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1Academic Journal
المؤلفون: Diana Zatreanu, Helen M. R. Robinson, Omar Alkhatib, Marie Boursier, Harry Finch, Lerin Geo, Diego Grande, Vera Grinkevich, Robert A. Heald, Sophie Langdon, Jayesh Majithiya, Claire McWhirter, Niall M. B. Martin, Shaun Moore, Joana Neves, Eeson Rajendra, Marco Ranzani, Theresia Schaedler, Martin Stockley, Kimberley Wiggins, Rachel Brough, Sandhya Sridhar, Aditi Gulati, Nan Shao, Luned M. Badder, Daniela Novo, Eleanor G. Knight, Rebecca Marlow, Syed Haider, Elsa Callen, Graeme Hewitt, Joost Schimmel, Remko Prevo, Christina Alli, Amanda Ferdinand, Cameron Bell, Peter Blencowe, Chris Bot, Mathew Calder, Mark Charles, Jayne Curry, Tennyson Ekwuru, Katherine Ewings, Wojciech Krajewski, Ellen MacDonald, Hollie McCarron, Leon Pang, Chris Pedder, Laurent Rigoreau, Martin Swarbrick, Ed Wheatley, Simon Willis, Ai Ching Wong, Andre Nussenzweig, Marcel Tijsterman, Andrew Tutt, Simon J. Boulton, Geoff S. Higgins, Stephen J. Pettitt, Graeme C. M. Smith, Christopher J. Lord
المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2041-1723
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المؤلفون: Christina Alli, Christopher J. Lord, Marcel Tijsterman, Katherine Ewings, Marco Ranzani, Ai Ching Wong, Claire McWhirter, Martin Swarbrick, Harry Finch, Robert A. Heald, Rachel Brough, Nan Shao, Rebecca Marlow, Shaun Moore, Vera Grinkevich, Ellen Macdonald, Jayne Curry, Helen M. R. Robinson, Graeme Hewitt, Eleanor Knight, Christopher Bot, Syed Haider, Mathew Calder, Theresia A. Schaedler, Hollie McCarron, Luned M. Badder, Aditi Gulati, Martin Stockley, Eeson Rajendra, Sophie Langdon, Stephen J. Pettitt, Simon J. Boulton, Chris Pedder, Elsa Callen, Ed Wheatley, Wojciech Krajewski, André Nussenzweig, Daniela Novo, Peter Blencowe, Jayesh B. Majithiya, Laurent Rigoreau, Lerin Geo, Cameron Bell, Kimberley A. Wiggins, Diana Zatreanu, Geoff S. Higgins, Remko Prevo, Tennyson Ekwuru, Leon Pang, Simon N. Willis, Sandhya Sridhar, Marie Boursier, Diego Grande, Joana F. Neves, Mark Charles, Joost Schimmel, Andrew Tutt, Niall M. B. Martin, Omar Alkhatib, Amanda Ferdinand, Graeme C. M. Smith
المصدر: Nature Communications, 12(1). NATURE RESEARCH
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communicationsمصطلحات موضوعية: 0301 basic medicine, DNA Repair, DNA polymerase, General Physics and Astronomy, Apoptosis, Cell Cycle Proteins, Synthetic lethality, DNA-Directed DNA Polymerase, Poly (ADP-Ribose) Polymerase Inhibitor, Mice, 0302 clinical medicine, Homologous Recombination, Polymerase, Cancer, Ovarian Neoplasms, Multidisciplinary, Deoxyribonucleases, biology, Drug discovery, Chemistry, BRCA1 Protein, DNA-Binding Proteins, Organoids, 030220 oncology & carcinogenesis, PARP inhibitor, Female, Tumor Suppressor p53-Binding Protein 1, DNA repair, DNA damage, Cell Survival, Science, Poly(ADP-ribose) Polymerase Inhibitors, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Inhibitory Concentration 50, Allosteric Regulation, Cell Line, Tumor, Animals, Humans, Cell Proliferation, Nucleic Acid Synthesis Inhibitors, BRCA2 Protein, General Chemistry, Rats, 030104 developmental biology, Drug Resistance, Neoplasm, biology.protein, Cancer research, Drug Screening Assays, Antitumor, Homologous recombination, Synthetic Lethal Mutations, Biomarkers, DNA Damage
وصف الملف: application/pdf
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المؤلفون: Diana A. Zatreanu, Helen M. R. Robinson, Omar Alkhatib, Marie Boursier, Harry Finch, Lerin Geo, Diego Grande, Vera Grinkevich, Robert Heald, Sophie Langdon, Jayesh Majithiya, Claire McWhirter, Niall M. B. Martin, Shaun Moore, Joana Neves, Eeson Rajendra, Marco Ranzani, Theresia Schaedler, Martin Stockley, Kimberley Wiggins, Rachel Brough, Sandhya Sridhar, Aditi Gulati, Nan Shao, Luned M Badder, Daniela Novo, Eleanor G. Knight, Rebecca Marlow, Syed Haider, Elsa Callen, Graeme Hewitt, Joost Schimmel, Remko Prevo, Christina Alli, Amanda Ferdinand, Cameron Bell, Peter Blencowe, Mathew Calder, Mark Charles, Jayne Curry, Tennyson Ekwuru, Katherine Ewings, Andre Nussenzweig, Marcel Tijsterman, Andrew Tutt, Simon J. Boulton, Geoff S. Higgins, Steve Pettitt, Graeme C. M. Smith, Christopher J. Lord
المصدر: Molecular Cancer Therapeutics. 20:P056-P056
مصطلحات موضوعية: Cancer Research, Oncology
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المؤلفون: Niall M. B. Martin, Bastiaan Evers, Charlotte Knights, Janneke E. Jaspers, Jos Jonkers, Attilla Ting, Henry Brown, Keith W. Caldecott, Sven Rottenberg, Rajesh Odedra, Lenka Oplustil O'Connor, Robert Hugh Bradbury, Aaron Cranston, David Alan Rudge, Mark J. O'Connor, Marina Pajic, Louise J. Jones, Alan Lau, Stuart L. Rulten
المصدر: Cancer Research. 76:6084-6094
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, DNA Repair, medicine.medical_treatment, Genes, BRCA1, Synthetic lethality, Poly(ADP-ribose) Polymerase Inhibitors, Pharmacology, Biology, Q1, Piperazines, Olaparib, Mice, 03 medical and health sciences, chemistry.chemical_compound, Piperidines, Bone Marrow, Cell Line, Tumor, Drug Discovery, Temozolomide, medicine, Animals, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, PARP Inhibitor AZD2461, Chemotherapy, Cancer, Neoplasms, Experimental, medicine.disease, Xenograft Model Antitumor Assays, Rats, 3. Good health, Dacarbazine, 030104 developmental biology, medicine.anatomical_structure, Oncology, Tolerability, chemistry, PARP inhibitor, Phthalazines, Bone marrow, Poly(ADP-ribose) Polymerases, DNA Damage
وصف الملف: application/pdf
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المساهمون: Jackson, Stephen [0000-0001-9317-7937], Apollo - University of Cambridge Repository
المصدر: Nature Reviews. Drug Discovery
مصطلحات موضوعية: 0301 basic medicine, Proteasome Endopeptidase Complex, Drug Industry, Ubiquitylation, Computational biology, Article, Deubiquitinating enzyme, 03 medical and health sciences, Ubiquitin, Neoplasms, Medicine, Humans, Proteasome endopeptidase complex, Molecular Targeted Therapy, Drug industry, health care economics and organizations, Cancer, Pharmacology, Inflammation, Deubiquitylating enzyme, biology, Deubiquitinating Enzymes, business.industry, Drug discovery, Neurodegenerative diseases, General Medicine, Drugs, Investigational, 3. Good health, Ubiquitin ligase, 030104 developmental biology, Proteasome, biology.protein, Infectious diseases, business
وصف الملف: application/pdf
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المؤلفون: Yan Zhao, Nicola J. Curtin, Suzanne Kyle, Alan Lau, Niall M. B. Martin, Andrew Slade, Michael A. Batey, Caroline Richardson, David R. Newell
المصدر: Molecular Cancer Therapeutics. 12:959-967
مصطلحات موضوعية: Radiation-Sensitizing Agents, Cancer Research, DNA repair, Drug Evaluation, Preclinical, Ataxia Telangiectasia Mutated Proteins, Pharmacology, Article, Mice, Chemosensitization, In vivo, Neoplasms, medicine, Animals, Humans, Doxorubicin, Cytotoxicity, Etoposide, Clinical Trials as Topic, biology, Chemistry, Topoisomerase, HCT116 Cells, Xenograft Model Antitumor Assays, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Oncology, Drug Resistance, Neoplasm, Pyrones, biology.protein, Camptothecin, Tumor Suppressor Protein p53, Heterocyclic Compounds, 3-Ring, medicine.drug
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المؤلفون: Niall M. B. Martin, Heather Mary Ellen Duggan, Kurt Gordon Pike, Sarah L. Pass, Marc Geoffrey Hummersone, Sylvie Gomez, Karine Malagu, Linette Ruston, Keith Allan Menear, Martin Pass
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:1212-1216
مصطلحات موضوعية: Morpholines, Clinical Biochemistry, hERG, Pharmaceutical Science, Cell Growth Processes, Mechanistic Target of Rapamycin Complex 2, mTORC1, Mechanistic Target of Rapamycin Complex 1, Pharmacology, Biochemistry, mTORC2, Drug Discovery, Aqueous solubility, Humans, Potency, Protein Kinase Inhibitors, Molecular Biology, Cells, Cultured, biology, Chemistry, TOR Serine-Threonine Kinases, Organic Chemistry, Highly selective, Human hepatocyte, Pyrimidines, Multiprotein Complexes, Benzamides, Hepatocytes, biology.protein, Molecular Medicine
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المؤلفون: Ellen Wientjens, Niall M. B. Martin, Jos Jonkers, Ariena Kersbergen, Alan Lau, Liesbeth van Deemter, Sven Rottenberg, Serge A.L. Zander, Mark J. O'Connor, James H. Doroshow, Jiuping Ji, Ute Boon, Rinske Drost, Piet Borst, Amal Aly, Aaron Cranston, Janneke E. Jaspers, Shridar Ganesan, Wendy Sol
المساهمون: Other departments
المصدر: Cancer Discovery; Vol 3
Cancer discovery, 3(1), 68-81. American Association for Cancer Research Inc.مصطلحات موضوعية: PARP Inhibitor AZD2461, 0303 health sciences, Cancer, Drug resistance, Biology, medicine.disease, Poly (ADP-Ribose) Polymerase Inhibitor, 3. Good health, Olaparib, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Oncology, chemistry, 030220 oncology & carcinogenesis, PARP inhibitor, Immunology, medicine, Cancer research, Neoplasm, Homologous recombination, 030304 developmental biology
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المؤلفون: Celine Cano, Pia Thommes, Niall M. B. Martin, Yan Zhao, Liam Cornell, Michael A. Batey, Helen Jenkins, Jody Barbeau, Keith Allan Menear, Julia Bardos, Nicola J. Curtin, Michele Tavecchio, David R. Newell, Roger J. Griffin, Caroline Richardson, Graeme C. M. Smith, Andrew Slade, Joanne M. Munck
المصدر: Molecular Cancer Therapeutics. 11:1789-1798
مصطلحات موضوعية: Cancer Research, Antineoplastic Agents, DNA-Activated Protein Kinase, Thiophenes, Article, Mice, Chemosensitization, Cell Line, Tumor, Neoplasms, medicine, Animals, Humans, Cytotoxic T cell, Enzyme Inhibitors, Cytotoxicity, Etoposide, Phosphoinositide-3 Kinase Inhibitors, biology, Chemistry, Cell growth, Topoisomerase, fungi, Xenograft Model Antitumor Assays, Molecular biology, Tumor Burden, Enzyme Activation, enzymes and coenzymes (carbohydrates), Oncology, Chromones, Drug Resistance, Neoplasm, Cell culture, Cancer cell, Immunology, MCF-7 Cells, biology.protein, Female, biological phenomena, cell phenomena, and immunity, medicine.drug
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المؤلفون: Sylvie Gomez, Karine Malagu, Thomas Presnot, Sally Ewen, Mihiro Sunose, Xiao-Ling Fan Cockcroft, Niall M. B. Martin, Alexandra Fundo, Armelle Le Gall, Keith Allan Menear, Hermann Gesine Johanna, Luisa Sebastian, Kristel Blackburn, Ian Hickson, Christine Bailey, Graeme C. M. Smith, Eleanor Torode, Kurt Gordon Pike
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:5898-5901
مصطلحات موضوعية: Morpholines, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Non-specific serine/threonine protein kinase, Biochemistry, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Humans, Protein Kinase Inhibitors, Molecular Biology, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, chemistry.chemical_classification, biology, Triazines, Kinase, Chemistry, TOR Serine-Threonine Kinases, Organic Chemistry, Pyrimidines, Enzyme, Enzyme inhibitor, Benzene derivatives, biology.protein, Molecular Medicine, Signal transduction, Pharmacophore, Protein Kinases
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المؤلفون: Bernard T. Golding, Laurent Rigoreau, Graeme Cameron Murray Smith, Jonathan James Hollick, Niall M. B. Martin, Ian R. Hardcastle, Roger John Griffin, Caroline Richardson
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:3083-3086
مصطلحات موضوعية: DNA repair, Stereochemistry, Morpholines, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, DNA-Activated Protein Kinase, Protein Serine-Threonine Kinases, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Humans, Phosphatidylinositol, Enzyme Inhibitors, Protein kinase A, IC50, Molecular Biology, chemistry.chemical_classification, Thiopyran, biology, Chemistry, Kinase, Organic Chemistry, Nuclear Proteins, General Medicine, DNA-Binding Proteins, Enzyme, Chromones, Pyrones, Pyran, Enzyme inhibitor, biology.protein, Molecular Medicine, DNA
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المؤلفون: Krystyna J. Dillon, Niall M. B. Martin, Graeme C. M. Smith
المصدر: SLAS Discovery. 8:347-352
مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Oligonucleotide, Poly ADP ribose polymerase, High-throughput screening, Substrate (chemistry), 01 natural sciences, Biochemistry, 0104 chemical sciences, Analytical Chemistry, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Enzyme, Scintillation proximity assay, chemistry, Molecular Medicine, Plate reader, DNA, Biotechnology
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المؤلفون: Stephen P. Jackson, Kemp Mark Ian, Niall M. B. Martin, Xavier Jacq
المصدر: Cell Biochemistry and Biophysics
Cell Biochemistry and Biophysics; Vol 67مصطلحات موضوعية: Ubiquitin-Specific Proteases, Synthetic lethality, DNA Repair, DNA repair, DNA damage, Biophysics, Biology, Deubiquitylating enzyme, DUB, DNA damage response, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Ubiquitin, Neoplasms, Humans, 030304 developmental biology, 0303 health sciences, Original Paper, Mechanism (biology), Drug discovery, Cell Biology, General Medicine, 3. Good health, Cell biology, Ubiquitin ligase, body regions, Oxidative Stress, 030220 oncology & carcinogenesis, biology.protein, Checkpoint control, Tumor Suppressor Protein p53, Ubiquitin Thiolesterase, DNA Damage
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المؤلفون: Mark Boothby, Michael O. Hottiger, Mathias Ziegler, Zhao-Qi Wang, Bernhard Lüscher, Ruth Plummer, Niall M. B. Martin, Friedrich Koch-Nolte
المصدر: Science Signaling. 4
مصطلحات موضوعية: chemistry.chemical_classification, biology, Poly ADP ribose polymerase, Cell Biology, Nicotinamide adenine dinucleotide, Biochemistry, Poly (ADP-Ribose) Polymerase Inhibitor, chemistry.chemical_compound, Enzyme, chemistry, ADP-ribosylation, Sirtuin, Hydrolase, biology.protein, NAD+ kinase, Molecular Biology
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المؤلفون: Michael D. Threadgill, Niall M. B. Martin, Mary F. Mahon, Archana Dhami, Peter T. Sunderland, Esther C. Y. Woon, Hashim Javaid, Aoife B Bergin, Pauline J. Wood, Sophie R. Tully, Matthew D. Lloyd, Andrew S. Thompson, Louise A. Jones
المصدر: Sunderland, P T, Woon, E C Y, Dhami, A, Bergin, A B, Mahon, M F, Wood, P J, Jones, L A, Tully, S R, Lloyd, M D, Thompson, A S, Javaid, H, Martin, N M B & Threadgill, M D 2011, ' 5-benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2) ', Journal of Medicinal Chemistry, vol. 54, no. 7, pp. 2049-2059 . https://doi.org/10.1021/jm1010918
مصطلحات موضوعية: Gene isoform, Models, Molecular, Lactams, Stereochemistry, Protein Conformation, Poly ADP ribose polymerase, Alkylation, Poly(ADP-ribose) Polymerase Inhibitors, Substrate Specificity, Acylation, Hydrolysis, Inhibitory Concentration 50, Mice, Heck reaction, Cell Line, Tumor, Drug Discovery, Animals, Humans, Enzyme Inhibitors, Polymerase, biology, Chemistry, Hydrogen Bonding, Isoquinolines, Isoenzymes, Oxygen, biology.protein, Molecular Medicine, Poly [ADP-Ribose] Polymerase 2, Poly(ADP-ribose) Polymerases
وصف الملف: application/pdf
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المؤلفون: Niall M. B. Martin, Michael D. Threadgill, Louise A. Jones, Sophie R. Tully, Mary F. Mahon, Peter T. Sunderland, Hashim Javaid, Archana Dhami, Matthew D. Lloyd, Andrew S. Thompson
المصدر: Sunderland, P T, Dhami, A, Mahon, M F, Jones, L A, Tully, S R, Lloyd, M D, Thompson, A S, Javaid, H, Martin, N M B & Threadgill, M D 2011, ' Synthesis of 4-alkyl-, 4-aryl-and 4-arylamino-5-aminoisoquinolin-1-ones and identification of a new PARP-2 selective inhibitor ', Organic and Biomolecular Chemistry, vol. 9, no. 3, pp. 881-891 . https://doi.org/10.1039/c0ob00665c
مصطلحات موضوعية: Steric effects, Models, Molecular, Alkylation, Poly(ADP-ribose) Polymerase Inhibitors, Crystallography, X-Ray, Biochemistry, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Organic chemistry, Humans, Physical and Theoretical Chemistry, Amines, Enzyme Inhibitors, Alkyl, Demethylation, chemistry.chemical_classification, Molecular Structure, Aryl, Organic Chemistry, Hydrogen bromide, Halogenation, Isoquinolines, Combinatorial chemistry, Stille reaction, chemistry, Lactam
وصف الملف: application/pdf
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المؤلفون: Gabriele Fontana, Martin Stockley, Niall M. B. Martin, Roger John Griffin, Bernard T. Golding, Laurent Rigoreau, Graeme Cameron Murray Smith, William Clegg
المصدر: ChemInform. 33
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Stereochemistry, Biological property, DNA-Dependent Protein Kinase, Value (computer science), General Medicine, Crystal structure, DNA
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المؤلفون: Stephanie Maine, Niall M. B. Martin, Marc Geoffrey Hummersone, Carrie-Anne Molyneaux, Christine Bailey, Sharon Maguire, Frederic Georges Marie Leroux, Hermann Gesine Johanna, Graeme C. M. Smith, Ian Hickson, Mar Jimenez Quesada, James R. Pullen, Heather Mary Ellen Duggan, Keith Allan Menear, Peter D. Edwards, Martin Pass, Sylvie Gomez, Lisa Smith, Jan Drzewiecki, Karine Malagu, Armelle Le Gall
المصدر: Bioorganicmedicinal chemistry letters. 19(20)
مصطلحات موضوعية: Stereochemistry, Morpholines, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Diamines, Mechanistic Target of Rapamycin Complex 1, Biochemistry, mTORC2, Cell Line, Structure-Activity Relationship, Drug Discovery, Humans, Kinase activity, Molecular Biology, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Serine/threonine-specific protein kinase, Chemistry, Kinase, Drug discovery, TOR Serine-Threonine Kinases, Organic Chemistry, Proteins, Pyrimidines, Multiprotein Complexes, Molecular Medicine, Signal transduction, Protein Kinases, Transcription Factors
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المؤلفون: James Matthews, Niall M. B. Martin, Lucie Pietzka, A. Douglas-Jones, Alan Lau, Aaron Cranston, Alan Richard Clarke, Trevor Hay, Mark J. O'Connor, Anders O.H. Nygren, Graeme C. M. Smith
المصدر: Cancer research. 69(9)
مصطلحات موضوعية: Cancer Research, endocrine system diseases, Tumor suppressor gene, Combination therapy, Mammary gland, Genes, BRCA2, Poly (ADP-Ribose) Polymerase-1, Mice, Transgenic, Biology, Poly(ADP-ribose) Polymerase Inhibitors, Poly (ADP-Ribose) Polymerase Inhibitor, Piperazines, Carboplatin, chemistry.chemical_compound, Mice, Antineoplastic Combined Chemotherapy Protocols, medicine, Animals, BRCA2 Protein, Cancer, Mammary Neoplasms, Experimental, medicine.disease, Genes, p53, Disease Models, Animal, medicine.anatomical_structure, Oncology, chemistry, PARP inhibitor, Mutation, Cancer research, Phthalazines, Female, Growth inhibition, Tumor Suppressor Protein p53
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المؤلفون: Michiel de Bruin, Ariena Kersbergen, Niall M. B. Martin, Piet Borst, Jos Jonkers, Sven Rottenberg, Janneke E. Jaspers, Robert Boulter, Alan Lau, Mark J. O'Connor, Patrick W. B. Derksen, Anders O.H. Nygren, John Zevenhoven, Serge A.L. Zander, Eline van der Burg, Aaron Cranston
المصدر: Proceedings of the National Academy of Sciences of the United States of America. 105(44)
مصطلحات موضوعية: DNA Repair, Tariquidar, Antineoplastic Agents, Mammary Neoplasms, Animal, Mice, Transgenic, Platinum Compounds, Biology, Poly(ADP-ribose) Polymerase Inhibitors, Poly (ADP-Ribose) Polymerase Inhibitor, Piperazines, Olaparib, chemistry.chemical_compound, Mice, Breast cancer, medicine, Animals, Cisplatin, Multidisciplinary, Aromatase Inhibitors, BRCA1 Protein, Cancer, Biological Sciences, medicine.disease, Molecular biology, Carboplatin, chemistry, Drug Resistance, Neoplasm, Cancer research, Phthalazines, Female, Iniparib, Poly(ADP-ribose) Polymerases, Neoplasm Transplantation, medicine.drug, DNA Damage
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