المؤلفون: Sarath Ramachandran, Nikolai Makukhin, Kevin Haubrich, Manjula Nagala, Beth Forrester, Dylan M. Lynch, Ryan Casement, Andrea Testa, Elvira Bruno, Rosaria Gitto, Alessio Ciulli

المصدر: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/8bf42e914ed440c3a94fb07330693da9

المؤلفون: Wei-Wei Kung, Sarath Ramachandran, Nikolai Makukhin, Elvira Bruno, Alessio Ciulli

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/5f64f9c2c7dd475d9276013f7571de57

المؤلفون: Xingui Liu, Alexia F. Kalogeropulou, Sofia Domingos, Nikolai Makukhin, Raja S. Nirujogi, Francois Singh, Natalia Shpiro, Anton Saalfrank, Esther Sammler, Ian G. Ganley, Rui Moreira, Dario R. Alessi, Alessio Ciulli

المصدر: Journal of the American Chemical Society. 144:16930-16952

مصطلحات موضوعية: Mice, Colloid and Surface Chemistry, Blood-Brain Barrier, Leucine, Ubiquitin-Protein Ligases, Proteolysis, Animals, General Chemistry, Sulfides, Ligands, Protein Kinase Inhibitors, Biochemistry, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a3eb51d09b3ba5e57b1a459b49ca89
https://doi.org/10.1021/jacs.2c05499

المؤلفون: Vesna Vetma, Kristin M. Riching, Satomi Imaide, Marjeta Urh, Claire Whitworth, Chiara Maniaci, Angus D. Cowan, Nicole Trainor, Sarah D. Mahan, Alessio Ciulli, Andrea Testa, Nancy Murphy, Conner Craigon, Kwok-Ho Chan, Nikolai Makukhin, Scott J. Hughes, Danette L. Daniels

المصدر: Nature chemical biology

مصطلحات موضوعية: 0303 health sciences, 010405 organic chemistry, Chemistry, Ubiquitin-Protein Ligases, Cooperative binding, Cooperativity, Cell Biology, Protein degradation, Ligand (biochemistry), 01 natural sciences, Article, 0104 chemical sciences, Bromodomain, 03 medical and health sciences, Proteolysis, Biophysics, Humans, Target protein, Molecular Biology, Linker, Ternary complex, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48142d6a1b031c2e4ceee52a00283704
https://doi.org/10.1038/s41589-021-00878-4

المؤلفون: Alessandra Cipriano, Ciro Milite, Alessandra Feoli, Monica Viviano, Giacomo Pepe, Pietro Campiglia, Giuliana Sarno, Sarah Picaud, Satomi Imaide, Nikolai Makukhin, Panagis Filippakopoulos, Alessio Ciulli, Sabrina Castellano, Gianluca Sbardella

المصدر: ChemMedChem. 17

مصطلحات موضوعية: Pharmacology, Organic Chemistry, Drug Discovery, Molecular Medicine, General Pharmacology, Toxicology and Pharmaceutics, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9b5edef4d66f5f45de556d8c894a9297
https://doi.org/10.1002/cmdc.202200528

المؤلفون: Sarath Ramachandran, Nikolai Makukhin, Kevin Haubrich, Ryan Casement, Manjula Nagala, Dylan Lynch, Andrea Testa, Elvira Bruno, Rosaria Gitto, Alessio Ciulli

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::82d77c848a427d2770c6b000aaf03c40
https://doi.org/10.26434/chemrxiv-2022-bvj80

المؤلفون: Eugenio Gaudio, Fabrizio Manetti, Sinforosa Gagliardi, Elena Petricci, Silvia Pietrobono, Laura Carrassa, Mariapaola Zitani, Nikolai Makukhin, Adam G. Bond, Barbara Stecca, Martin E. Fernandez-Zapico, Francesca Migliorini, Francesco Bertoni, Alessio Ciulli, Brooke D. Paradise

المصدر: Oncogene

مصطلحات موضوعية: 0301 basic medicine, Neuroblastoma RAS viral oncogene homolog, Cancer Research, GLI1, Cell Cycle Proteins, Guanidines, Hedgehog pathway, Mice, 0302 clinical medicine, Antineoplastic Combined Chemotherapy Protocols, Molecular Targeted Therapy, Melanoma, SOX2-BRD4 transcriptional complex, biology, integumentary system, Drug Synergism, Dipeptides, Smoothened Receptor, Hedgehog signaling pathway, 030220 oncology & carcinogenesis, embryonic structures, Female, Heterocyclic Compounds, 3-Ring, Cell signalling, Signal Transduction, BRD4, Mice, Nude, GLI1, Hedgehog pathway, melanoma, SOX2-BRD4 transcriptional complex, acylguanidine, Zinc Finger Protein GLI1, Article, 03 medical and health sciences, SOX2, Cell Line, Tumor, Spheroids, Cellular, Genetics, medicine, Animals, Humans, Hedgehog Proteins, Molecular Biology, Hedgehog, Cell Proliferation, SOXB1 Transcription Factors, acylguanidine, medicine.disease, Xenograft Model Antitumor Assays, 030104 developmental biology, biology.protein, Cancer research, Smoothened, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e59f3217cfe70e7ff818657bbc2d15
http://europepmc.org/articles/PMC8175236

المؤلفون: Xingui Liu, Alexia Kalogeropulou, Sofia Domingos, Nikolai Makukhin, Raja Nirujogi, Francois Singh, Natalia Shpiro, Anton Saalfrank, Esther Sammler, Ian Ganley, Rui Moreira, Dario Alessi, Alessio Ciulli

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::213a6be7c5453a5c33432f09907f7fdf
https://doi.org/10.26434/chemrxiv-2022-4gzm0-v2

المؤلفون: Alessio Ciulli, Nikolai Makukhin

المصدر: RSC Medicinal Chemistry

مصطلحات موضوعية: Pharmacology, 010405 organic chemistry, Organic Chemistry, Pharmaceutical Science, 010402 general chemistry, 01 natural sciences, Biochemistry, Phosphonate, Medicinal chemistry, 0104 chemical sciences, Dephosphorylation, Chemistry, chemistry.chemical_compound, chemistry, Drug Discovery, Molecular Medicine, Protein phosphorylation, Phosphotyrosine-binding domain, Signalling pathways

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::476de6305ca25f954ba5b0d62797c666
https://doi.org/10.1039/d0md00272k

المؤلفون: Xingui Liu, Alexia Kalogeropulou, Sofia Domingos, Nikolai Makukhin, Raja Nirujogi, Francois Singh, Natalia Shpiro, Anton Saalfrank, Esther Sammler, Ian Ganley, Rui Moreira, Dario Alessi, Alessio Ciulli

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::769e2998e21086f46fc4df52f8b411fb
https://doi.org/10.26434/chemrxiv-2022-4gzm0

المؤلفون: Alessandra Cipriano, Ciro Milite, Alessandra Feoli, Monica Viviano, Giacomo Pepe, Pietro Campiglia, Giuliana Sarno, Sarah Picaud, Satomi Imaide, Nikolai Makukhin, Panagis Filippakopoulos, Alessio Ciulli, Sabrina Castellano, Gianluca Sbardella

مصطلحات موضوعية: Male, Pharmacology, Sulfonamides, Bioisosteres, Organic Chemistry, Imidazoles, Nuclear Proteins, Bromodomain, Cell Cycle Proteins, Structure-activity relationships, Biochemistry, Benzimidazole-6-sulfonamide, Selectivity, Drug Discovery, Benzo(a)pyrene, Humans, Molecular Medicine, Benzimidazoles, General Pharmacology, Toxicology and Pharmaceutics, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b97485ad4f5fc3bfd314a88b32c4c543
http://hdl.handle.net/11386/4803392

المؤلفون: Sarath Ramachandran, Wei-Wei Kung, Nikolai Makukhin, Alessio Ciulli, Elvira Bruno

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, General Physics and Astronomy, Suppressor of Cytokine Signaling Proteins, Growth hormone receptor, 02 engineering and technology, Crystallography, X-Ray, Biochemistry, Epitope, Substrate Specificity, 0302 clinical medicine, Protein structure, Ubiquitin, Receptors, Erythropoietin, lcsh:Science, Receptor, SOCS2, 0303 health sciences, Multidisciplinary, biology, Chemistry, 021001 nanoscience & nanotechnology, 3. Good health, Ubiquitin ligase, Cell biology, 030220 oncology & carcinogenesis, Phosphorylation, 0210 nano-technology, Structural biology, Protein subunit, Ubiquitin-Protein Ligases, Science, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Humans, Phosphotyrosine, 030304 developmental biology, X-ray crystallography, Ubiquitination, Substrate (chemistry), Proteins, General Chemistry, Receptors, Somatotropin, 030104 developmental biology, Biophysics, biology.protein, lcsh:Q, Degron, Peptides, Sequence Alignment

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700c4a961488f4693fc9dc2d90a8b43b
https://doaj.org/article/5f64f9c2c7dd475d9276013f7571de57

المؤلفون: Jiří Míšek, Nikolai Makukhin, Vladimír Nosek

المصدر: Synthesis. 50:772-777

مصطلحات موضوعية: chemistry.chemical_classification, Methionine, Fluorophore, 010405 organic chemistry, Organic Chemistry, Sulfoxide, 010402 general chemistry, 01 natural sciences, Fluorescence, Catalysis, 0104 chemical sciences, chemistry.chemical_compound, Enzyme, chemistry, Biochemistry, BODIPY, Function (biology), MSRA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::005279085d3a63683931e857b87cb8e9
https://doi.org/10.1055/s-0036-1591888

المؤلفون: Jiří Míšek, Nikolai Makukhin, Vyacheslav Tretyachenko, Jackob Moskovitz

المصدر: Angewandte Chemie. 128:12919-12922

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, 010402 general chemistry, 01 natural sciences, Catalysis, chemistry.chemical_compound, 03 medical and health sciences, Bathochromic shift, Escherichia coli, Humans, Fluorescent Dyes, chemistry.chemical_classification, Molecular Structure, Chemistry, Methionine sulfoxide, 010405 organic chemistry, Optical Imaging, Sulfoxide, General Chemistry, General Medicine, Fluorescence, Small molecule, 0104 chemical sciences, Enzyme, 030104 developmental biology, Biochemistry, Methionine Sulfoxide Reductases, BODIPY, MSRA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b6a0789944604c2fefff3f019041e7d
https://doi.org/10.1002/ange.201605833