المؤلفون: Deal, Milena, Kar, Asha, Lee, Seung, Alvarez, Marcus, Rajkumar, Sandhya, Arasu, Uma, Kaminska, Dorota, Männistö, Ville, Heinonen, Sini, van der Kolk, Birgitta, Säiläkivi, Ulla, Saarinen, Tuure, Juuti, Anne, Pihlajamäki, Jussi, Kaikkonen, Minna, Laakso, Markku, Pietiläinen, Kirsi, Pajukanta, Päivi

المصدر: American Journal of Human Genetics. 111(11)

مصطلحات موضوعية: SAT, T-box transcription factor 15, TBX15, WHRadjBMI, abdominal obesity, adipocyte hypertrophy, population genetics, selection, single nucleus RNA sequencing, subcutaneous adipose tissue, thermogenesis, trans regulation, waist-hip ratio adjusted for body mass index, T-Box Domain Proteins, Humans, Thermogenesis, Mutation, Missense, Adipocytes, Cold Temperature, Obesity, Abdominal, Male, Female, Finland, Adaptation, Physiological, Gene Frequency, Polymorphism, Single Nucleotide, Subcutaneous Fat, Genome-Wide Association Study, Animals

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/4h30d1tr
https://escholarship.org/content/qt4h30d1tr/qt4h30d1tr.pdf

المؤلفون: Lee, Seung Hyuk, Garske, Kristina, Arasu, Uma, Kar, Asha, Miao, Zong, Alvarez, Marcus, Koka, Amogha, Darci-Maher, Nicholas, Benhammou, Jihane, Pan, David, Örd, Tiit, Kaminska, Dorota, Männistö, Ville, Heinonen, Sini, Wabitsch, Martin, Laakso, Markku, Agopian, Vatche, Pisegna, Joseph, Pietiläinen, Kirsi, Pihlajamäki, Jussi, Kaikkonen, Minna, Pajukanta, Päivi

مصطلحات موضوعية: Abdominal obesity, Colocalization, Expression quantitative trait loci (eQTL), Genome-wide association study (GWAS), Metabolic dysfunction-associated steatotic liver disease (MASLD), Single-nucleus RNA-sequencing (snRNA-seq), Waist-hip ratio adjusted for body mass index (WHRadjBMI), Humans, Obesity, Abdominal, Genome-Wide Association Study, Quantitative Trait Loci, Genetic Predisposition to Disease, Non-alcoholic Fatty Liver Disease, Polymorphism, Single Nucleotide, Sequence Analysis, RNA, Protein Phosphatase 2, Cell Nucleus, Adipogenesis, Single-Cell Analysis, Gene Expression Regulation

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/2fk3w0xb
https://escholarship.org/content/qt2fk3w0xb/qt2fk3w0xb.pdf

المؤلفون: Matilainen, Johanna, Berg, Viivi, Vaittinen, Maija, Impola, Ulla, Mustonen, Anne-Mari, Männistö, Ville, Malinen, Marjo, Luukkonen, Veera, Rosso, Natalia, Turunen, Tanja, Käkelä, Pirjo, Palmisano, Silvia, Arasu, Uma, Sihvo, Sanna, Aaltonen, Niina, Härkönen, Kai, Caddeo, Andrea, Kaminska, Dorota, Pajukanta, Päivi, Kaikkonen, Minna, Tiribelli, Claudio, Käkelä, Reijo, Laitinen, Saara, Pihlajamäki, Jussi, Nieminen, Petteri, Rilla, Kirsi

المصدر: Journal of Translational Medicine. 22(1)

مصطلحات موضوعية: Adipocyte, Adipose tissue, Extracellular vesicles, Fatty acids, Inflammation, Obesity, Humans, Extracellular Vesicles, Obesity, Adipocytes, Inflammation, Adipose Tissue, Lipid Metabolism, Female, Male, Adult, Fatty Acids

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/1bq1t2xg
https://escholarship.org/content/qt1bq1t2xg/qt1bq1t2xg.pdf

المؤلفون: Sotomayor-Rodriguez, Irene, Rahman, Afra, Péterfy, Miklós, Pajukanta, Päivi, Pihlajamäki, Jussi, Chella Krishnan, Karthickeyan, Talari, Noble, Mattam, Ushodaya, Kaminska, Dorota

المصدر: iScience. 27(5)

مصطلحات موضوعية: Biochemistry, Biological sciences, Cell biology, Physiology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/45f5v6c2

المؤلفون: Kar, Asha, Alvarez, Marcus, Garske, Kristina, Huang, Huiling, Lee, Seung, Deal, Milena, Das, Sankha, Koka, Amogha, Jamal, Zoeb, Mohlke, Karen, Laakso, Markku, Heinonen, Sini, Pietiläinen, Kirsi, Pajukanta, Päivi

المصدر: Genome Medicine. 16(1)

مصطلحات موضوعية: Adipose stem and precursor cells (ASPCs), Aging, Gene-age interactions, Obesity, Polygenic risk score (PRS), Humans, Cell Differentiation, Obesity, Adipose Tissue, Adipocytes, Aging, Transcription Factors

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/89m5044w
https://escholarship.org/content/qt89m5044w/qt89m5044w.pdf

المؤلفون: An, Ulzee, Pazokitoroudi, Ali, Alvarez, Marcus, Huang, Lianyun, Bacanu, Silviu, Schork, Andrew, Kendler, Kenneth, Pajukanta, Päivi, Flint, Jonathan, Cai, Na, Dahl, Andy, Sankararaman, Sriram, Zaitlen, Noah

المصدر: Nature Genetics. 55(12)

مصطلحات موضوعية: Humans, Genome-Wide Association Study, Genotype, Biological Specimen Banks, Deep Learning, Polymorphism, Single Nucleotide, Phenotype

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/7mj7b3zt
https://escholarship.org/content/qt7mj7b3zt/qt7mj7b3zt.pdf

المؤلفون: Das, Sankha, Kar, Asha, Rajkumar, Sandhya, Lee, Seung Hyuk, Alvarez, Marcus, Pietiläinen, Kirsi, Pajukanta, Päivi

المصدر: Arteriosclerosis, Thrombosis, and Vascular Biology. 43(10)

مصطلحات موضوعية: adipocytes, cell communication, coronary artery disease, heart, subcutaneous fat, Humans, Propionates, RNA, Coronary Artery Disease, Genome-Wide Association Study, Ligands, Adipocytes, Sequence Analysis, RNA

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/1p33s2r7
https://escholarship.org/content/qt1p33s2r7/qt1p33s2r7.pdf

المؤلفون: Lea, Amanda, Clark, Andrew, Dahl, Andrew, Devinsky, Orrin, Garcia, Angela, Golden, Christopher, Kamau, Joseph, Kraft, Thomas, Lim, Yvonne, Martins, Dino, Mogoi, Donald, Pajukanta, Päivi, Perry, George, Pontzer, Herman, Trumble, Benjamin, Urlacher, Samuel, Venkataraman, Vivek, Wallace, Ian, Lieberman, Daniel, Ayroles, Julien, Gurven, Michael

المصدر: PLoS Biology. 21(9)

مصطلحات موضوعية: Humans, Disease Susceptibility, Diabetes Mellitus, Type 2, Biological Evolution, Cardiovascular Diseases, Genomics

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/5919v104
https://escholarship.org/content/qt5919v104/qt5919v104.pdf

المؤلفون: Lea, Amanda J., Clark, Andrew G., Dahl, Andrew W., Devinsky, Orrin, Garcia, Angela R., Golden, Christopher D., Kamau, Joseph, Kraft, Thomas S., Lim, Yvonne A. L., Martins, Dino, Mogoi, Donald, Pajukanta, Paivi, Perry, George, Pontzer, Herman, Trumble, Benjamin C., Urlacher, Samuel S., Venkataraman, Vivek V., Wallace, Ian J., Gurven, Michael, Lieberman, Daniel, Ayroles, Julien F.

مصطلحات موضوعية: Quantitative Biology - Populations and Evolution, Quantitative Biology - Genomics

URL الوصول: http://arxiv.org/abs/2301.05255

المؤلفون: Darci-Maher, Nicholas, Alvarez, Marcus, Arasu, Uma Thanigai, Selvarajan, Ilakya, Lee, Seung Hyuk T, Pan, David Z, Miao, Zong, Das, Sankha Subhra, Kaminska, Dorota, Örd, Tiit, Benhammou, Jihane N, Wabitsch, Martin, Pisegna, Joseph R, Männistö, Ville, Pietiläinen, Kirsi H, Laakso, Markku, Sinsheimer, Janet S, Kaikkonen, Minna U, Pihlajamäki, Jussi, Pajukanta, Päivi

مصطلحات موضوعية: Liver, Humans, Obesity, Genome-Wide Association Study, Non-alcoholic Fatty Liver Disease, Biomarkers, Adipogenesis, Dual-tissue transcriptomics screening, Liver histology, Non-alcoholic fatty liver disease, Serum biomarkers, cis regulatory variants, Chronic Liver Disease and Cirrhosis, Digestive Diseases, Liver Disease, Prevention, Nutrition, Biotechnology, Genetics, Aetiology, 2.1 Biological and endogenous factors, Metabolic and endocrine, Clinical Sciences, Public Health and Health Services

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/29h649mt
https://escholarship.org/content/qt29h649mt/qt29h649mt.pdf

المؤلفون: Hui, Simon T, Gong, Lili, Swichkow, Chantle, Blencowe, Montgomery, Kaminska, Dorota, Diamante, Graciel, Pan, Calvin, Dalsania, Meet, French, Samuel W, Magyar, Clara E, Pajukanta, Päivi, Pihlajamäki, Jussi, Boström, Kristina I, Yang, Xia, Lusis, Aldons J

المصدر: Cellular and Molecular Gastroenterology and Hepatology. 16(6)

مصطلحات موضوعية: Biological Sciences, Biomedical and Clinical Sciences, Genetics, Chronic Liver Disease and Cirrhosis, Liver Disease, Digestive Diseases, Hepatitis, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Good Health and Well Being, Animals, Humans, Mice, Liver Cirrhosis, Non-alcoholic Fatty Liver Disease, Transforming Growth Factor beta, Transforming Growth Factors, Matrix Gla Protein, Gene Network Analysis, Liver Fibrosis, Nonalcoholic Steatohepatitis, Systems Genetics, Biochemistry and cell biology, Clinical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/2542x3z9
https://escholarship.org/content/qt2542x3z9/qt2542x3z9.pdf

المؤلفون: Alvarez, Marcus, Benhammou, Jihane N, Darci-Maher, Nicholas, French, Samuel W, Han, Steven B, Sinsheimer, Janet S, Agopian, Vatche G, Pisegna, Joseph R, Pajukanta, Päivi

المصدر: Genome Medicine. 14(1)

مصطلحات موضوعية: Biological Sciences, Bioinformatics and Computational Biology, Cancer, Clinical Research, Orphan Drug, Digestive Diseases, Liver Cancer, Rare Diseases, Human Genome, Chronic Liver Disease and Cirrhosis, Liver Disease, Genetics, Cancer Genomics, 2.1 Biological and endogenous factors, Good Health and Well Being, Biomarkers, Tumor, Carcinoma, Hepatocellular, Gene Expression Regulation, Neoplastic, Humans, Liver Neoplasms, Prognosis, Sequence Analysis, RNA, Clinical Sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/9v9756bm
https://escholarship.org/content/qt9v9756bm/qt9v9756bm.pdf

المؤلفون: Meijnikman, Abraham, van Olden, Casper, Aydin, Ömrüm, Herrema, Hilde, Kaminska, Dorota, Lappa, Dimitra, Männistö, Ville, Tremaroli, Valentina, Olofsson, Louise, de Brauw, Maurits, van de Laar, Arnold, Verheij, Joanne, Gerdes, Victor, Schwartz, Thue, Nielsen, Jens, Bäckhed, Fredrik, Pajukanta, Päivi, Pihlajamäki, Jussi, Tchkonia, Tamar, Kirkland, James, Kuipers, Folkert, Nieuwdorp, Max, Groen, Albert

المصدر: Diabetes. 71(9)

مصطلحات موضوعية: Biomarkers, Diabetes Mellitus, Type 2, Humans, Hyperinsulinism, Insulin, Insulin Resistance, Liver, Non-alcoholic Fatty Liver Disease

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/5rs475tp

المؤلفون: Miao, Zong, Garske, Kristina, Pan, David, Koka, Amogha, Kaminska, Dorota, Männistö, Ville, Sinsheimer, Janet, Pihlajamäki, Jussi, Pajukanta, Päivi

المصدر: HGG Advances. 3(1)

مصطلحات موضوعية: GWAS, Mendelian randomization, NAFLD, UK Biobank, polygenic risk score

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/5s49c8df
https://escholarship.org/content/qt5s49c8df/qt5s49c8df.pdf

المؤلفون: Rao, Shuyun, Yang, Xiaochun, Ohshiro, Kazufumi, Zaidi, Sobia, Wang, Zhanhuai, Shetty, Kirti, Xiang, Xiyan, Hassan, Md, Mohammad, Taj, Latham, Patricia, Nguyen, Bao-Ngoc, Wong, Linda, Yu, Herbert, Al-Abed, Yousef, Mishra, Bibhuti, Vacca, Michele, Guenigault, Gareth, Allison, Michael, Vidal-Puig, Antonio, Benhammou, Jihane, Alvarez, Marcus, Pajukanta, Päivi, Pisegna, Joseph, Mishra, Lopa

المصدر: Science Translational Medicine. 13(624)

مصطلحات موضوعية: Animals, Diet, High-Fat, Liver, Mice, Mice, Inbred C57BL, Neoplasms, Non-alcoholic Fatty Liver Disease, Spectrin

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/9748v9ds
https://escholarship.org/content/qt9748v9ds/qt9748v9ds.pdf

المؤلفون: Chang, Chih-Chiang, Huang, Zi-Yu, Shih, Shu-Fu, Luo, Yuan, Ko, Arthur, Cui, Qingyu, Sumner, Jennifer, Cavallero, Susana, Das, Swarna, Gao, Wei, Sinsheimer, Janet, Bui, Alex, Jacobs, Jonathan P, Pajukanta, Päivi, Wu, Holden, Tai, Yu-Chong, Li, Zhaoping, Hsiai, Tzung K

المصدر: Scientific reports. 11(1)

مصطلحات موضوعية: Digestive Diseases, Clinical Research, Biomedical Imaging, Chronic Liver Disease and Cirrhosis, Liver Disease, Oral and gastrointestinal

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/1fg4m0hb

المؤلفون: Pan, David Z, Miao, Zong, Comenho, Caroline, Rajkumar, Sandhya, Koka, Amogha, Lee, Seung Hyuk T, Alvarez, Marcus, Kaminska, Dorota, Ko, Arthur, Sinsheimer, Janet S, Mohlke, Karen L, Mancuso, Nicholas, Muñoz-Hernandez, Linda Liliana, Herrera-Hernandez, Miguel, Tusié-Luna, Maria Teresa, Aguilar-Salinas, Carlos, Pietiläinen, Kirsi H, Pihlajamäki, Jussi, Laakso, Markku, Garske, Kristina M, Pajukanta, Päivi

المصدر: Genome medicine. 13(1)

مصطلحات موضوعية: Master transcription factor, Polygenic risk score, Trans regulation of genes, Transcriptional regulation of abdominal obesity, Type 2 diabetes, Waist-hip ratio adjusted for body mass index, Genetics, Clinical Sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/5482z1w8

المؤلفون: Selvarajan, Ilakya, Toropainen, Anu, Garske, Kristina M, López Rodríguez, Maykel, Ko, Arthur, Miao, Zong, Kaminska, Dorota, Õunap, Kadri, Örd, Tiit, Ravindran, Aarthi, Liu, Oscar H, Moreau, Pierre R, Jawahar Deen, Ashik, Männistö, Ville, Pan, Calvin, Levonen, Anna-Liisa, Lusis, Aldons J, Heikkinen, Sami, Romanoski, Casey E, Pihlajamäki, Jussi, Pajukanta, Päivi, Kaikkonen, Minna U

المصدر: American Journal of Human Genetics. 108(3)

مصطلحات موضوعية: Biological Sciences, Genetics, Digestive Diseases, Atherosclerosis, Liver Disease, Heart Disease - Coronary Heart Disease, Heart Disease, Biotechnology, Human Genome, Cardiovascular, Prevention, 2.1 Biological and endogenous factors, Alleles, Chromatin, Coronary Artery Disease, Enhancer Elements, Genetic, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genomics, Humans, Liver, Male, Molecular Sequence Annotation, Organ Specificity, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Protein Binding, Quantitative Trait Loci, Risk Factors, CRISPR, GWAS, SNP, STARR-seq, cholesterol, coronary artery disease, enhancer, functional genomics, hepatocyte, liver, Medical and Health Sciences, Genetics & Heredity, Biological sciences, Biomedical and clinical sciences, Health sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/8dh4860j
https://escholarship.org/content/qt8dh4860j/qt8dh4860j.pdf

المؤلفون: Karunakaran, Denuja, Turner, Adam W, Duchez, Anne-Claire, Soubeyrand, Sebastien, Rasheed, Adil, Smyth, David, Cook, David P, Nikpay, Majid, Kandiah, Joshua W, Pan, Calvin, Geoffrion, Michele, Lee, Richard, Boytard, Ludovic, Wyatt, Hailey, Nguyen, My-Anh, Lau, Paulina, Laakso, Markku, Ramkhelawon, Bhama, Alvarez, Marcus, Pietiläinen, Kirsi H, Pajukanta, Päivi, Vanderhyden, Barbara C, Liu, Peter, Berger, Scott B, Gough, Peter J, Bertin, John, Harper, Mary-Ellen, Lusis, Aldons J, McPherson, Ruth, Rayner, Katey J

المصدر: Nature Metabolism. 2(10)

مصطلحات موضوعية: Medical Biochemistry and Metabolomics, Medical Physiology, Biomedical and Clinical Sciences, Nutrition and Dietetics, Obesity, Infectious Diseases, Genetics, Nutrition, 2.1 Biological and endogenous factors, 5.1 Pharmaceuticals, Cardiovascular, Metabolic and endocrine, Stroke, Cancer, Good Health and Well Being, Adipocytes, Adipose Tissue, Animals, Basic-Leucine Zipper Transcription Factors, Energy Metabolism, Gene Silencing, Glucose Tolerance Test, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Obese, Polymorphism, Genetic, Receptor-Interacting Protein Serine-Threonine Kinases, Subcutaneous Fat, Medical biochemistry and metabolomics, Medical physiology, Nutrition and dietetics

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/6xf6v8xv
https://escholarship.org/content/qt6xf6v8xv/qt6xf6v8xv.pdf

المؤلفون: Alvarez, Marcus, Rahmani, Elior, Jew, Brandon, Garske, Kristina M, Miao, Zong, Benhammou, Jihane N, Ye, Chun Jimmie, Pisegna, Joseph R, Pietiläinen, Kirsi H, Halperin, Eran, Pajukanta, Päivi

المصدر: Scientific reports. 10(1)

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/7j87m4kt