Biomedicine, 11832 Microbiology and virology
وصف الملف: application/pdf
Relation: This study was supported by grants from the Helsinki University Hospital Research Fund, and the Finnish Cancer Foundation. We gratefully acknowledge Eija Heili_o, P_aivi Peltokangas, Tiiu Arum_ae, and Petri Lankila for their technical assistance. We also thank Professor Leif Andersson for his assistance in the Western blot analysis.; Remes , S M , Leijon , H , Vesterinen , T , Louhimo , J , Pulkkinen , V , Ezer , S , Kere , J , Haglund , C & Arola , J 2020 , ' PCSK2 expression in neuroendocrine tumors points to a midgut, pulmonary, or pheochromocytoma-paraganglioma origin ' , APMIS : Acta pathologica, microbiologica et immunologica Scandinavica , vol. 128 , no. 11 , pp. 563-572 . https://doi.org/10.1111/apm.13071; ORCID: /0000-0002-6208-978X/work/82752150; ORCID: /0000-0003-2997-0337/work/83840570; http://hdl.handle.net/10138/320822; a9585073-edfc-4cef-a9d1-1ea2ec03b5b1; 000573361300001
الاتاحة: http://hdl.handle.net/10138/320822
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3
المؤلفون: Tiina Vesterinen, Ville Pulkkinen, Johanna Louhimo, Johanna Arola, Helena Leijon, Juha Kere, Satu Maria Remes, Sini Ezer, Caj Haglund
المساهمون: HUSLAB, Department of Pathology, Helsinki University Hospital Area, University of Helsinki, Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE, HUS Abdominal Center, Department of Surgery, HUS Heart and Lung Center, Biosciences, Clinicum, Keuhkosairauksien yksikkö, STEMM - Stem Cells and Metabolism Research Program, Research Programs Unit, Juha Kere / Principal Investigator, Medicum, II kirurgian klinikka, CAN-PRO - Translational Cancer Medicine Program, Faculty of Medicine
المصدر: Apmis
مصطلحات موضوعية: Male, Pathology, Lung Neoplasms, Adrenal Gland Neoplasms, Gene Expression, Neuroendocrine tumors, CHROMOGRANIN-A, CONVERTASE-2, PC2, 0302 clinical medicine, MARKERS, Paraganglioma, Immunology and Allergy, Gastrointestinal Neoplasms, 11832 Microbiology and virology, 0303 health sciences, Tissue microarray, biology, Chromogranin A, General Medicine, Primary tumor, PROTEIN 7B2, 3. Good health, Proprotein Convertase 2, Lymphatic Metastasis, 030220 oncology & carcinogenesis, immunohistochemistry, Immunohistochemistry, Female, Original Article, STANDARDS, Microbiology (medical), medicine.medical_specialty, Carcinoid tumors, Pheochromocytoma, Adenocarcinoma, HUMAN TISSUES, Pathology and Forensic Medicine, 03 medical and health sciences, Biomarkers, Tumor, medicine, Humans, primary origin, Thyroid Neoplasms, Neoplasm Staging, 030304 developmental biology, MEDICINE, business.industry, Original Articles, PCSK2, medicine.disease, Carcinoma, Neuroendocrine, Ki-67 Antigen, CELLS, biology.protein, 3111 Biomedicine, business
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4
المؤلفون: Bart O. Roep
المصدر: Diabetes
مصطلحات موضوعية: Adult, Male, T-Lymphocytes, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Population, CD8-Positive T-Lymphocytes, HLA-A3 Antigen, Cytoplasmic Granules, Islets of Langerhans, Epitopes, Mice, Neuroendocrine Secretory Protein 7B2, Young Adult, Mice, Inbred NOD, Commentaries, Organelle, Chromogranins, Internal Medicine, medicine, Animals, Data Mining, Humans, Insulin, Computer Simulation, Secretion, RNA, Messenger, education, Urocortins, Proinsulin, education.field_of_study, Delta cell, Chemistry, Intercellular transport, Granule (cell biology), Cell biology, Alternative Splicing, Diabetes Mellitus, Type 1, Gene Expression Regulation, Case-Control Studies, Female, Protein Binding
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5Academic Journal
المؤلفون: Citil, Cihan, Konar, Vahit, Aydin, Suleyman, Yilmaz, Musa, Albayrak, Serdal, Ozercan, Ibrahim Hanifi, Ozkan, Yusuf
المساهمون: Citil, Cihan Kafkas Univ, Ataturk Vocat Sch Hlth Sci, Kars, Turkey -- Konar, Vahit Amasya Univ, Dept Biol Sci, Amasya, Turkey -- Aydin, Suleyman -- Yilmaz, Musa Firat Univ, Sch Med, Dept Med Biochem & Clin Biochem, Firat Hormones Res Grp, Elazig, Turkey -- Albayrak, Serdal Elazig Educ & Res Hosp, Dept Brain Surg, Elazig, Turkey -- Ozercan, Ibrahim Hanifi Firat Univ, Sch Med, Dept Pathol, Elazig, Turkey -- Ozkan, Yusuf Firat Univ, Dept Internal Med Endocrine & Metab, Elazig, Turkey
مصطلحات موضوعية: 14-3-3 Proteins, Liver Failure, Acute, Neuroendocrine Secretory Protein 7B2
Relation: MEDICAL SCIENCE MONITOR; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/20.500.12450/1413; 20; 1326; 1333
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6Academic Journal
المؤلفون: Muller, Laurent, Lindberg, I
المساهمون: Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS-PSL), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris Sciences et Lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
المصدر: ISSN: 0079-6603 ; Progress in Nucleic Acid Research and Molecular Biology ; https://hal.science/hal-02157639 ; Progress in Nucleic Acid Research and Molecular Biology, 1999, 63, pp.69-108. ⟨10.1016/S0079-6603(08)60720-5⟩.
مصطلحات موضوعية: MESH: Animals, MESH: Aspartic Acid Endopeptidases, MESH: Nerve Tissue Proteins, MESH: Neuroendocrine Secretory Protein 7B2, MESH: Pituitary Hormones, MESH: Proprotein Convertase 2, MESH: Proprotein Convertases, MESH: Protein Binding, MESH: Protein Processing, Post-Translational, MESH: Subtilisins, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV]Life Sciences [q-bio], [SDV.BC]Life Sciences [q-bio]/Cellular Biology
Relation: info:eu-repo/semantics/altIdentifier/pmid/10506829; hal-02157639; https://hal.science/hal-02157639; PUBMED: 10506829
الاتاحة: https://hal.science/hal-02157639
https://doi.org/10.1016/S0079-6603(08)60720-5 -
7
المؤلفون: Valeria Albornoz, Iris Lindberg, Hiroyuki Yamamoto, Bruno Ramos-Molina, Lynda F. Bonewald, Matthew Prideaux, Adam N. Lick
المصدر: Bone. 84:120-130
مصطلحات موضوعية: 0301 basic medicine, DNA, Complementary, Glycosylation, Histology, Physiology, Endocrinology, Diabetes and Metabolism, Prohormone convertase, 030209 endocrinology & metabolism, CHO Cells, Transfection, urologic and male genital diseases, Osteocytes, Article, Mice, Neuroendocrine Secretory Protein 7B2, 03 medical and health sciences, Cricetulus, 0302 clinical medicine, Cricetinae, Bone cell, medicine, Animals, Humans, Phosphorylation, Furin, Osteoblasts, biology, Chemistry, Kinase, Cell Differentiation, Osteoblast, Proprotein convertase, Immunohistochemistry, Recombinant Proteins, Rats, Fibroblast Growth Factors, Fibroblast Growth Factor-23, stomatognathic diseases, 030104 developmental biology, medicine.anatomical_structure, Biochemistry, Osteocyte, biology.protein, N-Acetylgalactosaminyltransferases, Proprotein Convertases, Protein Processing, Post-Translational
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8
المؤلفون: Shaobo Zhou, David G.A. Morgan, Heidi R. Fuller, Carl P.C. Chen, Jane E. Preston, Ruoli Chen
المصدر: Chen, C P C, Preston, J E, Zhou, S, Fuller, H R, Morgan, D G A & Chen, R 2018, ' Proteomic analysis of age-related changes in ovine cerebrospinal fluid ', Experimental Gerontology, vol. 108, pp. 181-188 . https://doi.org/10.1016/j.exger.2018.04.012
مصطلحات موضوعية: 0301 basic medicine, Proteomics, Aging, Vimentin, CSF, Choroid plexus, Neurodegenerative disease, Biochemistry, RS, 03 medical and health sciences, Neuroendocrine Protein 7B2, Endocrinology, Cerebrospinal fluid, Tandem Mass Spectrometry, Genetics, Animals, Molecular Biology, CSF albumin, Chromatography, High Pressure Liquid, Sheep, biology, Chemistry, Haptoglobin, Neurodegenerative Diseases, Cell Biology, Molecular biology, Peptide Fragments, Ageing, 030104 developmental biology, biology.protein, Female, Biomarkers
وصف الملف: application/pdf
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9
المؤلفون: Mohammed Baqur S. Al-Shuhaib, Hussein Ali Imran Al-Juhaishi, Milad Ali Badi, J. Francis Borgio, Sayed AbdulAzeez, Kasi Marimuthu, Fadhil R. Al-Kafajy
المصدر: Computers in biology and medicine. 100
مصطلحات موضوعية: 0301 basic medicine, Nonsynonymous substitution, In silico, Population, Mutation, Missense, Health Informatics, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, Avian Proteins, 03 medical and health sciences, Neuroendocrine Secretory Protein 7B2, Polymorphism (computer science), Genotype, Missense mutation, Animals, education, Placenta Growth Factor, Genetics, education.field_of_study, Struthioniformes, 0402 animal and dairy science, Single-strand conformation polymorphism, 04 agricultural and veterinary sciences, Cytochromes b, 040201 dairy & animal science, Adaptation, Physiological, Computer Science Applications, Prolactin, 030104 developmental biology, Genetics, Population, Africa, Cyclooxygenase 1, Keratin-2
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10
المؤلفون: Andinet Amare Wadhams, Geert Baggerman, Elena V. Romanova, Suresh P. Annangudi, Eric B. Monroe, Liliane Schoofs, Bruce R. Southey, Ning Yang, T.A. Richmond, Jonathan V. Sweedler
مصطلحات موضوعية: 0301 basic medicine, Proteomics, Technology, Sea urchin, Prohormone, Tandem mass spectrometry, Homology (biology), Structural Biology, Tandem Mass Spectrometry, SALMFAMIDE NEUROPEPTIDES, Peptidomics, Peptide sequence, Spectroscopy, biology, Chemistry, Chemistry, Physical, PROTEIN 7B2, FAMILY, GENOME, Physical Sciences, Life Sciences & Biomedicine, medicine.drug, Biochemistry & Molecular Biology, Spectrometry, Mass, Electrospray Ionization, Bioinformatics, Computational biology, Biochemical Research Methods, Article, 03 medical and health sciences, STRONGYLOCENTROTUS-PURPURATUS, biology.animal, PITUITARY, medicine, Animals, Amino Acid Sequence, Science & Technology, Mass spectrometry, IDENTIFICATION, Phylum, APLYSIA, Chemistry, Analytical, Neuropeptides, biology.organism_classification, Strongylocentrotus purpuratus, Hormones, THYROTROPIN-RELEASING-HORMONE, PEDAL PEPTIDE, 030104 developmental biology, Sea Urchins
وصف الملف: Print-Electronic
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11
المؤلفون: Tasha Womack, Polymnia Georgiou, Todd D. Gould, Iris Lindberg, Jason L. Eriksen, Timothy S. Jarvela
المصدر: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)مصطلحات موضوعية: 0301 basic medicine, Heterozygote, Genotype, lcsh:Medicine, Morris water navigation task, Plaque, Amyloid, Protein aggregation, Article, 03 medical and health sciences, chemistry.chemical_compound, Neuroendocrine Secretory Protein 7B2, In vivo, Memory, Animals, Humans, Benzothiazoles, Transgenes, lcsh:Science, Mice, Knockout, Multidisciplinary, Amyloid beta-Peptides, biology, Clusterin, Chemistry, lcsh:R, Brain, In vitro, 3. Good health, Cell biology, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Proteostasis, Solubility, Chaperone (protein), biology.protein, lcsh:Q, Thioflavin, Female
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12
المؤلفون: Iris Lindberg, Laura Sanglas, Jan J. Enghild, Indrani Dasgupta
المصدر: Biochemistry
Dasgupta, I, Sanglas, L, Enghild, J J & Lindberg, I 2012, ' The Neuroendocrine Protein 7B2 Is Intrinsically Disordered ', Biochemistry, vol. 51, no. 38, pp. 7456–7464 . https://doi.org/10.1021/bi300871kمصطلحات موضوعية: Circular dichroism, Globular protein, Protein domain, Protein aggregation, Biology, Biochemistry, Article, Protein Structure, Secondary, 03 medical and health sciences, Neuroendocrine Protein 7B2, Neuroendocrine Secretory Protein 7B2, 0302 clinical medicine, Protein structure, Humans, Protein secondary structure, Nuclear Magnetic Resonance, Biomolecular, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Circular Dichroism, Spectrometry, Fluorescence, chemistry, Chaperone (protein), Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, biology.protein, Chromatography, Gel, 030217 neurology & neurosurgery
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13
المؤلفون: Sushil K. Mahata, Y. Peng Loh, Alessandro Bartolomucci, Stephen R.J. Salton, Roberta Possenti, Reiner Fischer-Colbrie
المصدر: Endocrine reviews 32(6) (2011): 755–797.
info:cnr-pdr/source/autori:Bartolomucci A., Possenti R., Mahata S.K., Fischer-Colbrie R., Loh Y.P., Salton S.R./titolo:The extended granin family: structure, function, and biomedical implications/doi:/rivista:Endocrine reviews/anno:2011/pagina_da:755/pagina_a:797/intervallo_pagine:755–797/volume:32(6)مصطلحات موضوعية: endocrine system, Endocrinology, Diabetes and Metabolism, Transgene, Reviews, Biology, Settore BIO/09, Neuroendocrine Secretory Protein 7B2, Neuroendocrine Protein 7B2, Endocrinology, Neuroendocrine Cells, Chromogranins, GTP-Binding Protein alpha Subunits, Gs, Animals, Humans, Glucose homeostasis, Nerve Growth Factors, Secretogranin III, Neurons, Sequence Homology, Amino Acid, Secretory Vesicles, Neuropeptides, Chromogranin A, Granin, Peptide Fragments, Cell biology, Biochemistry, biology.protein, Endocrine Cells, Biomarkers, Biogenesis
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14
المؤلفون: Iris Lindberg, Bruno Ramos-Molina
مصطلحات موضوعية: Molecular Sequence Data, Prohormone convertase, Proprotein convertase 2, Biology, Endoplasmic Reticulum, Phosphorylation cascade, Serine, Neuroendocrine Protein 7B2, Neuroendocrine Secretory Protein 7B2, Endocrinology, Humans, Amino Acid Sequence, Threonine, Phosphorylation, Molecular Biology, Endoplasmic Reticulum Chaperone BiP, Heat-Shock Proteins, Original Research, Extracellular Matrix Proteins, Casein Kinase I, Alternative splicing, General Medicine, Enzyme Activation, Alternative Splicing, HEK293 Cells, Proprotein Convertase 2, Biochemistry, Protein Processing, Post-Translational
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15
المؤلفون: Toru Takano, Yoshio Murakami, Akira Teramoto, Susumu Tanaka, Nobuyuki Amino, Kozo Hashimoto, Shigeyuki Tahara, Toshihiro Takao, Ke-ita Tatsumi, Yuzuru Kato
المصدر: Endocrine. 22:335-340
مصطلحات موضوعية: Adenoma, Adult, Male, endocrine system, medicine.medical_specialty, Pituitary gland, RNA, Untranslated, Pituitary disorder, Adolescent, Hypophysitis, Endocrinology, Diabetes and Metabolism, Immunoglobulins, Prohormone convertase, Nerve Tissue Proteins, Neuroendocrine Secretory Protein 7B2, Neuroendocrine Protein 7B2, Endocrinology, Internal medicine, Biomarkers, Tumor, medicine, Humans, Pituitary Neoplasms, Aged, Autoantibodies, Aged, 80 and over, biology, Human Growth Hormone, business.industry, Pituitary tumors, Autoantibody, Carboxypeptidase H, Membrane Proteins, Proteins, Middle Aged, medicine.disease, Pituitary Hormones, Proprotein Convertase 2, medicine.anatomical_structure, Proprotein Convertase 1, Carboxypeptidase E, Phosphopyruvate Hydratase, biology.protein, Female, RNA, Long Noncoding, business
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المؤلفون: Miroslav S. Sarac, Iris Lindberg, Maria G. Castro, S. Windeatt
المصدر: Endocrinology. 143:2314-2323
مصطلحات موضوعية: Blood Glucose, endocrine system, medicine.medical_specialty, Pituitary gland, Transgene, Genetic Vectors, Longevity, Alpha (ethology), Prohormone convertase, Proprotein convertase 2, Mice, Transgenic, Nerve Tissue Proteins, Biology, Antibodies, Viral, Endocrine System Diseases, Adenoviridae, Mice, Neuroendocrine Secretory Protein 7B2, chemistry.chemical_compound, Neuroendocrine Protein 7B2, Endocrinology, Adrenocorticotropic Hormone, Corticosterone, Internal medicine, medicine, Animals, Endocrine system, Subtilisins, Mice, Knockout, Genetic Therapy, beta-Galactosidase, Pituitary Hormones, Proprotein Convertase 2, medicine.anatomical_structure, chemistry, alpha-MSH, Pituitary Gland
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المؤلفون: Brandie Heald, Carol A. Burke, Kathryn Brown, James M. Church, Lisa LaGuardia, Margaret O'Malley, Thomas Plesec, Charles Allen, Matthew F. Kalady
المصدر: Human pathology. 60
مصطلحات موضوعية: Adult, Pathology, medicine.medical_specialty, Heredity, Adenoma, Databases, Factual, medicine.medical_treatment, Biopsy, Colonic Polyps, Locus (genetics), Gastroenterology, Pathology and Forensic Medicine, 03 medical and health sciences, Chromosome 15, Neuroendocrine Secretory Protein 7B2, Young Adult, 0302 clinical medicine, Internal medicine, Gene Duplication, Gene duplication, otorhinolaryngologic diseases, medicine, Biomarkers, Tumor, Humans, Genetic Predisposition to Disease, Child, Colectomy, Aged, medicine.diagnostic_test, business.industry, Colonoscopy, Middle Aged, medicine.disease, digestive system diseases, Endoscopy, Pedigree, Phenotype, Hyperplastic Polyp, Adenomatous Polyposis Coli, Hamartomatous polyposis, 030220 oncology & carcinogenesis, Jews, Intercellular Signaling Peptides and Proteins, 030211 gastroenterology & hepatology, Gene Fusion, business
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18
المؤلفون: Stephen Bowman, Jian Q. Feng, Ying Liu, Iris Lindberg, Baozhi Yuan, Marc K. Drezner, Robert D. Blank
المصدر: Journal of Bone and Mineral Research. 28:56-72
مصطلحات موضوعية: Male, endocrine system, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Proprotein convertase 2, Biology, Bone and Bones, Article, Bone morphogenetic protein 1, Mice, Neuroendocrine Secretory Protein 7B2, Internal medicine, medicine, Protein biosynthesis, Animals, Humans, Orthopedics and Sports Medicine, RNA, Messenger, Extracellular Matrix Proteins, Messenger RNA, Osteoblasts, PHEX, Genetic Diseases, X-Linked, Transfection, X-linked hypophosphatemia, medicine.disease, Molecular biology, Mice, Mutant Strains, DMP1, Fibroblast Growth Factors, Mice, Inbred C57BL, Radiography, Fibroblast Growth Factor-23, Phenotype, Proprotein Convertase 2, Endocrinology, Gene Expression Regulation, Female, Familial Hypophosphatemic Rickets, Oligopeptides
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19
المؤلفون: Joan Josep Bech-Serra, Darío Gándara, Francesc Canals, Maria A. Poca, Marta García-Ramírez, Cristina Hernández, Rafael Simó, Nuria Colomé, Albert Lecube
المصدر: Journal of Neuroendocrinology. 24:944-952
مصطلحات موضوعية: medicine.medical_specialty, Pathology, biology, Endocrine and Autonomic Systems, Endocrinology, Diabetes and Metabolism, Binding protein, Haptoglobin, Inflammation, Fibrinogen, Pathogenesis, Cellular and Molecular Neuroscience, Neuroendocrine Protein 7B2, Endocrinology, Cerebrospinal fluid, Internal medicine, medicine, biology.protein, Osteopontin, medicine.symptom, medicine.drug
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20
المؤلفون: Iris Lindberg, Ekaterina V. Apletalina, Laurent Muller
المصدر: Journal of Biological Chemistry. 275:14667-14677
مصطلحات موضوعية: endocrine system, Molecular Sequence Data, Mutant, Prohormone convertase, Nerve Tissue Proteins, Peptide, Cleavage (embryo), Biochemistry, Cell Line, Mice, Neuroendocrine Secretory Protein 7B2, Neuroendocrine Protein 7B2, Proopiomelanocortin, Catalytic Domain, Animals, Humans, Amino Acid Sequence, Subtilisins, Enzyme Inhibitors, Protein Precursors, Molecular Biology, DNA Primers, chemistry.chemical_classification, Base Sequence, biology, Hydrolysis, Enkephalins, Cell Biology, Proenkephalin, Pituitary Hormones, Proprotein Convertase 2, chemistry, alpha-MSH, Culture Media, Conditioned, Mutation, biology.protein, Proprotein Convertases, Protein Processing, Post-Translational, Protein Binding