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1Academic Journal
المؤلفون: Antonia Efstathiou, Cássio Santana Meira, Nicolas Gaboriaud-Kolar, Tanira Matutino Bastos, Vinícius Pinto Costa Rocha, Konstantina Vougogiannopoulou, Alexios-Leandros Skaltsounis, Despina Smirlis, Milena Botelho Pereira Soares
المصدر: Virulence, Vol 9, Iss 1, Pp 1658-1668 (2018)
مصطلحات موضوعية: Indirubins, T. cruzi, antiparasitic, in vivo efficacy, Infectious and parasitic diseases, RC109-216
وصف الملف: electronic resource
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2Academic Journal
المؤلفون: Antonia Efstathiou, Nicolas Gaboriaud-Kolar, Despina Smirlis, Vassilios Myrianthopoulos, Konstantina Vougogiannopoulou, Alexandros Alexandratos, Marina Kritsanida, Emmanuel Mikros, Ketty Soteriadou, Alexios-Leandros Skaltsounis
المصدر: Parasites & Vectors, Vol 7, Iss 1, Pp 1-12 (2014)
مصطلحات موضوعية: Leishmania, Indirubins, L GSK-3, Szmap, Binding site solvation, Infectious and parasitic diseases, RC109-216
وصف الملف: electronic resource
Relation: https://doaj.org/toc/1756-3305
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3
المؤلفون: Georgia Sarikaki, Ioannis K. Kostakis, Nicolas Gaboriaud-Kolar, Amos B. Smith, Nikoleta Christoforidou, Alexios-Leandros Skaltsounis
المصدر: Journal of Natural Products. 83:1735-1739
مصطلحات موضوعية: Iridoid Glucosides, Pharmaceutical Science, 01 natural sciences, Cyclopentane Monoterpenes, Analytical Chemistry, Structure-Activity Relationship, chemistry.chemical_compound, Human health, Phenols, Biomimetics, Oleuropein, Olea, Biomimetic synthesis, Drug Discovery, Oleocanthal, Organic chemistry, Pharmacology, Aldehydes, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Stereoisomerism, 0104 chemical sciences, Plant Leaves, 010404 medicinal & biomolecular chemistry, Complementary and alternative medicine, chemistry, Molecular Medicine
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4Academic Journal
المؤلفون: Vassilios Myrianthopoulos, Nicolas Gaboriaud-Kolar, Cynthia Tallant, Michelle-Lynn Hall, Stylianos Grigoriou, Peter Moore Brownlee, Oleg Fedorov, Catherine Rogers, David Heidenreich, Marek Wanior, Nikolaos Drosos, Nikitia Mexia, Pavel Savitsky, Tina Bagratuni, Efstathios Kastritis, Evangelos Terpos, Panagis Filippakopoulos, Susanne Müller, Alexios-Leandros Skaltsounis, Jessica Ann Downs, Stefan Knapp, Emmanuel Mikros
مصطلحات موضوعية: Uncategorised value
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5
المؤلفون: Nicolas Gaboriaud-Kolar, Alexios-Leandros Skaltsounis, Despina Smirlis, Antonia Efstathiou, Cássio Santana Meira, Milena Botelho Pereira Soares, Konstantina Vougogiannopoulou, Vinícius Pinto Costa Rocha, Tanira Matutino Bastos
المصدر: Virulence
Virulence, Vol 9, Iss 1, Pp 1658-1668 (2018)مصطلحات موضوعية: 0301 basic medicine, Microbiology (medical), Chagas disease, Indoles, antiparasitic, Antiparasitic, medicine.drug_class, Trypanosoma cruzi, Immunology, Parasitemia, Microbiology, Compound 32, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, chemistry.chemical_compound, Mice, parasitic diseases, medicine, Animals, lcsh:RC109-216, Chagas Disease, Mode of action, Amastigote, Mice, Inbred BALB C, biology, in vivo efficacy, medicine.disease, biology.organism_classification, Leishmania, Flow Cytometry, Trypanocidal Agents, T. cruzi, 3. Good health, Disease Models, Animal, 030104 developmental biology, Infectious Diseases, chemistry, Biochemistry, Nitroimidazoles, Parasitology, Female, Indirubin, Indirubins, Research Paper
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6
المؤلفون: Eleni N. Tsakiri, Alexios-Leandros Skaltsounis, Konstantinos D. Tallas, Maria Halabalaki, Nicolas Gaboriaud-Kolar, Sofia Chatzigeorgiou, Job Tchoumtchoua, Emmanuel Mikros, Kalliopi K. Iliaki, Eleni-Dimitra Papanagnou, Ioannis P. Trougakos
المصدر: Antioxidants & Redox Signaling
مصطلحات موضوعية: Male, 0301 basic medicine, Aging, Indoles, Bioenergetics, NF-E2-Related Factor 2, Physiology, Clinical Biochemistry, Administration, Oral, Biology, Biochemistry, Gsk-3, Nrf-2, Glycogen Synthase Kinase 3, 03 medical and health sciences, chemistry.chemical_compound, In vivo, GSK-3, Oximes, Animals, Drosophila Proteins, Humans, Kinase activity, Pdpk1, Molecular Biology, Transcription factor, General Environmental Science, 2. Zero hunger, proteostasis, Cell Biology, biology.organism_classification, 6-bromoindirubin-3′-oxime, Disease Models, Animal, Original Research Communications, Drosophila melanogaster, 030104 developmental biology, Proteostasis, chemistry, General Earth and Planetary Sciences, Female, Indirubin, Energy Metabolism, Metabolic Networks and Pathways
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7
المؤلفون: Ioannis P. Trougakos, Issidora S. Papassideri, Alexios-Leandros Skaltsounis, Aimilia D. Sklirou, Nicolas Gaboriaud-Kolar
المصدر: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reportsمصطلحات موضوعية: 0301 basic medicine, Senescence, Indoles, DNA damage, Cell, lcsh:Medicine, Biology, medicine.disease_cause, Protective Agents, Antioxidants, Article, 03 medical and health sciences, GSK-3, Oximes, medicine, Humans, lcsh:Science, Cellular Senescence, Multidisciplinary, Glycogen Synthase Kinase 3 beta, 030102 biochemistry & molecular biology, Activator (genetics), Kinase, lcsh:R, Fibroblasts, Cell biology, Oxidative Stress, 030104 developmental biology, Proteostasis, medicine.anatomical_structure, Biochemistry, lcsh:Q, Oxidative stress, DNA Damage
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8Indirubin Analogues Inhibit Trypanosoma brucei Glycogen Synthase Kinase 3 Short and T. brucei Growth
المؤلفون: Alexios-Leandros Skaltsounis, Nicolas Gaboriaud-Kolar, Ketty Soteriadou, Philippe Bastin, Despina Smirlis, Stephanie Aicher, Konstantina Vougogiannopoulou, Antonia Efstathiou, Ines Subota, Emmanuel Mikros, Vassilios Myrianthopoulos
المصدر: Antimicrobial Agents and Chemotherapy. 63
مصطلحات موضوعية: Pharmacology, Drug, 0303 health sciences, biology, 030306 microbiology, Chemistry, Drug discovery, media_common.quotation_subject, Trypanosoma brucei, biology.organism_classification, medicine.disease, 03 medical and health sciences, chemistry.chemical_compound, Infectious Diseases, Biochemistry, GSK-3, RNA interference, In vivo, medicine, Pharmacology (medical), African trypanosomiasis, Indirubin, 030304 developmental biology, media_common
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9
المؤلفون: S Theocharis, Maria Halabalaki, Nicolas Gaboriaud-Kolar, Anastasia E. Konstantinidou, Antonia Efstathiou, E. Patsouris, AL Skaltsounis, Despina Smirlis, Job Tchoumtchoua
المصدر: Planta Medica. 81:S1-S381
مصطلحات موضوعية: Pharmacology, chemistry.chemical_compound, Complementary and alternative medicine, chemistry, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Indirubin, Combinatorial chemistry, Derivative (chemistry), Analytical Chemistry
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10
المؤلفون: Antonia, Efstathiou, Nicolas, Gaboriaud-Kolar, Vassilios, Myrianthopoulos, Konstantina, Vougogiannopoulou, Ines, Subota, Stephanie, Aicher, Emmanuel, Mikros, Philippe, Bastin, Alexios-Leandros, Skaltsounis, Ketty, Soteriadou, Despina, Smirlis
المصدر: Antimicrobial agents and chemotherapy. 63(6)
مصطلحات موضوعية: Glycogen Synthase Kinase 3, Structure-Activity Relationship, Indoles, Insecta, Trypanosomiasis, African, Susceptibility, Trypanosoma brucei brucei, Animals, Protein Kinase Inhibitors, Trypanocidal Agents, Cell Line
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11
المؤلفون: Panagiotis Efentakis, Ioanna Andreadou, Nicolas Gaboriaud-Kolar, Panagiota-Efstathia Nikolaou, Andreas Papapetropoulos, AL Skaltsounis, M Tsoumani, Konstantina Vougogiannopoulou, Efstathios K. Iliodromitis, V. Myrianthopoulos
المصدر: European Heart Journal. 39
مصطلحات موضوعية: Cardioprotection, Region specific, business.industry, Phosphorylation, Medicine, Pharmacology, Cardiology and Cardiovascular Medicine, business
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12
المصدر: Expert Opinion on Therapeutic Patents. 25:583-593
مصطلحات موضوعية: Pharmacology, Active ingredient, Indoles, Research groups, Antineoplastic Agents, General Medicine, Biology, medicine.disease, Patents as Topic, Leukemia, chemistry.chemical_compound, Solubility, Biochemistry, chemistry, Drug Design, Neoplasms, Drug Discovery, medicine, Animals, Humans, Medicine, Chinese Traditional, Indirubin, Signal Transduction
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13
المؤلفون: V. Myrianthopoulos, Panagiota-Efstathia Nikolaou, Ioanna Andreadou, AL Skaltsounis, S.I. Bibli, Andreas Papapetropoulos, E. Iliodromitis, Nicolas Gaboriaud-Kolar, Panagiotis Efentakis
المصدر: European Heart Journal. 38
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, business.industry, MPTP, Ischemia, Medicine, Pharmacology, Cardiology and Cardiovascular Medicine, business, medicine.disease, Reperfusion injury
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14
المؤلفون: Eirini Kouloura, Antonietta Rossi, Lidia Sautebin, Alexios-Leandros Skaltsounis, Simona Pace, Ulrike Garscha, Carlo Pergola, Verena Krauth, Oliver Werz, Maria Halabalaki, Nicolas Gaboriaud-Kolar, Alexandra Svouraki
المساهمون: Svouraki, Alexandra, Garscha, Ulrike, Kouloura, Eirini, Pace, Simona, Pergola, Carlo, Krauth, Verena, Rossi, Antonietta, Sautebin, Lidia, Halabalaki, Maria, Werz, Oliver, Gaboriaud Kolar, Nicola, Skaltsounis, Alexios Leandros
المصدر: Journal of natural products. 80(3)
مصطلحات موضوعية: 0301 basic medicine, Anti-Inflammatory Agents, Pharmaceutical Science, 01 natural sciences, Acronychia, Analytical Chemistry, 03 medical and health sciences, chemistry.chemical_compound, Lipoxygenase, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, Biosynthesis, Prenylation, Drug Discovery, Animals, Humans, Hydroxyurea, Lipoxygenase Inhibitors, Rutaceae, Prostaglandin-E Synthases, Pharmacology, chemistry.chemical_classification, Arachidonate 5-Lipoxygenase, biology, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Acetophenones, Acronychia pedunculata, biology.organism_classification, 0104 chemical sciences, Intramolecular Oxidoreductases, Disease Models, Animal, 030104 developmental biology, Enzyme, Complementary and alternative medicine, chemistry, Biochemistry, Arachidonate 5-lipoxygenase, biology.protein, Molecular Medicine, Cyclooxygenase
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المؤلفون: Vassilios, Myrianthopoulos, Nicolas, Gaboriaud-Kolar, Cynthia, Tallant, Michelle-Lynn, Hall, Stylianos, Grigoriou, Peter Moore, Brownlee, Oleg, Fedorov, Catherine, Rogers, David, Heidenreich, Marek, Wanior, Nikolaos, Drosos, Nikitia, Mexia, Pavel, Savitsky, Tina, Bagratuni, Efstathios, Kastritis, Evangelos, Terpos, Panagis, Filippakopoulos, Susanne, Müller, Alexios-Leandros, Skaltsounis, Jessica Ann, Downs, Stefan, Knapp, Emmanuel, Mikros
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: Models, Molecular, Nuclear Proteins, Crystallography, X-Ray, Ligands, Article, Cell Line, DNA-Binding Proteins, Small Molecule Libraries, Structure-Activity Relationship, Protein Domains, Drug Design, Humans, Computer Simulation, QD, Protein Binding, Transcription Factors
وصف الملف: application/pdf
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16
المؤلفون: Paul Greengard, Stefan Knapp, Laurent Meijer, Nicolas Gaboriaud-Kolar, AL Skaltsounis, Emmanuel Mikros, S Nam, A Brivanlou, Prokopios Magiatis, R Jove
مصطلحات موضوعية: Pharmacology, Complementary and alternative medicine, Chemistry, Kinase, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Computational biology, Combinatorial chemistry, Analytical Chemistry
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17
المصدر: Expert Opinion on Therapeutic Patents. 21:1925-1929
مصطلحات موضوعية: Indazoles, Indoles, Enzyme Activators, Patents as Topic, Structure-Activity Relationship, chemistry.chemical_compound, Enzyme activator, Drug Discovery, Animals, Humans, Hypoglycemic Agents, Structure–activity relationship, Glycogen synthase, Biological evaluation, Pharmacology, chemistry.chemical_classification, Indole test, Indazole, Molecular Structure, biology, Type 2 Diabetes Mellitus, General Medicine, Enzyme Activation, Glycogen Synthase, Enzyme, Diabetes Mellitus, Type 2, chemistry, Biochemistry, Drug Design, biology.protein
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18
المؤلفون: Laurent Meijer, Gerald F. Späth, Alexios-Leandros Skaltsounis, Nicolas Gaboriaud-Kolar, Nathalie Aulner, Olivier Leclercq, Konstantina Vougogiannopoulou, Audrey Defontaine, Nassima Oumata, Hervé Galons, Emilie Durieu, Eric Prina, Najma Rachidi, Sandrine Ruchaud, Joo Hwan No
المساهمون: Phophorylation de protéines et Pathologies Humaines (P3H), Station biologique de Roscoff [Roscoff] (SBR), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Immunophysiologie et Parasitisme Intracellulaire, Institut Pasteur [Paris] (IP), Parasitologie moléculaire et Signalisation / Molecular Parasitology and Signaling, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), ManRos Therapeutics, Department of Pharmacognosy and Chemistry of Natural Products, National and Kapodistrian University of Athens (NKUA), Imagopole (CITECH), Institut Pasteur Korea - Institut Pasteur de Corée, Réseau International des Instituts Pasteur (RIIP), Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques (LCBPT - UMR 8601), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), This study was supported by the 7th Framework Program of the European Commission through grants to the LEISHDRUG project (223414), by ANR-11-RPIB-0016 TRANSLEISH, and by the French Government's Investissements d'Avenir Program Laboratoire d'Excellence Integrative Biology of Emerging Infectious Diseases (grant ANR-10-LABX-62-IBEID). The Imagopole-CiTech is part of the FranceBioImaging infrastructure supported by the French National Research Agency (ANR-10-INSB-04-01, Investments for the Future) and is supported by the Conseil de la Region Ile-de-France (program Sesame 2007, project Imagopole, S. Shorte) and the Fondation Française pour la Recherche Médicale (Programme Grands Equipements [N.A.]), ANR-11-RPIB-0016,TRANSLEISH,Découverte de nouvelles protéines kinases chez Leishmania donovani à partir des inhibiteurs tête de série issus d'un criblage phénotypique(2011), ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-10-INBS-0004,France-BioImaging,Développment d'une infrastructure française distribuée coordonnée(2010), European Project: 223414,EC:FP7:HEALTH,FP7-HEALTH-2007-B,LEISHDRUG(2008), Institut Pasteur [Paris], Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur [Paris], Parasitologie moléculaire et Signalisation, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), National and Kapodistrian University of Athens = University of Athens (NKUA | UoA), Institut Pasteur de Corée, Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), ANR-11-RPIB-0016,TRANSLEISH,Découverte de nouvelles protéines kinases chez Leishmania donovani à partir des inhibiteurs tête de série issus d’un criblage phénotypique(2011), ANR-10-LABX-0062/10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-10-INBS-04-01/10-INBS-0004,France-BioImaging,Développment d'une infrastructure française distribuée coordonnée(2010), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Station biologique de Roscoff [Roscoff] (SBR), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)
المصدر: Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, 2016, ⟨10.1128/AAC.00021-16⟩
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2016, ⟨10.1128/AAC.00021-16⟩مصطلحات موضوعية: 0301 basic medicine, 030106 microbiology, Antiprotozoal Agents, Biology, Cell Line, 03 medical and health sciences, Casein Kinase I, Drug Discovery, Animals, Humans, Protein Isoforms, [CHIM]Chemical Sciences, Pharmacology (medical), Amastigote, Leishmania, Pharmacology, Kinase, Drug discovery, Intracellular parasite, Macrophages, Biological activity, biology.organism_classification, 3. Good health, 030104 developmental biology, Infectious Diseases, Biochemistry, Casein kinase 1
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19
المؤلفون: A. Lazari, Nicolas Gaboriaud-Kolar, C Pergola, Oliver Werz, AL Skaltsounis, Konstantina Vougogiannopoulou
المصدر: Planta Medica. 80
مصطلحات موضوعية: Pharmacology, Chemotype, Traditional medicine, biology, business.industry, Organic Chemistry, Pharmaceutical Science, Analytical Chemistry, Complementary and alternative medicine, Intervention (counseling), Drug Discovery, Arachidonate 5-lipoxygenase, biology.protein, Molecular Medicine, Medicine, business
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20
المؤلفون: Antonia Efstathiou, Nicolas Gaboriaud-Kolar, Ketty Soteriadou, Konstantina Vougogiannopoulou, Leandros Skaltsounis, Despina Smirlis
المصدر: Planta Medica. 80
مصطلحات موضوعية: Pharmacology, chemistry.chemical_compound, Complementary and alternative medicine, Biochemistry, Chemistry, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Identification (biology), Indirubin, Analytical Chemistry
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