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1Academic Journal
المؤلفون: Huiting, Wouter, Dekker, Suzanne L, van der Lienden, Joris C J, Mergener, Rafaella, Musskopf, Maiara K, Furtado, Gabriel V, Gerrits, Emma, Coit, David, Oghbaie, Mehrnoosh, Di Stefano, Luciano H, Schepers, Hein, van Waarde-Verhagen, Maria A W H, Couzijn, Suzanne, Barazzuol, Lara, LaCava, John, Kampinga, Harm H, Bergink, Steven
المصدر: Huiting , W , Dekker , S L , van der Lienden , J C J , Mergener , R , Musskopf , M K , Furtado , G V , Gerrits , E , Coit , D , Oghbaie , M , Di Stefano , L H , Schepers , H , van Waarde-Verhagen , M A W H , Couzijn , S , Barazzuol , L , LaCava , J , Kampinga , H H & Bergink , S 2022 , ' Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation ....
مصطلحات موضوعية: genotoxic stress, protein homeostasis, protein aggregation, DNA damage response, chaperone, Human, HEAT-SHOCK PROTEINS, ALPHA-B-CRYSTALLIN, MOLECULAR CHAPERONE, NEURODEGENERATIVE DISEASES, POLYGLUTAMINE AGGREGATION, PHASE-TRANSITION, STRESS-PROTEIN, ATM, PROTEOSTASIS, ALZHEIMERS
وصف الملف: application/pdf
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2Academic Journal
المصدر: Klaips , C L , Gropp , M H M , Hipp , M S & Hartl , F U 2020 , ' Sis1 potentiates the stress response to protein aggregation and elevated temperature ' , Nature Communications , vol. 11 , no. 1 , 6271 . https://doi.org/10.1038/s41467-020-20000-x
مصطلحات موضوعية: SHOCK TRANSCRIPTION FACTORS, POLYGLUTAMINE AGGREGATION, MOLECULAR CHAPERONES, CO-CHAPERONES, HEAT-STRESS, HSP40 SIS1, IN-VIVO, HSP70, HUNTINGTIN, EXPRESSION
وصف الملف: application/pdf
الاتاحة: https://hdl.handle.net/11370/897b4be0-ba90-445e-9b0a-7ca53664dbbd
https://research.rug.nl/en/publications/897b4be0-ba90-445e-9b0a-7ca53664dbbd
https://doi.org/10.1038/s41467-020-20000-x
https://pure.rug.nl/ws/files/160757461/Sis1_potentiates_the_stress_response_to_protein_aggregation_and_elevated_temperature.pdf -
3Academic Journal
المؤلفون: Thiruvalluvan, Arun, de Mattos, Eduardo P., Brunsting, Jeanette F., Bakels, Rob, Serlidaki, Despina, Barazzuol, Lara, Conforti, Paola, Fatima, Azra, Koyuncu, Seda, Cattaneo, Elena, Vilchez, David, Bergink, Steven, Boddeke, Erik H. W. G., Copray, Sjef, Kampinga, Harm H.
المصدر: Thiruvalluvan , A , de Mattos , E P , Brunsting , J F , Bakels , R , Serlidaki , D , Barazzuol , L , Conforti , P , Fatima , A , Koyuncu , S , Cattaneo , E , Vilchez , D , Bergink , S , Boddeke , E H W G , Copray , S & Kampinga , H H 2020 , ' DNAJB6, a Key Factor in Neuronal Sensitivity to Amyloidogenesis ' , Molecular Cell , vol. 78 , no. 2 , pp. 346-+ . https://doi.org/10.1016/j.molcel.2020.02.022
مصطلحات موضوعية: HEAT-SHOCK PROTEINS, POLYGLUTAMINE AGGREGATION, HUNTINGTONS-DISEASE, ASYMMETRIC INHERITANCE, MOLECULAR CHAPERONES, ANDROGEN RECEPTOR, DAMAGED PROTEINS, RICH REGION, CELL LINES, MUTATIONS
وصف الملف: application/pdf
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4
المؤلفون: Madlen Hotze, Miriam Gehrmann, Manuela Hessmann, Longbin Liu, Christoph Scheich, Kathrin Petersen, Nicole Hoeschen, Peter Johnson, Sabine Schaertl, Stefanie Jahn, Matthew R. Mills, Ignacio Munoz-Sanjuan, Alex S. Kiselyov, John Wityak, Anass Chiki, Vinod Khetarpal, Karsten Kottig, Gerhard Schmiedel, Galina Bursow, Stefanie Ladewig, Christopher J. Brown, Karola Berg-Rosseburg, Michael Prime, Sven Letschert, Andreas Ebneth, Jonathan Bard, Celia Dominguez, Frank Herrmann, Hilal A. Lashuel
المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Scientific Reportsمصطلحات موضوعية: exon-1, Huntingtin, Mutant, law.invention, Mice, Radioligand Assay, amyloid fibrils, Exon, law, alzheimers-disease, Huntingtin Protein, dysfunction, Multidisciplinary, Chemistry, Immunohistochemistry, Recombinant Proteins, Cell biology, small molecules, Huntington Disease, Recombinant DNA, Medicine, Preclinical imaging, congenital, hereditary, and neonatal diseases and abnormalities, brain, Science, Mice, Transgenic, Protein Aggregation, Pathological, Article, Protein Aggregates, Alzheimer Disease, mental disorders, Animals, Humans, Radioactive Tracers, beta-sheet structure, Pharmacology, Nitrogen Radioisotopes, toxicity, In vitro, nervous system diseases, Disease Models, Animal, polyglutamine aggregation, Positron-Emission Tomography, Diseases of the nervous system, Autoradiography, identification, Radiopharmaceuticals, Trinucleotide repeat expansion, Biomarkers, Ex vivo
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5Academic JournalFrequency of Nuclear Mutant Huntingtin Inclusion Formation in Neurons and Glia is Cell-Type-Specific
المؤلفون: Jansen, Anne H P, van Hal, Maurik, op den Kelder, Ilse C., Meier, Romy T., de Ruiter, Anna-Aster, Schut, Menno H., Smith, Donna L., Grit, Corien, Brouwer, Nieske, Kamphuis, Willem, Boddeke, H. W. G. M., den Dunnen, Wilfred F. A., van Roon, Willeke M. C., Bates, Gillian P., Hol, Elly M., Reits, Eric A.
المصدر: Jansen , A H P , van Hal , M , op den Kelder , I C , Meier , R T , de Ruiter , A-A , Schut , M H , Smith , D L , Grit , C , Brouwer , N , Kamphuis , W , Boddeke , H W G M , den Dunnen , W F A , van Roon , W M C , Bates , G P , Hol , E M & Reits , E A 2017 , ' Frequency of Nuclear Mutant Huntingtin Inclusion Formation in Neurons and Glia ....
مصطلحات موضوعية: Huntington's disease, inclusions, astrocytes, microglia, oligodendrocytes, neurons, IN MOUSE MODEL, DISEASE TRANSGENIC MICE, CENTRAL-NERVOUS-SYSTEM, POLYGLUTAMINE AGGREGATION, EXPANDED HUNTINGTIN, ALZHEIMERS-DISEASE, GENE-EXPRESSION, BRAIN
وصف الملف: application/pdf
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6
المؤلفون: Furtado Gv, Mergener R, Steven Bergink, Emma Gerrits, Mehrnoosh Oghbaie, Suzanne L Dekker, Maiara Kolbe Musskopf, Di Stefano Lh, van waarde-Verhagen Ma, Couzijn S, John LaCava, Wouter Huiting, Lara Barazzuol, Harm H. Kampinga, van der Lienden J
المساهمون: Molecular Neuroscience and Ageing Research (MOLAR), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Department of Sciences
المصدر: eLife, 11:e70726. ELIFE SCIENCES PUBLICATIONS LTD
مصطلحات موضوعية: Protein Folding, Huntingtin, Proteome, DNA damage, PROTEOSTASIS, ALPHA-B-CRYSTALLIN, Ataxia Telangiectasia Mutated Proteins, Protein aggregation, DNA damage response, General Biochemistry, Genetics and Molecular Biology, protein aggregation, Protein Aggregates, chemistry.chemical_compound, medicine, Humans, chaperone, HEAT-SHOCK PROTEINS, HSP70 Heat-Shock Proteins, ALZHEIMERS, protein homeostasis, MOLECULAR CHAPERONE, POLYGLUTAMINE AGGREGATION, biology, General Immunology and Microbiology, Kinase, General Neuroscience, Neurodegeneration, alpha-Crystallin B Chain, General Medicine, STRESS-PROTEIN, medicine.disease, genotoxic stress, Cell biology, HEK293 Cells, chemistry, Chaperone (protein), ATM, biology.protein, PHASE-TRANSITION, Peptides, NEURODEGENERATIVE DISEASES, DNA Topoisomerases, DNA, DNA Damage, Molecular Chaperones, Human
وصف الملف: application/pdf
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7Academic Journal
المؤلفون: Vos, Michel J., Carra, Serena, Kanon, Bart, Bosveld, Floris, Klauke, Karin, Sibon, Ody C. M., Kampinga, Harm H.
المصدر: Vos , M J , Carra , S , Kanon , B , Bosveld , F , Klauke , K , Sibon , O C M & Kampinga , H H 2016 , ' Specific protein homeostatic functions of small heat-shock proteins increase lifespan ' , Aging Cell , vol. 15 , no. 2 , pp. 217-226 . https://doi.org/10.1111/acel.12422
مصطلحات موضوعية: protein homeostasis, longevity, aging, Drosophila melanogaster, small heat-shock protein, HSPB family, DROSOPHILA-MELANOGASTER, MOLECULAR CHAPERONES, GENE-EXPRESSION, GENOME-WIDE, IN-VIVO, POLYGLUTAMINE AGGREGATION, CAENORHABDITIS-ELEGANS, HUNTINGTONS-DISEASE, OXIDATIVE STRESS, MAMMALIAN-CELLS
وصف الملف: application/pdf
الاتاحة: https://hdl.handle.net/11370/70f1ef3a-a9f0-452d-a7a9-cb995e6ea300
https://research.rug.nl/en/publications/70f1ef3a-a9f0-452d-a7a9-cb995e6ea300
https://doi.org/10.1111/acel.12422
https://pure.rug.nl/ws/files/41126892/Specific_protein_homeostatic_functions_of_small_heat_shock_proteins_increase_lifespan.pdf -
8Academic Journal
المؤلفون: JungKyun Im, Sangjune Kim, Young-Hun Jeong, Wanil Kim, Dohyun Lee, Woo Sirl Lee, Chang, Young-Tae, Kim, KT, Sung-Kee Chung
المساهمون: 융합생명공학부, 10104775, Chang, Young-Tae, Kim, KT
مصطلحات موضوعية: POLYGLUTAMINE AGGREGATION, MOLECULAR TRANSPORTERS, TRANSGENIC MICE, MOUSE MODEL, AUTOPHAGY, DELIVERY, NEURODEGENERATION, INCLUSIONS, CLEARANCE, PATHOLOGY
Relation: MedChemCOmm; 310; 316; SCI급, SCOPUS 등재논문; SCI; Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology & Pharmacy; 2015-OAK-0000028161; https://oasis.postech.ac.kr/handle/2014.oak/11367; 14598; MedChemCOmm, v.4, no.2, pp.310 - 316; 000314311600002; 2-s2.0-84876700771
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9
المؤلفون: Mark S. Hipp, Courtney L. Klaips, Michael H. M. Gropp, F. Ulrich Hartl
المصدر: Nature Communications, 11(1):6271. Nature Publishing Group
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)مصطلحات موضوعية: 0301 basic medicine, EXPRESSION, Protein Folding, SHOCK TRANSCRIPTION FACTORS, Huntingtin, Saccharomyces cerevisiae Proteins, Science, Regulator, General Physics and Astronomy, Nerve Tissue Proteins, Saccharomyces cerevisiae, Protein aggregation, Biochemistry, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Gene Knockout Techniques, Protein Aggregates, 0302 clinical medicine, HUNTINGTIN, Chaperones, Humans, Heat shock, HSF1, Heat-Shock Proteins, IN-VIVO, HSP70, POLYGLUTAMINE AGGREGATION, Multidisciplinary, Chemistry, HEK 293 cells, General Chemistry, CO-CHAPERONES, HSP40 Heat-Shock Proteins, Cell biology, Hsp70, DNA-Binding Proteins, 030104 developmental biology, HEK293 Cells, MOLECULAR CHAPERONES, Protein folding, HSP40 SIS1, Peptides, 030217 neurology & neurosurgery, Heat-Shock Response, Transcription Factors, HEAT-STRESS
وصف الملف: application/pdf; application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
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10Academic Journal
المؤلفون: Sugaya Keizo, Matsubara Shiro
المصدر: Molecular Neurodegeneration, Vol 7, Iss 1, p 20 (2012)
مصطلحات موضوعية: Huntington’s disease, Polyglutamine aggregation, SCA3, Stochastic kinetics model, Cumulative damage, One-hit model, Nucleated growth polymerization, Nucleation, Elongation, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6
Relation: http://www.molecularneurodegeneration.com/content/7/1/20; https://doaj.org/toc/1750-1326; https://doaj.org/article/63603a086b1545a492593e07a4f701fe
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11Academic Journal
المؤلفون: Sugaya, Keizo, Matsubara, Shiro
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12Academic Journal
المصدر: van Ham , T J , Breitling , R , Swertz , M A & Nollen , E A A 2009 , ' Neurodegenerative diseases : Lessons from genome-wide screens in small model organisms ' , EMBO Molecular Medicine , vol. 1 , no. 8-9 , pp. 360-370 . https://doi.org/10.1002/emmm.200900051
مصطلحات موضوعية: neurodegeneration, protein aggregation, genetic modifiers, small model organisms, meta-analysis, AGE-OF-ONSET, ALPHA-SYNUCLEIN, PARKINSONS-DISEASE, POLYGLUTAMINE AGGREGATION, CAENORHABDITIS-ELEGANS, HUNTINGTONS-DISEASE, C-ELEGANS, SACCHAROMYCES-CEREVISIAE, CELLULAR TOXICITY
وصف الملف: application/pdf
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المصدر: Lancet Neurology. 15(7):748-759
مصطلحات موضوعية: POLYGLUTAMINE AGGREGATION, ALPHA-SYNUCLEIN, QUALITY-CONTROL, MOLECULAR CHAPERONES, HUNTINGTONS-DISEASE, CHAPERONE-MEDIATED AUTOPHAGY, CONFORMATIONAL SWITCH, SPINOCEREBELLAR ATAXIA TYPE-3, AMYOTROPHIC-LATERAL-SCLEROSIS, MISFOLDED PROTEINS
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14
المؤلفون: Bonfanti S., Lionetti M.C., Fumagalli M.R., Chirasani V.R., Tiana G., Dokholyan N.V., Zapperi S., La Porta C.A.M.
المصدر: Scientific reports (Nature Publishing Group) 9 (2019). doi:10.1038/s41598-019-44151-0
info:cnr-pdr/source/autori:Bonfanti S.; Lionetti M.C.; Fumagalli M.R.; Chirasani V.R.; Tiana G.; Dokholyan N.V.; Zapperi S.; La Porta C.A.M./titolo:Molecular mechanisms of heterogeneous oligomerization of huntingtin proteins/doi:10.1038%2Fs41598-019-44151-0/rivista:Scientific reports (Nature Publishing Group)/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:9مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, MUTANT HUNTINGTIN, POLYGLUTAMINE AGGREGATION, mental disorders, WILD-TYPE HUNTINGTIN, nervous system diseases
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15
المؤلفون: Steven Bergink, Paola Conforti, Sjef Copray, Azra Fatima, Lara Barazzuol, Seda Koyuncu, Harm H. Kampinga, David Vilchez, Rob Bakels, Eduardo Preusser de Mattos, Jeanette F. Brunsting, Despina Serlidaki, Erik H.W.G. Boddeke, Elena Cattaneo, Arun Thiruvalluvan
المساهمون: Molecular Neuroscience and Ageing Research (MOLAR), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Translational Immunology Groningen (TRIGR)
المصدر: Molecular Cell, 78(2), 346-+. CELL PRESS
مصطلحات موضوعية: ASYMMETRIC INHERITANCE, RICH REGION, Protein aggregation, DAMAGED PROTEINS, 03 medical and health sciences, 0302 clinical medicine, Heat shock protein, medicine, HEAT-SHOCK PROTEINS, Induced pluripotent stem cell, Molecular Biology, 030304 developmental biology, 0303 health sciences, POLYGLUTAMINE AGGREGATION, biology, MUTATIONS, Neurodegeneration, Glutamate receptor, ANDROGEN RECEPTOR, Cell Biology, medicine.disease, Cell biology, CELL LINES, MOLECULAR CHAPERONES, Chaperone (protein), HUNTINGTONS-DISEASE, biology.protein, Spinocerebellar ataxia, Stem cell, 030217 neurology & neurosurgery
وصف الملف: application/pdf
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16Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell-type-specific
المؤلفون: Jansen, Anne H. P., van Hal, Maurik, Op den Kelder, Ilse C., Meier, Romy T., de Ruiter, Anna-Aster, Schut, Menno H., Smith, Donna L., Grit, Corien, Brouwer, Nieske, Kamphuis, Willem, Boddeke, H. W. G. M., den Dunnen, Wilfred F. A., van Roon, Willeke M. C., Bates, Gillian P., Hol, Elly M., Reits, Eric A.
المساهمون: Netherlands Institute for Neuroscience (NIN), Molecular Neuroscience and Ageing Research (MOLAR), Translational Immunology Groningen (TRIGR), Graduate School, Medical Biology, ANS - Cellular & Molecular Mechanisms, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Cell Biology and Histology
المصدر: GLIA, 65, 50-61. John Wiley and Sons Inc.
Glia, 65(1), 50-61. Wiley
Glia, 65(1), 50-61. John Wiley and Sons Inc.مصطلحات موضوعية: POLYGLUTAMINE AGGREGATION, inclusions, CENTRAL-NERVOUS-SYSTEM, astrocytes, microglia, oligodendrocytes, neurons, Huntington's disease, DISEASE TRANSGENIC MICE, ALZHEIMERS-DISEASE, nervous system, IN MOUSE MODEL, EXPANDED HUNTINGTIN, BRAIN, GENE-EXPRESSION
وصف الملف: application/pdf
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17
المؤلفون: Serena Carra, Karin Klauke, Bart Kanon, Floris Bosveld, Ody C. M. Sibon, Harm H. Kampinga, Michel J. Vos
المساهمون: Génétique et Biologie du Développement, Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Endocrinology Laboratory, Molecular Neuroscience and Ageing Research (MOLAR), Movement Disorder (MD)
المصدر: Aging Cell
Aging Cell, Wiley Open Access, 2016, 15 (2), pp.217-226. ⟨10.1111/acel.12422⟩
Aging Cell, 2016, 15 (2), pp.217-226. ⟨10.1111/acel.12422⟩
Aging cell, 15(2), 217-226. Wiley-Blackwell
Aging Cell, 15(2), 217-226. Wileyمصطلحات موضوعية: 0301 basic medicine, Male, [SDV]Life Sciences [q-bio], Protein aggregation, Biology, 03 medical and health sciences, JUNQ and IPOD, longevity, MAMMALIAN-CELLS, Gene expression, HSPB family, small heat-shock protein, Animals, Homeostasis, OXIDATIVE STRESS, Caenorhabditis elegans, IN-VIVO, ComputingMilieux_MISCELLANEOUS, GENE-EXPRESSION, protein homeostasis, POLYGLUTAMINE AGGREGATION, Drosophila melanogaster, Aging, Longevity, Protein homeostasis, Small heat-shock protein, Drosophila, Female, Heat-Shock Proteins, Small, Cell Biology, aging, GENOME-WIDE, Original Articles, biology.organism_classification, Cell biology, 030104 developmental biology, MOLECULAR CHAPERONES, DROSOPHILA-MELANOGASTER, Proteome, small heat‐shock protein, HUNTINGTONS-DISEASE, Protein folding, Original Article, CAENORHABDITIS-ELEGANS, Protein quality
وصف الملف: application/pdf
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18Academic Journal
المؤلفون: Kampinga, Harm H., Bergink, Steven
المصدر: Kampinga , H H & Bergink , S 2016 , ' Heat shock proteins as potential targets for protective strategies in neurodegeneration ' , Lancet Neurology , vol. 15 , no. 7 , pp. 748-759 . https://doi.org/10.1016/S1474-4422(16)00099-5
مصطلحات موضوعية: AMYOTROPHIC-LATERAL-SCLEROSIS, SPINOCEREBELLAR ATAXIA TYPE-3, CHAPERONE-MEDIATED AUTOPHAGY, ALPHA-SYNUCLEIN, QUALITY-CONTROL, MOLECULAR CHAPERONES, HUNTINGTONS-DISEASE, POLYGLUTAMINE AGGREGATION, MISFOLDED PROTEINS, CONFORMATIONAL SWITCH
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19
المصدر: EMBO Molecular Medicine. 1(8-9):360-370
مصطلحات موضوعية: POLYGLUTAMINE AGGREGATION, AGE-OF-ONSET, ALPHA-SYNUCLEIN, neurodegeneration, small model organisms, genetic modifiers, protein aggregation, meta-analysis, SACCHAROMYCES-CEREVISIAE, PARKINSONS-DISEASE, HUNTINGTONS-DISEASE, CELLULAR TOXICITY, C-ELEGANS, CAENORHABDITIS-ELEGANS, PROTEIN AGGREGATION
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20
المؤلفون: Harm H. Kampinga, Steven Bergink
المصدر: The Lancet. Neurology. 15(7)
مصطلحات موضوعية: 0301 basic medicine, ALPHA-SYNUCLEIN, Biology, Protein aggregation, AMYOTROPHIC-LATERAL-SCLEROSIS, 03 medical and health sciences, chemistry.chemical_compound, Chaperone-mediated autophagy, QUALITY-CONTROL, Heat shock protein, medicine, Animals, Humans, HSPA1L, CONFORMATIONAL SWITCH, SPINOCEREBELLAR ATAXIA TYPE-3, Heat-Shock Proteins, Alpha-synuclein, POLYGLUTAMINE AGGREGATION, Neurodegeneration, Neurodegenerative Diseases, medicine.disease, HSPA1A, 030104 developmental biology, chemistry, MOLECULAR CHAPERONES, HUNTINGTONS-DISEASE, Protein folding, CHAPERONE-MEDIATED AUTOPHAGY, Neurology (clinical), Neuroscience, MISFOLDED PROTEINS
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