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1
المؤلفون: Nese Kurt Yilmaz, Desaboini Nageswara Rao, Hasahn L. Conway, Mohsan Saeed, Alicia Newton, Adam K. Hedger, Jacqueto Zephyr, Ashley N. Matthew, Akbar Ali, Mina Henes, Elise T Chan, Wei Huang, Christos J. Petropoulos, Celia A. Schiffer
المصدر: J Med Chem
مصطلحات موضوعية: Male, Macrocyclic Compounds, Hepatitis C virus, medicine.medical_treatment, Hepacivirus, Drug resistance, Viral Nonstructural Proteins, Crystallography, X-Ray, medicine.disease_cause, Antiviral Agents, Cocrystal, Article, Rats, Sprague-Dawley, Structure-Activity Relationship, chemistry.chemical_compound, Quinoxaline, Quinoxalines, Drug Resistance, Viral, Drug Discovery, Genotype, medicine, Animals, Protease Inhibitors, Protease, Molecular Structure, Chemistry, Glecaprevir, Hepatitis C, Biochemistry, Molecular Medicine, Serine Proteases, Ns3 4a protease, Protein Binding
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2
المؤلفون: Nicholas A. Meanwell, Ravi Kumar Trivedi, Tatyana Zvyaga, Richard Rampulla, Sarkunam Kandhasamy, Debarati Mazumder Tagore, Sureshbabu Vishwakrishnan, Arvind Mathur, Sunitha Puttaswamy, Abhijith Rao, Hua Fang, Sankar Sivaprasad, Susan Jenkins, Eric Mull, Kathy Mosure, Kaushik Ghosh, Barbara Zheng, Subba Reddy, Fiona McPhee, Chaoqun Chen, Bowsher Michael S, James Loy, Ying-Kai Wang, Amit Kumar, Ramkumar Rajamani, Kishore Rendunchintala, Paul Michael Scola, Gillis Eric P, Salil D. Desai, Li-Qiang Sun, Rushith Kumar Anumula, Nagalakshmi Pulicharla, Sheldon Hiebert, Venkata Rao Baratam, Paul Falk, Sarmistha Sinha, Stanley D'andrea
المصدر: Journal of Medicinal Chemistry. 63:14740-14760
مصطلحات موضوعية: Serine Proteinase Inhibitors, viruses, Hepatitis C virus, CHO Cells, Hepacivirus, Microbial Sensitivity Tests, Tripeptide, Viral Nonstructural Proteins, medicine.disease_cause, Antiviral Agents, Peptides, Cyclic, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, Cricetulus, Drug Stability, Drug Discovery, Genotype, medicine, Animals, 030304 developmental biology, 0303 health sciences, NS3, Molecular Structure, Chemistry, virus diseases, Virology, digestive system diseases, Third generation, Rats, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Microsomes, Liver, Molecular Medicine, Ns3 4a protease
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3
المؤلفون: Daniel D. Caspi, Kenneth M. Engstrom, Seble H. Wagaw, Nandkishor K. Nere, Dean S. Clyne, Clifford Mitchell, Timothy A. Grieme, Ahmad Y. Sheikh, Jianzhang Mei, Moiz Diwan, Hongqiang Zhang, Robert W. Miller, Russell D. Cink, Matthew M. Ravn, José G. Napolitano
المصدر: Tetrahedron. 75:4271-4286
مصطلحات موضوعية: NS3, Dipeptide, Chemistry, Process development, Organic Chemistry, Biochemistry, Combinatorial chemistry, First generation, chemistry.chemical_compound, Ring-closing metathesis, Drug Discovery, Hcv treatment, Protease inhibitor (pharmacology), Ns3 4a protease
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4
المصدر: Virology. 557:101-102
مصطلحات موضوعية: DDB1, Virology, Hepatitis C virus, medicine, Substrate (chemistry), Biology, medicine.disease_cause, Ns3 4a protease
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5
المؤلفون: Ying Wei, Jiang Du, Jing-Jie Zhang, Meena Kishore Sakharkar, Xia Wang, Jian Yang, Qin Liu
مصطلحات موضوعية: Protease, 010405 organic chemistry, Hepatitis C virus, medicine.medical_treatment, Organic Chemistry, Extraction (chemistry), Ethyl acetate, virus diseases, Plant Science, Hepatitis C, medicine.disease, medicine.disease_cause, 01 natural sciences, Biochemistry, digestive system diseases, 0104 chemical sciences, Analytical Chemistry, Microbiology, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, medicine, Inhibitory effect, Lead compound, Ns3 4a protease
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6
المؤلفون: Sanja Glisic, Milan Sencanski
المصدر: Frontiers in Clinical Drug Research-Anti Infectives
Frontiers in Clinical Drug Research: Anti-Infectivesمصطلحات موضوعية: Hepatitis C Virus, Direct-Acting Antivirals, Hepatitis C virus, NS3/4A protease, Chemical Synthesis, Clinical Trials Data, medicine.disease_cause, Virology, Clinical trial, Drug Design, medicine, Protease Inhibitors, Direct acting, Ns3 4a protease
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7
المؤلفون: Jungchul Kim, Jacob H. Waldman, Paul N. Devine, Feng Xu, Tao Wang
المصدر: Organic letters. 20(22)
مصطلحات موضوعية: Cyclopropanes, Hepatitis C virus, Hepacivirus, Viral Nonstructural Proteins, 010402 general chemistry, medicine.disease_cause, 01 natural sciences, Biochemistry, Antiviral Agents, Quinoxalines, medicine, Physical and Theoretical Chemistry, Sulfonamides, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Virology, Amides, 0104 chemical sciences, Grazoprevir, Cyclization, Yield (chemistry), Carbamates, Serine Proteases, Ns3 4a protease
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8
المؤلفون: Hong-Ping Liang, Jian-Min Ji, Hotta Hak
المصدر: European Journal of Inflammation, Vol 16 (2018)
مصطلحات موضوعية: 0301 basic medicine, NS3, Hepatitis C virus, viruses, Immunology, lcsh:R, virus diseases, lcsh:Medicine, Endogeny, Transfection, Biology, biology.organism_classification, medicine.disease_cause, Virology, Nuclear translocation, Sendai virus, 03 medical and health sciences, 030104 developmental biology, Interferon, medicine, Immunology and Allergy, Ns3 4a protease, medicine.drug
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9
المؤلفون: Guofeng Cheng, Diana M. Brainard, Eric Lawitz, Jenny C. Yang, Hongmei Mo, Michael D. Miller, James G Taylor, Hadas Dvory-Sobol, Luisa M. Stamm
المصدر: Antiviral therapy. 23(4)
مصطلحات موضوعية: 0301 basic medicine, Cyclopropanes, Aminoisobutyric Acids, Macrocyclic Compounds, Time Factors, Genotype, Proline, viruses, Voxilaprevir, Lactams, Macrocyclic, HCV genotypes, Hepacivirus, Virus Replication, Cell Line, 03 medical and health sciences, Leucine, Quinoxalines, Drug Resistance, Viral, Humans, Pharmacology (medical), Protease inhibitor (pharmacology), Protease Inhibitors, Pharmacology, NS3, Sulfonamides, Chemistry, Sequence Analysis, RNA, virus diseases, Viral Load, Virology, Hepatitis C, digestive system diseases, 030104 developmental biology, Infectious Diseases, Treatment Outcome, RNA, Viral, Ns3 4a protease
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10
المؤلفون: Mahmoud E. S. Soliman, Letitia Shunmugam, Pritika Ramharack
المصدر: The protein journal. 36(5)
مصطلحات موضوعية: 0301 basic medicine, HCV NS3/4A Protease Inhibitors, Bioengineering, Computational biology, Biology, Viral Nonstructural Proteins, Biochemistry, Antiviral Agents, Analytical Chemistry, 03 medical and health sciences, Humans, Protease Inhibitors, Road map, Drug discovery, Organic Chemistry, Hepatitis C, Molecular Docking Simulation, 030104 developmental biology, Viral protease, Covalent bond, Drug Design, Structure based, Serine Proteases, Ns3 4a protease, Potential toxicity
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11
المؤلفون: Stuart C. Gordon, Lisa Moorehead, Eric Lawitz, William E. Delaney, Michael Demicco, John G. McHutchison, Maribel Rodriguez-Torres, Jenny C. Yang, J. Hill, Hongmei Mo, Thomas Marbury, Anita Mathias
المصدر: Antiviral Therapy. 18:311-319
مصطلحات موضوعية: Adult, Male, Genotype, medicine.medical_treatment, Hepacivirus, Viral Nonstructural Proteins, Pharmacology, Placebo, Antiviral Agents, Hcv genotype 1, Pharmacokinetics, Drug Resistance, Viral, medicine, Humans, Protease Inhibitors, Pharmacology (medical), Aged, Protease, business.industry, Intracellular Signaling Peptides and Proteins, Hepatitis C, Middle Aged, Viral Load, medicine.disease, In vitro, Treatment Outcome, Infectious Diseases, Mutation, Quinolines, RNA, Viral, Female, Carrier Proteins, business, Ns3 4a protease
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12
المؤلفون: Nuria Cañete, Ester Aparicio, Montserrat García-Retortillo, Cristina Tural, Sandra Franco, Rocío Bellido, Ricard Solà, Miguel Angel Martinez, Roger Paredes, Bonaventura Clotet
المصدر: Journal of Viral Hepatitis. 18:e578-e582
مصطلحات موضوعية: NS3, Protease, High prevalence, Hepatology, medicine.medical_treatment, Hepatitis C virus, Ribavirin, Mutant, virus diseases, Biology, medicine.disease_cause, Virology, digestive system diseases, chemistry.chemical_compound, Infectious Diseases, chemistry, medicine, Variants of PCR, Ns3 4a protease
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13
المؤلفون: Elina Teicher, Yazdan Yazdanpanah, Stanislas Pol, J.-M. Molina, Eric Rosenthal, A. Naqvi, M Dupon, E. Billaud, Vincent Leroy, G.-P. Pageaux, P. Perré, Stéphanie Dominguez, Lionel Piroth, S. Metivier, Marc-Antoine Valantin, Hugues Aumaitre, Alain Renault, Patrizia Carrieri, Philippe Morlat, Claire Fougerou-Leurent, I. Amri, R. Garraffo, David Zucman, Stéphane Chevaliez, Isabelle Poizot-Martin, P. de Truchis, Thierry Allegre, Julie Chas, Jacques Reynes, A. Pailhé, Karine Lacombe, Laurent Cotte, Pierre-Marie Girard, Dominique Salmon-Ceron, Eric Bellissant, V. Jeantils, François Bailly, M. Bourlière, François Raffi, Didier Neau
المساهمون: Hôpital l'Archet, Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Hôpital Bicêtre, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Service d'hépatologie médicale [CHU Cochin], Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Département d'infectiologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service des maladies infectieuses, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Service des maladies infectieuses et tropicales [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Services de Maladies Infectieuses et Tropicales [CHU Bichat], AP-HP - Hôpital Bichat - Claude Bernard [Paris], Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Hôpital Foch [Suresnes], Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U912 INSERM - Aix Marseille Univ - IRD), Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), Services des Maladies Infectieuses et Tropicales [CHU Saint-Antoine], CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service d'Hépato-gastroentérologie, Assistance Publique - Hôpitaux de Marseille (APHM), Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre d'Investigation Clinique [Rennes] ( CIC ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Bicêtre, Centre Hospitalier Lyon Sud [CHU - HCL] ( CHLS ), Hospices Civils de Lyon ( HCL ), CHU Cochin [AP-HP]-Assistance publique - Hôpitaux de Paris (AP-HP), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), CHU Cochin [AP-HP], Centre hospitalier universitaire de Nantes ( CHU Nantes ), Service des maladies infectieuses [CHU Bichat], Hôpital Sainte-Marguerite [CHU - APHM] ( Hôpitaux Sud ), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale ( SESSTIM - U912 INSERM - AMU - IRD ), Institut de Recherche pour le Développement ( IRD ) -Aix Marseille Université ( AMU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Saint-Antoine [APHP], Assistance Publique - Hôpitaux de Marseille ( APHM )
المصدر: Journal of Hepatology
Journal of Hepatology, Elsevier, 2016, 64, pp.S764--S764
Journal of Hepatology, 2016, 64, pp.S764--S764مصطلحات موضوعية: 0303 health sciences, [ SDV ] Life Sciences [q-bio], Hepatology, business.industry, [SDV]Life Sciences [q-bio], Virology, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Hcv genotype 1, LEDIPASVIR/SOFOSBUVIR, Medicine, 030211 gastroenterology & hepatology, business, Ns3 4a protease, Hiv co infection, 030304 developmental biology
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14
المؤلفون: Masayuki Murata, Takeo Hayashi, Jun Hayashi, Takeshi Uchiumi, Haru Mukae, Motohiro Shimizu, Norihiro Furusyo, Eiichi Ogawa, Kazuhiro Toyoda, Taeko Hotta
المصدر: Antiviral research. 126
مصطلحات موضوعية: Simeprevir, Male, medicine.medical_specialty, Hepatitis C virus, Hepacivirus, Viral Nonstructural Proteins, medicine.disease_cause, Real-Time Polymerase Chain Reaction, Gastroenterology, Antiviral Agents, Telaprevir, 03 medical and health sciences, 0302 clinical medicine, Pegylated interferon, Virology, Internal medicine, medicine, Humans, Protease inhibitor (pharmacology), Protease Inhibitors, 030212 general & internal medicine, Aged, Pharmacology, NS3, business.industry, virus diseases, Hepatitis C, Chronic, Middle Aged, digestive system diseases, Real-time polymerase chain reaction, Treatment Outcome, RNA, Viral, 030211 gastroenterology & hepatology, Drug Therapy, Combination, Female, business, Ns3 4a protease, medicine.drug
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15
المؤلفون: Simone Susser, Oliver Lenz, D. Perner, Bart Fevery, L. Gilles, Christoph Sarrazin, Gavin Cloherty, Sandra De Meyer, Patrick De Locht, Gaston Picchio
المصدر: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 72
مصطلحات موضوعية: Simeprevir, Genotype, Concordance, Hepatitis C virus, Hepacivirus, medicine.disease_cause, Antiviral Agents, chemistry.chemical_compound, Virology, Ribavirin, TaqMan, Medicine, Humans, Protease Inhibitors, Retrospective Studies, NS3, business.industry, virus diseases, Interferon-alpha, Hepatitis C, Chronic, Viral Load, digestive system diseases, Infectious Diseases, chemistry, Clinical Trials, Phase III as Topic, RNA, Viral, Drug Monitoring, business, Ns3 4a protease
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16
المؤلفون: Cynthia A. Gates, John A. Thomson, Kevin M. Cottrell, Yu P. Luong, Scott L. Harbeson, Robert B. Perni, John H. Van Drie, David D. Deininger, Roger D. Tung, Shawn D. Britt, Chao Lin, Janos Pitlik, Luc J. Farmer, John J. Court, Yunyi Wei, John Maxwell, Kai Lin, Bhisetti Govinda Rao, Lawrence F. Courtney, Wayne C. Schairer
المصدر: Letters in Drug Design & Discovery. 2:497-502
مصطلحات موضوعية: NS3, Hepatitis B virus DNA polymerase, Chemistry, Hepatitis C virus, Pharmaceutical Science, medicine.disease_cause, Virology, Hepatitis B virus PRE beta, NS2-3 protease, Drug Discovery, medicine, Molecular Medicine, Proline, Ns3 4a protease
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17
المؤلفون: Bert M Klebl
المصدر: Expert Opinion on Investigational Drugs. 14:343-348
مصطلحات موضوعية: Pharmacology, Ribavirin, Hepatitis C virus, High mortality, Human immunodeficiency virus (HIV), virus diseases, Influenza a, General Medicine, Biology, medicine.disease_cause, Virology, chemistry.chemical_compound, chemistry, Immunology, medicine, Pharmacology (medical), Ns3 4a protease
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18
المؤلفون: Armen Asatryan, Thomas Reisch, Rakesh Tripathi, Gretja Schnell, Preethi Krishnan, Tatyana Dekhtyar, Y. Lei, Tami Pilot-Matias, Teresa I. Ng, Michelle Irvin, Federico J. Mensa, Christine Collins, Jill Beyer
المصدر: Journal of Hepatology. 66:S708-S709
مصطلحات موضوعية: 0301 basic medicine, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Hepatology, business.industry, Medicine, 030211 gastroenterology & hepatology, Glecaprevir / pibrentasvir, NS5A, business, Virology, Ns3 4a protease
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المؤلفون: Claudia Bianco, Andrea De Luca, Barbara Rossetti
المصدر: Current opinion in pharmacology. 18
مصطلحات موضوعية: Drug, Pharmacology, media_common.quotation_subject, Ribavirin, Drug Discovery3003 Pharmaceutical Science, Biology, Viral Nonstructural Proteins, Settore MED/17 - MALATTIE INFETTIVE, Antiviral Agents, Hepatitis C, chemistry.chemical_compound, Humans, Protease Inhibitors, Tolerability, Grazoprevir, chemistry, Drug Discovery, Toxicity, Genotype, Potency, Ns3 4a protease, media_common
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20
المصدر: JAIDS Journal of Acquired Immune Deficiency Syndromes. 51:106-108
مصطلحات موضوعية: Adult, Male, Genes, Viral, Anti-HIV Agents, Mutant, HIV Infections, Hepacivirus, Viral Nonstructural Proteins, Viral Proteins, Drug Resistance, Viral, medicine, Humans, Protease Inhibitors, Pharmacology (medical), business.industry, Intracellular Signaling Peptides and Proteins, Hepatitis C, Middle Aged, medicine.disease, Virology, Antiretroviral therapy, Natural resistance, Infectious Diseases, Mutation, Female, Carrier Proteins, business, Ns3 4a protease