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1
المؤلفون: Nico Scheer, Helmut Kewes, Ulrich Kettling
المصدر: Cell and Gene Therapy Insights. 8:1469-1474
مصطلحات موضوعية: General Economics, Econometrics and Finance
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2
المؤلفون: Nico Scheer
المصدر: Cell and Gene Therapy Insights. :351-351
مصطلحات موضوعية: General Economics, Econometrics and Finance
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3Academic Journal
المؤلفون: Harri, Lempiäinen, Philippe, Couttet, Federico, Bolognani, Arne, Müller, Valérie, Dubost, Raphaëlle, Luisier, Espinola Alberto, Del Rio, Veronique, Vitry, ElifB, Unterberger, John P., Thomson, Fridolin, Treindl, Ute, Metzger, Clemens, Wrzodek, Florian, Hahne, Tulipan, Zollinger, Sarah, Brasa, Magdalena, Kalteis, Magali, Marcellin, Fanny, Giudicelli, Albert, Braeuning, Laurent, Morawiec, Natasa, Zamurovic, Ulrich, Längle, Nico, Scheer, Dirk, Schübeler, Jay, Goodman, Salah-Dine, Chibout, Jennifer, Marlowe, Diethilde, Theil, David J., Heard, Olivier, Grenet, Andreas, Zell, Markus F., Templin, Richard R., Meehan, Roland, Wolf C., Clifford R., Elcombe, Michael, Schwarz, Pierre, Moulin, Rémi, Terranova, Jonathan, Moggs G.
مصطلحات موضوعية: Research Article
وصف الملف: text/html
Relation: http://toxsci.oxfordjournals.org/cgi/content/short/kfs303v1; http://dx.doi.org/10.1093/toxsci/kfs303
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4
المؤلفون: K. Schreiter, Ian D. Wilson, E. M. Wilson, J. Bial, A. P. Dickie, Claire E. Wilson, Robert J. Riley, Nico Scheer, R. Wehr
المصدر: Archives of Toxicology. 92:1953-1967
مصطلحات موضوعية: Male, 0301 basic medicine, Drug, Taurine, Diclofenac, Health, Toxicology and Mutagenesis, media_common.quotation_subject, Urine, Pharmacology, Reactive metabolites, Toxicology, Excretion, Feces, Mice, 03 medical and health sciences, chemistry.chemical_compound, Species Specificity, Biotransformation, Pharmacokinetics, Humanized mice, SODIUM VOLTAREN, medicine, Animals, Bile, Humans, DRUG, media_common, Science & Technology, IDENTIFICATION, Chimera, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, General Medicine, Metabolism, Mice, Inbred C57BL, 030104 developmental biology, Liver, Area Under Curve, 1115 Pharmacology and Pharmaceutical Sciences, Life Sciences & Biomedicine, Half-Life, medicine.drug
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5
المؤلفون: Silke Wissing, Helmut Kewes, Nico Scheer
المصدر: Genetic Engineering & Biotechnology News. 41:29-29
مصطلحات موضوعية: Management of Technology and Innovation, Biomedical Engineering, Bioengineering, Biotechnology
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6
المؤلفون: Silke Wissing, Nicole Faust, Nico Scheer
المصدر: Genetic Engineering & Biotechnology News. 41:35-35
مصطلحات موضوعية: Scale (ratio), Computer science, Management of Technology and Innovation, Biomedical Engineering, Bioengineering, Industrial engineering, Biotechnology
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7
المؤلفون: Jin Zhang, Wen Lin, Tycho Heimbach, Avantika Barve, Nico Scheer, Wenkui Li, Handan He
المصدر: Journal of Pharmaceutical Sciences. 105:1398-1404
مصطلحات موضوعية: Male, Physiologically based pharmacokinetic modelling, Anti-HIV Agents, Pharmaceutical Science, Pharmacology, Models, Biological, 030226 pharmacology & pharmacy, Mice, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, In vivo, medicine, Animals, Cytochrome P-450 CYP3A, Humans, Computer Simulation, Drug Interactions, Ritonavir, CYP3A4, Chemistry, Clinical study design, Drug interaction, Liver, 030220 oncology & carcinogenesis, Humanized mouse, Cytochrome P-450 CYP3A Inhibitors, medicine.drug
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8
المؤلفون: Minori Osamura, Mitsuo Oshimura, Mari Hashimoto, Masato Takiguchi, Kanako Kazuki, Rika Hirashima, Naoto Senda, Nico Scheer, Daisuke Satoh, Takehito Kaneko, Yasuko Tsukazaki, Jiro Kuze, Naoyo Kajitani, Shoko Takehara, Yasuhiro Kazuki, Tsuneo Deguchi, Takashi Yamamoto, Tetsushi Sakuma, Riko Wakatsuki, Ryoichi Fujiwara, Satoshi Abe, Tomoji Mashimo, Kaoru Kobayashi, Masumi Hirabayashi, Atsushi Kurihara
المصدر: Proceedings of the National Academy of Sciences of the United States of America
مصطلحات موضوعية: CYP3A, Metabolic Clearance Rate, humanized animal model, Transgene, Mice, Transgenic, Computational biology, Biology, chromosome transfer, Mice, Genome editing, Gene expression, Genetics, Animals, Cytochrome P-450 CYP3A, Humans, genome editing, Glucuronosyltransferase, mouse artificial chromosome, Gene, Gene Editing, Multidisciplinary, Genome, Drug discovery, Gene Transfer Techniques, Chromosome, Biological Sciences, Embryonic stem cell, Rats, PNAS Plus, transchromosomic rat, Inactivation, Metabolic
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9
المؤلفون: Xinxin Ding, Lindsay B. Hough, Nico Scheer, Julia W. Nalwalk
المصدر: Drug Metabolism and Disposition. 43:1326-1330
مصطلحات موضوعية: Mice, Knockout, Pharmacology, Gene isoform, CYP3A, Analgesic, Short Communications, Pharmaceutical Science, Biology, Isozyme, Analgesics, Opioid, Isoenzymes, Mice, Inbred C57BL, Mice, Cytochrome P-450 Enzyme System, Opioid, Gene cluster, Knockout mouse, Morphine, medicine, Animals, medicine.drug
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10
المؤلفون: Nico Scheer, E. M. Wilson, R. Wehr, Claire E. Wilson, A. P. Dickie, J. Bial, Ian D. Wilson, K. Schreiter, Robert J. Riley
مصطلحات موضوعية: 0301 basic medicine, Drug, Male, Taurine, Diclofenac, ADDUCT FORMATION, media_common.quotation_subject, Acyl glucuronide, Urine, HUMAN LIVER-MICROSOMES, Pharmacology, TRAP MASS-SPECTROMETRY, 0601 Biochemistry and Cell Biology, 030226 pharmacology & pharmacy, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Pharmacokinetics, Biotransformation, Species Specificity, Glucuronide conjugation, medicine, Animals, Humans, Pharmacology & Pharmacy, media_common, Reactive intermediates, Science & Technology, QUINONE IMINE, Cyclooxygenase 2 Inhibitors, Chimera, Taurine conjugation, Metabolism, DIPEPTIDYL PEPTIDASE-IV, Mice, Inbred C57BL, ACYL GLUCURONIDE METABOLITE, 030104 developmental biology, HUMAN HEPATOCYTES, chemistry, DRUG-METABOLISM, Lumiracoxib, LIQUID-CHROMATOGRAPHY, RAT BILE, 1115 Pharmacology and Pharmaceutical Sciences, Life Sciences & Biomedicine, medicine.drug
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11
المؤلفون: Raymond Evers, Nico Scheer, Anja Rode, Laurent Salphati, Xiaoyan Chu, Robert A.B. van Waterschoot, Jodie Pang, Jashvant D. Unadkat, Jeevan Kunta, Liangfu Chen, Matthew G. Soars, Loic Laplanche, Shannon Dallas, Jocelyn Yabut, Alfred H. Schinkel, Mario Mezler, Bhagwat Prasad, Ethan G. Geier, Jonathan R Kehler, Donna Mamaril-Fishman
المصدر: Drug Metabolism and Disposition. 42:1301-1313
مصطلحات موضوعية: Male, Organic anion transporter 1, Organic Anion Transporters, Pharmaceutical Science, Organic Anion Transporters, Sodium-Independent, Pharmacology, Mice, Solute Carrier Organic Anion Transporter Family Member 1B3, In vivo, medicine, Animals, Humans, Drug Interactions, Rosuvastatin, RNA, Messenger, Rosuvastatin Calcium, Pitavastatin, Pravastatin, Sulfonamides, biology, Liver-Specific Organic Anion Transporter 1, Chemistry, In vitro, Fluorobenzenes, Organic anion-transporting polypeptide, Pyrimidines, Liver, Humanized mouse, Hepatocytes, biology.protein, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Drug metabolism, medicine.drug
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12
المؤلفون: Philippe Couttet, Jonathan G. Moggs, Valerie Dubost, Antonio Vitobello, Diethilde Theil, Bettina Grasl-Kraupp, Salah-Dine Chibout, Heidrun Ellinger-Ziegelbauer, Hisanori Hara, Colin J. Henderson, Nico Scheer, Rémi Terranova, Harri Lempiäinen, Frank Picard, Michael Schwarz, Clifford R. Elcombe, Pierre Moulin, John P. Thomson, Arne Müller, Olivier Grenet, C. Roland Wolf, Richard R. Meehan, Raphaëlle Luisier, Miriam Geissler, Nina Scherbichler, Albert Braeuning
المصدر: Toxicological Sciences. 139:501-511
مصطلحات موضوعية: Male, Receptors, Steroid, medicine.medical_specialty, Receptors, Cytoplasmic and Nuclear, Toxicology, digestive system, Xenobiotics, chemistry.chemical_compound, Species Specificity, Downregulation and upregulation, Internal medicine, Constitutive androstane receptor, medicine, Animals, Humans, Receptor, Constitutive Androstane Receptor, Cell Proliferation, Mice, Knockout, Pregnane X receptor, Gene Expression Profiling, Cell Cycle, Pregnane, Pregnane X Receptor, Wnt signaling pathway, Molecular biology, digestive system diseases, Mice, Inbred C57BL, Endocrinology, Liver, Nuclear receptor, chemistry, Phenobarbital, Androstane, Transcriptome
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13
المؤلفون: A. Kenneth MacLeod, Nico Scheer, Colin J. Henderson, Anja Rode, Lesley A. McLaughlin, C. Roland Wolf
المصدر: Drug Metabolism and Disposition. 42:1022-1030
مصطلحات موضوعية: Male, Mice, Knockout, Pharmacology, Cytochrome, CYP3A, Pharmaceutical Science, Cytochrome P450, Biology, Monooxygenase, Isozyme, Mice, Cytochrome P-450 Enzyme System, Pharmaceutical Preparations, Biochemistry, Pharmacokinetics, In vivo, Intestine, Small, Microsomes, Liver, biology.protein, Animals, Gene Deletion, Drug metabolism
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14
المؤلفون: Colin J. Henderson, Nico Scheer, Yury Kapelyukh, Aileen McLaren, Kenneth MacLeod, Anja Rode, De Lin, C Roland Wolf
المصدر: Cancer Research. 79:2933-2933
مصطلحات موضوعية: Cancer Research, Oncology
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15
المؤلفون: C. Roland Wolf, Nico Scheer, Jost Seibler, Mike R Snaith
المصدر: Drug Discovery Today. 18:1200-1211
مصطلحات موضوعية: Pharmacology, Drug-Related Side Effects and Adverse Reactions, Drug discovery, business.industry, Mice, Transgenic, Translational research, Computational biology, Biology, Biotechnology, Animals, Genetically Modified, Translational Research, Biomedical, Mice, Basic research, Drug Design, Models, Animal, Drug Discovery, Humanized mouse, Animals, Humans, Genetic Engineering, business, Drug toxicity
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16
المؤلفون: Colin J. Henderson, Ian D. Wilson, Nico Scheer, Kristin Samuelsson, C R Wolf
مصطلحات موضوعية: Pharmacokinetics, Drug discovery, Knockout mouse, Toxicity, Computational biology, Pharmacology, Biology, Selection (genetic algorithm), Drug metabolism
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17
مصطلحات موضوعية: Drug, Drug development, Pharmacokinetics, In vivo, media_common.quotation_subject, In vitro toxicology, Distribution (pharmacology), Transporter, Computational biology, Pharmacology, Biology, Drug metabolism, media_common
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18
المؤلفون: Yury Kapelyukh, Nico Scheer, Sandra Buechel, C. Roland Wolf, Lynsey R. Chatham, Anja Rode
المصدر: Molecular Pharmacology. 82:1022-1029
مصطلحات موضوعية: Tolbutamide, Hydroxylation, Mice, Cytochrome P-450 Enzyme System, In vivo, Gene cluster, Animals, Cytochrome P-450 Enzyme Inhibitors, Humans, Gene, Cytochrome P-450 CYP2C9, Mice, Knockout, Pharmacology, Genetics, biology, Cytochrome P450, Phenotype, Cell biology, Mice, Inbred C57BL, Liver, Multigene Family, Inactivation, Metabolic, Humanized mouse, biology.protein, Molecular Medicine, Aryl Hydrocarbon Hydroxylases, Drug metabolism
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19
المؤلفون: Sandra Buechel, Michael D. Hayward, Gunther Kauselmann, Nico Scheer, C. Roland Wolf, Praveen Balimane
المصدر: Drug Metabolism and Disposition. 40:2212-2218
مصطلحات موضوعية: Male, Pharmaceutical Science, Biology, Pharmacology, Kidney, Cell Line, Mice, Cytochrome P-450 Enzyme System, In vivo, Animals, Humans, Gene Knock-In Techniques, RNA, Messenger, Intestinal Mucosa, Gene, Embryonic Stem Cells, Multidrug resistance-associated protein 2, Membrane Transport Proteins, Kidney metabolism, Cytochrome P450, Bilirubin, Biological Transport, Transporter, Molecular biology, Multidrug Resistance-Associated Protein 2, Mice, Inbred C57BL, Liver, Cell culture, Humanized mouse, biology.protein, Multidrug Resistance-Associated Proteins
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20
المؤلفون: Anja Rode, Clifford R. Elcombe, Simon Plummer, Nico Scheer, C. Roland Wolf, Ortwin Vogel, Jillian Ross, Conrad C. Bower, Colin J. Henderson
المصدر: Toxicological Sciences. 116:452-466
مصطلحات موضوعية: Receptors, Steroid, medicine.medical_specialty, Receptors, Cytoplasmic and Nuclear, Toxicology, Mice, chemistry.chemical_compound, Liver Neoplasms, Experimental, Species Specificity, In vivo, Internal medicine, Constitutive androstane receptor, medicine, Animals, Cytochrome P-450 CYP3A, Humans, Cytochrome P450 Family 2, Receptor, Constitutive Androstane Receptor, Cell Proliferation, Pregnane X receptor, Hyperplasia, Chemistry, Cell growth, Pregnane X Receptor, Membrane Proteins, Hypertrophy, medicine.disease, Mice, Inbred C57BL, Endocrinology, Liver, Chlordan, Phenobarbital, Steroid Hydroxylases, Androstane, Aryl Hydrocarbon Hydroxylases, medicine.drug