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1Academic Journal
المؤلفون: Patsy R Tomlinson, Rachel G Knox, Olga Perisic, Helen Su, Gemma V Brierley, Roger L Williams, Robert K Semple
المصدر: eLife, Vol 13 (2025)
مصطلحات موضوعية: PIK3R1, immunodeficiency, APDS2, SHORT syndrome, insulin resistance, phosphoinositide 3-kinase, Medicine, Science, Biology (General), QH301-705.5
وصف الملف: electronic resource
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2Academic Journal
المؤلفون: Shirley Tremel, Yohei Ohashi, Dustin R. Morado, Jessie Bertram, Olga Perisic, Laura T. L. Brandt, Marie-Kristin von Wrisberg, Zhuo A. Chen, Sarah L. Maslen, Oleksiy Kovtun, Mark Skehel, Juri Rappsilber, Kathrin Lang, Sean Munro, John A. G. Briggs, Roger L. Williams
المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2041-1723
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3Academic Journal
المؤلفون: Maren Heimhalt, Alex Berndt, Jane Wagstaff, Madhanagopal Anandapadamanaban, Olga Perisic, Sarah Maslen, Stephen McLaughlin, Conny Wing-Heng Yu, Glenn R Masson, Andreas Boland, Xiaodan Ni, Keitaro Yamashita, Garib N Murshudov, Mark Skehel, Stefan M Freund, Roger L Williams
المصدر: eLife, Vol 10 (2021)
مصطلحات موضوعية: mTOR, DEPTOR, cryo-EM, partial inhibition, cancer, signal transduction, Medicine, Science, Biology (General), QH301-705.5
وصف الملف: electronic resource
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4
المؤلفون: Wen-Ting Lo, Hassane Belabed, Murat Kücükdisli, Juliane Metag, Yvette Roske, Polina Prokofeva, Yohei Ohashi, André Horatscheck, Davide Cirillo, Michael Krauss, Christopher Schmied, Martin Neuenschwander, Jens Peter von Kries, Guillaume Médard, Bernhard Kuster, Olga Perisic, Roger L. Williams, Oliver Daumke, Bernard Payrastre, Sonia Severin, Marc Nazaré, Volker Haucke
مصطلحات موضوعية: Phosphatidylinositol 3-Kinases, Cancer Research, Phosphatidylinositol Phosphates, Small molecules, 500 Naturwissenschaften und Mathematik::570 Biowissenschaften, Biologie::570 Biowissenschaften, Biologie, Membrane trafficking, Cell Biology, Phosphatidylinositol 3-Kinase, Technology Platforms, Phosphatidylinositols, Molecular Biology, X-ray crystallography
وصف الملف: application/pdf
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5
المؤلفون: Madhanagopal Anandapadamanaban, Andreas Boland, Alex Berndt, Olga Perisic, Xiaodan Ni, Stefan M.V. Freund, Jane L. Wagstaff, Roger L. Williams, Sarah L. Maslen, Stephen H. McLaughlin, Keitaro Yamashita, Conny Wing-Heng Yu, Mark Skehel, Maren Heimhalt, Garib N. Murshudov, Glenn R. Masson
مصطلحات موضوعية: Chemistry, Bipartite graph, DEPTOR, PI3K/AKT/mTOR pathway, Cell biology, Partial inhibition
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6
المؤلفون: Alex Berndt, Madhanagopal Anandapadamanaban, Keitaro Yamashita, Sarah L. Maslen, Mark Skehel, Glenn R. Masson, Stefan M.V. Freund, Maren Heimhalt, Garib N. Murshudov, Roger L. Williams, Olga Perisic, Conny Wing-Heng Yu, Xiaodan Ni, Jane L. Wagstaff, Stephen H. McLaughlin, Andreas Boland
المساهمون: Heimhalt, Maren [0000-0001-9993-2884], Anandapadamanaban, Madhanagopal [0000-0002-4237-0048], McLaughlin, Stephen [0000-0001-9135-6253], Williams, Roger L [0000-0001-7754-4207], Apollo - University of Cambridge Repository
المصدر: eLife, Vol 10 (2021)
eLifeمصطلحات موضوعية: Models, Molecular, Protein Conformation, Structural Biology and Molecular Biophysics, PDZ Domains, mTORC1, Image Processing, Computer-Assisted, structural biology, Biology (General), biology, Chemistry, General Neuroscience, TOR Serine-Threonine Kinases, Intracellular Signaling Peptides and Proteins, General Medicine, Recombinant Proteins, Cell biology, mTOR, Medicine, Phosphorylation, Signal transduction, biological phenomena, cell phenomena, and immunity, signal transduction, Research Article, Protein Binding, RHEB, QH301-705.5, Science, PDZ domain, chemical biology, Mechanistic Target of Rapamycin Complex 1, DEPTOR, General Biochemistry, Genetics and Molecular Biology, partial inhibition, Biochemistry and Chemical Biology, molecular biophysics, Escherichia coli, biochemistry, Humans, cancer, human, PI3K/AKT/mTOR pathway, Binding Sites, General Immunology and Microbiology, Cell growth, Cryoelectron Microscopy, Gene Expression Regulation, biology.protein, cryo-EM, Function (biology)
وصف الملف: text/xml; application/pdf; application/zip
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7
المؤلفون: Julian Downward, Phillip T. Hawkins, Olga Perisic, Sabine Suire, Len R. Stephens, Suhasini Kulkarni, David Oxley, T. N. Durrant, N. Tsolakos, Roger L. Williams, Tamara Chessa
المصدر: Proceedings of the National Academy of Sciences of the United States of America
مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Protein subunit, GTPase, P110α, Biochemistry, PI3K, Receptor, Platelet-Derived Growth Factor beta, 03 medical and health sciences, Mice, In vivo, Avi-tag, Animals, Protein Isoforms, Receptors, Platelet-Derived Growth Factor, Phosphorylation, Receptor, Multidisciplinary, biology, Chemistry, Biological Sciences, Fibroblasts, Cell biology, Class Ia Phosphatidylinositol 3-Kinase, Mice, Inbred C57BL, 030104 developmental biology, Biotinylation, biology.protein, Dimerization, Platelet-derived growth factor receptor, isoform-selective, Protein Binding, Signal Transduction
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8
المؤلفون: Balaji Santhanam, Kacper B. Rogala, David M. Sabatini, Alex Berndt, Roger L. Williams, Glenn R. Masson, Olga Perisic, Christopher M. Johnson, Madhanagopal Anandapadamanaban, Jonathan Kaufman
المصدر: PMC
مصطلحات موضوعية: Models, Molecular, Protein Conformation, alpha-Helical, Saccharomyces cerevisiae Proteins, GTP', Protein Conformation, Protein subunit, Allosteric regulation, Guanosine, Plasma protein binding, mTORC1, GTPase, Mechanistic Target of Rapamycin Complex 1, Crystallography, X-Ray, Guanosine Diphosphate, Article, Mass Spectrometry, chemistry.chemical_compound, Humans, Protein Interaction Domains and Motifs, Amino Acids, Monomeric GTP-Binding Proteins, Multidisciplinary, biology, Cryoelectron Microscopy, Regulatory-Associated Protein of mTOR, Cell biology, chemistry, Mutation, biology.protein, Guanosine Triphosphate, biological phenomena, cell phenomena, and immunity, Lysosomes, Dimerization, Signal Transduction, RHEB, Protein Binding, Transcription Factors
وصف الملف: application/pdf
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9Academic Journal
المؤلفون: Edward H. Walker, Michael E. Pacold, Olga Perisic, Len Stephens, Philip T. Hawkins, Matthias P. Wymann, Roger L. Williams
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.322.2346; http://www.mrc-lmb.cam.ac.uk/rlw/text/pdffiles/11090628.pdf
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10Academic Journal
المؤلفون: Bazbek Davletov, Olga Perisic, Roger L. Williams
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.638.6187; http://www.mrc-lmb.cam.ac.uk/rlw/text/pdffiles/9668093.pdf
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11Academic Journal
المؤلفون: Yiqin Wu, Olga Perisic, Roger L. Williams, Matilda Katan, Mary F. Roberts
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.639.628; http://www.mrc-lmb.cam.ac.uk/rlw/text/pdffiles/9287165.pdf
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12Academic Journal
المؤلفون: Phospholipase C-δ, Lars-oliver Essen, Olga Perisic, Denise E. Lynch, Matilda Katan, Roger L. Williams
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.327.5987; http://www.mrc-lmb.cam.ac.uk/rlw/text/pdffiles/9062102.pdf
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13Academic Journal
المؤلفون: Phosphoinositide-specific Phospholipase C, Lars-oliver Essen, Olga Perisic, Matilda Katan, Yiqin Wu, Mary F. Roberts, Roger L. Williams
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.326.4983; http://www.mrc-lmb.cam.ac.uk/rlw/text/pdffiles/9048554.pdf
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14
المؤلفون: Alex Berndt, David M. Sabatini, Glenn R. Masson, Madhan Anandapadamanaban, Christopher M. Johnson, Roger L. Williams, Jonathan Kaufman, Olga Perisic, Stephen H. McLaughlin
المصدر: Molecular Cancer Research. 18:IA10-IA10
مصطلحات موضوعية: Protein kinase complex, Cancer Research, biology, Chemistry, Protein subunit, Mutant, mTORC1, GTPase, Ragulator complex, Cell biology, Oncology, G-domain, biology.protein, Cancer research, biological phenomena, cell phenomena, and immunity, Molecular Biology, RHEB
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15
المؤلفون: Sichen Shao, Olga Perisic, Glenn R. Masson, Stephen H. McLaughlin, Roger L. Williams, Alison J. Inglis, Ramanujan S. Hegde
المصدر: Proceedings of the National Academy of Sciences of the United States of America
مصطلحات موضوعية: ribosome stalling, Protein subunit, Amino Acid Motifs, Eukaryotic Initiation Factor-2, GTPase, Protein Serine-Threonine Kinases, Ribosome, Biochemistry, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Protein Domains, Integrated stress response, Humans, Phosphorylation, HDX-MS, 030304 developmental biology, P-stalk, 0303 health sciences, Multidisciplinary, Chemistry, Translation (biology), Ribosomal RNA, Biological Sciences, 3. Good health, Cell biology, Elongation factor, PNAS Plus, uL10/P1/P2, Transfer RNA, GCN2, Ribosomes, 030217 neurology & neurosurgery
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16
المؤلفون: Carsten Sachse, Nicholas T. Ktistakis, Marie L. Kirsten, Lufei Zhang, Miguel García Ortegón, Olga Perisic, Maki Ohashi, Apostolos A. Apostolakis, Nicolas Soler, Glenn R. Masson, John E. Burke, Yohei Ohashi, Roger L. Williams, Christopher M. Johnson, Arjen J. Jakobi
المصدر: 'Autophagy ', vol: 12, pages: 2129-2144 (2016)
Autophagyمصطلحات موضوعية: 0301 basic medicine, crystal structure, Saccharomyces cerevisiae Proteins, Protein subunit, Autophagy-Related Proteins, Atg38, Saccharomyces cerevisiae, Vps15, macromolecular substances, Biology, Crystallography, X-Ray, Endocytosis, EM structure, Mass Spectrometry, Vps34, 03 medical and health sciences, chemistry.chemical_compound, Protein Domains, Vps30, Protein Interaction Mapping, Atg14, Autophagy, Humans, Phosphatidylinositol, Molecular Biology, NRBF2, Structural organization, complex I, fungi, Deuterium Exchange Measurement, Cell Biology, Beclin 1, Class III Phosphatidylinositol 3-Kinases, Basic Research Paper, Cell biology, Protein Subunits, HEK293 Cells, 030104 developmental biology, chemistry, Multiprotein Complexes, Trans-Activators, Protein Multimerization, Protein Binding
وصف الملف: application/pdf
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17
المؤلفون: Anne Durandy, Fabien Garçon, Len R. Stephens, Jeffrey C. Barrett, Sergey Nejentsev, Anna Kielkowska, James Curtis, Menna R. Clatworthy, Dinakantha S. Kumararatne, Edwin R. Chilvers, Edward Banham-Hall, Andrew J. Cant, Oscar Vadas, George Farmer, Klaus Okkenhaug, Sven Kracker, Jatinder K. Juss, Deirdre Cilliers, Katherine G. Blake-Palmer, Olga Perisic, Alison M. Condliffe, Jonathan Clark, James Morris, Anita Chandra, Helen Baxendale, Vincent Plagnol, Rainer Doffinger, Capucine Picard, Mario Abinun, Christine A Fiddler, Timothy Ronan Leahy, Ivan Angulo, Mailis Maes, Nada Jabado, Phillip T. Hawkins, Marianne Debré, Tanya I. Coulter, Changxin Wu, Roger L. Williams, Gabriela Barcenas-Morales, Deborah J. Smyth, Gašper Markelj, Alain Fischer, Isabelle Pellier
المصدر: Science; Vol 342
Scienceمصطلحات موضوعية: Class I Phosphatidylinositol 3-Kinases, Activated PI3K-delta syndrome, Gene mutation, medicine.disease_cause, Phosphatidylinositol 3-Kinases, 03 medical and health sciences, 0302 clinical medicine, Phosphatidylinositol Phosphates, PIK3R1, medicine, Humans, Genetic Predisposition to Disease, Lymphocytes, Kinase activity, Respiratory Tract Infections, 030304 developmental biology, 0303 health sciences, Mutation, Multidisciplinary, Phosphoinositide 3-kinase, biology, Immunologic Deficiency Syndromes, Respiratory infection, Pedigree, 3. Good health, P110δ, Immunology, biology.protein, Proto-Oncogene Proteins c-akt, 030215 immunology
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18
المؤلفون: Takayuki Obita, Olga Perisic, Juan Martin-Serrano, Monica Agromayor, Anna Caballe, Michael A. Hadders, Roger L. Williams, Magdalena Kloc, Meindert H. Lamers
المصدر: Proceedings of the National Academy of Sciences. 109:17424-17429
مصطلحات موضوعية: Models, Molecular, Protein Folding, Multidisciplinary, Endosomal Sorting Complexes Required for Transport, Cell division, Phospholipase D, Binding protein, Membrane Proteins, macromolecular substances, Plasma protein binding, Biological Sciences, Biology, Crystallography, X-Ray, ESCRT, Cell biology, Transport protein, Midbody, Humans, Microtubule-Associated Proteins, Cytokinesis, HeLa Cells, Protein Binding
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19
المؤلفون: Mark D. Allen, Yu Ye, Roger L. Williams, Monica Agromayor, Anna Caballe, Stefan M.V. Freund, Bethan McDonald, Olga Perisic, Kay Hofmann, Mark Bycroft, Tonya Kueck, Hartmut Scheel, Stuart J. D. Neil, Nicolas Soler, Juan Martin-Serrano
المصدر: Structure. 20:414-428
مصطلحات موضوعية: Models, Molecular, Protein subunit, Human Immunodeficiency Virus Proteins, Molecular Sequence Data, macromolecular substances, Crystallography, X-Ray, GPI-Linked Proteins, Article, Immediate early protein, ESCRT, Immediate-Early Proteins, 03 medical and health sciences, 0302 clinical medicine, Ubiquitin, Antigens, CD, Structural Biology, Humans, TSG101, Viral Regulatory and Accessory Proteins, Amino Acid Sequence, Nuclear Magnetic Resonance, Biomolecular, Molecular Biology, 030304 developmental biology, 0303 health sciences, Endosomal Sorting Complexes Required for Transport, biology, Protein Structure, Tertiary, 3. Good health, Transport protein, Cell biology, Ubiquitin ligase, Biochemistry, Chromatography, Gel, biology.protein, Tetherin, Carrier Proteins, 030217 neurology & neurosurgery, Protein Binding
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20
المؤلفون: Jonathan Clark, Phillip T. Hawkins, Oscar Vadas, Olga Perisic, Roger L. Williams, Len R. Stephens, Karen E. Anderson, Xuxiao Zhang
المصدر: Molecular Cell
Molecular cellمصطلحات موضوعية: Insecta, Protein Conformation, Protein subunit, Amino Acid Motifs, Lipid kinase activity, Biology, SH2 domain, Article, Gene Expression Regulation, Enzymologic, src Homology Domains, 03 medical and health sciences, Mice, 0302 clinical medicine, Protein structure, Animals, Humans, Binding site, Phosphorylation, Molecular Biology, 030304 developmental biology, 0303 health sciences, Binding Sites, Kinase, fungi, Class Ia Phosphatidylinositol 3-Kinase, Hydrogen Bonding, Cell Biology, Cell biology, Protein Structure, Tertiary, Biochemistry, Mutagenesis, 030220 oncology & carcinogenesis, Mutation
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