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1
المؤلفون: Peter Kolb, Terry Kenakin, Stephen P. H. Alexander, Marcel Bermudez, Laura M. Bohn, Christian S. Breinholt, Michel Bouvier, Stephen J. Hill, Evi Kostenis, Kirill A. Martemyanov, Rick R. Neubig, H. Ongun Onaran, Sudarshan Rajagopal, Bryan L. Roth, Jana Selent, Arun K. Shukla, Martha E. Sommer, David E. Gloriam
المصدر: Kolb, P, Kenakin, T, Alexander, S P H, Bermudez, M, Bohn, L M, Breinholt, C S, Bouvier, M, Hill, S J, Kostenis, E, Martemyanov, K A, Neubig, R R, Onaran, H O, Rajagopal, S, Roth, B L, Selent, J, Shukla, A K, Sommer, M E & Gloriam, D E 2022, ' Community guidelines for GPCR ligand bias : IUPHAR review 32 ', British Journal of Pharmacology, vol. 179, no. 14, pp. 3651-3674 . https://doi.org/10.1111/bph.15811
مصطلحات موضوعية: Pharmacology, Drug Discovery, Reproducibility of Results, Ligands, Receptors, G-Protein-Coupled, Signal Transduction
وصف الملف: application/pdf
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2
المؤلفون: Karim Nagi, H. Ongun Onaran
المصدر: Cellular signalling. 83
مصطلحات موضوعية: 0301 basic medicine, Computer science, Drug discovery, Cell Biology, Computational biology, Receptors, G-Protein-Coupled, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Signalling, 030220 oncology & carcinogenesis, Drug Discovery, Functional selectivity, Animals, Humans, Signalling pathways, G protein-coupled receptor, Signal Transduction
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3Book
المؤلفون: Ongun Onaran, H, Costa, Tommaso
المصدر: Handbooks in Pharmacology and Toxicology ; Biomedical Applications of Computer Modeling ; page 109-134 ; ISSN 2154-6061 ; ISBN 9780849301001 9781420041873
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4
المؤلفون: Tommaso Costa, H. Ongun Onaran
المصدر: Cellular Signalling. 82:109955
مصطلحات موضوعية: 0301 basic medicine, Cognitive science, Classical theory, Allosteric effect, Context (language use), Cell Biology, Ligands, Receptors, G-Protein-Coupled, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Signalling, 030220 oncology & carcinogenesis, Functional selectivity, Animals, Humans, Agonism, Receptor theory, Protein Binding, Signal Transduction
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5
المؤلفون: H. Ongun Onaran, Vanessa Vezzi, Erzsebet Madaras Koncz, Maria Cristina Grò, Caterina Ambrosio, Sudarshan Rajagopal, Tommaso Costa, Özlem Uğur
المصدر: Scientific Reports
مصطلحات موضوعية: 0301 basic medicine, Systematic error, Current (mathematics), Epinephrine, Computer science, Dopamine, Gene Expression, Computational biology, Transduction (psychology), GTP-Binding Protein alpha Subunits, Gi-Go, Ligands, Article, 03 medical and health sciences, Bias, Chromogranins, GTP-Binding Protein alpha Subunits, Gs, Isoetharine, Functional selectivity, Humans, Clenbuterol, beta-Arrestins, Multidisciplinary, Isoproterenol, Regression analysis, Adrenergic Agonists, Recombinant Proteins, HEK293 Cells, 030104 developmental biology, Regression Analysis, Biological Assay, Receptors, Adrenergic, beta-2, Monte Carlo Method, Receptor theory, Protein Binding
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6
المؤلفون: Tommaso Costa, Girolamo Calo, H. Ongun Onaran, Vanessa Vezzi, Remo Guerrini, Paola Molinari, Gianfranco Balboni
المصدر: Journal of Biological Chemistry. 288:23964-23978
مصطلحات موضوعية: Quinuclidines, Drug Inverse Agonism, Arrestins, Stereochemistry, G protein, Receptors, Opioid, mu, Cooperativity, Ligands, Guanosine Diphosphate, Models, Biological, Biochemistry, GTP-binding protein regulators, GTP-Binding Proteins, Cell Line, Tumor, Receptors, Opioid, delta, Humans, Inverse agonist, Computer Simulation, Receptor, Molecular Biology, Ternary complex, beta-Arrestins, Chemistry, Cell Biology, Coupling (electronics), Tyrosine, Signal Transduction
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7
المؤلفون: H. Ongun Onaran, Tommaso Costa
المصدر: Allosterism in Drug Discovery ISBN: 9781782624592
مصطلحات موضوعية: Allosteric effect, Allosteric enzyme, biology, Chemistry, Stereochemistry, Allosteric regulation, biology.protein, Molecular mechanism, A protein, Computational biology, Protein thermodynamics, G protein-coupled receptor
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8
المؤلفون: Ali Kaya, H. Ongun Onaran, Tommaso Costa, Sezen Balli, Gulnihal Ozcan, Özlem Uğur, Caterina Ambrosio
المصدر: Journal of Biological Chemistry. 287:6362-6374
مصطلحات موضوعية: MAPK/ERK pathway, medicine.medical_specialty, Adrenergic receptor, Intrinsic activity, Arrestins, MAP Kinase Signaling System, G protein, Biology, Ligands, Biochemistry, GTP-Binding Proteins, Internal medicine, Cell Adhesion, Cyclic AMP, medicine, Functional selectivity, Humans, Phosphorylation, RNA, Small Interfering, Receptor, Protein Kinase Inhibitors, Molecular Biology, beta-Arrestins, Sulfonamides, Receptor Cross-Talk, Cell Biology, Isoquinolines, Cyclic AMP-Dependent Protein Kinases, Cell biology, HEK293 Cells, Endocrinology, Receptors, Adrenergic, beta-2, Signal transduction, Signal Transduction, Adenylyl Cyclases
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9
المؤلفون: Gulnihal Ozcan, Ş. Sadık Öner, H. Ongun Onaran, Ali Kaya, Özlem Uğur
المصدر: European Journal of Pharmacology. 630:42-52
مصطلحات موضوعية: Detergents, Adenylate kinase, Caveolae, Cell Fractionation, Kidney, Cyclase, Cell Line, Cell membrane, Membrane Microdomains, Glucosides, GTP-Binding Protein alpha Subunits, Gs, medicine, Humans, Beta (finance), Lipid raft, Pharmacology, Chemistry, Cell Membrane, Colforsin, Isoproterenol, medicine.anatomical_structure, Biochemistry, Caveolin 1, Biophysics, Receptors, Adrenergic, beta-2, Cyclase activity, Adenylyl Cyclases, Signal Transduction
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10
المؤلفون: Ongun Onaran, Terry P. Kenakin
المصدر: Trends in Pharmacological Sciences. 23:275-280
مصطلحات موضوعية: Pharmacology, Protein Conformation, Stereochemistry, Chemistry, Drug discovery, Ligand, Chemical biology, Receptors, Cell Surface, Plasma protein binding, Computational biology, Ligands, Toxicology, Protein structure, Models, Chemical, Receptor, Receptor theory, Protein Binding, G protein-coupled receptor
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11
المؤلفون: Hakan Gurdal, Demet Akin, H. Ongun Onaran
المصدر: British Journal of Pharmacology. 136:171-176
مصطلحات موضوعية: Pharmacology, Agonist, medicine.medical_specialty, Naratriptan, Chemistry, medicine.drug_class, Antagonist, Stimulation, Sumatriptan, Endocrinology, Internal medicine, cardiovascular system, medicine, Eletriptan, Receptor, medicine.drug, Serotonin Agonist
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12
المؤلفون: H. Ongun Onaran, Hakan Gurdal
المصدر: European Journal of Pharmacology. 425:181-188
مصطلحات موضوعية: Agonist, Time Factors, Macromolecular Substances, medicine.drug_class, Stereochemistry, G protein, Guinea Pigs, Binding, Competitive, Guanosine Diphosphate, Iodine Radioisotopes, chemistry.chemical_compound, Receptors, Adrenergic, beta, GTP-Binding Protein alpha Subunits, Gs, medicine, Animals, Nucleotide, Binding site, Pindolol, Lung, Ternary complex, Pharmacology, chemistry.chemical_classification, Binding Sites, Membranes, Dose-Response Relationship, Drug, Isoproterenol, Adrenergic beta-Agonists, Guanine Nucleotides, Membrane, chemistry, Guanosine diphosphate, medicine.drug
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13
المؤلفون: H. Ongun Onaran, Sudarshan Rajagopal, Tommaso Costa
مصطلحات موضوعية: Pharmacology, Intrinsic activity, Stereochemistry, Allosteric regulation, Computational biology, Transduction (psychology), Biology, Toxicology, Ligand (biochemistry), Receptors, G-Protein-Coupled, Kinetics, Functional selectivity, Thermodynamics, Receptor theory, Ternary complex, G protein-coupled receptor
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14
المؤلفون: Tommaso Costa, H. Ongun Onaran
المصدر: Annals of the New York Academy of Sciences. 812:98-115
مصطلحات موضوعية: Models, Molecular, Agonist, Protein Conformation, medicine.drug_class, General Neuroscience, Allosteric regulation, Receptors, Cell Surface, Pharmacology, Ligands, Models, Biological, Partial agonist, General Biochemistry, Genetics and Molecular Biology, Protein structure, Allosteric Regulation, History and Philosophy of Science, medicine, Inverse agonist, Receptor, Mathematics, Probability
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15
المؤلفون: H. Ongun Onaran, Tommaso Costa
المصدر: Nature chemical biology. 8(8)
مصطلحات موضوعية: Models, Molecular, Arrestin, Drug discovery, Chemistry, Protein Conformation, Allosteric regulation, Cell Membrane, Cell Biology, Plasma protein binding, Ligands, Receptors, G-Protein-Coupled, Protein structure, Biochemistry, Allosteric Regulation, Gene Expression Regulation, Drug Discovery, Functional selectivity, Animals, Signal transduction, Receptor, Molecular Biology, Neuroscience, Protein Binding, Signal Transduction
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16
المؤلفون: Carlos Eduardo Ambrósio, Ozlem Ugur, Caterina Ambrosio, Paola Molinari, Hasan Ongun Onaran, Sukru Sadik Oner, Kemal Sayar
المصدر: Molecular pharmacology. 68(3)
مصطلحات موضوعية: Pharmacology, Gs alpha subunit, GTP', G protein, Cholera toxin, Guanosine, medicine.disease_cause, Guanosine Diphosphate, Cell Line, Adenylyl cyclase, Enzyme Activation, chemistry.chemical_compound, chemistry, Biochemistry, RHO protein GDP dissociation inhibitor, medicine, GTP-Binding Protein alpha Subunits, Gs, Molecular Medicine, cAMP-dependent pathway, Humans, Guanosine Triphosphate, Receptors, Adrenergic, beta-2, Adenylyl Cyclases
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18Academic Journal
المؤلفون: Ongun Onaran, Hasan, Gürdal, Hakan
المصدر: Trends in Pharmacological Sciences ; volume 20, issue 7, page 274-278 ; ISSN 0165-6147
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19
المؤلفون: H. Ongun Onaran, Hatice Gürbüz, T.Arda Bökesoy
المصدر: General Pharmacology: The Vascular System. 22:659-661
مصطلحات موضوعية: Male, medicine.medical_specialty, Drug Resistance, In Vitro Techniques, Systemic circulation, chemistry.chemical_compound, medicine.artery, Internal medicine, medicine, Animals, Pharmacology, Aorta, Lagomorpha, biology, Histaminergic, Arteries, Anatomy, biology.organism_classification, Endocrinology, medicine.anatomical_structure, chemistry, Vasoconstriction, Circulatory system, Receptors, Histamine, Female, Rabbits, medicine.symptom, Histamine, Muscle contraction, Artery
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20
المؤلفون: Hakan Gurdal, H. Ongun Onaran
المصدر: Trends in pharmacological sciences. 20(9)
مصطلحات موضوعية: Pharmacology, Stereochemistry, Chemistry, Dimer, Thermodynamics, Context (language use), Function (mathematics), State (functional analysis), Toxicology, chemistry.chemical_compound, Distribution (mathematics), Receptor model, Constant (mathematics), Receptor