نتائج البحث - "PF9601N"

1

Academic Journal

In vitro and in silico ADME-Tox profiling and safety significance of multifunctional monoamine oxidase inhibitors targeting neurodegenerative deseases

المؤلفون: Wiȩckowska, Anna, Szałaj, Natalia, Góral, Izabella, Bucki, Adam, Latacz, Gniewomir, Kiec-Kononowicz, Katarzyna, Bautista-Aguilera, Òscar M., Romero, Alejandro, Ramos, Eva, Egea, Javier, Farré Alíns, Victor, González-Rodríguez, Águeda, López-Muñoz, Francisco, Chioua, Mourad, Marco-Contelles, José

المساهمون: Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-IP), Instituto Teófilo Hernando de I+D del Medicamento (ITH), Neurotransmisión y Neuroprotección Farmacológica Teófilo Hernando (BIO M-026)

مصطلحات موضوعية: ADME-tox, Alzheimer's disease, ASS234, Contilisant, Cytochrome P450 enzymes, Cytotoxicity, MAO inhibitors, Metabolism, Multitarget directed ligands, PF9601N, Farmacia

وصف الملف: application/pdf

Relation: ACS Chemical Neuroscience; https://dx.doi.org/10.1021/acschemneuro.0c00489; ACS Chemical Neuroscience 11.22 (2020): 3793−3801; http://hdl.handle.net/10486/697966; 3793; 22; 3801; 11

الاتاحة: http://hdl.handle.net/10486/697966
https://doi.org/10.1021/acschemneuro.0c00489

View record in BASE

2

In vitro and in silico ADME-tox profiling and safety significance of multifunctional monoamine oxidase inhibitors targeting neurodegenerative diseases

المؤلفون: José Marco-Contelles, Mourad Chioua, Eva Ramos, Gniewomir Latacz, Izabella Góral, Águeda González-Rodríguez, Oscar M. Bautista-Aguilera, Víctor Farré Alins, Natalia Szałaj, Adam Bucki, Francisco López-Muñoz, Alejandro Romero, Anna Więckowska, Javier Egea, Katarzyna Kieć-Kononowicz

المساهمون: Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-IP), Instituto Teófilo Hernando de I+D del Medicamento (ITH), Neurotransmisión y Neuroprotección Farmacológica Teófilo Hernando (BIO M-026)

المصدر: Biblos-e Archivo. Repositorio Institucional de la UAM
instname
ACS Chemical Neuroscience

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa85a307aedfd9889b82ebe41f34bc9
https://ruj.uj.edu.pl/xmlui/handle/item/264594

View record in OpenAIRE

3

The effect of monoamine oxidase A and B inhibitors on the phosphporylation of tau proteins testing the therapeutic effect on Alzheimers disease

المؤلفون: Langer, Lea

المساهمون: Šimić, Goran, Hranilović, Dubravka

مصطلحات موضوعية: PRIRODNE ZNANOSTI. Biologija, hiperfosforilacija, PF9601N, klorgilin, hiperphosphorylation, NATURAL SCIENCES. Biology, Alzheimerova bolest, Tau protein, monoaminoksidaza, ASS234, Alzheimer's disease

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0f60463b3bbf850a16b3d5c21b30cff6
https://repozitorij.pmf.unizg.hr/islandora/object/pmf:662

View record in OpenAIRE

4

Academic Journal

Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease

المؤلفون: Esteban, Gerard, Allan, Jennifer, Samadi, Abdelouahid, Mattevi, Andrea, Unzeta, Mercedes, Marco-Contelles, José, Binda, Claudia, Ramsay, Rona R.

المصدر: Esteban , G , Allan , J , Samadi , A , Mattevi , A , Unzeta , M , Marco-Contelles , J , Binda , C & Ramsay , R R 2014 , ' Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease ' , Biochimica et Biophysica Acta - Proteins and Proteomics , vol. 1844 , no. 6 , pp. 1104–1110 . https://doi.org/10.1016/j.bbapap.2014.03.006

مصطلحات موضوعية: Multi-target drug, Flavin adduct, Alzheimer’s disease, ASS234, PF9601N, Crystal structure

الاتاحة: https://risweb.st-andrews.ac.uk/portal/en/researchoutput/kinetic-and-structural-analysis-of-the-irreversible-inhibition-of-human-monoamine-oxidases-by-ass234-a-multitarget-compound-designed-for-use-in-alzheimers-disease(5f3f415e-6dbb-4287-9094-0e7deb090f59).html
https://doi.org/10.1016/j.bbapap.2014.03.006

View record in BASE

5

Dissertation/ Thesis

Utjecaj inhibitora monoaminooksidaze A i B na fosforilaciju proteina tau - terapijski učinak u Alzheimerovoj bolesti ; The effect of monoamine oxidase A and B inhibitors on the phosphporylation of tau proteins testing the therapeutic effect on Alzheimers disease

المؤلفون: Langer, Lea

المساهمون: Šimić, Goran, Hranilović, Dubravka

مصطلحات موضوعية: PRIRODNE ZNANOSTI. Biologija, NATURAL SCIENCES. Biology, Alzheimerova bolest, hiperfosforilacija, PF9601N, klorgilin, Alzheimer's disease, hiperphosphorylation

وصف الملف: application/pdf

Relation: https://zir.nsk.hr/islandora/object/pmf:662; https://urn.nsk.hr/urn:nbn:hr:217:590637; https://repozitorij.unizg.hr/islandora/object/pmf:662; https://repozitorij.unizg.hr/islandora/object/pmf:662/datastream/PDF

الاتاحة: https://zir.nsk.hr/islandora/object/pmf:662
https://urn.nsk.hr/urn:nbn:hr:217:590637
https://repozitorij.unizg.hr/islandora/object/pmf:662
https://repozitorij.unizg.hr/islandora/object/pmf:662/datastream/PDF

View record in BASE

6

Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease

المؤلفون: Mercedes Unzeta, Claudia Binda, Jennifer Allan, Andrea Mattevi, José Marco-Contelles, Rona R. Ramsay, Abdelouahid Samadi, Gerard Ferrer Esteban

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a606b2b1eab2118855680535ddd9527c
http://hdl.handle.net/10261/97216

View record in OpenAIRE

7

Academic Journal

Anti-apoptotic effect of Mao-B inhibitor PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] is mediated by p53 pathway inhibition in MPP+-treated SH-SY5Y human dopaminergic cells.

المؤلفون: Sanz E., Quintana A., Battaglia V., Toninello A., Hidalgo J., Ambrosio S., Marco J. L., Tipton K. F., Unzeta M., VALOTI, MASSIMO

المساهمون: Sanz, E., Quintana, A., Battaglia, V., Toninello, A., Hidalgo, J., Ambrosio, S., Valoti, Massimo, Marco, J. L., Tipton, K. F., Unzeta, M.

مصطلحات موضوعية: apoptosi, caspase-2, MPP+, p53, PF9601N

وصف الملف: STAMPA

Relation: info:eu-repo/semantics/altIdentifier/pmid/18331475; info:eu-repo/semantics/altIdentifier/wos/WOS:000256377800029; volume:105; issue:6; firstpage:2404; lastpage:2417; numberofpages:14; journal:JOURNAL OF NEUROCHEMISTRY; http://hdl.handle.net/11365/22733; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-44649196507

الاتاحة: http://hdl.handle.net/11365/22733
https://doi.org/10.1111/j.1471-4159.2008.05326.x
http://onlinelibrary.wiley.com/doi/10.1111/jnc.2008.105.issue-6/issuetoc

View record in BASE

8

Anti-apoptotic effect of Mao-B inhibitor PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] is mediated by p53 pathway inhibition in MPP+-treated SH-SY5Y human dopaminergic cells

المؤلفون: Elisenda, Sanz, Albert, Quintana, Valentina, Battaglia, Antonio, Toninello, Juan, Hidalgo, Santiago, Ambrosio, Massimo, Valoti, Jose Luis, Marco, Keith F, Tipton, Mercedes, Unzeta

مصطلحات موضوعية: Neurons, caspase-2, p53, 1-Methyl-4-phenylpyridinium, Indoles, Monoamine Oxidase Inhibitors, Cell Death, PF9601N, apoptosis, Rats, MPP+, Neuroprotective Agents, Cell Line, Tumor, Animals, Humans, Tumor Suppressor Protein p53, Monoamine Oxidase, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::15f1b2f3a2589b5e46b3e489bd63b8b7
http://hdl.handle.net/11365/22733

View record in OpenAIRE

تنقيح النتائج