المؤلفون: Nielsen, Alexander L., Bognar, Zsolt, Mothukuri, Ganesh K., Zarda, Anne, Schüttel, Mischa, Merz, Manuel L., Ji, Xinjian, Will, Edward J., Chinellato, Monica, Bartling, Christian R. O., Strømgaard, Kristian, Cendron, Laura, Angelini, Alessandro, Heinis, Christian

المساهمون: Nielsen, Alexander L., Bognar, Zsolt, Mothukuri, Ganesh K., Zarda, Anne, Schüttel, Mischa, Merz, Manuel L., Ji, Xinjian, Will, Edward J., Chinellato, Monica, Bartling, Christian R. O., Strømgaard, Kristian, Cendron, Laura, Angelini, Alessandro, Heinis, Christian

مصطلحات موضوعية: cell permeability, cyclization, high-throughput screening, macrocycle, protease inhibitor, Settore BIO/10 - Biochimica

Relation: info:eu-repo/semantics/altIdentifier/pmid/38602024; volume:1; journal:ANGEWANDTE CHEMIE. INTERNATIONAL EDITION; https://hdl.handle.net/10278/5059381

الاتاحة: https://hdl.handle.net/10278/5059381
https://doi.org/10.1002/anie.202400350

المؤلفون: Lin, Lucy, Olson, Margaret E, Sugane, Takashi, Turner, Lewis D, Tararina, Margarita A, Nielsen, Alexander L, Kurbanov, Elbek K, Pellett, Sabine, Johnson, Eric A, Cohen, Seth M, Allen, Karen N, Janda, Kim D

المصدر: Journal of Medicinal Chemistry. 63(19)

مصطلحات موضوعية: Infectious Diseases, Emerging Infectious Diseases, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Botulinum Toxins, Type A, Crystallography, X-Ray, Humans, Induced Pluripotent Stem Cells, Mass Spectrometry, Protein Conformation, Medicinal and Biomolecular Chemistry, Organic Chemistry, Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/0x76f31w

المؤلفون: Bolding, Julie E., Nielsen, Alexander L., Jensen, Iben, Hansen, Tobias N., Ryberg, Line A., Jameson, Samuel T., Harris, Pernille, Peters, Günther H. J., Denu, John M., Rogers, Joseph M., Olsen, Christian A.

المصدر: Bolding , J E , Nielsen , A L , Jensen , I , Hansen , T N , Ryberg , L A , Jameson , S T , Harris , P , Peters , G H J , Denu , J M , Rogers , J M & Olsen , C A 2023 , ' Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide-Activated Sirtuin 7 ' , Angewandte Chemie International Edition , vol. 62 , e20231459 . https://doi.org/10.1002/anie.202314597

وصف الملف: application/pdf

Relation: https://orbit.dtu.dk/en/publications/2c8bfd65-008d-48de-a731-709411249ca3

الاتاحة: https://orbit.dtu.dk/en/publications/2c8bfd65-008d-48de-a731-709411249ca3
https://doi.org/10.1002/anie.202314597
https://backend.orbit.dtu.dk/ws/files/344711366/Angew_Chem_Int_Ed_-_2023_-_Bolding_-_Substrates_and_Cyclic_Peptide_Inhibitors_of_the_Oligonucleotide_Activated_Sirtuin_7.pdf

المؤلفون: Ji, Xinjian, Nielsen, Alexander L., Heinis, Christian

المساهمون: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, H2020 European Research Council

المصدر: Angewandte Chemie International Edition ; volume 63, issue 3 ; ISSN 1433-7851 1521-3773

الاتاحة: http://dx.doi.org/10.1002/anie.202308251
https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202308251

المؤلفون: Nolan, Mark D., Schüttel, Mischa, Scanlan, Eoin M., Nielsen, Alexander L.

المساهمون: Science Foundation Ireland

المصدر: Peptide Science ; volume 116, issue 1 ; ISSN 2475-8817 2475-8817

الاتاحة: http://dx.doi.org/10.1002/pep2.24310
https://onlinelibrary.wiley.com/doi/pdf/10.1002/pep2.24310

المؤلفون: Merz, Manuel L., Habeshian, Sevan, Li, Bo, David, Jean-Alexandre G. L., Nielsen, Alexander L., Ji, Xinjian, Il Khwildy, Khaled, Duany Benitez, Maury M., Phothirath, Phoukham, Heinis, Christian

المصدر: Nature Chemical Biology ; volume 20, issue 5, page 624-633 ; ISSN 1552-4450 1552-4469

الاتاحة: http://dx.doi.org/10.1038/s41589-023-01496-y
https://www.nature.com/articles/s41589-023-01496-y.pdf
https://www.nature.com/articles/s41589-023-01496-y

المؤلفون: Ji, Xinjian, Nielsen, Alexander L., Heinis, Christian

مصطلحات الفهرس: Text

URL: http://infoscience.epfl.ch/record/307395
https://infoscience.epfl.ch/record/307395/files/Ji_et_al_Angewandte_2023.pdf
https://infoscience.epfl.ch/record/307395/files/Ji_et_al_Angewandte_2023_Corrigendum.pdf

المؤلفون: Rajabi, Nima, Hansen, Tobias N., Nielsen, Alexander L., Nguyen, Huy T., Bæk, Michael, Bolding, Julie E., Bahlke, Oskar, Petersen, Sylvester E.G., Bartling, Christian R.O., Strømgaard, Kristian, Olsen, Christian A.

المصدر: Rajabi , N , Hansen , T N , Nielsen , A L , Nguyen , H T , Bæk , M , Bolding , J E , Bahlke , O , Petersen , S E G , Bartling , C R O , Strømgaard , K & Olsen , C A 2022 , ' Investigation of Carboxylic Acid Isosteres and Prodrugs for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme** ' , Angewandte Chemie - International Edition , vol. 61 , no. 22 , e202115805 . https://doi.org/10.1002/anie.202115805

مصطلحات موضوعية: Bioisosteres, Enzyme Inhibitors, Prodrugs, SIRT5, Sirtuins

وصف الملف: application/pdf

الاتاحة: https://researchprofiles.ku.dk/da/publications/investigation-of-carboxylic-acid-isosteres-and-prodrugs-for-inhibition-of-the-human-sirt5-lysine-deacylase-enzyme(30614323-0e9e-4a4a-a1f4-3ac1d53aea94).html
https://doi.org/10.1002/anie.202115805
https://curis.ku.dk/ws/files/308041103/Angew_Chem_Int_Ed_2022_Rajabi_Investigation_of_Carboxylic_Acid_Isosteres_and_Prodrugs_for_Inhibition_of_the_Human.pdf

المؤلفون: Moreno-Yruela, Carlos, Zhang, Di, Wei, Wei, Bæk, Michael, Liu, Wenchao, Gao, Jinjun, Danková, Daniela, Nielsen, Alexander L., Bolding, Julie E., Yang, Lu, Jameson, Samuel T., Wong, Jiemin, Olsen, Christian A., Zhao, Yingming

المصدر: Moreno-Yruela , C , Zhang , D , Wei , W , Bæk , M , Liu , W , Gao , J , Danková , D , Nielsen , A L , Bolding , J E , Yang , L , Jameson , S T , Wong , J , Olsen , C A & Zhao , Y 2022 , ' Class I histone deacetylases (HDAC1-3) are histone lysine delactylases ' , Science Advances , vol. 8 , no. 3 , eabi6696 . https://doi.org/10.1126/sciadv.abi6696

وصف الملف: application/pdf

الاتاحة: https://researchprofiles.ku.dk/da/publications/class-i-histone-deacetylases-hdac13-are-histone-lysine-delactylases(ea93bdb4-39f2-4037-8b76-d9029117ca83).html
https://doi.org/10.1126/sciadv.abi6696
https://curis.ku.dk/ws/files/291668012/sciadv.abi6696.pdf

المؤلفون: Turner, Lewis D., Nielsen, Alexander L., Lin, Lucy, Pellett, Sabine, Sugane, Takashi, Olson, Margaret E., Janda, Kim D.

المصدر: Turner , L D , Nielsen , A L , Lin , L , Pellett , S , Sugane , T , Olson , M E & Janda , K D 2021 , ' Covalent inhibition of botulinum neurotoxin A : Exploration of warhead reactivity and function using a bifunctional approach ' , Toxicon , vol. 190 , no. Suppl. 1 , pp. S72-S73 . https://doi.org/10.1016/j.toxicon.2020.11.496

مصطلحات موضوعية: Bifunctional, Botulinum neurotoxin A, Covalent, Reactivity

وصف الملف: application/pdf

الاتاحة: https://researchprofiles.ku.dk/da/publications/covalent-inhibition-of-botulinum-neurotoxin-a(00dc38f4-2eec-417a-af94-d115adbce829).html
https://doi.org/10.1016/j.toxicon.2020.11.496
https://curis.ku.dk/ws/files/285453656/1_s2.0_S0041010120309405_main_1_.pdf

المؤلفون: Schüttel, Mischa, Will, Edward, Sangouard, Gontran, Zarda, Anne, Habeshian, Sevan, Nielsen, Alexander L., Heinis, Christian

المساهمون: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, European Research Council

المصدر: Journal of Peptide Science ; volume 30, issue 4 ; ISSN 1075-2617 1099-1387

الاتاحة: http://dx.doi.org/10.1002/psc.3555
https://onlinelibrary.wiley.com/doi/pdf/10.1002/psc.3555

المؤلفون: Turner, Lewis D., Nielsen, Alexander L., Lin, Lucy, Pellett, Sabine, Sugane, Takashi, Olson, Margaret E., Johnson, Eric A., Janda, Kim D.

المصدر: Turner , L D , Nielsen , A L , Lin , L , Pellett , S , Sugane , T , Olson , M E , Johnson , E A & Janda , K D 2021 , ' Irreversible inhibition of BoNT/A protease : proximity-driven reactivity contingent upon a bifunctional approach ' , RSC Medicinal Chemistry , vol. 12 , no. 6 , pp. 960-969 . https://doi.org/10.1039/d1md00089f

مصطلحات موضوعية: CLOSTRIDIUM-BOTULINUM NEUROTOXIN, IDENTIFICATION, MECHANISM, SEROTYPE, POTENT, TOXIN, DISCOVERY, CYSTEINE, PRODRUG

الاتاحة: https://researchprofiles.ku.dk/da/publications/irreversible-inhibition-of-bonta-protease(57c91aef-40b7-4fd7-b64f-1781c7c50ab8).html
https://doi.org/10.1039/d1md00089f
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221255/pdf/MD-012-D1MD00089F.pdf

المؤلفون: Troelsen, Kathrin S., Bæk, Michael, Nielsen, Alexander L., Madsen, Andreas S., Rajabi, Nima, Olsen, Christian A.

المصدر: Troelsen , K S , Bæk , M , Nielsen , A L , Madsen , A S , Rajabi , N & Olsen , C A 2021 , ' Mitochondria-targeted inhibitors of the human SIRT3 lysine deacetylase ' , RSC Chemical Biology , vol. 2 , pp. 627-635 . https://doi.org/10.1039/D0CB00216J

وصف الملف: application/pdf

الاتاحة: https://researchprofiles.ku.dk/da/publications/mitochondriatargeted-inhibitors-of-the-human-sirt3-lysine-deacetylase(bc58f7c1-1d5a-466f-b2bf-1d228e7f7703).html
https://doi.org/10.1039/D0CB00216J
https://curis.ku.dk/ws/files/262855239/d0cb00216j.pdf

المؤلفون: Nielsen, Alexander L., Rajabi, Nima, Kudo, Norio, Lundø, Kathrine, Moreno-Yruela, Carlos, Bæk, Michael, Fontenas, Martin, Lucidi, Alessia, Madsen, Andreas S., Yoshida, Minoru, Olsen, Christian A.

المصدر: Nielsen , A L , Rajabi , N , Kudo , N , Lundø , K , Moreno-Yruela , C , Bæk , M , Fontenas , M , Lucidi , A , Madsen , A S , Yoshida , M & Olsen , C A 2021 , ' Mechanism-based inhibitors of SIRT2: structure–activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration ' , RSC Chemical Biology , vol. 2 , pp. 612-626 . https://doi.org/10.1039/D0CB00036A

وصف الملف: application/pdf

الاتاحة: https://researchprofiles.ku.dk/da/publications/mechanismbased-inhibitors-of-sirt2-structureactivity-relationship-xray-structures-target-engagement-regulation-of-tubulin-acetylation-and-inhibition-of-breast-cancer-cell-migration(185748a6-8ce2-43c1-bdcb-044aa76671e0).html
https://doi.org/10.1039/D0CB00036A
https://curis.ku.dk/ws/files/262855154/d0cb00036a.pdf

المؤلفون: Shirey, Ryan J., Hart, Jonathan R., Sridharan, BanuPriya, Novick, Scott J., Turner, Lewis D., Zhou, Bin, Nielsen, Alexander L., Eubanks, Lisa M., Ueno, Lynn, Hixon, Mark S., Lairson, Luke L., Spicer, Timothy P., Scampavia, Louis D., Griffin, Patrick R., Vogt, Peter K., Janda, Kim D.

المساهمون: Skaggs Institute for Chemical Biology, Scripps Research Institute, National Institutes of Health, National Cancer Institute, Scripps Research Institute

المصدر: Bioorganic & Medicinal Chemistry ; volume 42, page 116246 ; ISSN 0968-0896

الاتاحة: http://dx.doi.org/10.1016/j.bmc.2021.116246
https://api.elsevier.com/content/article/PII:S0968089621002546?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0968089621002546?httpAccept=text/plain

المؤلفون: Nolan, Mark D., Schüttel, Mischa, Scanlan, Eoin M., Nielsen, Alexander L.

المصدر: Peptide Science; Jan2024, Vol. 116 Issue 1, p1-8, 8p

مصطلحات موضوعية: PEPTIDES, DRUG discovery, PEPTIDE synthesis, BIOCHEMICAL substrates, MIXTURES, CHEMOSELECTIVITY

المؤلفون: Lin, Lucy, Patel, Ealin N., Nielsen, Alexander L., Turner, Lewis D., Tepp, William H., Nguyen, Kong, Pellett, Sabine, Janda, Kim

المصدر: International Journal of Molecular Sciences
Volume 24
Issue 5
Pages: 4303

مصطلحات موضوعية: botulinum neurotoxin, covalent inhibitors, structure-based drug design, catch and anchor inhibition

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=multidiscipl::4bbd0334c2ca0d0302624b238d85de4b

المؤلفون: Merz, Manuel L., Habeshian, Sevan, Li, Bo, David, Jean-Alexandre G. L., Nielsen, Alexander L., Ji, Xinjian, Il Khwildy, Khaled, Duany Benitez, Maury M., Phothirath, Phoukham, Heinis, Christian

المصدر: Nature Chemical Biology; 20240101, Issue: Preprints p1-10, 10p

المؤلفون: Dmytriyeva, Oksana, Ajenjo, Amaia de Diego, Lundo, Kathrine, Hertz, Henrik, Rasmussen, Kim K., Christiansen, Anders T., Klingelhofer, Jorg, Nielsen, Alexander L., Hoeber, Jan, 1986, Kozlova, Elena, Woldbye, David P. D., Pankratova, Stanislava

المصدر: ACS Chemical Neuroscience. 11(9):1270-1282

مصطلحات موضوعية: VEGFB, peptide, neurite outgrowth, neuronal survival

وصف الملف: print

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-414318

المؤلفون: Bognar, Zsolt, Mothukuri, Ganesh K., Nielsen, Alexander L., Merz, Manuel L., Panzar, Peter M. F., Heinis, Christian

المصدر: http://infoscience.epfl.ch/record/295445.

Relation: http://infoscience.epfl.ch/record/295445; isi:000825696300001; https://infoscience.epfl.ch/record/295445/files/Bognar_Org_Biomol_Chem_2022_Preprint.pdf

الاتاحة: http://infoscience.epfl.ch/record/295445
https://doi.org/10.1039/d2ob00910b
https://infoscience.epfl.ch/record/295445/files/Bognar_Org_Biomol_Chem_2022_Preprint.pdf