المؤلفون: Liyang Zhang, John A. Zuris, Ramya Viswanathan, Jasmine N. Edelstein, Rolf Turk, Bernice Thommandru, H. Tomas Rube, Steve E. Glenn, Michael A. Collingwood, Nicole M. Bode, Sarah F. Beaudoin, Swarali Lele, Sean N. Scott, Kevin M. Wasko, Steven Sexton, Christopher M. Borges, Mollie S. Schubert, Gavin L. Kurgan, Matthew S. McNeill, Cecilia A. Fernandez, Vic E. Myer, Richard A. Morgan, Mark A. Behlke, Christopher A. Vakulskas

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/0168163683a24415a8a5f32e5a19e09a

المؤلفون: Liyang Zhang, John A. Zuris, Ramya Viswanathan, Jasmine N. Edelstein, Rolf Turk, Bernice Thommandru, H. Tomas Rube, Steve E. Glenn, Michael A. Collingwood, Nicole M. Bode, Sarah F. Beaudoin, Swarali Lele, Sean N. Scott, Kevin M. Wasko, Steven Sexton, Christopher M. Borges, Mollie S. Schubert, Gavin L. Kurgan, Matthew S. McNeill, Cecilia A. Fernandez, Vic E. Myer, Richard A. Morgan, Mark A. Behlke, Christopher A. Vakulskas

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/8e393b3b2eaf4c56989cd44fec2d1138

المؤلفون: M. Kyle Cromer, Kiran R. Majeti, Garrett R. Rettig, Karthik Murugan, Gavin L. Kurgan, Nicole M. Bode, Jessica P. Hampton, Christopher A. Vakulskas, Mark A. Behlke, Matthew H. Porteus

المصدر: Molecular Therapy. 31:1074-1087

مصطلحات موضوعية: Pharmacology, Drug Discovery, Genetics, Molecular Medicine, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::82f779700be01951f9a084396b896b8a
https://doi.org/10.1016/j.ymthe.2023.02.011

المؤلفون: Renata M. Martin, Waracharee Srifa, Ravindra Majeti, Ezequiel Ponce, Daniel P. Dever, Yankai Zhang, Benjamin J. Lesch, Matthew H. Porteus, Garrett R. Rettig, Vivien A. Sheehan, Feifei Zhao, Mark A. Behlke, Michael A. Collingwood, Christopher A. Vakulskas, Nicole M. Bode, Gavin Kurgan, M. Kyle Cromer, Rasmus O. Bak, Viktor T. Lemgart, Ankush Goyal, Naoya Uchida, Joab Camarena, John F. Tisdale

المصدر: Nat Med
Cromer, M K, Camarena, J, Martin, R M, Lesch, B J, Vakulskas, C A, Bode, N M, Kurgan, G, Collingwood, M A, Rettig, G R, Behlke, M A, Lemgart, V T, Zhang, Y, Goyal, A, Zhao, F, Ponce, E, Srifa, W, Bak, R O, Uchida, N, Majeti, R, Sheehan, V A, Tisdale, J F, Dever, D P & Porteus, M H 2021, ' Gene replacement of α-globin with β-globin restores hemoglobin balance in β-thalassemia-derived hematopoietic stem and progenitor cells ', Nature Medicine, vol. 27, no. 4, pp. 677-687 . https://doi.org/10.1038/s41591-021-01284-y

مصطلحات موضوعية: 0301 basic medicine, Erythrocytes, Transgene, Thalassemia, medicine.medical_treatment, Antigens, CD34, Anemia, Sickle Cell, beta-Globins, Hematopoietic stem cell transplantation, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Hemoglobins, Mice, 03 medical and health sciences, 0302 clinical medicine, alpha-Globins, Genes, Reporter, hemic and lymphatic diseases, medicine, Animals, Humans, Globin, Progenitor cell, Promoter Regions, Genetic, Gene Editing, Messenger RNA, beta-Thalassemia, Hematopoietic Stem Cell Transplantation, Genetic Therapy, General Medicine, Dependovirus, Hematopoietic Stem Cells, medicine.disease, Cell biology, Haematopoiesis, 030104 developmental biology, Genetic Loci, 030220 oncology & carcinogenesis, Hemoglobin, RNA, Guide, Kinetoplastida

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78fed0c19389bd72360d35b2f89a625
https://doi.org/10.1038/s41591-021-01284-y

المؤلفون: Ramya Viswanathan, Rolf Turk, Kevin Wasko, Steve E. Glenn, Michael A. Collingwood, Richard A. Morgan, Swarali Lele, Steven Sexton, Christopher M. Borges, Liyang Zhang, Jasmine Edelstein, Mollie S. Schubert, Sean N. Scott, Sarah F. Beaudoin, Vic E. Myer, Bernice Thommandru, H. Tomas Rube, Nicole M. Bode, John A. Zuris, Matthew S. McNeill, Christopher A. Vakulskas, Cecilia Fernández, Mark A. Behlke, Gavin Kurgan

المصدر: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

مصطلحات موضوعية: 0301 basic medicine, CRISPR-Cas9 genome editing, T cell, Science, T-Lymphocytes, CRISPR-Associated Proteins, Induced Pluripotent Stem Cells, General Physics and Astronomy, Computational biology, Jurkat cells, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Jurkat Cells, 0302 clinical medicine, Genome editing, Bacterial Proteins, Bacterial genetics, medicine, CRISPR, Humans, Acidaminococcus, Induced pluripotent stem cell, Author Correction, Cells, Cultured, Gene Editing, Nuclease, Multidisciplinary, biology, Targeted Gene Repair, HEK 293 cells, food and beverages, Reproducibility of Results, General Chemistry, Endonucleases, Hematopoietic Stem Cells, Killer Cells, Natural, Targeted gene repair, 030104 developmental biology, medicine.anatomical_structure, HEK293 Cells, 030220 oncology & carcinogenesis, Genetic engineering, biology.protein, CRISPR-Cas Systems

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11cb6f438509134b91c7260779016014
https://pubmed.ncbi.nlm.nih.gov/34282150

المؤلفون: Benton S. Purnell, Stephanie L. Alberico, Nicole Leibold, Cornelius Gross, Haleigh R. Smith, Callie M. Ginapp, Enrica Audero, Gordon F. Buchanan, Daniel A. Rappoport, Nicole M. Bode, Youngcho Kim

المساهمون: RS: MHeNs - R2 - Mental Health, Psychiatrie & Neuropsychologie

المصدر: Journal of Neuroscience, 38(8), 1915-1925. Society for Neuroscience

مصطلحات موضوعية: Dorsal Raphe Nucleus, Male, 0301 basic medicine, 5-HT, Mice, Transgenic, Optogenetics, SUDDEN UNEXPECTED DEATH, BRAIN-STEM, Arousal, CARBON-DIOXIDE, Mice, 03 medical and health sciences, 0302 clinical medicine, Dorsal raphe nucleus, Reflex, Animals, Medicine, NUCLEUS, IN-VIVO, EPILEPSY, Research Articles, 5-HT receptor, RECEPTOR, Raphe, business.industry, General Neuroscience, HYPERCAPNIA, chemosensation, Carbon Dioxide, Sudden infant death syndrome, serotonin, Mice, Inbred C57BL, 030104 developmental biology, CO2, SEIZURES, Serotonin, Sleep, business, Neuroscience, 030217 neurology & neurosurgery, Serotonergic Neurons

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90377fd8b92d754852445328ed4cb976
https://doi.org/10.1523/jneurosci.2182-17.2018

المؤلفون: N. Charles Harata, Kevin A. Glenn, Pedro Gonzalez-Alegre, Jaime L. Watson, Genevieve Beauvais, Hsiang Wen, Hiroyuki Kawano, Nicole M. Bode, Michelle E. Ehrlich

المصدر: The Journal of Neuroscience. 36:10245-10256

مصطلحات موضوعية: 0301 basic medicine, Genotype, Biology, Endoplasmic Reticulum, Mice, 03 medical and health sciences, Cerebellum, Gene knockin, medicine, Animals, Humans, Calcium Signaling, Gene Knock-In Techniques, Protein kinase B, Protein maturation, PI3K/AKT/mTOR pathway, Secretory pathway, Mice, Knockout, Neurons, Dystonia, Behavior, Animal, General Neuroscience, Endoplasmic reticulum, Articles, HSP40 Heat-Shock Proteins, Endoplasmic Reticulum Stress, medicine.disease, Cell biology, 030104 developmental biology, Gene Expression Regulation, Unfolded protein response, Molecular Chaperones, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb59d35f8468ee890970577f3f9a54be
https://doi.org/10.1523/jneurosci.0669-16.2016

المؤلفون: Matthew H. Porteus, Sruthi Mantri, Nicole M. Bode, Carsten T. Charlesworth, Natalia Gomez-Ospina, Mark A. Behlke, Joab Camarena, Kenneth I. Weinberg, Daniel P. Dever, Benjamin J. Lesch, Rosa Romano, M. Kyle Cromer, Christopher A. Vakulskas, Priyanka S. Deshpande, Michael A. Collingwood, Viktor T. Lemgart, Beruh Dejene, Liyang Zhang, Mara Pavel-Dinu, Brandon Cieniewicz

المصدر: Nat Med

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, T-Lymphocytes, Genetic enhancement, Population, Cell Separation, Adaptive Immunity, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, 0302 clinical medicine, Immune system, Antigen, Immunity, CRISPR-Associated Protein 9, Humans, education, Gene Editing, education.field_of_study, biology, Cas9, General Medicine, Acquired immune system, Immunity, Humoral, 030104 developmental biology, 030220 oncology & carcinogenesis, Immunology, biology.protein, Female, Antibody, CRISPR-Cas Systems

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191749d0b74266ff6e713c593ad462be
https://europepmc.org/articles/PMC7199589/

المؤلفون: Amitai D. Mandelbaum, Jesus S. Mora, Giancarlo Costaguta, Timothy M. Miller, Guy Haim, Revital Ravid, Ofer Yizhar, Cristiane de Araújo Martins Moreno, Irit Reichenstein, Tsviya Olender, Nicole M. Bode, Smita Saxena, Karen E. Morrison, Hemali Phatnani, Natali Rivkin, Orla Hardiman, Robert H. Brown, Matthew B. Harms, Kim A. Lennox, Kristel R. van Eijk, Jing Liang, Sandra Diaz-Garcia, A. Nazli Basak, Gilad Beck, Samuel L. Pfaff, John Ravits, Chen Eitan, Thomas Möller, Beáta Tóth, Jan H. Veldink, Eran Yanowski, Sali M.K. Farhan, Pamela J. Shaw, Ammar Al-Chalabi, Iddo Magen, Mark A. Behlke, Leonard H. van den Berg, John Landers, Rivka Levy, Elena Ainbinder, Jeffrey K. Rymer, Eran Hornstein, Christina Gross, Aviad Siany, Mariah L. Hoye

المساهمون: Başak, Ayşe Nazlı (ORCID 0000-0001-9257-3540 & YÖK ID 1512), Reichenstein,I., Eitan, C., Diaz-Garcia, S., Haim, G., Magen, I., Siany, A., Hoye, M.L., Rivkin, N., Olender, T., Toth, B., Ravid, R., Mandelbaum, A.D., Yanowski, E., Liang, J., Rymer, J.K., Levy, R., Beck, G., Ainbinder, E., Farhan,S.M.K., Lennox, K.A., Bode, N.M., Behlke, M.A., Möller, T., Saxena, S., Moreno, C.A.M., Costaguta, G., van Eijk, K.R., Phatnani, H., Al-Chalabi, A., van den Berg, L.H., Hardiman, O., Landers, J.E., Mora, J.S., Morrison, K.E., Shaw, P.J., Veldink, J.H., Pfaff S.L., Yizhar, O., Gross, C., Brown, R.H. Jr., Ravits, J.M., Harms, M.B., Miller, T.M., Hornstein, E., Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM)

المصدر: Sci Transl Med
Science Translational Medicine, 11(523). American Association for the Advancement of Science
Science Translational Medicine

مصطلحات موضوعية: Neuropathology, Article, 03 medical and health sciences, Mice, 0302 clinical medicine, medicine, Journal Article, Premovement neuronal activity, Animals, Humans, Amyotrophic lateral sclerosis, 610 Medicine & health, Gene, 030304 developmental biology, Motor Neurons, Neurons, 0303 health sciences, biology, Amyotrophic Lateral Sclerosis, General Medicine, Motor neuron, medicine.disease, Transgenic mouse model, In-situ detection, Motor-neurons, RNA interference, Rare variants, Microrna, ALS, Motoneurons, Disease, Excitability, Human genetics, Ether-A-Go-Go Potassium Channels, MicroRNAs, medicine.anatomical_structure, nervous system, biology.protein, 570 Life sciences, Cell biology, Medicine, research and experimental, Neuron, Neuroscience, 030217 neurology & neurosurgery, Dicer

وصف الملف: application/pdf; image/pdf; text/plain; pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d030811dc749c7fe7014cc4299036f
https://pubmed.ncbi.nlm.nih.gov/31852800

المؤلفون: Henry L. Paulson, Pedro Gonzalez-Alegre, Kara L. Gordon, Kevin A. Glenn, Nicole M. Bode, Hsiang M. Wen

المصدر: Neuroscience. 224:160-171

مصطلحات موضوعية: biology, Ubiquitin, Proteasome, General Neuroscience, Gene knockin, Autophagy, biology.protein, Endoplasmic-reticulum-associated protein degradation, Protein degradation, Molecular biology, F-box protein, Ubiquitin ligase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fb5536600a8cf1aa74538e50d4394ab5
https://doi.org/10.1016/j.neuroscience.2012.08.023

المؤلفون: Pedro Gonzalez-Alegre, Nicole M. Bode, Cory A. Massey

المصدر: PLoS ONE, Vol 7, Iss 8, p e42644 (2012)
PLoS ONE

مصطلحات موضوعية: medicine.medical_specialty, Mouse, Genotype, lcsh:Medicine, Oxidative phosphorylation, Striatum, Motor Activity, Mitochondrion, Biology, medicine.disease_cause, Rotarod performance test, Mice, Model Organisms, Internal medicine, Molecular Cell Biology, Neurobiology of Disease and Regeneration, Genetics, medicine, Animals, Gene Knock-In Techniques, lcsh:Science, Cellular Stress Responses, Motor Systems, Movement Disorders, Multidisciplinary, Electron Transport Complex II, lcsh:R, Wild type, Parkinson Disease, Heterozygote advantage, Animal Models, Nitro Compounds, Mitochondria, Neostriatum, Endocrinology, Mitochondrial respiratory chain, Neurology, Biochemistry, Rotarod Performance Test, Medicine, lcsh:Q, Disease Susceptibility, Propionates, Animal Genetics, Oxidative stress, Research Article, Neuroscience, Molecular Chaperones

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fdf9b4f59438ff75ec375ac87f2ece
http://europepmc.org/articles/PMC3411799?pdf=render

المؤلفون: Thomas B. Bair, Nicole M. Bode, Pedro Gonzalez-Alegre, Janine N. Martin, William T. Dauer

مصطلحات موضوعية: Proteomics, Transcription, Genetic, Nuclear Envelope, Mutant, Blotting, Western, Biology, medicine.disease_cause, Endoplasmic Reticulum, Article, Cell Line, Microscopy, Electron, Transmission, Cell Line, Tumor, medicine, Animals, Humans, Point Mutation, Genetics, Regulation of gene expression, Neurons, Mutation, General Neuroscience, Endoplasmic reticulum, Point mutation, Rats, Gene Expression Regulation, Microscopy, Fluorescence, Dystonic Disorders, Cellular model, Dystonic disorder, Molecular Chaperones

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e79e8537423253c96a62f5cf3245ec76
https://europepmc.org/articles/PMC2774817/

المؤلفون: Pedro Gonzalez-Alegre, Henry L. Paulson, Nicole M. Bode, Beverly L. Davidson

المصدر: The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(45)

مصطلحات موضوعية: Genetic enhancement, Blotting, Western, Green Fluorescent Proteins, Fluorescent Antibody Technique, Cell Count, Biology, medicine.disease_cause, Transfection, Small hairpin RNA, Mice, RNA interference, Interferon, Ciprofloxacin, Neurobiology of Disease, Chlorocebus aethiops, medicine, Gene silencing, Animals, Humans, Gene Silencing, Cloning, Molecular, RNA, Small Interfering, Cells, Cultured, Sequence Deletion, Dystonia, Cerebral Cortex, Neurons, Mutation, General Neuroscience, Lentivirus, RNA, Organotechnetium Compounds, medicine.disease, Embryo, Mammalian, Virology, Cell biology, Gene Expression Regulation, Mutagenesis, Doxycycline, Interferons, medicine.drug, Molecular Chaperones

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd3fa60568607a2a8a2965bcc055c1bf
https://pubmed.ncbi.nlm.nih.gov/16280588