-
1
المؤلفون: Liang Ouyang, Yao Liu, Jie Liu, Lu Feng, Guan Wang, Yi Chen, Meng Wang, Tingting Jiang
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 355-372 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: NTRK, neurotrophic receptor tyrosine kinase, FISH, fluorescence in situ hybridization, Review, Tropomyosin receptor kinase B, HNSCC, head and neck squamous cell carcinoma, Tropomyosin receptor kinase A, HTS, high-throughput screening, ring finger and WD repeat domain 2, E3 ubiquitin protein ligase, Tropomyosin receptor kinase C, LMNA, lamin A/C, Receptor tyrosine kinase, TPM3, tropomyosin 3, 0302 clinical medicine, MASC, mammary analogue secretory carcinoma, PROTAC proteolysis targeting chimera, QKI, SQSTM1, sequestosome 1, TPR, translocated promoter region, General Pharmacology, Toxicology and Pharmaceutics, RABGTPase activating protein 1-like, RFWD2, AML, acute myeloid leukemia, 0303 health sciences, ICC, intrahepatic cholangiocarcinoma, TRK, tropomyosin receptor kinase, Neurotrophic receptor tyrosine kinase fusions, PPL, periplakin, TP53, tumor protein P53, SBC, secretory breast carcinoma, OAK, osteoarthritis of the knee, TFG, TRK-fused gene, ARHGEF2, Rho/Rac guanine nucleotide exchange factor 2, NT3, neurotrophin-3, quaking I protein, RABGAP1L, ETV6, ETS translocation variant 6, 030220 oncology & carcinogenesis, CR, complete response, CRC, colorectal cancer, BCAN, brevican, BDNF, brain-derived neurotrophic factor, BTBD1, BTB (POZ) domain containing 1, RTK, receptor tyrosine kinase, DOR, durable objective responses, CDK-2, cyclin-dependent kinase 2, Tyrosine kinase, EWG, electron-withdrawing group, ORR, overall response rate, Neurotrophin, NCCN, National Comprehensive Cancer Network, VCL, vinculin, NGF, nerve growth factor, MPRIP, myosin phosphatase Rho interacting protein, Biology, PAN3, poly(A) nuclease 3, TRIM24, tripartite motif containing 24, Small-molecule inhibitor, NTRK fusion cancer, SCYL3, SCY1 like pseudokinase 3, 03 medical and health sciences, NACC2, NACC family member 2, NSCLC, non-small cell lung cancer, SAR, structure–activity relationship, Protein kinase B, VEGFR2, vascular endothelial growth factor receptor 2, 030304 developmental biology, DFG, Asp-Phe-Gly, CTCs, sequencing of circulating tumor cells, lcsh:RM1-950, GBM, glioblastoma multiforme, NFASC, neurofascin, NGS, next-generation sequencing of tumor tissue, FDA, U.S. Food and Drug Administration, lcsh:Therapeutics. Pharmacology, nervous system, Trk receptor, IG-C2, Ig-like C2 type I, Cancer research, biology.protein, Tropomyosin receptor kinase, AFAP1, actin filament-associated protein 1
-
2
المؤلفون: David Bar-Or, Leonard T. Rael, Elizabeth D. Frederick, Edward Brody, Gregory W. Thomas, Melissa Hausburg
المصدر: Biochemistry and Biophysics Reports
مصطلحات موضوعية: 0301 basic medicine, HSF-OAs, human synovial fibroblasts from patients with osteoarthritis, Prostaglandin, ΔΔCT, comparative threshold cycle, Biochemistry, chemistry.chemical_compound, 0302 clinical medicine, Prostaglandin E2, qPCR, quantitative real-time polymerase chain reaction, LMWF-5A, molecular weight fraction of human serum albumin under 5000 Da, TNF, tumor necrosis factor, medicine.diagnostic_test, biology, SDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, Human serum albumin, ELISA, enzyme-linked immunosorbent assay, OAK, osteoarthritis of the knee, NSAIDs, non-steroidal anti-inflammatory drugs, 15d-PGJ2, 15-deoxy-Δ12,14-prostaglandin J2, medicine.anatomical_structure, PGD2, prostaglandin D2, OA, osteoarthritis, Tumor necrosis factor alpha, Prostaglandin D2, medicine.symptom, medicine.drug, Research Article, medicine.medical_specialty, PVDF, polyvinylidene fluoride, Biophysics, PGH2, prostaglandin H2, IgG, immunoglobulin G, NF-κB, nuclear factor-κB, Inflammation, Synovial fibroblast, SEM, standard error of the mean, 03 medical and health sciences, Western blot, FBS, fetal bovine serum, Internal medicine, Osteoarthritis, medicine, PGE2, prostaglandin E2, PG, prostaglandin, 030203 arthritis & rheumatology, PBMCs, peripheral blood mononuclear cells, LOD, limit of detection, business.industry, IL, interleukin, COX, cyclooxygenase, PPARγ, peroxisome proliferator-activated receptor γ, 030104 developmental biology, Endocrinology, chemistry, DMEM/F12, Dulbecco’s Modified Eagle Medium/Nutrient Mixture F-12, Cyclooxygenase 2, Immunology, biology.protein, Cyclooxygenase, Synovial membrane, business, hMSCs, human mesenchymal stem cells, HSA, human serum albumin