المؤلفون: Swastika Maitra, Nobendu Mukerjee, Dattatreya Mukherjee, Arabinda Ghosh, Athanasios T. Alexiou

المصدر: Clinical and Translational Discovery, Vol 4, Iss 4, Pp n/a-n/a (2024)

مصطلحات موضوعية: colorectal cancer (CRC), exosome‐based delivery, nanomedicine, PROTACs (PROteolysis Targeting Chimeras), targeted protein degradation, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2768-0622

URL الوصول: https://doaj.org/article/372d1695656d40abb5248e44b75915c5

المؤلفون: Sobia Tabassum

المصدر: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

مصطلحات موضوعية: PROTACs (proteolysis targeting chimeras), cancer therapy, targeted drug, technolody development, technology innovation, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2023.1131638/full; https://doaj.org/toc/2296-634X

URL الوصول: https://doaj.org/article/dd3e3eaf12234b3ca761d98810ab97ca

المؤلفون: Yamit Shorer Arbel, Ben-Zion Katz, Ronen Gabizon, Amit Shraga, Yotam Bronstein, Talia Kamdjou, Anat Globerson Levin, Chava Perry, Irit Avivi, Nir London, Yair Herishanu

المصدر: Frontiers in Oncology, Vol 11 (2021)

مصطلحات موضوعية: PROTACs (proteolysis targeting chimeras), BTK - Bruton’s tyrosine kinase, CLL (Chronic Lymphocytic Leukemia), ibrutinib, BCR (B cell receptor) signaling, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.646971/full; https://doaj.org/toc/2234-943X

URL الوصول: https://doaj.org/article/650b70fb17db4836a1e4c93f379c112c

المؤلفون: John Spencer, Anthony Edmonds

مصطلحات موضوعية: Biological sciences, Chemical sciences, Health sciences, PROTACs (proteolysis targeting chimeras), medicinal chemistry, chemical biology, chemical probes, structural biology

Relation: https://figshare.com/articles/dataset/Data_for_The_development_of_DUAL_BRD4_and_CBP_p300_degraders_from_ISOX-DUAL_thesis_by_Anthony_Edmonds_2022_/24588942

الاتاحة: https://doi.org/10.25377/sussex.24588942.v1
https://figshare.com/articles/dataset/Data_for_The_development_of_DUAL_BRD4_and_CBP_p300_degraders_from_ISOX-DUAL_thesis_by_Anthony_Edmonds_2022_/24588942

المؤلفون: Tingting Chen, Ancheng Shen, Ao Zhang, Chunyong Ding, Zilan Song

المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 12, Pp 2272-2298 (2020)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: PD-L1, programmed death ligand 1, TBK1, medicine.medical_treatment, ICI, immune checkpoint inhibitor, DC50, concentration for 50% degradation, Review, ACMA, 9-amino-6-chloro-2-methoxyacridine, PD-1, programmed death receptor 1, ULD, ubiquitin-like domain, Anti-tumor, ABZI, amidobenzimidazole, 0302 clinical medicine, GMP, guanosine monophosphate, LBD, ligand-binding domain, GTP, guanosine triphosphate, PRRs, pattern recognition receptors, Interferon, cAIMP, cyclic adenosine-inosine monophosphate, Medicine, CMA, 10-carboxymethyl-9-acridanone, General Pharmacology, Toxicology and Pharmaceutics, IKK, IκB kinase, ISG, interferon stimulated gene, MinEC5×, minimum effective concentration for inducing 5-fold luciferase activity, 0303 health sciences, KD, kinase domain, dsDNA, double-stranded DNA, MG, Mangostin, ITC, isothermal titration calorimetry, Immunogenicity, PBMCs, peripheral-blood mononuclear cells, MDCK, Madin–Darby canine kidney, PROTACs, proteolysis targeting chimeras, FAA, flavone-8-acetic acid, CTD, C-terminal domain, DMXAA, 5,6-dimethylxanthenone-4-acetic acid, DSDP, dispiro diketopiperzine, STAT, signal transducer and activator of transcription, medicine.anatomical_structure, 030220 oncology & carcinogenesis, CDN, cyclic dinucleotide, QC, quinacrine, FP, fluorescence polarization, PDK1, 3-phosphoinositide-dependent protein kinase 1, Immunotherapy, Signal transduction, DCs, dendritic cells, CDA, cyclic diadenosine monophosphate (c-di-AMP), medicine.drug, Ntase, nucleotidyl transferase, ATP, adenosine triphosphate, CDG, cyclic diguanosine monophosphate (c-di-GMP), T cell, SDD, scaffold and dimerization domain, NF-κB, nuclear factor-κB, STING, stimulator of interferon genes, TNFRSF, tumor necrosis factor receptor superfamily, EM, cryo-electron microscopy, ER, endoplasmic reticulum, 03 medical and health sciences, MLK, mixed lineage kinase, Immune system, CBD, cyclic dinucleotide-binding domain, THIQCs, tetrahydroisoquinolone acetic acids, SAR, structure–activity relationship, HCQ, hydrochloroquine, ENPP1, ecto-nucleotide pyrophosphatase/phosphodiesterase, HTS, high throughput screening, 030304 developmental biology, MI, maximum induction, CXCL, chemokine (C-X-C motif) ligand, Innate immune system, PDE, phosphodiesterases, IO, immune-oncology, business.industry, IRF3, interferon regulatory factor 3, i.t., intratumoral, CTT, C-terminal tail, lcsh:RM1-950, BNBC, 6-bromo-N-(naphthalen-1-yl)benzo[d][1,3]dioxole-5-carboxamide, Chimeric antigen receptor, PPi, pyrophosphoric acid, Small molecule modulators, FDA, U.S. Food and Drug Administration, VHL, von Hippel–Lindau, lcsh:Therapeutics. Pharmacology, AMP, adenosine monophosphate, TBK1, TANK-binding kinase 1, Cancer research, cGAMP, cyclic guanosine monophosphate-adenosine monophosphate, business, cGAS, cyclic guanosine monophosphate-adenosine monophosphate synthase, CTLA-4, cytotoxic T lymphocyte associated protein 4, cGAS, STING

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c604607610f05b2d37da5b2cce00382
http://www.sciencedirect.com/science/article/pii/S2211383519316946

المؤلفون: Lupei Du, Xiaodong Shi, Yuxing Lin, Xiaojun Qin, Minyong Li, Hui Song, Xiang Li, Zheng Zhang, Gaopan Dong, Zhongxia Yu, Wei Zhao, Zhenzhen Li

المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 9, Pp 1669-1679 (2020)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: DMSO, dimethylsulfoxide, Ubiquitylation, 03 medical and health sciences, Degradation, 0302 clinical medicine, Ubiquitin, α1A-AR, α1A-adrenergic receptor, TEA, triethylamine, BPH, benign prostatic hyperplasia, CRBN, cereblon, General Pharmacology, Toxicology and Pharmaceutics, Receptor, α1D-AR, α1D-adrenergic receptor, GPCR, G-protein-coupled receptor, 030304 developmental biology, G protein-coupled receptor, 0303 health sciences, Prostate cancer, biology, Chemistry, Cereblon, lcsh:RM1-950, PROTACs, proteolysis targeting chimeras, hPCE, human prostate cancer epithelial, Ligand (biochemistry), Small molecule, DCM, dichloromethane, Cell biology, Ubiquitin ligase, α1A-Adrenergic receptor, lcsh:Therapeutics. Pharmacology, 030220 oncology & carcinogenesis, HPLC, high-performance liquid chromatography, α1B-AR, α1B-adrenergic receptor, biology.protein, Small-molecule PROTACs, Original Article, DMF, dimethylformamide, Target protein, α1-ARs, α1-adrenergic receptors, LUTS, lower urinary tract symptoms, THF, tetrahydrofuran

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2ee89c25ae13d3b9aa09ea20848e78
http://www.sciencedirect.com/science/article/pii/S2211383519313188

المؤلفون: Wenzhi Tian (11142939)

مصطلحات موضوعية: Pharmacology, proteasome function, proteasome inhibition strategies, proteasome activities, PROTACs (proteolysis targeting chimeras)

Relation: https://figshare.com/articles/thesis/DISCOVERY_OF_A_SELECTIVE_BINDER_OF_PROTEASOMAL_SUBUNIT_RPN-6_AND_ITS_EFFECT_ON_PROTEASOME_ACTIVITY/14993049

الاتاحة: https://doi.org/10.25394/pgs.14993049.v1

المؤلفون: Yamit Shorer Arbel (10793412), Ben-Zion Katz (8860952), Ronen Gabizon (160721), Amit Shraga (8860934), Yotam Bronstein (10793415), Talia Kamdjou (6695483), Anat Globerson Levin (10793418), Chava Perry (468607), Irit Avivi (10793421), Nir London (137267), Yair Herishanu (8860955)

مصطلحات موضوعية: Cancer, Cancer Cell Biology, Cancer Diagnosis, Cancer Genetics, Cancer Therapy (excl. Chemotherapy and Radiation Therapy), Chemotherapy, Haematological Tumours, Molecular Targets, Radiation Therapy, Solid Tumours, Oncology and Carcinogenesis not elsewhere classified, PROTACs (proteolysis targeting chimeras), BTK - Bruton’s tyrosine kinase, CLL (Chronic Lymphocytic Leukemia), ibrutinib, BCR (B cell receptor) signaling

Relation: https://figshare.com/articles/dataset/DataSheet_1_Proteolysis_Targeting_Chimeras_for_BTK_Efficiently_Inhibit_B-Cell_Receptor_Signaling_and_Can_Overcome_Ibrutinib_Resistance_in_CLL_Cells_pdf/14585571

الاتاحة: https://doi.org/10.3389/fonc.2021.646971.s001

المؤلفون: Wenzhi Tian (11142939)

مصطلحات موضوعية: Pharmacology, proteasome function, proteasome inhibition strategies, proteasome activities, PROTACs (proteolysis targeting chimeras)

Relation: https://figshare.com/articles/thesis/DISCOVERY_OF_A_SELECTIVE_BINDER_OF_PROTEASOMAL_SUBUNIT_RPN-6_AND_ITS_EFFECT_ON_PROTEASOME_ACTIVITY/14993049