المؤلفون: Sicheng Yang, Donghuan Sun, Ying Wu, Shuqiang Chen, Yuan Guo, Jian Li, Guoqiang Dong, Chunquan Sheng

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Physiology, Pharmacology, Science Policy, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sup >+, showed potent activity, limiting enzyme involved, new nampt activators, effectively activated nampt, promising lead compound, effectively alleviated age, c8 , vivo <, vitro <, senescent hl, related dysfunctions, related diseases, nicotinamide phosphoribosyltransferase, improving aging, improve aging, delaying aging, crucial role, caenorhabditis elegans, associated dysfunctions

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_a_Potent_Nicotinamide_Phosphoribosyltransferase_Activator_for_Improving_Aging-associated_Dysfunctions/25238366

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c02370.s001
https://figshare.com/articles/journal_contribution/Discovery_of_a_Potent_Nicotinamide_Phosphoribosyltransferase_Activator_for_Improving_Aging-associated_Dysfunctions/25238366

المؤلفون: Sandra Johannsen, Robin M. Gierse, Arne Krüger, Rachel L. Edwards, Vittoria Nanna, Anna Fontana, Di Zhu, Tiziana Masini, Lais Pessanha de Carvalho, Mael Poizat, Bart Kieftenbelt, Dana M. Hodge, Sophie Alvarez, Daan Bunt, Antoine Lacour, Atanaz Shams, Kamila Anna Meissner, Edmarcia Elisa de Souza, Melloney Dröge, Bernard van Vliet, Jack den Hartog, Michael C. Hutter, Jana Held, Audrey R. Odom John, Carsten Wrenger, Anna K. H. Hirsch

مصطلحات موضوعية: Biochemistry, Microbiology, Pharmacology, Biotechnology, Science Policy, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, human liver cells, close structural similarities, tuberculosis prompted investigation, three different methods, high target homology, 50 , 1 , target validation, mycobacterium tuberculosis, enzyme 1, different modes, urgently needed, resistant strains, potent activity, new mode, methylerythritol 4, low toxicity, known drugs, inhibitor classes, guarantee inhibition, based activity

Relation: https://figshare.com/articles/journal_contribution/High_Target_Homology_Does_Not_Guarantee_Inhibition_Aminothiazoles_Emerge_as_Inhibitors_of_Plasmodium_falciparum/25239882

الاتاحة: https://doi.org/10.1021/acsinfecdis.3c00670.s002
https://figshare.com/articles/journal_contribution/High_Target_Homology_Does_Not_Guarantee_Inhibition_Aminothiazoles_Emerge_as_Inhibitors_of_Plasmodium_falciparum/25239882

المؤلفون: Ruiqin Cui, Jinyong Zhang, Xiaodi Liu, Chunxia Hu, Fan Zhou, Min Zhang, Xiao Wang, Quanming Zou, Wei Huang

مصطلحات موضوعية: Biochemistry, Microbiology, Neuroscience, Pharmacology, Biotechnology, Developmental Biology, Cancer, Infectious Diseases, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, quorum sensing system, drug combination regimens, adrenergic receptor inhibitors, luxs quorum sensing, adrenergic blockers, vivo <, vitro <, thermal stability, study provides, promising anti, potential ability, potent activity, polymyxin b, future development, direct binding, biofilm formation, bacterial infections, appealing target

Relation: https://figshare.com/articles/journal_contribution/Dronedarone_Enhances_the_Antibacterial_Activity_of_Polymyxin_B_and_Inhibits_the_Quorum_Sensing_System_by_Interacting_with_LuxS/25150999

الاتاحة: https://doi.org/10.1021/acsinfecdis.3c00591.s001
https://figshare.com/articles/journal_contribution/Dronedarone_Enhances_the_Antibacterial_Activity_of_Polymyxin_B_and_Inhibits_the_Quorum_Sensing_System_by_Interacting_with_LuxS/25150999

المؤلفون: Yeonwoo Cho, Chinmayee Bawkar, Jung Mi Hyun, Myung Jin Song, Kwiwan Jeong, Yeon-Ju Lee

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Ecology, Inorganic Chemistry, Infectious Diseases, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, specific rotation values, norterpene cyclic peroxides, diacarnus spinipoculum <, 0 μm ), methoxy (< b, hydroxy (< b, 19 , 12 , 10 (< b, based empirical method, 50 , showing inhibitory activity, inhibitory activity, established based, potent activity, unprecedented analogs, marine sponge, epimeric mixtures, cyclohexanone moiety, absolute configurations, >, inhibitors

Relation: https://figshare.com/articles/journal_contribution/Norterpene_Cyclic_Peroxides_from_the_Marine_Sponge_i_Diacarnus_spinipoculum_i_Inhibitors_of_Transient_Receptor_Potential_Ankyrin_1/25156211

الاتاحة: https://doi.org/10.1021/acs.jnatprod.3c01104.s001
https://figshare.com/articles/journal_contribution/Norterpene_Cyclic_Peroxides_from_the_Marine_Sponge_i_Diacarnus_spinipoculum_i_Inhibitors_of_Transient_Receptor_Potential_Ankyrin_1/25156211

المؤلفون: Jarvis Hill, Robert M. Jones, David Crich

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, underrepresented functional group, toxicity commonly surmised, murine model suggesting, molecule targeted therapies, induced tumor regression, drug optimization campaigns, trisubstituted hydroxylamine moiety, drug scaffold without, cell lung cancer, 9 , penetrant egfr inhibitor, lung cancer, vivo <, significant problem, severely limited, potential lead, potent activity, orally bioavailable

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_a_Hydroxylamine-Based_Brain-Penetrant_EGFR_Inhibitor_for_Metastatic_Non-Small-Cell_Lung_Cancer/24520562

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01669.s001
https://figshare.com/articles/journal_contribution/Discovery_of_a_Hydroxylamine-Based_Brain-Penetrant_EGFR_Inhibitor_for_Metastatic_Non-Small-Cell_Lung_Cancer/24520562

المؤلفون: Xukai Jiang, Nitin A. Patil, Yuwen Xu, Hasini Wickremasinghe, Qi Tony Zhou, Fanfan Zhou, Philip E. Thompson, Lushan Wang, Min Xiao, Kade D. Roberts, Tony Velkov, Jian Li

مصطلحات موضوعية: Medicine, Microbiology, Pharmacology, Biotechnology, Immunology, Cancer, Infectious Diseases, molecular dynamics simulations, integrated chemical biology, global public health, generation lipopeptide antibiotics, exhibited potent activity, based permeability barrier, negative bacterial pneumonia, critical surfactant layer, lung surfactant multidrug, negative bacteria present, effectively treat gram, lung surfactant, negative bacteria, target bacteria, sequestration mechanism, resort therapy, resistant gram, rational design, pulmonary infection, novel analog, importantly pave, formidable threat

Relation: https://figshare.com/articles/journal_contribution/Structure_Interaction_Relationship_of_Polymyxins_with_Lung_Surfactant/24665318

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01497.s001
https://figshare.com/articles/journal_contribution/Structure_Interaction_Relationship_of_Polymyxins_with_Lung_Surfactant/24665318

المؤلفون: Andrej Emanuel Cotman (5203904), Martina Durcik (8648943), Davide Benedetto Tiz (10499510), Federica Fulgheri (10499513), Daniela Secci (1456555), Maša Sterle (10499516), Štefan Možina (7827599), Žiga Skok (9526072), Nace Zidar (1550383), Anamarija Zega (145577), Janez Ilaš (1550377), Lucija Peterlin Mašič (14420614), Tihomir Tomašič (1550395), Diarmaid Hughes (55014), Douglas L. Huseby (5082230), Sha Cao (194620), Linnéa Garoff (14420617), Talía Berruga Fernández (14420620), Paraskevi Giachou (14420623), Lisa Crone (14420626), Ivailo Simoff (13298093), Richard Svensson (1294284), Bryndis Birnir (113570), Sergiy V. Korol (13999896), Zhe Jin (43692), Francisca Vicente (484392), Maria C. Ramos (9616038), Mercedes de la Cruz (484390), Björn Glinghammar (14420629), Lena Lenhammar (4004096), Sara R. Henderson (14420632), Julia E. A. Mundy (7140383), Anthony Maxwell (9506), Clare E. M. Stevenson (9526084), David M. Lawson (357139), Guido V. Janssen (14420635), Geert Jan Sterk (3832357), Danijel Kikelj (1550389)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Pharmacology, Cancer, Infectious Diseases, Space Science, Chemical Sciences not elsewhere classified, plasma free fraction, ion channel liabilities, fold decreased inhibition, escherichia coli gyrb24, dna gyrase inhibitor, human topoisomerase iiα, fold improved inhibition, aeruginosa gyrb24 revealed, 27 , 1 , topoisomerase iv, >)-< b, retained anti, resistant bacteria, pseudomonas aeruginosa, promising activity, priority list, potent activity, optimization steps, negative activity, mitochondrial toxicity

Relation: https://figshare.com/articles/journal_contribution/Discovery_and_Hit-to-Lead_Optimization_of_Benzothiazole_Scaffold-Based_DNA_Gyrase_Inhibitors_with_Potent_Activity_against_Acinetobacter_baumannii_and_Pseudomonas_aeruginosa/21893086

الاتاحة: https://doi.org/10.1021/acs.jmedchem.2c01597.s001

المؤلفون: Xianzhe Fan (14290924), Yang Han (269027), Li Deng (442821), Jiaqi Song (8072837), Yangli Zhu (7546208), Tingmi Yang (8179275), Ting Liu (45625), Lijun Zhang (483325), Haibing Liao (381594)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Neuroscience, Developmental Biology, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, six known congeners, ray diffraction analysis, electronic circular dichroism, diaphorina citri kuwayama, corrected mortality rate, 9 , 8 , 7 , 4 , 3 , 12 , 42 ± 2, 50 , 2 , exhibited insecticidal activity, insecticidal activity, 2 cells, potent activity, undescribed epimers, trolox ), positive control

Relation: https://figshare.com/articles/journal_contribution/Quassinoids_from_Picrasma_chinensis_with_Insecticidal_Activity_against_Adults_and_Larvae_of_Diaphorina_citri_Kuwayama_and_Neuroprotective_Effect/21766723

الاتاحة: https://doi.org/10.1021/acs.jafc.2c06243.s001

المؤلفون: Shaimaa R. Ahmed (11986882), Ahmed R. Hamed (4722810), Mohammed I. Ali (11986885), Mohamed S. Sedeek (7479953), Narek Abelyan (7305671), Mohammad M. Al-Sanea (8604162)

مصطلحات موضوعية: Biochemistry, Genetics, Pharmacology, Biotechnology, Cancer, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, μm trolox equivalent, quinone oxidoreductase 1, molecular docking study, future chemopreventive lead, euphorbia abyssinica endowed, essential transcription factor, associated protein 1, 5 ± 95, 3 ± 1, 1 ± 1, 03 ± 37, potent activity compared, cancer chemopreventive potential, aerial part extract, extracts including flavonoids, aerial part extracts, promising inducer compounds, protein expression level, chemopreventive marker nqo1, 50 , abyssinica fruit extract

Relation: https://figshare.com/articles/journal_contribution/Cancer_Chemopreventive_Potential_and_Chemical_Profiling_of_Euphorbia_abyssinica_Endowed_with_Docking_Studies/18864064

الاتاحة: https://doi.org/10.1021/acsomega.1c06148.s001

المؤلفون: Osama Mostafa, Mohammed Al-Shehri, Mahmoud Moustafa

المصدر: Saudi Journal of Biological Sciences, Vol 29, Iss 1, Pp 217-227 (2022)

مصطلحات موضوعية: Marine sponges, Novel antiparasitic drugs, Potent activity, Bioactive compounds, Biology (General), QH301-705.5

Relation: http://www.sciencedirect.com/science/article/pii/S1319562X21007567; https://doaj.org/toc/1319-562X; https://doaj.org/article/0968580686cd45c39eb7c32682a544fd

الاتاحة: https://doi.org/10.1016/j.sjbs.2021.08.068
https://doaj.org/article/0968580686cd45c39eb7c32682a544fd

المؤلفون: Arisetti, Nanaji, Fuchs, Hazel L. S., Coetzee, Janetta, Orozco, Manuel, Ruppelt, Dominik, Bauer, Armin, Heimann, Dominik, Kuhnert, Eric, Bhamidimarri, Satya P., Bafna, Jayesh A., Hinkelmann, Bettina, Eckel, Konstantin, Sieber, Stephan A., Müller, Peter P., Herrmann, Jennifer, Müller, Rolf, Winterhalter, Mathias, Steinem, Claudia, Brönstrup, Mark

المصدر: Chemical Science 12 (2021), Nr. 48 ; Chemical Science

مصطلحات موضوعية: Lipid bilayers, Synthesis (chemical), Antibiotic activity, Antimicrobial resistances, Breakings, Chloropyrroles, Copper catalyzed, Gram-positive pathogens, Mechanism of action, Potent activity, Total mechanism, Total synthesis, Antibiotics, ddc:540

Relation: ESSN:2041-6539; http://dx.doi.org/10.15488/16564; https://www.repo.uni-hannover.de/handle/123456789/16691

الاتاحة: https://www.repo.uni-hannover.de/handle/123456789/16691
https://doi.org/10.15488/16564

المؤلفون: Sunil Kumar (102321), Aathira Sujathan Nair (11371359), Vaishnav Bhashkar (11371362), Sachithra Thazhathuveedu Sudevan (11371365), Vishal Payyalot Koyiparambath (11371368), Ahmed Khames (11371371), Mohamed A. Abdelgawad (9973921), Bijo Mathew (3711802)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Neuroscience, Pharmacology, Biotechnology, Science Policy, Mental Health, Chemical Sciences not elsewhere classified, targeting associated diseases, small molecules beneficial, simple molecular conversion, principal component analysis, potent activity needs, machine learning tool, even though scrutinization, central nervous system, activity cliff analysis, significant biological activity, hypothesis wherein pyrazole, conclusive structural requirement, chemical compound structure, bring new perceptions, favorable scaffold structures, many promising drugs, potent mao inhibitors, monoamine oxidase inhibitors, cns target drugs, monoamine oxidase, acting drugs

Relation: https://figshare.com/articles/journal_contribution/Navigating_into_the_Chemical_Space_of_Monoamine_Oxidase_Inhibitors_by_Artificial_Intelligence_and_Cheminformatics_Approach/16553535

الاتاحة: https://doi.org/10.1021/acsomega.1c03250.s001

المؤلفون: Ahmed H. Tantawy (11723977), Mohammed Farrag El-Behairy (11723980), Walaa Hamada Abd-Allah (11723983), Hong Jiang (79543), Man-Qun Wang (482845), Adel A. Marzouk (11723986)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, novel fluorinated candidates, maximal inhibitory concentration, lower toxic effects, aminothiadiazole (< b, 8b , 7b , 6c , one (< b, 50 , vitro <, silico <, potent one, selectivity index, results showed, potent activity, physicochemical parameters, molecular docking, latent lead, enzyme inhibition, cytotoxic activity, biological evaluation, anticancer agents

Relation: https://figshare.com/articles/journal_contribution/Design_Synthesis_Biological_Evaluation_and_Computational_Studies_of_Novel_Fluorinated_Candidates_as_PI3K_Inhibitors_Targeting_Fluorophilic_Binding_Sites/17040580

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01674.s001

المؤلفون: Grzegorz Mlostoń (2824004), Mateusz Kowalczyk (11741856), Małgorzata Celeda (1930228), Katarzyna Gach-Janczak (11741859), Anna Janecka (1601698), Marcin Jasiński (1732258)

مصطلحات موضوعية: Biochemistry, Physiology, Biotechnology, Cancer, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, stable nhc representative, less efficient due, adamantyloxy analogue displayed, 7 cell lines, selected structural analogues, >- benzylation opens, 6 , significant cytotoxic activity, g ., 3 , 2 , cytotoxic activity, n <, diphenyl analogues, >- oxides, potent activity, yielding imidazole, unsubstituted imidazole, unambiguously confirmed, subsequent deoxygenation, studied series, straightforward access, smoothly reacted

Time: 4

Relation: https://figshare.com/articles/journal_contribution/Synthesis_and_Cytotoxic_Activity_of_Lepidilines_A_D_Comparison_with_Some_4_5-Diphenyl_Analogues_and_Related_Imidazole-2-thiones/17064783

الاتاحة: https://doi.org/10.1021/acs.jnatprod.1c00797.s002

المؤلفون: Wendy Tran (11771539), Ali S. Kusay (11771542), Paige M. E. Hawkins (10882626), Chen-Yi Cheung (5727815), Gayathri Nagalingam (163194), Venugopal Pujari (1314981), Daniel J. Ford (8810324), Alexander Stoye (1989343), Jessica L. Ochoa (2746918), Rebecca E. Audette (11771545), Elinor Hortle (5065370), Stefan H. Oehlers (5065349), Susan A. Charman (1294689), Roger G. Linington (132483), Eric J. Rubin (7443881), Christopher G. Dowson (261998), David I. Roper (349176), Dean C. Crick (364125), Thomas Balle (104765), Gregory M. Cook (7319351), Warwick J. Britton (7253093), Richard J. Payne (401410)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Molecular Biology, Pharmacology, Immunology, Infectious Diseases, Chemical Sciences not elsewhere classified, uridylpeptide natural products, reduced mycobacterial burden, natural product scaffold, lead analogue bearing, synthetic sansanmycin analogues, mycobacterium tuberculosis (<, sansanmycin family, zebrafish model, vivo <, vitro <, profile similar, privileged structure, potent activity, peptidic end, pentapeptide translocase, mycobacteria reside, first membrane, associated step, also capable, >) phospho

Relation: https://figshare.com/articles/journal_contribution/Synthetic_Sansanmycin_Analogues_as_Potent_Mycobacterium_tuberculosis_Translocase_I_Inhibitors/17099362

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01407.s001

المؤلفون: E. M. Kithsiri Wijeratne (11408994), Ya-Ming Xu (1344258), Manping X. Liu (1533415), Marielle C. Inacio (11777143), Alan D. Brooks (11777146), Poonam Tewary (3850039), Thomas J. Sayers (613029), A. A. Leslie Gunatilaka (8262510)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Physiology, Pharmacology, Biotechnology, Evolutionary Biology, Immunology, Developmental Biology, Cancer, Chemical Sciences not elsewhere classified, unique anticancer potential, significantly increased ability, reducing cell number, reduce cell number, develop natural products, 1 , readily accessible compound, 50 , hydroxywithanolide natural product, vitro antiproliferative activity, 22rv1 ), rc, pc cell lines, 23 , dependent lncap cells, cell lines, antiproliferative activity, achn ), potent activity

Relation: https://figshare.com/articles/journal_contribution/Ring_A_B-Modified_17_-Hydroxywithanolide_Analogues_as_Antiproliferative_Agents_for_Prostate_Cancer_and_Potentiators_of_Immunotherapy_for_Renal_Carcinoma_and_Melanoma/17105413

الاتاحة: https://doi.org/10.1021/acs.jnatprod.1c00724.s001

المؤلفون: Andrea A. Stierle (1451869), Donald B. Stierle (1451872), Jeremy Alverson (10758021), Nathan Gibson (7043771)

مصطلحات موضوعية: Biochemistry, Microbiology, Genetics, Pharmacology, Ecology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, hexadecanoic acid skeleton, exhibited potent activity, eli lilly company, streptococcus pyogenes <, staphylococcus aureus <, bacillus anthracis <, 9 , 8 , 7 , 4 , 2 , citreohybriddional (< b, penicillium turbatum <, lactones (< b, a26771b (< b, (< b, turbatum <, penicillium <, −< b, – h, two extremophilic

Relation: https://figshare.com/articles/journal_contribution/Berkeleylactones_and_a_Citreohybriddione_Analogue_from_i_Penicillium_turbatum_i_/17105842

الاتاحة: https://doi.org/10.1021/acs.jnatprod.1c00791.s002

المؤلفون: Nikos Kühl (9128695), Mila M. Leuthold (6195185), Mira A. M. Behnam (9128698), Christian D. Klein (1456204)

مصطلحات موضوعية: Biochemistry, Pharmacology, Infectious Diseases, Plant Biology, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, off-target interactions, replication assays, drug discovery, novel benzamide derivatives, pharmacokinetic liabilities, host proteases, serine protease NS 2B, active-site-directed flaviviral pro., submicromolar activities, EC, off-target proteases, dengue virus, Potent Activity, Cell Culture, flaviviral proteases, recognition preferences, small-molecular inhibitors, protease favor, DENV 2proHeLa system, reporter gene assay, dengue protease

Relation: https://figshare.com/articles/journal_contribution/Beyond_Basicity_Discovery_of_Nonbasic_DENV_2_Protease_Inhibitors_with_Potent_Activity_in_Cell_Culture/14414659

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02042.s002

المؤلفون: Kim, Chang-Kwon, Riswanto, Riswanto, Won, Tae Hyung, Kim, Heegyu, Elya, Berna, Sim, Chung J., Oh, Dong-Chan, Oh, Ki-Bong, Shin, Jongheon

المساهمون: Oh, Dong-Chan, Oh, Ki-Bong, Shin, Jongheon

مصطلحات موضوعية: MARINE NATURAL-PRODUCTS, ANTIMALARIAL ACTIVITY, POTENT ACTIVITY, HALICLONA SP, DISEASES, GROWTH, INGENS, INFECTIONS, INHIBITORS, ANALOGS

Relation: Journal of Natural Products, Vol.80 No.5, pp.1575-1583; https://hdl.handle.net/10371/206723; 000402498300041; 2-s2.0-85019677372; 303

الاتاحة: https://hdl.handle.net/10371/206723
https://doi.org/10.1021/acs.jnatprod.7b00121

المؤلفون: İlker Kelle

المصدر: Dicle Medical Journal, Vol 33, Iss 2, Pp 113-126 (2006)

مصطلحات موضوعية: Pharmazooticals, Venom Peptides, Potent Activity, Few Side Effects, Medicine, Medicine (General), R5-920

Relation: http://4181.indexcopernicus.com/fulltxt.php?ICID=888086; https://doaj.org/toc/1300-2945; https://doaj.org/toc/1308-9889; https://doaj.org/article/37e181ea4b32415ca34a411c5b4b8133

الاتاحة: https://doaj.org/article/37e181ea4b32415ca34a411c5b4b8133