المؤلفون: Meng Zhang, Xiaoqi Zeng, Meiling She, Xingduo Dong, Jun Chen, Qingquan Xiong, Guobin Qiu, Shuyi Yang, Xiangqi Li, Guanghui Ren

المصدر: Brazilian Journal of Medical and Biological Research, Vol 57 (2024)

مصطلحات موضوعية: FRAX486, p21-activated kinase (PAK) inhibitor, Multidrug resistance, ABC transporter, ABCB1, Medicine (General), R5-920, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2024000100654&lng=en&tlng=en; http://www.scielo.br/pdf/bjmbr/v57/1414-431X-bjmbr-57-e13357.pdf; https://doaj.org/toc/1414-431X

URL الوصول: https://doaj.org/article/2822698d56194bf1845e291b61ac846c

المؤلفون: Masaki Ishii, Yasuhiko Matsumoto, Tsuyoshi Yamada, Hideko Uga, Toshiaki Katada, Shinya Ohata

المصدر: Microbiology Spectrum, Vol 11, Iss 6 (2023)

مصطلحات موضوعية: dermatophytosis, p21-activated kinase, PAK inhibitor, IPA-3, actin polymerization, Trichophyton rubrum, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2165-0497

URL الوصول: https://doaj.org/article/025cef73ab7a4f1681ab0bfb8d4d406e

المؤلفون: Gabriela M. Wright (10987620), Nick T. Gimbrone (10987623), Bhaswati Sarcar (109573), Trent R. Percy (10987626), Edna R. Gordián (10987629), Fumi Kinose (846843), Natália J. Sumi (10987632), Uwe Rix (236984), W. Douglas Cress (10987635)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, combination treatment, non-small cell lung cancer, viability ratios, FRAX 597, PAK inhibitors, non-small cell lung cancers, cell cycle arrest, synergy, P 21-Activated Kinases, pan-PAK inhibitor PF 03758309 syner., cancer treatment, PAK combination, p 21-activated kinase, PAK 4, PAK inhibitors FRAX 486, inhibitor PF 03758309, Ribociclib, 4 cell lines, lung cancer cell lines, non-small cell lung cancer lines

Relation: https://figshare.com/articles/journal_contribution/This_pdf_annotates_the_uncropped_original_Western-Blot_gel_images_for_Figs_3_S5_and_S9_captured_by_the_LI-COR_instrument_and_exported_in_tiff_format_/14800776

الاتاحة: https://doi.org/10.1371/journal.pone.0252927.s012

المؤلفون: Gabriela M. Wright (10987620), Nick T. Gimbrone (10987623), Bhaswati Sarcar (109573), Trent R. Percy (10987626), Edna R. Gordián (10987629), Fumi Kinose (846843), Natália J. Sumi (10987632), Uwe Rix (236984), W. Douglas Cress (10987635)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, combination treatment, non-small cell lung cancer, viability ratios, FRAX 597, PAK inhibitors, non-small cell lung cancers, cell cycle arrest, synergy, P 21-Activated Kinases, pan-PAK inhibitor PF 03758309 syner., cancer treatment, PAK combination, p 21-activated kinase, PAK 4, PAK inhibitors FRAX 486, inhibitor PF 03758309, Ribociclib, 4 cell lines, lung cancer cell lines, non-small cell lung cancer lines

Relation: https://figshare.com/articles/figure/Synergy_assays_for_FRAX486_and_Ribociclib_in_multiple_cancer_cell_lines_/14800746

الاتاحة: https://doi.org/10.1371/journal.pone.0252927.s002

المؤلفون: Gabriela M. Wright (10987620), Nick T. Gimbrone (10987623), Bhaswati Sarcar (109573), Trent R. Percy (10987626), Edna R. Gordián (10987629), Fumi Kinose (846843), Natália J. Sumi (10987632), Uwe Rix (236984), W. Douglas Cress (10987635)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, combination treatment, non-small cell lung cancer, viability ratios, FRAX 597, PAK inhibitors, non-small cell lung cancers, cell cycle arrest, synergy, P 21-Activated Kinases, pan-PAK inhibitor PF 03758309 syner., cancer treatment, PAK combination, p 21-activated kinase, PAK 4, PAK inhibitors FRAX 486, inhibitor PF 03758309, Ribociclib, 4 cell lines, lung cancer cell lines, non-small cell lung cancer lines

Relation: https://figshare.com/articles/figure/Synergy_assays_for_PF03758309_and_Ribociclib_in_multiple_cancer_cell_lines_/14800743

الاتاحة: https://doi.org/10.1371/journal.pone.0252927.s001

المؤلفون: Gabriela M. Wright (10987620), Nick T. Gimbrone (10987623), Bhaswati Sarcar (109573), Trent R. Percy (10987626), Edna R. Gordián (10987629), Fumi Kinose (846843), Natália J. Sumi (10987632), Uwe Rix (236984), W. Douglas Cress (10987635)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, combination treatment, non-small cell lung cancer, viability ratios, FRAX 597, PAK inhibitors, non-small cell lung cancers, cell cycle arrest, synergy, P 21-Activated Kinases, pan-PAK inhibitor PF 03758309 syner., cancer treatment, PAK combination, p 21-activated kinase, PAK 4, PAK inhibitors FRAX 486, inhibitor PF 03758309, Ribociclib, 4 cell lines, lung cancer cell lines, non-small cell lung cancer lines

Relation: https://figshare.com/articles/figure/BAD_phosphorylation_at_Serine_112_is_reduced_following_treatment_with_PAKi_/14800755

الاتاحة: https://doi.org/10.1371/journal.pone.0252927.s005

المؤلفون: Gabriela M. Wright (10987620), Nick T. Gimbrone (10987623), Bhaswati Sarcar (109573), Trent R. Percy (10987626), Edna R. Gordián (10987629), Fumi Kinose (846843), Natália J. Sumi (10987632), Uwe Rix (236984), W. Douglas Cress (10987635)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, combination treatment, non-small cell lung cancer, viability ratios, FRAX 597, PAK inhibitors, non-small cell lung cancers, cell cycle arrest, synergy, P 21-Activated Kinases, pan-PAK inhibitor PF 03758309 syner., cancer treatment, PAK combination, p 21-activated kinase, PAK 4, PAK inhibitors FRAX 486, inhibitor PF 03758309, Ribociclib, 4 cell lines, lung cancer cell lines, non-small cell lung cancer lines

Relation: https://figshare.com/articles/figure/Autophagy_and_cell_survival_/14800761

الاتاحة: https://doi.org/10.1371/journal.pone.0252927.s007

المؤلفون: Gabriela M. Wright (10987620), Nick T. Gimbrone (10987623), Bhaswati Sarcar (109573), Trent R. Percy (10987626), Edna R. Gordián (10987629), Fumi Kinose (846843), Natália J. Sumi (10987632), Uwe Rix (236984), W. Douglas Cress (10987635)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, combination treatment, non-small cell lung cancer, viability ratios, FRAX 597, PAK inhibitors, non-small cell lung cancers, cell cycle arrest, synergy, P 21-Activated Kinases, pan-PAK inhibitor PF 03758309 syner., cancer treatment, PAK combination, p 21-activated kinase, PAK 4, PAK inhibitors FRAX 486, inhibitor PF 03758309, Ribociclib, 4 cell lines, lung cancer cell lines, non-small cell lung cancer lines

Relation: https://figshare.com/articles/figure/EC_sub_50_sub_values_for_each_single_drug_used_/14800752

الاتاحة: https://doi.org/10.1371/journal.pone.0252927.s004

المؤلفون: Gabriela M. Wright (10987620), Nick T. Gimbrone (10987623), Bhaswati Sarcar (109573), Trent R. Percy (10987626), Edna R. Gordián (10987629), Fumi Kinose (846843), Natália J. Sumi (10987632), Uwe Rix (236984), W. Douglas Cress (10987635)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, combination treatment, non-small cell lung cancer, viability ratios, FRAX 597, PAK inhibitors, non-small cell lung cancers, cell cycle arrest, synergy, P 21-Activated Kinases, pan-PAK inhibitor PF 03758309 syner., cancer treatment, PAK combination, p 21-activated kinase, PAK 4, PAK inhibitors FRAX 486, inhibitor PF 03758309, Ribociclib, 4 cell lines, lung cancer cell lines, non-small cell lung cancer lines

Relation: https://figshare.com/articles/figure/Apoptosis_assays_based_on_Celigo_imaging_of_caspase_3_7_cleavage_/14800758

الاتاحة: https://doi.org/10.1371/journal.pone.0252927.s006

المؤلفون: Gabriela M. Wright (10987620), Nick T. Gimbrone (10987623), Bhaswati Sarcar (109573), Trent R. Percy (10987626), Edna R. Gordián (10987629), Fumi Kinose (846843), Natália J. Sumi (10987632), Uwe Rix (236984), W. Douglas Cress (10987635)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, combination treatment, non-small cell lung cancer, viability ratios, FRAX 597, PAK inhibitors, non-small cell lung cancers, cell cycle arrest, synergy, P 21-Activated Kinases, pan-PAK inhibitor PF 03758309 syner., cancer treatment, PAK combination, p 21-activated kinase, PAK 4, PAK inhibitors FRAX 486, inhibitor PF 03758309, Ribociclib, 4 cell lines, lung cancer cell lines, non-small cell lung cancer lines

Relation: https://figshare.com/articles/figure/Combination_drug_effects_of_clinical_CDK4_6is_in_lung_cancer_cells_/14800779

الاتاحة: https://doi.org/10.1371/journal.pone.0252927.g001

المؤلفون: Gabriela M. Wright (10987620), Nick T. Gimbrone (10987623), Bhaswati Sarcar (109573), Trent R. Percy (10987626), Edna R. Gordián (10987629), Fumi Kinose (846843), Natália J. Sumi (10987632), Uwe Rix (236984), W. Douglas Cress (10987635)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, combination treatment, non-small cell lung cancer, viability ratios, FRAX 597, PAK inhibitors, non-small cell lung cancers, cell cycle arrest, synergy, P 21-Activated Kinases, pan-PAK inhibitor PF 03758309 syner., cancer treatment, PAK combination, p 21-activated kinase, PAK 4, PAK inhibitors FRAX 486, inhibitor PF 03758309, Ribociclib, 4 cell lines, lung cancer cell lines, non-small cell lung cancer lines

Relation: https://figshare.com/articles/figure/PAK_inhibition_and_apoptosis_/14800767

الاتاحة: https://doi.org/10.1371/journal.pone.0252927.s009

المؤلفون: Gabriela M. Wright (10987620), Nick T. Gimbrone (10987623), Bhaswati Sarcar (109573), Trent R. Percy (10987626), Edna R. Gordián (10987629), Fumi Kinose (846843), Natália J. Sumi (10987632), Uwe Rix (236984), W. Douglas Cress (10987635)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, combination treatment, non-small cell lung cancer, viability ratios, FRAX 597, PAK inhibitors, non-small cell lung cancers, cell cycle arrest, synergy, P 21-Activated Kinases, pan-PAK inhibitor PF 03758309 syner., cancer treatment, PAK combination, p 21-activated kinase, PAK 4, PAK inhibitors FRAX 486, inhibitor PF 03758309, Ribociclib, 4 cell lines, lung cancer cell lines, non-small cell lung cancer lines

Relation: https://figshare.com/articles/dataset/Genotypes_and_key_mutations_in_the_cell_lines_used_in_this_study_/14800770

الاتاحة: https://doi.org/10.1371/journal.pone.0252927.s010

المؤلفون: Gabriela M. Wright (10987620), Nick T. Gimbrone (10987623), Bhaswati Sarcar (109573), Trent R. Percy (10987626), Edna R. Gordián (10987629), Fumi Kinose (846843), Natália J. Sumi (10987632), Uwe Rix (236984), W. Douglas Cress (10987635)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, combination treatment, non-small cell lung cancer, viability ratios, FRAX 597, PAK inhibitors, non-small cell lung cancers, cell cycle arrest, synergy, P 21-Activated Kinases, pan-PAK inhibitor PF 03758309 syner., cancer treatment, PAK combination, p 21-activated kinase, PAK 4, PAK inhibitors FRAX 486, inhibitor PF 03758309, Ribociclib, 4 cell lines, lung cancer cell lines, non-small cell lung cancer lines

Relation: https://figshare.com/articles/figure/Cell_cycle_arrest_and_apoptosis_/14800782

الاتاحة: https://doi.org/10.1371/journal.pone.0252927.g002

المؤلفون: Gabriela M. Wright (10987620), Nick T. Gimbrone (10987623), Bhaswati Sarcar (109573), Trent R. Percy (10987626), Edna R. Gordián (10987629), Fumi Kinose (846843), Natália J. Sumi (10987632), Uwe Rix (236984), W. Douglas Cress (10987635)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, combination treatment, non-small cell lung cancer, viability ratios, FRAX 597, PAK inhibitors, non-small cell lung cancers, cell cycle arrest, synergy, P 21-Activated Kinases, pan-PAK inhibitor PF 03758309 syner., cancer treatment, PAK combination, p 21-activated kinase, PAK 4, PAK inhibitors FRAX 486, inhibitor PF 03758309, Ribociclib, 4 cell lines, lung cancer cell lines, non-small cell lung cancer lines

Relation: https://figshare.com/articles/dataset/Summary_of_drug_treatment_phenotype_/14800803

الاتاحة: https://doi.org/10.1371/journal.pone.0252927.t004

المؤلفون: Gabriela M. Wright (10987620), Nick T. Gimbrone (10987623), Bhaswati Sarcar (109573), Trent R. Percy (10987626), Edna R. Gordián (10987629), Fumi Kinose (846843), Natália J. Sumi (10987632), Uwe Rix (236984), W. Douglas Cress (10987635)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, combination treatment, non-small cell lung cancer, viability ratios, FRAX 597, PAK inhibitors, non-small cell lung cancers, cell cycle arrest, synergy, P 21-Activated Kinases, pan-PAK inhibitor PF 03758309 syner., cancer treatment, PAK combination, p 21-activated kinase, PAK 4, PAK inhibitors FRAX 486, inhibitor PF 03758309, Ribociclib, 4 cell lines, lung cancer cell lines, non-small cell lung cancer lines

Relation: https://figshare.com/articles/dataset/In_vitro_IC_sub_50_sub_and_Ki_values_of_PF03758309_FRAX486_and_FRAX597_/14800797

الاتاحة: https://doi.org/10.1371/journal.pone.0252927.t002

المؤلفون: Gabriela M. Wright (10987620), Nick T. Gimbrone (10987623), Bhaswati Sarcar (109573), Trent R. Percy (10987626), Edna R. Gordián (10987629), Fumi Kinose (846843), Natália J. Sumi (10987632), Uwe Rix (236984), W. Douglas Cress (10987635)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, combination treatment, non-small cell lung cancer, viability ratios, FRAX 597, PAK inhibitors, non-small cell lung cancers, cell cycle arrest, synergy, P 21-Activated Kinases, pan-PAK inhibitor PF 03758309 syner., cancer treatment, PAK combination, p 21-activated kinase, PAK 4, PAK inhibitors FRAX 486, inhibitor PF 03758309, Ribociclib, 4 cell lines, lung cancer cell lines, non-small cell lung cancer lines

Relation: https://figshare.com/articles/figure/Cleavage_of_Caspase_3_and_PARP_following_treatment_with_PF03758309_and_its_combinations_/14800785

الاتاحة: https://doi.org/10.1371/journal.pone.0252927.g003

المؤلفون: Gabriela M. Wright (10987620), Nick T. Gimbrone (10987623), Bhaswati Sarcar (109573), Trent R. Percy (10987626), Edna R. Gordián (10987629), Fumi Kinose (846843), Natália J. Sumi (10987632), Uwe Rix (236984), W. Douglas Cress (10987635)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, combination treatment, non-small cell lung cancer, viability ratios, FRAX 597, PAK inhibitors, non-small cell lung cancers, cell cycle arrest, synergy, P 21-Activated Kinases, pan-PAK inhibitor PF 03758309 syner., cancer treatment, PAK combination, p 21-activated kinase, PAK 4, PAK inhibitors FRAX 486, inhibitor PF 03758309, Ribociclib, 4 cell lines, lung cancer cell lines, non-small cell lung cancer lines

Relation: https://figshare.com/articles/figure/PF03758309_and_its_combinations_induces_apoptosis_based_on_Celigo_imaging_/14800788

الاتاحة: https://doi.org/10.1371/journal.pone.0252927.g004

المؤلفون: Gabriela M. Wright (10987620), Nick T. Gimbrone (10987623), Bhaswati Sarcar (109573), Trent R. Percy (10987626), Edna R. Gordián (10987629), Fumi Kinose (846843), Natália J. Sumi (10987632), Uwe Rix (236984), W. Douglas Cress (10987635)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, combination treatment, non-small cell lung cancer, viability ratios, FRAX 597, PAK inhibitors, non-small cell lung cancers, cell cycle arrest, synergy, P 21-Activated Kinases, pan-PAK inhibitor PF 03758309 syner., cancer treatment, PAK combination, p 21-activated kinase, PAK 4, PAK inhibitors FRAX 486, inhibitor PF 03758309, Ribociclib, 4 cell lines, lung cancer cell lines, non-small cell lung cancer lines

Relation: https://figshare.com/articles/dataset/Apoptosis_in_H322_cells_or_H157_cells_/14800800

الاتاحة: https://doi.org/10.1371/journal.pone.0252927.t003

المؤلفون: Gabriela M. Wright (10987620), Nick T. Gimbrone (10987623), Bhaswati Sarcar (109573), Trent R. Percy (10987626), Edna R. Gordián (10987629), Fumi Kinose (846843), Natália J. Sumi (10987632), Uwe Rix (236984), W. Douglas Cress (10987635)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, combination treatment, non-small cell lung cancer, viability ratios, FRAX 597, PAK inhibitors, non-small cell lung cancers, cell cycle arrest, synergy, P 21-Activated Kinases, pan-PAK inhibitor PF 03758309 syner., cancer treatment, PAK combination, p 21-activated kinase, PAK 4, PAK inhibitors FRAX 486, inhibitor PF 03758309, Ribociclib, 4 cell lines, lung cancer cell lines, non-small cell lung cancer lines

Relation: https://figshare.com/articles/dataset/Synergy_values_/14800794

الاتاحة: https://doi.org/10.1371/journal.pone.0252927.t001