المؤلفون: Oscar Mammoliti (1923286), Koen Jansen (1822096), Sandy El Bkassiny (10740138), Adeline Palisse (10740135), Nicolas Triballeau (1400671), Denis Bucher (352807), Brigitte Allart (2944395), Alex Jaunet (1863439), Giovanni Tricarico (9941678), Maxim De Wachter (11494630), Christel Menet (9941675), Javier Blanc (1714399), Vatroslav Letfus (11494633), Renata Rupčić (2115004), Mario Šmehil (11494636), Tanja Poljak (11494639), Beatrice Coornaert (10740141), Kathleen Sonck (5898149), Inge Duys (10740144), Ludovic Waeckel (11494642), Lola Lecru (332155), Florence Marsais (11494645), Catherine Jagerschmidt (753692), Marielle Auberval (3989720), Philippe Pujuguet (11494648), Line Oste (1705675), Monica Borgonovi (4747311), Emanuelle Wakselman (1705648), Thierry Christophe (242276), Nicolas Houvenaghel (10740147), Mia Jans (4376776), Bertrand Heckmann (632958), Laurent Sanière (10740150), Reginald Brys (1705672)

مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Biotechnology, Ecology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, potent phthalazone series, orally bioavailable phthalazone, increasing evidence suggests, chemical enablement strategy, progressive lung disease, s1p2 antagonists could, 6 , s1p2 antagonists, disease progression, vivo <, vitro <, s1p2 activity, three different, therapeutic setting, suboptimal pharmacokinetics, scaffold hopping, rapid exploration, position adjacent, mouse models, kg bid, homology model, good pharmacokinetics

Relation: https://figshare.com/articles/journal_contribution/Discovery_and_Optimization_of_Orally_Bioavailable_Phthalazone_and_Cinnolone_Carboxylic_Acid_Derivatives_as_S1P2_Antagonists_against_Fibrotic_Diseases/16692334

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01066.s001

المؤلفون: Franck Brebion (2439052), Romain Gosmini (1738168), Pierre Deprez (1705699), Marie Varin (2479900), Christophe Peixoto (2035117), Luke Alvey (2035129), Hélène Jary (2035114), Natacha Bienvenu (1705657), Nicolas Triballeau (1400671), Roland Blanque (3989681), Céline Cottereaux (9412031), Thierry Christophe (242276), Nele Vandervoort (3989705), Patrick Mollat (206614), Robert Touitou (4376779), Philip Leonard (1621432), Frédéric De Ceuninck (1417306), Iuliana Botez (1701322), Alain Monjardet (3989687), Ellen van der Aar (3989690), David Amantini (232220)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Neuroscience, Physiology, Pharmacology, Biotechnology, Cancer, Science Policy, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, phase 2, knee OA, 1.5 μ M, DMOAD, hydantoin series, Biochemical activity, cocrystal structure, anticatabolic activity, IC 50, glycosaminoglycan release, disease-modifying osteoarthritis, mouse cartilage explants, NCT, GLPG, aggrecanase ADAMTS, HTS, fluorescence-based assay, AGC ELISA

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_GLPG1972_S201086_a_Potent_Selective_and_Orally_Bioavailable_ADAMTS_5_Inhibitor_for_the_Treatment_of_Osteoarthritis/14217024

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02008.s001

المؤلفون: Alain Monjardet, Thierry Christophe, Nicolas Triballeau, Helene Jary, Luke Jonathan Alvey, Romain Luc Marie Gosmini, Frédéric André De Ceuninck, Pierre Deprez, Robert Touitou, Roland Blanque, D. Amantini, Nele Vandervoort, Ellen van der Aar, Philip Leonard, F. Brebion, Patrick Mollat, Natacha Bienvenu, C. Cottereaux, I. Botez, Varin Marie Laurence Claire, Christophe Peixoto

المصدر: Journal of Medicinal Chemistry. 64:2937-2952

مصطلحات موضوعية: Cartilage, Articular, Models, Molecular, Osteoarthritis, Pharmacology, 01 natural sciences, law.invention, Glycosaminoglycan, Mice, 03 medical and health sciences, Dogs, law, Drug Discovery, medicine, Animals, Humans, IC50, Aggrecan, Glycosaminoglycans, 030304 developmental biology, Aggrecanase, 0303 health sciences, Chemistry, Cartilage, ADAMTS, medicine.disease, Rats, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, Recombinant DNA, Molecular Medicine, ADAMTS5 Protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63e1d09bcd2c3ffc719892459e89ab3
https://doi.org/10.1021/acs.jmedchem.0c02008

المؤلفون: Nicolas Triballeau, Bertrand Heckmann, Nicolas Houvenaghel, Tanja Poljak, F. Marsais, Adeline Marie Elise Palisse, Emanuelle Wakselman, Mario Smehil, Mia Jans, Kathleen Sonck, Monica Borgonovi, Denis Bucher, Sandy El Bkassiny, Javier Blanc, Beatrice Coornaert, Thierry Christophe, Philippe Pujuguet, Vatroslav Letfus, M. Auberval, Lola Lecru, Laurent Saniere, Inge Duys, Reginald Brys, Line Oste, Brigitte Allart, Alex Jaunet, Maxim De Wachter, Catherine Jagerschmidt, Koen Karel Jansen, Oscar Mammoliti, Ludovic Waeckel, Giovanni Tricarico, Christel Jeanne Marie Menet, Renata Rupčić

المصدر: Journal of medicinal chemistry. 64(19)

مصطلحات موضوعية: Indole test, chemistry.chemical_classification, Benzimidazole, Carboxylic acid, Carboxylic Acids, Administration, Oral, Biological Availability, Transporter, Pharmacology, medicine.disease, In vitro, Idiopathic Pulmonary Fibrosis, chemistry.chemical_compound, Idiopathic pulmonary fibrosis, Disease Models, Animal, Mice, chemistry, Pharmacokinetics, In vivo, Drug Discovery, medicine, Molecular Medicine, Animals, Humans, Sphingosine-1-Phosphate Receptors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045dde34db98ae7f215ad12e45f175db
https://pubmed.ncbi.nlm.nih.gov/34581584

المؤلفون: Pieter F. W. Stouten, Denis Bucher, Nicolas Triballeau

المصدر: Journal of Chemical Information and Modeling. 58:692-699

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, General Chemical Engineering, Library and Information Sciences, Ligands, 010402 general chemistry, 01 natural sciences, Mice, 03 medical and health sciences, Drug Discovery, Animals, Humans, Binding Sites, Phosphoric Diester Hydrolases, Chemistry, Phosphotransferases, Water, General Chemistry, Grid based, 0104 chemical sciences, Computer Science Applications, 030104 developmental biology, Docking (molecular), Drug Design, Thermodynamics, Water chemistry, Biochemical engineering, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4622d158a534d9392269d9e57ca60ea
https://doi.org/10.1021/acs.jcim.7b00642

المؤلفون: Christelle David, Nele Vandervoort, Damien Fleury, Denis Annoot, Laëtitia Cherel, Willem Jan Hengeveld, Thierry Christophe, Sameh H. Soror, Agnès Marie Joncour, Christopher Gaëtan Housseman, Alain Monjardet, R Galien, Patrick Mollat, Reginald Brys, Veronique Roncoroni, Luce Lepissier, Natacha Bienvenu, Lionel Vercheval, Alexandre Wohlkonig, Christophe Peixoto, Jörg Heiermann, Katja Conrath, Mia Jans, Sandrine Le Tallec, Bertrand Heckmann, Robert Touitou, Nicolas Desroy, Jan Steyaert, Virginie Labeguere, Gregor Pilzak, Ellen van der Aar, Xavier Marie Bock, Nicolas Triballeau, Emanuelle Wakselman

المساهمون: Department of Bio-engineering Sciences, Structural Biology Brussels

المصدر: Journal of Medicinal Chemistry. 60:7371-7392

مصطلحات موضوعية: Male, 0301 basic medicine, Phosphodiesterase Inhibitors, Pyridines, Stereochemistry, Inflammation, 01 natural sciences, Cocrystal, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Lysophosphatidic acid, Hydrolase, medicine, Animals, Humans, Structure–activity relationship, chemistry.chemical_classification, Phosphoric Diester Hydrolases, 010405 organic chemistry, Chemistry, Drug discovery, Imidazoles, Lysophosphatidylcholines, Rats, 0104 chemical sciences, Molecular Docking Simulation, 030104 developmental biology, Enzyme, Biochemistry, Molecular Medicine, lipids (amino acids, peptides, and proteins), Lysophospholipids, Autotaxin, medicine.symptom

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1bab957aedfbab6da364d90d0e33f16
https://doi.org/10.1021/acs.jmedchem.7b00647

المؤلفون: Renaud Lépine, Dinko Žiher, Johan Wouters, Paul A. Hubbard, Nicolas Triballeau, Julien Doyon, Ana Čikoš, Laurent Saniere, Pieter F. W. Stouten, Tiny Deschrijver

المصدر: Organic Letters. 18:780-783

مصطلحات موضوعية: Molecular Structure, Molecular model, 010405 organic chemistry, Stereochemistry, Chemistry, Organic Chemistry, Molecular Conformation, Stereoisomerism, Nuclear magnetic resonance spectroscopy, Crystal structure, Crystallography, X-Ray, 010402 general chemistry, 01 natural sciences, Biochemistry, Solution structure, Molecular conformation, 0104 chemical sciences, Crystallography, branimycin, stereochemistry, NMR, Molecule, Macrolides, Physical and Theoretical Chemistry, Nuclear Magnetic Resonance, Biomolecular, Branimycin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4595f93bca6e0a91fea5fa266400c789
https://doi.org/10.1021/acs.orglett.6b00044

المؤلفون: Nicolas Triballeau, Jonas Verhoeven, Gert Jules Hector De Wilde, Karlijn Hollanders, Patrick Mollat, Charlotte Martin, Steven Emiel Van Der Plas, Steven Ballet, Victor Terrier

المصدر: Proceedings of the 35th European Peptide Symposium.

مصطلحات موضوعية: Design synthesis, Chemistry, Computational biology, Biological evaluation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7b3cd937b96a834750a705d4951da9a5
https://doi.org/10.17952/35eps.2018.279

المؤلفون: Elsa De Lemos, Vanessa Quenehen, Laëtitia Cherel, Nicolas Triballeau, Reginald Brys, Stéphane Beaumont, Florilène Soulas, Murielle Manioc, Thierry Christophe, Emanuelle Wakselman, Ellen van der Aar, Natacha Bienvenu, Christelle L’Ebraly, Luc Nelles, Line Oste, Laurent Saniere, Fatoumata Djata, Stéphanie Lavazais, Philippe Delerive, Stephen Robert Fletcher, Steve De Vos, Mathieu Rafaël Pizzonero, Sabrina Kopiejewski, S. Dupont, Nick Vandeghinste, Jean-Michel Lefrancois, Benedetta Crescenzi, Denis Polancec, Marielle Babel, Pierre Deprez, Roland Blanque

المصدر: Journal of Medicinal Chemistry. 57:10044-10057

مصطلحات موضوعية: Azetidine, Receptors, Cell Surface, Thiophenes, Pharmacology, Rats, Sprague-Dawley, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Free fatty acid receptor 2, Animals, Humans, Potency, Structure–activity relationship, Leukocyte disorder, Receptor, ADME, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Antagonist, Butyrates, Immune System Diseases, Biochemistry, Microsomes, Liver, Azetidines, Molecular Medicine, Leukocyte Disorders

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33097c7d0222ebea1a74983132fa64b7
https://doi.org/10.1021/jm5012885

المؤلفون: Nele Vandervoort, Xavier Marie Bock, Patrick Mollat, Jovica Ralić, Alain Monjardet, Nicolas Triballeau, Thierry Christophe, Ellen van der Aar, Marieke Lamers, Boska Hrvacic, Nicolas Desroy, Bertrand Heckmann, Line Oste, Emilie Rondet, Virginie Labeguere, Roland Blanque, Veronique Roncoroni, Christopher Gaëtan Housseman, Sandrine Le Tallec, Natacha Bienvenu, C. Cottereaux, M. Auberval, Reginald Brys, Laëtitia Cherel, Emanuelle Wakselman, Picolet Olivier Laurent, Jean-Marie Grassot, Agnès Marie Joncour, Christophe Peixoto, Denis Annoot

مصطلحات موضوعية: 0301 basic medicine, hERG, Pharmacology, autoaxin inhibitor, LPA, pulmonary fibrosis, bleomycin-induced model in mice, 03 medical and health sciences, Idiopathic pulmonary fibrosis, chemistry.chemical_compound, Mice, 0302 clinical medicine, In vivo, Drug Discovery, Pulmonary fibrosis, medicine, Animals, Humans, Thiazole, Mice, Knockout, Lung, medicine.diagnostic_test, biology, Chemistry, Phosphoric Diester Hydrolases, Imidazoles, medicine.disease, Idiopathic Pulmonary Fibrosis, Rats, 030104 developmental biology, Bronchoalveolar lavage, medicine.anatomical_structure, Pyrimidines, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, lipids (amino acids, peptides, and proteins), Autotaxin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c6f6e80895c7ca93e77aad9243c383
https://www.bib.irb.hr/981523

المؤلفون: Catherine Robin-Jagerschmidt, Helene Jary, Ellen van der Aar, Nicolas Triballeau, Luke Jonathan Alvey, Francois Nique, Denis Guédin, Kris Van Beeck, Dominque Minet, Florence Namour, Jean H.M. Feyen, Pierre Deprez, Hugo Klaassen, Jean-Michel Lefrancois, Roland Blanque, Christophe Peixoto, Murielle Manioc, Séverine Hebbe, Stephen Robert Fletcher, Christopher Gaëtan Housseman

المصدر: Journal of Medicinal Chemistry. 55:8236-8247

مصطلحات موضوعية: Male, Models, Molecular, Transcriptional Activation, Stereochemistry, Molecular Conformation, Biological Availability, Hydantoin, Pharmacology, Partial agonist, Rats, Sprague-Dawley, Structure-Activity Relationship, chemistry.chemical_compound, Anabolic Agents, In vivo, Drug Discovery, Androgen Receptor Antagonists, Animals, Humans, Hydroxymethyl, Muscle, Skeletal, Trifluoromethyl, Hydantoins, Prostate, Stereoisomerism, Organ Size, Rats, Bioavailability, Drug Partial Agonism, Androgen receptor, chemistry, Selective androgen receptor modulator, Receptors, Androgen, Androgens, Molecular Medicine, Orchiectomy, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::841982488e4fec11bfd3145a00ecb1c9
https://doi.org/10.1021/jm300281x

المؤلفون: Reginald Brys, Emanuelle Wakselman, Lionel Vercheval, Christelle David, Nele Vandervoort, Laëtitia Cherel, Christopher Gaëtan Housseman, Luce Lepissier, Natacha Bienvenu, Mia Jans, Alain Monjardet, Agnès Marie Joncour, Nicolas Desroy, Gregor Pilzak, Willem Jan Hengeveld, Sandrine Le Tallec, Ellen van der Aar, Bertrand Heckmann, Nicolas Triballeau, Jan Steyaert, Patrick Mollat, Veronique Roncoroni, Virginie Labeguere, Sameh H. Soror, Damien Fleury, Thierry Christophe, Christophe Peixoto, Xavier Marie Bock, Denis Annoot, Jörg Heiermann, Katja Conrath, R Galien, Robert Touitou, Alexandre Wohlkonig

المصدر: Journal of Medicinal Chemistry. 61:4270-4270

مصطلحات موضوعية: chemistry.chemical_compound, Series (mathematics), chemistry, Stereochemistry, Drug Discovery, Pyridine, Molecular Medicine, Structure–activity relationship, Autotaxin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93dee812f5866eca6cabf47d605a46ce
https://doi.org/10.1021/acs.jmedchem.8b00579

المؤلفون: Hugues-Olivier Bertrand, Francine Acher, Nicolas Triballeau

المصدر: Pharmacophores and Pharmacophore Searches

مصطلحات موضوعية: Visual inspection, Validation methods, business.industry, Computer science, Artificial intelligence, business, Machine learning, computer.software_genre, computer, Simulation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d719e77118955162582356178ab536a2
https://doi.org/10.1002/3527609164.ch15

المؤلفون: Anne-Sophie Bessis, Jean-Philippe Pin, Philippe Rondard, Isabelle Brabet, Francine Acher, Nicolas Triballeau, Laurent Prézeau, Florence Gaven

المصدر: Proceedings of the National Academy of Sciences. 99:11097-11102

مصطلحات موضوعية: Protein Conformation, G protein, Stereochemistry, Glutamic Acid, Kidney, Ligands, Receptors, Metabotropic Glutamate, Transfection, Cell Line, chemistry.chemical_compound, Protein structure, GTP-Binding Proteins, Excitatory Amino Acid Agonists, Humans, Amino Acid Sequence, Excitatory Amino Acid Agonist, Receptor, G protein-coupled receptor, Multidisciplinary, Glutamate binding, Glutamic acid, Biological Sciences, Recombinant Proteins, Kinetics, Amino Acid Substitution, chemistry, Mutagenesis, Site-Directed, Biophysics, Excitatory Amino Acid Antagonists, Dimerization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c149a4da1d11fd405dcca7cd57c41edf
https://doi.org/10.1073/pnas.162138699

المؤلفون: Francois Nique, Denis Guédin, Nicolas Triballeau, Eric Duval, Jean-Michel Lemoullec, Denis Annoot, Catherine Robin-Jagerschmidt, Maxime Thauvin, Jean-Michel Lefrancois, Thierry Prangé, Laurence Michoux, Philippe Clément-Lacroix, Damien Fleury, Pierre Deprez, Patrick Mollat, Séverine Hebbe, Dominique Minet, Christophe Peixoto

المصدر: Journal of medicinal chemistry. 55(19)

مصطلحات موضوعية: Male, Models, Molecular, Transcriptional Activation, medicine.medical_specialty, Antiandrogens, Hydantoin, Peptide, Pharmacology, Crystallography, X-Ray, Binding, Competitive, Bone and Bones, Transactivation, chemistry.chemical_compound, Structure-Activity Relationship, Anabolic Agents, Internal medicine, Drug Discovery, medicine, Androgen Receptor Antagonists, Potency, Animals, Humans, Muscle, Skeletal, chemistry.chemical_classification, Hydantoins, Prostate, Stereoisomerism, In vitro, Rats, Androgen receptor, Drug Partial Agonism, Endocrinology, Selective androgen receptor modulator, chemistry, Receptors, Androgen, Androgens, Molecular Medicine, Orchiectomy, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac608008905445d4f9b1a1f2414f5434
https://pubmed.ncbi.nlm.nih.gov/22897611

المؤلفون: Hugues-Olivier Bertrand, Pierre Paoletti, Laetitia Mony, Nicolas Triballeau, Francine Acher

المصدر: Bioorganicmedicinal chemistry letters. 20(18)

مصطلحات موضوعية: Models, Molecular, Databases, Factual, Xenopus, Clinical Biochemistry, Pharmaceutical Science, Computational biology, Ligands, Biochemistry, Receptors, N-Methyl-D-Aspartate, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Animals, Molecular Biology, Virtual screening, Molecular Structure, Chemistry, musculoskeletal, neural, and ocular physiology, Organic Chemistry, Antagonist, nervous system, Drug Design, Benzene derivatives, Molecular Medicine, NMDA receptor, Identification (biology), Pharmacophore, psychological phenomena and processes

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25150cbc1e931ad04ae67a7000ce022c
https://pubmed.ncbi.nlm.nih.gov/20692832

المؤلفون: Hugues-Olivier Bertrand, Tiphanie Courtiol, Sara Cesarini, Jean-Philippe Pin, Isabelle A. Lemasson, Isabelle Brabet, Nicolas Triballeau, Nadia Oueslati, Francine Acher, Delphine Rigault, Chelliah Selvam, Cyril Goudet

المصدر: Journal of medicinal chemistry. 53(7)

مصطلحات موضوعية: Models, Molecular, Stereochemistry, Molecular Sequence Data, Drug Evaluation, Preclinical, Molecular Conformation, Receptors, Metabotropic Glutamate, Cell Line, Structure-Activity Relationship, User-Computer Interface, Drug Discovery, Animals, Amino Acid Sequence, Binding Sites, Dose-Response Relationship, Drug, Metabotropic glutamate receptor 5, Chemistry, Metabotropic glutamate receptor 4, Metabotropic glutamate receptor 7, Metabotropic glutamate receptor 6, Glutamate binding, Stereoisomerism, Phosphinic Acids, Rats, Metabotropic glutamate receptor, Drug Design, Molecular Medicine, Metabotropic glutamate receptor 1, Metabotropic glutamate receptor 2

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::495d92182139f3faf4ebde0a427049c1
https://pubmed.ncbi.nlm.nih.gov/20218620

المؤلفون: Hugues-Olivier Bertrand, Nicolas Triballeau, Nadia Hubert, Pascal Neuville, Laurent Prézeau, Mélanie Frauli, Jean-Philippe Pin, Francine Acher, Stephan Schann

المساهمون: Faust Pharmaceuticals SA, Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Accelrys, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques (LCBPT - UMR 8601), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Contrat Bourse CIFRE, Centre National de la Recherche Scientifique (CNRS) - Université Montpellier 2 - Sciences et Techniques (UM2) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Université Montpellier 1 (UM1) - Université de Montpellier (UM), Université Paris Descartes - Paris 5 (UPD5) - Centre National de la Recherche Scientifique (CNRS), Prezeau, Laurent, Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Molecular Pharmacology
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2007, 71 (3), pp.704-12. ⟨10.1124/mol.106.030254⟩
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2007, 71 (3), pp.704-12. 〈10.1124/mol.106.030254〉
Molecular Pharmacology, 2007, 71 (3), pp.704-12. ⟨10.1124/mol.106.030254⟩

مصطلحات موضوعية: Models, Molecular, Pyrrolidines, Receptors, Metabotropic Glutamate, 0302 clinical medicine, MESH: Structure-Activity Relationship, mGluR, MESH: Animals, Cells, Cultured, 0303 health sciences, Metabotropic glutamate receptor 5, Chemistry, Metabotropic glutamate receptor 4, Metabotropic glutamate receptor 7, Metabotropic glutamate receptor 6, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, [SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences, MESH: Mutagenesis, Site-Directed, MESH: Calcium, Molecular Medicine, Metabotropic glutamate receptor 1, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], MESH: Models, Molecular, MESH: Cells, Cultured, Agonist, groupe III, MESH: Rats, medicine.drug_class, Stereochemistry, glutamate, Partial agonist, Structure-Activity Relationship, 03 medical and health sciences, medicine, Animals, Humans, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], MESH: Receptors, Metabotropic Glutamate, 030304 developmental biology, Binding Sites, MESH: Humans, MESH: Pyrrolidines, Tricarboxylic Acids, Rats, MESH: Binding Sites, Metabotropic glutamate receptor, MESH: Tricarboxylic Acids, Mutagenesis, Site-Directed, Calcium, activation, pharmacology, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8546ccdaec1231df6be56f42a24f7b21
https://www.hal.inserm.fr/inserm-00318866

المؤلفون: Hugues-Olivier Bertrand, Géraldine Mercier, Mélanie Frauli, Stanislas Mayer, Nicolas Triballeau, Francine Acher, Pascal Neuville, Christel Jeanne Marie Menet, Paul Arvault, Nadia Hubert, Stephan Schann

المصدر: Bioorganicmedicinal chemistry letters. 16(18)

مصطلحات موضوعية: Agonist, Models, Molecular, Pyrrolidines, Molecular model, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Carboxylic Acids, Pharmaceutical Science, Receptors, Metabotropic Glutamate, Biochemistry, Chemical synthesis, Cell Line, Structure-Activity Relationship, Drug Discovery, medicine, Humans, Receptor, Molecular Biology, Amination, Binding Sites, Molecular Structure, Chemistry, Organic Chemistry, Glutamate receptor, Metabotropic receptor, Docking (molecular), Metabotropic glutamate receptor, Drug Design, Molecular Medicine, Calcium

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a49a09e153e7792c4df1713082c5938
https://pubmed.ncbi.nlm.nih.gov/16828551

المؤلفون: Hugues-Olivier Bertrand, Francine Acher, Jean-Philippe Pin, Nicolas Triballeau, Isabelle Brabet

المصدر: Journal of medicinal chemistry. 48(7)

مصطلحات موضوعية: Models, Molecular, Virtual screening, Binding Sites, Receiver operating characteristic, Databases, Factual, Chemistry, business.industry, Drug discovery, Quantitative Structure-Activity Relationship, Bioinformatics, Machine learning, computer.software_genre, Receptors, Metabotropic Glutamate, Workflow, ROC Curve, Docking (molecular), Metabotropic glutamate receptor, Clinical diagnosis, Drug Design, Drug Discovery, Molecular Medicine, Statistical analysis, Artificial intelligence, business, computer

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf4a650d47569d4107184e9184b9a58
https://pubmed.ncbi.nlm.nih.gov/15801843