المؤلفون: Rudolf Mueller, Virsinha Reddy, Aloysius T. Nchinda, Fanuel Mebrahtu, Dale Taylor, Nina Lawrence, Lloyd Tanner, Marine Barnabe, Charles J. Eyermann, Bin Zou, Ravinder R. Kondreddi, Suresh B. Lakshminarayana, Matthias Rottmann, Leslie J. Street, Kelly Chibale

المصدر: ACS Omega, Vol 5, Iss 12, Pp 6967-6982 (2020)

مصطلحات موضوعية: Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2470-1343

URL الوصول: https://doaj.org/article/4ad36f674d374ec382c3bc8f6343258f

المؤلفون: Sandra Bowles, Elizabeth Joubert, Dalene de Beer, Johan Louw, Christel Brunschwig, Mathew Njoroge, Nina Lawrence, Lubbe Wiesner, Kelly Chibale, Christo Muller

المصدر: Molecules, Vol 22, Iss 4, p 554 (2017)

مصطلحات موضوعية: aspalathin, bioavailability, Caco-2, transport, metabolism, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1420-3049/22/4/554; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/0f064bbdcce244e3a69b33d3fc016f70

المؤلفون: Dickson Mambwe (6179453), Constance M. Korkor (10586893), Amanda Mabhula (9915321), Zama Ngqumba (14247424), Cleavon Cloete (14247427), Malkeet Kumar (3104340), Paula Ladeia Barros (14247430), Meta Leshabane (9470271), Dina Coertzen (2587168), Dale Taylor (1463830), Liezl Gibhard (1871662), Mathew Njoroge (1463821), Nina Lawrence (1463851), Janette Reader (1484494), Diogo Rodrigo Moreira (14247433), Lyn-Marie Birkholtz (1484512), Sergio Wittlin (181945), Timothy J. Egan (262760), Kelly Chibale (503778)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Cancer, Virology, Computational Biology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, stage antiplasmodium activity, parasitic digestive vacuole, highly potent 3, fold higher selectivity, affecting multiple processes, action using live, int , 50 , 23 , 1 , vivo <, pf <, preliminary interrogation, plasmodium berghei, oxadiazole analogues, organelles associated, oral dose, novel target, nf54 ic, k1 ic, infected mice, hlm cl

Relation: https://figshare.com/articles/journal_contribution/Novel_3_Trifluoromethyl-1_2_4-oxadiazole_Analogues_of_Astemizole_with_Multi-stage_Antiplasmodium_Activity_and_i_In_Vivo_i_Efficacy_in_a_Plasmodium_berghei_Mouse_Malaria_Infection_Model/21711349

الاتاحة: https://doi.org/10.1021/acs.jmedchem.2c01516.s001

المؤلفون: Lutete Peguy Khonde (11306135), Rudolf Müller (10988183), Grant A. Boyle (1463812), Virsinha Reddy (1566250), Aloysius T. Nchinda (1828519), Charles J. Eyermann (1667878), Stephen Fienberg (4710014), Vinayak Singh (848177), Alissa Myrick (8974562), Efrem Abay (4669087), Mathew Njoroge (1463821), Nina Lawrence (1463851), Qin Su (31034), Timothy G. Myers (7925411), Helena I. M. Boshoff (7437563), Clifton E. Barry (1287501), Frederick A. Sirgel (9937493), Paul D. van Helden (8940980), Lisa M. Massoudi (11306138), Gregory T. Robertson (1720168), Anne J. Lenaerts (354472), Gregory S. Basarab (1550479), Sandeep R. Ghorpade (1786699), Kelly Chibale (503778)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, pharmacophore model, Potent Anti-tuberculosis Agents Tar., compound, cell wall targets, Initial biology triage assays, series, cell potency, chemical space, vivo drug metabolism, Mycobacterium tuberculosis, novel mode-of-action, cholesterol-containing media, SAR, Mtb, cell high-throughput screening, vivo efficacy proof-of-concept studies, pharmacokinetics profiles, Mycobacterium tuberculosis Phenotypic, cell wall biosynthesis, MIC values

Relation: https://figshare.com/articles/journal_contribution/1_3-Diarylpyrazolyl-acylsulfonamides_as_Potent_Anti-tuberculosis_Agents_Targeting_Cell_Wall_Biosynthesis_in_Mycobacterium_tuberculosis/15673247

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00837.s001

المؤلفون: Renier van der Westhuyzen (1463818), Amanda Mabhula (9915321), Paul M. Njaria (10988180), Rudolf Müller (10988183), Denis Ngumbu Muhunga (10988186), Dale Taylor (1463830), Nina Lawrence (1463851), Mathew Njoroge (1463821), Christel Brunschwig (1463836), Atica Moosa (848176), Vinayak Singh (848177), Srinivasa P.S. Rao (1463809), Ujjini H. Manjunatha (9505), Paul W. Smith (1463833), Digby F. Warner (848178), Leslie J. Street (1463824), Kelly Chibale (503778)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Sociology, Science Policy, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Mycobacterium tuberculosis, oxime frontrunner compounds, hERG channel inhibition liability, series, biology triage assays, Biology Triaging Screening, benzoheterocyclic oxime carbamate, Benzoheterocyclic Oxime Carbamates, Mtb

Relation: https://figshare.com/articles/journal_contribution/Benzoheterocyclic_Oxime_Carbamates_Active_against_Mycobacterium_tuberculosis_Synthesis_Structure_Activity_Relationship_Metabolism_and_Biology_Triaging/14802752

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00707.s001

المؤلفون: Claire Le Manach (8974559), Jean Dam (6091964), John G. Woodland (5146733), Gurminder Kaur (5607425), Lutete P. Khonde (10134669), Christel Brunschwig (1463836), Mathew Njoroge (1463821), Kathryn J. Wicht (5149904), André Horatscheck (9561774), Tanya Paquet (1484530), Grant A. Boyle (1463812), Liezl Gibhard (1871662), Dale Taylor (1463830), Nina Lawrence (1463851), Tomas Yeo (10134672), Sachel Mok (258479), Richard T. Eastman (1502827), Dorjbal Dorjsuren (126214), Daniel C. Talley (10134675), Hui Guo (110581), Anton Simeonov (85099), Janette Reader (1484494), Mariëtte van der Watt (6116213), Erica Erlank (10134678), Nelius Venter (8717481), Jacek W. Zawada (10134681), Ayesha Aswat (10134684), Luisa Nardini (4578895), Theresa L. Coetzer (10134687), Sonja B. Lauterbach (6179459), Belinda C. Bezuidenhout (6179456), Anjo Theron (2898014), Dalu Mancama (2897957), Lizette L. Koekemoer (8442756), Lyn-Marie Birkholtz (1484512), Sergio Wittlin (181945), Michael Delves (181931), Sabine Ottilie (3601928), Elizabeth A. Winzeler (84966), Thomas W. von Geldern (7252547), Dennis Smith (4665544), David A. Fidock (248990), Leslie J. Street (1463824), Gregory S. Basarab (1550479), James Duffy (3397001), Kelly Chibale (503778)

مصطلحات موضوعية: Medicine, Cell Biology, Cancer, Infectious Diseases, Virology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, chemistry optimization, Multiple Stages, transmission-blocking activity, novel sp 3, falciparum cyclic amine resistance ., identification, Mechanistic studies, Optimization Efforts, parasite lifecycle, resistance selection, Plasmodium falciparum whole-cell hi., Human Malaria Parasite Plasmodium f., whole-genome sequencing

Relation: https://figshare.com/articles/journal_contribution/Identification_and_Profiling_of_a_Novel_Diazaspiro_3_4_octane_Chemical_Series_Active_against_Multiple_Stages_of_the_Human_Malaria_Parasite_Plasmodium_falciparum_and_Optimization_Efforts/13947852

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00034.s001

المؤلفون: Dickson Mambwe, Constance M. Korkor, Amanda Mabhula, Zama Ngqumba, Cleavon Cloete, Malkeet Kumar, Paula Ladeia Barros, Meta Leshabane, Dina Coertzen, Dale Taylor, Liezl Gibhard, Mathew Njoroge, Nina Lawrence, Janette Reader, Diogo Rodrigo Moreira, Lyn-Marie Birkholtz, Sergio Wittlin, Timothy J. Egan, Kelly Chibale

المصدر: Journal of Medicinal Chemistry. 65:16695-16715

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::be13f3671115eb74fe7def09b01a1d32
https://doi.org/10.1021/acs.jmedchem.2c01516

المؤلفون: Stephen Fienberg, Gregory S. Basarab, Anne J. Lenaerts, Virsinha Reddy, Sandeep R. Ghorpade, Mathew Njoroge, Grant A. Boyle, Charles J. Eyermann, Clifton E. Barry, Timothy G. Myers, Efrem Abay, Nina Lawrence, Alissa Myrick, Helena I. Boshoff, Vinayak Singh, Lutete Peguy Khonde, Lisa M. Massoudi, Paul D. van Helden, Frederick A. Sirgel, Gregory T. Robertson, Rudolf Müller, Kelly Chibale, Aloysius T. Nchinda, Qin Su

المصدر: Journal of Medicinal Chemistry. 64:12790-12807

مصطلحات موضوعية: biology, Chemistry, INHA, biology.organism_classification, In vitro, Cell wall, Mycobacterium tuberculosis, Biochemistry, In vivo, Drug Discovery, Molecular Medicine, Potency, Pharmacophore, Drug metabolism

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::dcd5171702dfa2d1b82d5b9180cddebb
https://doi.org/10.1021/acs.jmedchem.1c00837

المؤلفون: Ujjini H. Manjunatha, Christel Brunschwig, Mathew Njoroge, Srinivasa P. S. Rao, Nina Lawrence, Dale Taylor, Rudolf Müller, Kelly Chibale, Paul M. Njaria, Renier van der Westhuyzen, Vinayak Singh, Leslie J. Street, Amanda Mabhula, Atica Moosa, Digby F. Warner, Denis Ngumbu Muhunga, Paul W. Smith

المصدر: Journal of Medicinal Chemistry. 64:9444-9457

مصطلحات موضوعية: 0303 health sciences, Carbamate, biology, Chemistry, medicine.medical_treatment, hERG, Prodrug, biology.organism_classification, Oxime, 01 natural sciences, 0104 chemical sciences, Mycobacterium tuberculosis, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, Mechanism of action, Biochemistry, Drug Discovery, medicine, biology.protein, Molecular Medicine, Structure–activity relationship, medicine.symptom, Mode of action, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f22b2b0b4cd9366307e089958a09622f
https://doi.org/10.1021/acs.jmedchem.1c00707

المؤلفون: Constance M. Korkor, Kelly Chibale, Godwin Akpeko Dziwornu, Sergio Wittlin, Dina Coertzen, Cleavon K Cloete, Meta Leshabane, Mathew Njoroge, Janette Reader, Nina Lawrence, Lyn-Marie Birkholtz, Liezl Gibhard, Mariëtte van der Watt

المصدر: Journal of Medicinal Chemistry. 64:5198-5215

مصطلحات موضوعية: 0303 health sciences, Benzimidazole, Hemozoin, Mannich base, Parasitemia, medicine.disease, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, chemistry, Biochemistry, In vivo, Microtubule, Drug Discovery, Gametocyte, medicine, Molecular Medicine, Structure–activity relationship, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3b48aacb29375c8b07c5e4fbbf91b32a
https://doi.org/10.1021/acs.jmedchem.1c00354

المؤلفون: Theresa L. Coetzer, Lizette L. Koekemoer, Elizabeth A. Winzeler, Gregory S. Basarab, Richard T. Eastman, Jean Dam, Gurminder Kaur, André Horatscheck, Sonja B Lauterbach, Sabine Ottilie, Hui Guo, Michael J. Delves, Luisa Nardini, Jacek W. Zawada, Dennis A. Smith, James Duffy, Leslie J. Street, Tanya Paquet, Belinda C. Bezuidenhout, Claire Le Manach, Lyn-Marie Birkholtz, Dorjbal Dorjsuren, Liezl Gibhard, Dalu Mancama, Anton Simeonov, David A. Fidock, Christel Brunschwig, Sachel Mok, Daniel C. Talley, Nelius Venter, Mariëtte van der Watt, Grant A. Boyle, John G Woodland, Sergio Wittlin, Ayesha Aswat, Janette Reader, Nina Lawrence, Dale Taylor, Mathew Njoroge, Kelly Chibale, Tomas Yeo, Anjo Theron, Lutete Peguy Khonde, Erica Erlank, Thomas W. von Geldern, Kathryn J. Wicht

المصدر: Journal of Medicinal Chemistry. 64:2291-2309

مصطلحات موضوعية: Multiple stages, 0303 health sciences, biology, Plasmodium falciparum, Computational biology, biology.organism_classification, medicine.disease, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, chemistry, Drug Discovery, High-Throughput Screening Assays, Gametocyte, medicine, Molecular Medicine, Structure–activity relationship, Parasite hosting, Malaria, 030304 developmental biology, Octane

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::748b270a5ec97aeb6e2aead9a27947b0
https://doi.org/10.1021/acs.jmedchem.1c00034

المؤلفون: Sergio Wittlin, Lynn Wambua, Luyanda Centani, Lauren B. Arendse, Lyn-Marie Birkholtz, Dale Taylor, Kelly Chibale, Janette Reader, Dina Coertzen, Nina Lawrence, Malkeet Kumar, Shoneeze S Renga, Peter Mubanga Cheuka, Stephen Fienberg, Godwin Akpeko Dziwornu, Mariëtte van der Watt

المصدر: ACS Infectious Diseases. 7:34-46

مصطلحات موضوعية: 0301 basic medicine, biology, Chemistry, Kinase, 030106 microbiology, hERG, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Infectious Diseases, Biochemistry, In vivo, biology.protein, Phosphatidylinositol, Protein kinase A, cGMP-dependent protein kinase, Adenosine triphosphate, IC50

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::df75b11c41574c2c365ab07859345b41
https://doi.org/10.1021/acsinfecdis.0c00481

المؤلفون: Anthony J. Smith, Dale Taylor, Anne J. Lenaerts, Thomas R. Ioerger, Nina Lawrence, Kelly Chibale, Rudolf Mueller, Vinayak Singh, Claire Le Manach, Aloysius T. Nchinda, Alissa Myrick, Mathew Njoroge, Paul M. Njaria, Elizabeth J. Brooks, Atica Moosa, Jessica N. Akester, Gregory T. Robertson

المصدر: ACS Infectious Diseases

مصطلحات موضوعية: 0301 basic medicine, medicine.drug_class, 030106 microbiology, Mutant, Antitubercular Agents, Antimycobacterial, Article, Sulfone, drug discovery, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, In vivo, medicine, Glycerol, Structure–activity relationship, Animals, 2-aminoquinazolinones, Mycobacterium tuberculosis, In vitro, 030104 developmental biology, Infectious Diseases, chemistry, Biochemistry, Mechanism of action, tuberculosis, Drug Design, medicine.symptom

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5442c3902e05983890e5f02f889b02
http://europepmc.org/articles/PMC7359024

المؤلفون: Lutete Peguy, Khonde, Rudolf, Müller, Grant A, Boyle, Virsinha, Reddy, Aloysius T, Nchinda, Charles J, Eyermann, Stephen, Fienberg, Vinayak, Singh, Alissa, Myrick, Efrem, Abay, Mathew, Njoroge, Nina, Lawrence, Qin, Su, Timothy G, Myers, Helena I M, Boshoff, Clifton E, Barry, Frederick A, Sirgel, Paul D, van Helden, Lisa M, Massoudi, Gregory T, Robertson, Anne J, Lenaerts, Gregory S, Basarab, Sandeep R, Ghorpade, Kelly, Chibale

المصدر: Journal of medicinal chemistry. 64(17)

مصطلحات موضوعية: Models, Molecular, Structure-Activity Relationship, Sulfonamides, Molecular Structure, Cell Wall, Drug Discovery, Antitubercular Agents, Humans, Hep G2 Cells, Microbial Sensitivity Tests, Mycobacterium tuberculosis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::c9d052174dfa5e731d4d84ef57053ad6
https://pubmed.ncbi.nlm.nih.gov/34414766

المؤلفون: Renier, van der Westhuyzen, Amanda, Mabhula, Paul M, Njaria, Rudolf, Müller, Denis, Ngumbu Muhunga, Dale, Taylor, Nina, Lawrence, Mathew, Njoroge, Christel, Brunschwig, Atica, Moosa, Vinayak, Singh, Srinivasa P S, Rao, Ujjini H, Manjunatha, Paul W, Smith, Digby F, Warner, Leslie J, Street, Kelly, Chibale

المصدر: Journal of medicinal chemistry. 64(13)

مصطلحات موضوعية: Structure-Activity Relationship, Dose-Response Relationship, Drug, Molecular Structure, Heterocyclic Compounds, Oximes, Antitubercular Agents, Carbamates, Microbial Sensitivity Tests, Mycobacterium tuberculosis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::03d111d78c2e649bf21f94024eb5cf31
https://pubmed.ncbi.nlm.nih.gov/34138573

المؤلفون: Godwin Akpeko, Dziwornu, Dina, Coertzen, Meta, Leshabane, Constance M, Korkor, Cleavon K, Cloete, Mathew, Njoroge, Liezl, Gibhard, Nina, Lawrence, Janette, Reader, Mariëtte, van der Watt, Sergio, Wittlin, Lyn-Marie, Birkholtz, Kelly, Chibale

المصدر: Journal of medicinal chemistry. 64(8)

مصطلحات موضوعية: Hemeproteins, Male, Life Cycle Stages, Mice, Inbred BALB C, Plasmodium berghei, Drug Resistance, Administration, Oral, Microtubules, Malaria, Mannich Bases, Antimalarials, Disease Models, Animal, Mice, Structure-Activity Relationship, Drug Stability, Drug Design, Microsomes, Liver, Animals, Benzimidazoles, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::ff0281acb10c8791c77936bbb6e2278a
https://pubmed.ncbi.nlm.nih.gov/33844521

المؤلفون: Claire, Le Manach, Jean, Dam, John G, Woodland, Gurminder, Kaur, Lutete P, Khonde, Christel, Brunschwig, Mathew, Njoroge, Kathryn J, Wicht, André, Horatscheck, Tanya, Paquet, Grant A, Boyle, Liezl, Gibhard, Dale, Taylor, Nina, Lawrence, Tomas, Yeo, Sachel, Mok, Richard T, Eastman, Dorjbal, Dorjsuren, Daniel C, Talley, Hui, Guo, Anton, Simeonov, Janette, Reader, Mariëtte, van der Watt, Erica, Erlank, Nelius, Venter, Jacek W, Zawada, Ayesha, Aswat, Luisa, Nardini, Theresa L, Coetzer, Sonja B, Lauterbach, Belinda C, Bezuidenhout, Anjo, Theron, Dalu, Mancama, Lizette L, Koekemoer, Lyn-Marie, Birkholtz, Sergio, Wittlin, Michael, Delves, Sabine, Ottilie, Elizabeth A, Winzeler, Thomas W, von Geldern, Dennis, Smith, David A, Fidock, Leslie J, Street, Gregory S, Basarab, James, Duffy, Kelly, Chibale

المصدر: Journal of medicinal chemistry. 64(4)

مصطلحات موضوعية: Male, Molecular Structure, Plasmodium falciparum, High-Throughput Screening Assays, Rats, Antimalarials, Mice, Structure-Activity Relationship, Germ Cells, Parasitic Sensitivity Tests, Anopheles, Microsomes, Liver, Animals, Humans, Female, Spiro Compounds

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::ec7cacd693b294b3c6008da32ec3b00e
https://pubmed.ncbi.nlm.nih.gov/33573376

المؤلفون: Kirsteen I. Buchanan, Clifton E. Barry, Simon Green, Gregory S. Basarab, Qin Su, Charles J. Eyermann, Curtis A. Engelhart, Anuradha Kumar, Paul D. van Helden, Frederick A. Sirgel, Paul G. Wyatt, Nina Lawrence, Sandeep R. Ghorpade, Dirk Schnappinger, Dale Taylor, Sandile B. Simelane, Helena I. Boshoff, Christel Brunschwig, Vinayak Singh, Kelly Chibale, Peter C. Ray, Tracy Bayliss, Candice Soares de Melo, Alissa Myrick, Tanya Parish, Timothy G. Myers

المصدر: Journal of Medicinal Chemistry

مصطلحات موضوعية: Male, Phenotypic screening, Iron, Mutant, Antitubercular Agents, Microbial Sensitivity Tests, Pyrimidinones, 01 natural sciences, Article, Mycobacterium tuberculosis, 03 medical and health sciences, Minimum inhibitory concentration, Mice, Structure-Activity Relationship, Bacterial Proteins, Microsomes, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, Mode of action, 030304 developmental biology, 0303 health sciences, biology, Chemistry, Membrane Transport Proteins, biology.organism_classification, In vitro, 0104 chemical sciences, Rats, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Biochemistry, Mechanism of action, Mutation, Molecular Medicine, Pyrazoles, medicine.symptom, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff5eafa1e33ac7c64b2164da5d55d9f9
https://pubmed.ncbi.nlm.nih.gov/33395287

المؤلفون: Peter Mubanga, Cheuka, Luyanda, Centani, Lauren B, Arendse, Stephen, Fienberg, Lynn, Wambua, Shoneeze S, Renga, Godwin Akpeko, Dziwornu, Malkeet, Kumar, Nina, Lawrence, Dale, Taylor, Sergio, Wittlin, Dina, Coertzen, Janette, Reader, Mariette, van der Watt, Lyn-Marie, Birkholtz, Kelly, Chibale

المصدر: ACS infectious diseases. 7(1)

مصطلحات موضوعية: Plasmodium, Plasmodium falciparum, Cyclic GMP-Dependent Protein Kinases, Phosphatidylinositols, 1-Phosphatidylinositol 4-Kinase, Protein Kinases, Guanidine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::5b31d5f4d31b055cbf9d3b039fa31aaf
https://pubmed.ncbi.nlm.nih.gov/33319990

المؤلفون: Jean Dam, Keletso Maepa, Lutete Peguy Khonde, Claire Le Manach, Janette Reader, Mariëtte van der Watt, Gregory S. Basarab, Sergio Wittlin, John Okombo, Kathryn J. Wicht, James Duffy, Aloysius T. Nchinda, Dale Taylor, André Horatscheck, Mathew Njoroge, Christel Brunschwig, Timothy J. Egan, Nina Lawrence, Ana Carolina C. de Sousa, Leslie J. Street, Kelly Chibale, Lyn-Marie Birkholtz, Ana Andrijevic, Liezl Gibhard, Tanya Paquet, Kailash P. Pawar, Paul V. Fish

المصدر: J Med Chem

مصطلحات موضوعية: Hemeproteins, Pyridines, Phenotypic screening, Plasmodium falciparum, Protozoan Proteins, Mice, SCID, Pharmacology, 01 natural sciences, Article, Antimalarials, Mice, Structure-Activity Relationship, 03 medical and health sciences, Mice, Inbred NOD, In vivo, Drug Discovery, parasitic diseases, Animals, Mode of action, Cytotoxicity, 030304 developmental biology, Life Cycle Stages, Mice, Inbred BALB C, 0303 health sciences, biology, Chemistry, Hemozoin, Imidazoles, biology.organism_classification, In vitro, Malaria, 0104 chemical sciences, Disease Models, Animal, 010404 medicinal & biomolecular chemistry, Microsomes, Liver, NSG mouse, Molecular Medicine, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0f65b29b16b46e7c416d1fc66f6377
https://europepmc.org/articles/PMC7756195/