نتائج البحث - "Nutraceutical combination"

المساهمون: Carrizzo, A., Moltedo, O., Damato, A., Martinello, K., Di Pietro, P., Oliveti, M., Acernese, F., Giugliano, G., Izzo, R., Sommella, E., Migliarino, S., Piazza, O., Izzo, C., Virtuoso, N., Strianese, A., Trimarco, V., Campiglia, P., Fucile, S., Puca, A., Trimarco, B., Vecchione, C.

المصدر: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

مصطلحات موضوعية: Male, AkP05 reduced BP and improved endothelial function, Disease, 030204 cardiovascular system & hematology, Camellia sinensis, chemistry.chemical_compound, and end-organ damage. However, Mice, 0302 clinical medicine, endothelial function, cardiovascular disease, Medicine, Stroke, Original Research, 0303 health sciences, Exercise Tolerance, and circulating nitric oxide were assessed before and at the end of 4 weeks of treatment. Twenty-four patients were randomized to diuretic or AkP05 for 4 weeks and underwent a cardiopulmonary exercise test to evaluate the effects of AkP05 on functional capacity of the cardiovascular, Exercise capacity, Middle Aged, Background-—High blood pressure (BP) has long been recognized as a major health threat and, exercise capacity, and muscular systems. Vascular and molecular studies were undertaken on mice to characterize the action of the single compounds contained in the AkP05 nutraceutical combination. AkP05 supplementation reduced BP, cardiopulmonary exercise test revealed that AkP05 increased maximum O2 uptake, Hypertension, Cardiology, Female, Background-—High blood pressure (BP) has long been recognized as a major health threat and, particularly, a major risk factor for stroke, cardiovascular disease, and end-organ damage. However, the identification of a novel, alternative, integrative approach for the control of BP and cardiovascular protection is still needed. Methods and Results-—Sixty-nine uncontrolled hypertension patients, aged 40 to 68 years, on antihypertensive medication were enrolled in 2 double-blind studies. Forty-five were randomized to placebo or a new nutraceutical combination named AkP05, and BP, endothelial function, and circulating nitric oxide were assessed before and at the end of 4 weeks of treatment. Twenty-four patients were randomized to diuretic or AkP05 for 4 weeks and underwent a cardiopulmonary exercise test to evaluate the effects of AkP05 on functional capacity of the cardiovascular, pulmonary, and muscular systems. Vascular and molecular studies were undertaken on mice to characterize the action of the single compounds contained in the AkP05 nutraceutical combination. AkP05 supplementation reduced BP, improved endothelial function, and increased nitric oxide release, cardiopulmonary exercise test revealed that AkP05 increased maximum O2 uptake, stress tolerance, and maximal power output. In mice, AkP05 reduced BP and improved endothelial function, evoking increased nitric oxide release through the PKCa/Akt/endothelial nitric oxide synthase pathway and reducing reactive oxygen species production via NADPH-oxidase inhibition. These effects were mediated by synergism of the single compounds of AkP05. Conclusions-—This is the first study reporting positive effects of a nutraceutical combination on the vasculature and exercise tolerance in treated hypertensive patients. Our findings suggest that AkP05 may be used as an adjunct for the improvement of cardiovascular protection and to better control BP in uncontrolled hypertension, Cardiology and Cardiovascular Medicine, evoking increased nitric oxide release through the PKCa/Akt/endothelial nitric oxide synthase pathway and reducing reactive oxygen species production via NADPH-oxidase inhibition. These effects were mediated by synergism of the single compounds of AkP05. Conclusions-—This is the first study reporting positive effects of a nutraceutical combination on the vasculature and exercise tolerance in treated hypertensive patients. Our findings suggest that AkP05 may be used as an adjunct for the improvement of cardiovascular protection and to better control BP in uncontrolled hypertension, integrative approach for the control of BP and cardiovascular protection is still needed. Methods and Results-—Sixty-nine uncontrolled hypertension patients, particularly, alternative, Adult, medicine.medical_specialty, pulmonary, on antihypertensive medication were enrolled in 2 double-blind studies. Forty-five were randomized to placebo or a new nutraceutical combination named AkP05, Phosphatidylserines, Nitric Oxide, Nitric oxide, 03 medical and health sciences, Nutraceutical, Double-Blind Method, Internal medicine, Animals, Humans, a major risk factor for stroke, and BP, Risk factor, aged 40 to 68 years, and maximal power output. In mice, 030304 developmental biology, Aged, stress tolerance, business.industry, Mechanism (biology), and increased nitric oxide release, Ginkgo biloba, vascular biology, medicine.disease, nitric oxide, improved endothelial function, Blood pressure, chemistry, Dietary Supplements, Exercise Test, Bacopa, Plant Preparations, the identification of a novel, business, Reactive Oxygen Species, Phytotherapy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e8335ac991dabbb0760a81cf9188c4
https://pubmed.ncbi.nlm.nih.gov/32078787

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9

Academic Journal

A nutraceutical combination reduces left ventricular mass in subjects with metabolic syndrome e and left ventricular hypertrophy: A multicenter, randomized, double-blind, placebo-controlled trial

المؤلفون: Mercurio V., Pucci G., Bosso G., Fazio V., Battista F., Iannuzzi A., Brambilla N., Vitalini C., D'Amato M., Giacovelli G., Vaudo G., Schillaci G., Galletti F., Bonaduce D.

المساهمون: Mercurio, V., Pucci, G., Bosso, G., Fazio, V., Battista, F., Iannuzzi, A., Brambilla, N., Vitalini, C., D'Amato, M., Giacovelli, G., Vaudo, G., Schillaci, G., Galletti, F., Bonaduce, D.

مصطلحات موضوعية: Echocardiography, Left ventricular hypertrophy, Metabolic syndrome, Nutraceutical combination

وصف الملف: STAMPA

Relation: info:eu-repo/semantics/altIdentifier/pmid/31371114; info:eu-repo/semantics/altIdentifier/wos/WOS:000530205900010; journal:CLINICAL NUTRITION; http://hdl.handle.net/11391/1453614; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85069851432; http://www.elsevier-international.com/journals/clnu/

الاتاحة: http://hdl.handle.net/11391/1453614
https://doi.org/10.1016/j.clnu.2019.06.026
http://www.elsevier-international.com/journals/clnu/

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10

A nutraceutical combination reduces left ventricular mass in subjects with metabolic syndrome and left ventricular hypertrophy: A multicenter, randomized, double-blind, placebo-controlled trial

المؤلفون: Ferruccio Galletti, Francesca Battista, Giorgio Bosso, Angela Iannuzzi, Giuseppe Schillaci, Giacomo Pucci, Nadia Brambilla, Giampaolo Giacovelli, Cristina Vitalini, Valeria Fazio, Valentina Mercurio, Gaetano Vaudo, Massimo D'Amato, Domenico Bonaduce

المساهمون: Mercurio, V., Pucci, G., Bosso, G., Fazio, V., Battista, F., Iannuzzi, A., Brambilla, N., Vitalini, C., D'Amato, M., Giacovelli, G., Vaudo, G., Schillaci, G., Galletti, F., Bonaduce, D.

المصدر: Clinical nutrition (Edinburgh, Scotland). 39(5)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e17f06cdaf5155506c20463d22e9e9b3
https://pubmed.ncbi.nlm.nih.gov/31371114

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