المؤلفون: Mingyan Cao, G. Patrick Hussmann, Yeqing Tao, Ellen O’Connor, Conner Parthemore, Diana Zhang-Hulsey, Dengfeng Liu, Yang Jiao, Niluka de Mel, Meagan Prophet, Samuel Korman, Jaytee Sonawane, Christina Grigoriadou, Yue Huang, Scott Umlauf, Xiaoyu Chen

المصدر: Antibodies, Vol 12, Iss 4, p 68 (2023)

مصطلحات موضوعية: deamidation, post-translational modification (PTM), antibody drug conjugate (ADC), critical quality attributes (CQAs), biological activity, Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2073-4468/12/4/68; https://doaj.org/toc/2073-4468

URL الوصول: https://doaj.org/article/4a1c6cf978184bb1870f19d9d0c1a91e

المؤلفون: Yue Huang, Jiaqi Yuan, Ruipeng Mu, Robert J. Kubiak, Kathryn Ball, Mingyan Cao, G. Patrick Hussmann, Niluka de Mel, Dengfeng Liu, Lorin K. Roskos, Meina Liang, Anton I. Rosenbaum

المصدر: Antibodies, Vol 12, Iss 4, p 66 (2023)

مصطلحات موضوعية: deamidation, hybrid liquid chromatography–mass spectrometry (LC-MS) assay, post-translational modification (PTM), biotransformation, antibody–drug conjugate (ADC), Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2073-4468/12/4/66; https://doaj.org/toc/2073-4468

URL الوصول: https://doaj.org/article/b0bf267e4c2342369ff9562c70aa3c06

المؤلفون: Jun Kim, Yoen Joo Kim, Mingyan Cao, Niluka De Mel, Kenneth Miller, Jared S. Bee, Jihong Wang, Xiangyang Wang, Methal Albarghouthi

المصدر: mAbs, Vol 12, Iss 1 (2020)

مصطلحات موضوعية: Quality attributes, monoclonal antibody, combination therapy, coformulated antibodies, hydrophobic interaction chromatography, higher-order structure, Therapeutics. Pharmacology, RM1-950, Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1942-0862; https://doaj.org/toc/1942-0870

URL الوصول: https://doaj.org/article/c401e00aa0004b988ffc64c379fc550f

المؤلفون: Niluka De Mel, Weimin Chen, Greg Kilby, Dengfeng Liu, Conner Parthemore, Jihong Wang, Yang Jiao, Mingyan Cao, Shihua Lin, Xiaoyu Chen

المصدر: Journal of Pharmaceutical Sciences. 111:335-344

مصطلحات موضوعية: Bispecific antibody, Chromatography, biology, medicine.drug_class, Chemistry, Hydrophilic interaction chromatography, Ion chromatography, Glutamate receptor, Antibodies, Monoclonal, Glutamic Acid, Pharmaceutical Science, Biological activity, Chromatography, Ion Exchange, Monoclonal antibody, Matrix (chemical analysis), Cyclization, medicine, biology.protein, Humans, Antibody, Hydrophobic and Hydrophilic Interactions

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468749accdc115b5fa791181d256b41f
https://doi.org/10.1016/j.xphs.2021.09.006

المؤلفون: Xiaojun Lu, Weichen Xu, Jihong Wang, Qun Du, Niluka De Mel, Michael Washabaugh, Xu-Rong Jiang, Lee Ann Machiesky

المصدر: Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, medicine.drug_class, lcsh:Medicine, Plasma protein binding, Monoclonal antibody, 01 natural sciences, Article, 03 medical and health sciences, Biophysical chemistry, medicine, Humans, Cytotoxicity, Deamidation, lcsh:Science, Antibody-dependent cell-mediated cytotoxicity, Multidisciplinary, biology, Mass spectrometry, Chemistry, 010401 analytical chemistry, Receptors, IgG, lcsh:R, Antibody-Dependent Cell Cytotoxicity, Antibodies, Monoclonal, Biological activity, Chromatography, Ion Exchange, Amides, 0104 chemical sciences, Immunoglobulin Fc Fragments, 030104 developmental biology, Mechanism of action, Biochemistry, Immunoglobulin G, biology.protein, lcsh:Q, Antibody therapy, Antibody, medicine.symptom, Asparagine, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2dc194f0e1ca4ed35e3eaa6f1d9c54
http://link.springer.com/article/10.1038/s41598-019-57184-2

المؤلفون: Samuel A. Korman, Yang Jiao, Dengfeng Liu, Niluka De Mel, Mingyan Cao, James Howard, Christopher Thompson, Michaela Wendeler, Conner Parthemore

المصدر: mAbs

مصطلحات موضوعية: Immunoconjugates, Stereochemistry, Immunology, Lysine, conjugation heterogeneity, Peptide, overconjugated species, conjugation time-course study, Immunoglobulin light chain, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Capillary electrophoresis, Antibody Specificity, Report, underconjugated species, Humans, Immunology and Allergy, Sodium dodecyl sulfate, Antibody-drug conjugate, unconjugated antibody, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Quenching (fluorescence), Chemistry, stereoisomer, Antibodies, Monoclonal, body regions, ADC, 030220 oncology & carcinogenesis, Reagent, disulfide bond exchange reaction, Immunoglobulin Heavy Chains, Oxidation-Reduction, Conjugate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0555bb7219b44885ed355fe5697a75
https://doi.org/10.1080/19420862.2019.1624127

المؤلفون: Ben Niu, Michael Martinelli, Niluka de Mel, Eric Meinke, Weiguo Zhai, Greg Kilby, Wei Xu, Xiaoyu Chen, Chunlei Wang

المصدر: Journal of chromatography. A. 1663

مصطلحات موضوعية: Organic Chemistry, Antibodies, Monoclonal, General Medicine, Chemical Fractionation, Artifacts, Biochemistry, Oxidation-Reduction, Chromatography, High Pressure Liquid, Analytical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081a981eac2ee5c8e19ec2d945bdd680
https://pubmed.ncbi.nlm.nih.gov/34968959

المؤلفون: Nayani Umesha Rajapaksha, Chrishantha Abeysena, Sujith P. Jayasooriya, Niluka De Mel, Gallage, Chandana Pushapalal, Malani Dissanayake, Sandya Gallage, Athukorala, Prisco

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c56839683022c5f688f4dc378c559430

المؤلفون: Dengfeng Liu, Niluka De Mel, Jun Kim, Shihua Lin, Jihong Wang, Anthony G. Shannon, Eric Meinke, Meagan Prophet, Chunlei Wang, Ben Niu, Xiangyang Wang, Methal Albarghouthi, Weichen Xu, Mingyan Cao

المصدر: mAbs

مصطلحات موضوعية: Quality Control, critical quality attribute, complementarity-determining regions, Stability test, Combination therapy, medicine.drug_class, Computer science, multi-attribute method, Immunology, CHO Cells, Computational biology, Monoclonal antibody, combination therapy, 03 medical and health sciences, Cricetulus, 0302 clinical medicine, Report, medicine, Critical to quality, Animals, Humans, Immunology and Allergy, Degree of similarity, Deamidation, 030304 developmental biology, 0303 health sciences, biology, Antibodies, Monoclonal, Complementarity Determining Regions, Highly sensitive, deamidation, monoclonal antibody, Immunoglobulin G, 030220 oncology & carcinogenesis, co-formulated combination antibodies charge variant, biology.protein, Drug Therapy, Combination, Immunotherapy, Antibody, focused peptide mapping

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9514d6dc64285e178048682f9e8b98c6
https://doi.org/10.1080/19420862.2019.1578137

المؤلفون: Madhu Pandey, Xiangyang Wang, Shihua Lin, Jared A. Delmar, Niluka De Mel, Xiaojun Lu, Arun Parupudi, Jihong Wang

مصطلحات موضوعية: Leukemia, Hairy Cell, Conformational change, Chemistry, Immunotoxins, Bacterial Toxins, Exotoxins, Pharmaceutical Science, Biological activity, 02 engineering and technology, 021001 nanoscience & nanotechnology, 030226 pharmacology & pharmacy, 03 medical and health sciences, Moxetumomab pasudotox, 0302 clinical medicine, Protein structure, Immunotoxin, Aspartic acid, Biophysics, Humans, Protein folding, Asparagine, 0210 nano-technology, Deamidation, Isoaspartic Acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b880af69b2614fd39e245e7342d586

المؤلفون: Mingyan Cao, Dengfeng Liu, Niluka De Mel, Sri Hari Raju Mulagapati

المصدر: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1116

مصطلحات موضوعية: Accuracy and precision, Immunoconjugates, Calibration curve, Clinical Biochemistry, Residual, Mass spectrometry, 030226 pharmacology & pharmacy, 01 natural sciences, Biochemistry, Mass Spectrometry, Analytical Chemistry, 03 medical and health sciences, 0302 clinical medicine, Limit of Detection, Sample preparation, Chromatography, Reverse-Phase, Chromatography, Chemistry, 010401 analytical chemistry, Reproducibility of Results, Cell Biology, General Medicine, Reversed-phase chromatography, 0104 chemical sciences, Wavelength, Pharmaceutical Preparations, Linear Models, Conjugate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c56712c9d7b0371c28854d8c7e90710
https://pubmed.ncbi.nlm.nih.gov/30981182