المؤلفون: Pölönen, R. P., Swan, H., Aalto-Setälä, K.

المساهمون: HUS Heart and Lung Center, University of Helsinki, Kardiologian yksikkö

مصطلحات موضوعية: hiPSC, Cardiomyocyte, CPVT, Patch clamp, Contraction, Carvedilol, Flecainide, POLYMORPHIC VENTRICULAR-TACHYCARDIA, CARDIAC RYANODINE RECEPTOR, CALCIUM TRANSIENTS, ACTION-POTENTIALS, COMMON DEFECT, CA2+ RELEASE, MODEL, WAVES, DEPOLARIZATION, REPOLARIZATION, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

Relation: The authors thank Henna Lappi and Markus Haponen for assistance in cell culture and Chandra Prajapati and Kim Larsson for technical assistance in patch clamp. RPP carried out the experiments and analyzed the data and wrote the manuscript, HS collected the biopsies, KAS worked the manuscript and designed the study. All authors read and approved the final manuscript. This work was financially supported by Academy of Finland, the Finnish Cultural Foundation, the Finnish Foundation for Cardiovascular Research, Paavo Nurmi foundation and the Pirkanmaa Hospital district. The authors acknowledge Tampere Facility of Electrophysiological Measurements for their service. Abstract of this manuscript has been presented in Europhysiology 2018 conference, London UK, organized by Scandinavian Physiological Society, The Physiological Society and The Deutsche Society of Physiology and The Annual meeting of Finnish Developmental Biologists 2018 at Murikka, Finland. The manuscript has been used in the PhD thesis "Modeling Arrhythmias and Drug Responses in CPVT Patient Specific hiPSC Derived Cardiomyocytes" by Risto-Pekka Polonen, Tampere University, Faculty of Medicine and Health Technology, Finland. The Heart Center, Tampere University Hospital, Tampere, Finland is affiliated to the ethical committee of Pirkanmaa Hospital District and performs research according to the guidelines of this regulatory body.; Pölönen , R P , Swan , H & Aalto-Setälä , K 2020 , ' Mutation-specific differences in arrhythmias and drug responses in CPVT patients : simultaneous patch clamp and video imaging of iPSC derived cardiomyocytes ' , Molecular Biology Reports , vol. 47 , no. 2 , pp. 1067-1077 . https://doi.org/10.1007/s11033-019-05201-y; http://hdl.handle.net/10138/325283; 0db049c6-b6dc-4bc4-b3c0-1c131bbaf8f7; 000499552000002

الاتاحة: http://hdl.handle.net/10138/325283

المؤلفون: Pekkanen-Mattila, M. (Mari), Häkli, M. (Martta), Pölönen, R.-P. (Risto-Pekka), Mansikkala, T. (Tuomas), Junnila, A. (Anni), Talvitie, E. (Elina), Koivisto, J. T. (Janne T.), Kellomäki, M. (Minna), Aalto-Setälä, K. (Katriina)

مصطلحات موضوعية: PET, biomaterials, cardiomyocytes, gene expression, iPS-cells, maturation, textile

وصف الملف: application/pdf

الاتاحة: http://urn.fi/urn:nbn:fi-fe2019101032188

المؤلفون: Pölönen, R. P., Swan, H., Aalto-Setälä, K.

المساهمون: Suomen Kulttuurirahasto, Paavo Nurmen Säätiö, Academy of Finland, Pirkanmaan Sairaanhoitopiiri, Sydäntutkimussäätiö

المصدر: Molecular Biology Reports ; volume 47, issue 2, page 1067-1077 ; ISSN 0301-4851 1573-4978

الاتاحة: http://dx.doi.org/10.1007/s11033-019-05201-y
http://link.springer.com/content/pdf/10.1007/s11033-019-05201-y.pdf
http://link.springer.com/article/10.1007/s11033-019-05201-y/fulltext.html

المؤلفون: Pölönen, R-P, Penttinen, K, Swan, H, Aalto-Setälä, K

المساهمون: Lääketieteen ja biotieteiden tiedekunta - Faculty of Medicine and Life Sciences, University of Tampere

مصطلحات موضوعية: Biolääketieteet - Biomedicine, Sisätaudit - Internal medicine

وصف الملف: fulltext

Relation: 9109503; Stem cells international; 2018; https://trepo.tuni.fi/handle/10024/103405; URN:NBN:fi:uta-201805151695

الاتاحة: https://trepo.tuni.fi/handle/10024/103405

المؤلفون: Ahola, A., Pölönen, R.-P., Aalto-Setälä, K., Hyttinen, J.

المساهمون: Pirkanmaan Rahasto, Paavo Nurmen Säätiö, Tekes

المصدر: Annals of Biomedical Engineering ; volume 46, issue 1, page 148-158 ; ISSN 0090-6964 1573-9686

الاتاحة: http://dx.doi.org/10.1007/s10439-017-1933-2
http://link.springer.com/article/10.1007/s10439-017-1933-2/fulltext.html
http://link.springer.com/content/pdf/10.1007/s10439-017-1933-2.pdf

المؤلفون: Pölönen, R. P., Swan, H., Aalto-Setälä, K.

المصدر: Molecular Biology Reports; Feb2020, Vol. 47 Issue 2, p1067-1077, 11p

المؤلفون: Ahola, A., Pölönen, R.-P., Aalto-Setälä, K., Hyttinen, J.

المصدر: Annals of Biomedical Engineering; Jan2018, Vol. 46 Issue 1, p148-158, 11p