المؤلفون: David M. Crizer, Julie R. Rice, Marci G. Smeltz, Katelyn S. Lavrich, Krishna Ravindra, John F. Wambaugh, Michael DeVito, Barbara A. Wetmore

المصدر: Toxics, Vol 12, Iss 9, p 672 (2024)

مصطلحات موضوعية: PFAS, toxicokinetics (TK), hepatic clearance, in vitro–in vivo extrapolation (IVIVE), New Approach Methods (NAMs), metabolism, Chemical technology, TP1-1185

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2305-6304/12/9/672; https://doaj.org/toc/2305-6304

URL الوصول: https://doaj.org/article/e1bcf9fb3f204f5fa7c8aeeeb7b6bb27

المؤلفون: Joshua Harrill

مصطلحات موضوعية: Toxicology (incl. clinical toxicology), ab initio next generation risk assessment (NGRA), New Approach Methods (NAMS), physiologically-based kinetic (PBK) models, points-of-departure (PODs) from in vitro assays, bioactivity exposure ratios (BER) to evaluate margin of safety

Relation: https://figshare.com/articles/presentation/Development_and_Evaluation_of_New_Approach_Methods_NAMs_for_Use_in_Next_Generation_Risk_Assessment_An_EPA_Unilever_Collaboration/25571967

الاتاحة: https://doi.org/10.23645/epacomptox.25571967.v1
https://figshare.com/articles/presentation/Development_and_Evaluation_of_New_Approach_Methods_NAMs_for_Use_in_Next_Generation_Risk_Assessment_An_EPA_Unilever_Collaboration/25571967

المؤلفون: Joshua A. Harrill

مصطلحات موضوعية: Toxicology (incl. clinical toxicology), New Approach Methods (NAMs), potency estimation, High-Throughput Transcriptomics [HTTr], High-Throughput Phenotypic Profiling [HTPP]

Relation: https://figshare.com/articles/presentation/Evaluating_the_Impact_of_Cell_Line_Choice_on_Determination_of_Human_Health_Protective_Molecular_Points-of-Departure/25439146

الاتاحة: https://doi.org/10.23645/epacomptox.25439146.v1
https://figshare.com/articles/presentation/Evaluating_the_Impact_of_Cell_Line_Choice_on_Determination_of_Human_Health_Protective_Molecular_Points-of-Departure/25439146

المؤلفون: Peter Schumann, Daniel Chang, Sally Mayasich, Sara Vliet

مصطلحات موضوعية: Toxicology (incl. clinical toxicology), New Approach Methods (NAMs), Species Extrapolation, SeqAPASS, Molecular Docking, Next Generation Risk Assessment

الاتاحة: https://doi.org/10.23645/epacomptox.27963888.v1
https://figshare.com/articles/presentation/Cross-Species_Molecular_Docking_Method_to_Support_Predictions_of_Species_Susceptibility_to_Chemical_Effects/27963888

المؤلفون: Joshua A. Harrill

مصطلحات موضوعية: Toxicology (incl. clinical toxicology), chemical bioactivity screening, in vitro hazard evaluation, molecular point of departure (mPOD) determination, New Approach Methods (NAMs), exposure

Relation: https://figshare.com/articles/presentation/In_Vitro_New_Approach_Methods_NAMs_for_Chemical_Bioactivity_Screening_and_Applications_to_Risk_Assessment/24511522

الاتاحة: https://doi.org/10.23645/epacomptox.24511522.v1
https://figshare.com/articles/presentation/In_Vitro_New_Approach_Methods_NAMs_for_Chemical_Bioactivity_Screening_and_Applications_to_Risk_Assessment/24511522

المؤلفون: Megan Culbreth

مصطلحات موضوعية: Toxicology (incl. clinical toxicology), developmental neurotoxicity, assay validation, new approach methods (NAMs), in vitro

Relation: https://figshare.com/articles/presentation/The_State_of_Developmental_Neurotoxicity_DNT_Potential_Use_of_an_In_Vitro_Testing_Battery_for_Regulatory_Assessments/24468148

الاتاحة: https://doi.org/10.23645/epacomptox.24468148.v1
https://figshare.com/articles/presentation/The_State_of_Developmental_Neurotoxicity_DNT_Potential_Use_of_an_In_Vitro_Testing_Battery_for_Regulatory_Assessments/24468148

المؤلفون: Logan Everett

مصطلحات موضوعية: Toxicology (incl. clinical toxicology), High-throughput Transcriptomics, New Approach Methods (NAMs), Toxicology, Chemical Safety Screening

Relation: https://figshare.com/articles/presentation/Leveraging_Transcriptomics_to_Evaluate_Chemical_Safety/24452044

الاتاحة: https://doi.org/10.23645/epacomptox.24452044.v1
https://figshare.com/articles/presentation/Leveraging_Transcriptomics_to_Evaluate_Chemical_Safety/24452044

المؤلفون: Kristin Isaacs, Katherine Phillips, Caroline Ring, John Wambaugh

مصطلحات موضوعية: Toxicology (incl. clinical toxicology), ExpoCast, chemical evaluation, new approach methods (NAMs), John Wambaugh

Relation: https://figshare.com/articles/presentation/EPA_s_ExpoCastProject_Advancing_Chemical_Evaluation_with_New_Approach_Methods_for_Exposure/24415522

الاتاحة: https://doi.org/10.23645/epacomptox.24415522.v1
https://figshare.com/articles/presentation/EPA_s_ExpoCastProject_Advancing_Chemical_Evaluation_with_New_Approach_Methods_for_Exposure/24415522

المؤلفون: Russell Thomas

مصطلحات موضوعية: Toxicology (incl. clinical toxicology), toxicity testing, New Approach Methods (NAMs), confidence frameworks, validation, computational toxicology

Relation: https://figshare.com/articles/presentation/Update_on_the_EPA_Biennial_NAM_Conference_and_U_S_NAS_Committee_on_Uncertainty_and_Variability_in_Traditional_Toxicity_Testing_Models/23587179

الاتاحة: https://doi.org/10.23645/epacomptox.23587179.v1
https://figshare.com/articles/presentation/Update_on_the_EPA_Biennial_NAM_Conference_and_U_S_NAS_Committee_on_Uncertainty_and_Variability_in_Traditional_Toxicity_Testing_Models/23587179

المؤلفون: Carlie LaLone, Peter Schumann

مصطلحات موضوعية: Bioinformatic methods development, Toxicology (incl. clinical toxicology), animal alternatives, new approach methods (NAMs), cross species extrapolation, bioinformatics

Relation: https://figshare.com/articles/presentation/Unilever-US_EPA_CRADA_Face_to_Face_Meeting_Environmental_Team_Status_Slides/22709725

الاتاحة: https://doi.org/10.23645/epacomptox.22709725.v1
https://figshare.com/articles/presentation/Unilever-US_EPA_CRADA_Face_to_Face_Meeting_Environmental_Team_Status_Slides/22709725

المؤلفون: Alison Harrill

مصطلحات موضوعية: Toxicology (incl. clinical toxicology), new approach methods (NAMs), toxicity testing, computational toxicology, Comptox Chemicals Dashboard, transcriptomics

Relation: https://figshare.com/articles/presentation/New_Approach_Methods_Development_at_EPA_s_Center_for_Computational_Toxicology_and_Exposure/22110305

الاتاحة: https://doi.org/10.23645/epacomptox.22110305.v1
https://figshare.com/articles/presentation/New_Approach_Methods_Development_at_EPA_s_Center_for_Computational_Toxicology_and_Exposure/22110305

المؤلفون: Christian Strupp, Marco Corvaro, Samuel M. Cohen, J. Christopher Corton, Kumiko Ogawa, Lysiane Richert, Miriam N. Jacobs

المصدر: International Journal of Molecular Sciences; Volume 24; Issue 17; Pages: 13246

مصطلحات موضوعية: non-genotoxic carcinogens, carcinogenicity, mitogenicity, regenerative proliferation, hazard assessment, molecular targets, new approach methods (NAMs)

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Toxicology; https://dx.doi.org/10.3390/ijms241713246

الاتاحة: https://doi.org/10.3390/ijms241713246

المؤلفون: Russell Thomas

مصطلحات موضوعية: Toxicology (incl. clinical toxicology), adverse outcome pathway, toxicity testing, new approach methods (NAMs), toxicogenomics

Relation: https://figshare.com/articles/presentation/Toxicogenomics_and_Its_Relevance_to_Support_Hazard_Assessment/19742332

الاتاحة: https://doi.org/10.23645/epacomptox.19742332.v1
https://figshare.com/articles/presentation/Toxicogenomics_and_Its_Relevance_to_Support_Hazard_Assessment/19742332

المؤلفون: Zunwei Chen, Suji Jang, James M. Kaihatu, Yi-Hui Zhou, Fred A. Wright, Weihsueh A. Chiu, Ivan Rusyn

المصدر: International Journal of Environmental Research and Public Health; Volume 18; Issue 24; Pages: 13378

مصطلحات موضوعية: new approach methods (NAMs), environmental mixtures, disaster research

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Environmental Health; https://dx.doi.org/10.3390/ijerph182413378

الاتاحة: https://doi.org/10.3390/ijerph182413378

المؤلفون: Joseph Bundy, Richard Judson, Antony Williams, Chris Grulke, Imran Shah, Logan Everett

مصطلحات موضوعية: Toxicology (incl. clinical toxicology), Transcriptomics, Molecular Initiating Events, New Approach Methods (NAMS), Machine Learning

Relation: https://figshare.com/articles/poster/Predicting_Molecular_Initiating_Events_From_Gene_Expression_Profiles/25833280

الاتاحة: https://doi.org/10.23645/epacomptox.25833280.v1
https://figshare.com/articles/poster/Predicting_Molecular_Initiating_Events_From_Gene_Expression_Profiles/25833280

المؤلفون: Carlie A. Lalone, Maxwell Botz, Peter Schumann, Wilson Melendez, Audrey Wilkinson, Cody Simmons

مصطلحات موضوعية: Bioinformatic methods development, Sequence analysis, Toxicology (incl. clinical toxicology), Bioavailability and ecotoxicology, Animal Alternatives, SeqAPASS, New Approach Methods (NAMs), Cross Species Extrapolation, Bioinfomatics

Relation: https://figshare.com/articles/poster/Expanding_SeqAPASS_Capabilities_to_Protein_Structural_Comparisons_Across_Species/25583235

الاتاحة: https://doi.org/10.23645/epacomptox.25583235.v1
https://figshare.com/articles/poster/Expanding_SeqAPASS_Capabilities_to_Protein_Structural_Comparisons_Across_Species/25583235

المؤلفون: Ryan Staub, Wilson Melendez, Audrey Wilkinson, Cody Simmons, Carlie A. Lalone

مصطلحات موضوعية: Bioinformatic methods development, Sequence analysis, Toxicology (incl. clinical toxicology), Bioavailability and ecotoxicology, New Approach Methods (NAMs), SeqAPASS, Protein Structural prediction, In silico methods, biological pathways

Relation: https://figshare.com/articles/poster/Integration_of_domain-specific_structural_prediction_into_the_Sequence_Alignment_to_Predict_Across_Species_Susceptibility_SeqAPASS_tool/25587444

الاتاحة: https://doi.org/10.23645/epacomptox.25587444.v1
https://figshare.com/articles/poster/Integration_of_domain-specific_structural_prediction_into_the_Sequence_Alignment_to_Predict_Across_Species_Susceptibility_SeqAPASS_tool/25587444

المؤلفون: Braak, S.J. ter, Niemeijer, M.C., Wolters, L., Le Dévédec, S.E., Bouwman, R.J.P., Water, B. van de

المصدر: Mutagenesis

مصطلحات موضوعية: DNA Damage, Mutagenicity, Test Method, HepG2 BAC GFP, 3D Model, Drug Metabolism, High Content Imaging, Next Generation Risk Assessment (NGRA), New Approach Methods (NAMs)

وصف الملف: application/pdf

Relation: lucris-id: 430117616; https://hdl.handle.net/1887/3216873

الاتاحة: https://hdl.handle.net/1887/3216873
https://doi.org/10.1093/mutage/geab031

المؤلفون: Basu, Niladri, Xu, Ke, Mittal, Krittika, Rulli, Samuel, Jakubowski, Jennifer, George, Saji

مصطلحات موضوعية: Agricultural Sciences, Earth and Environmental Sciences, Medicine, Health and Life Sciences, toxicogenomics, genomics, New Approach Methods NAMs, alternative to animal models, high throughput, toxicology, food safety

وصف الملف: text/tab-separated-values

الاتاحة: https://dx.doi.org/10.5683/sp3/1bbfce
https://borealisdata.ca/citation?persistentId=doi:10.5683/SP3/1BBFCE

المؤلفون: Bob van de Water, Liesanne Wolters, Sylvia E. Le Dévédec, Bas ter Braak, Peter Bouwman, Marije Niemeijer

المصدر: Mutagenesis, 37(2), 130-142
Mutagenesis

مصطلحات موضوعية: Test Method, HepG2 BAC GFP, 3D Model, DNA damage, Health, Toxicology and Mutagenesis, Next Generation Risk Assessment (NGRA), Toxicology, medicine.disease_cause, Green fluorescent protein, 03 medical and health sciences, 0302 clinical medicine, Drug Metabolism, Mutagenicity, New Approach Methods (NAMs), Genetics, medicine, Humans, Viability assay, Mode of action, Genetics (clinical), 030304 developmental biology, 0303 health sciences, BTG2, 3D Model, Mutagenicity Tests, Chemistry, DNA Damage, Mutagenicity, In vitro toxicology, High Content Imaging, Hep G2 Cells, HepG2 BAC GFP, In vitro, Biochemistry, Test Method, 030220 oncology & carcinogenesis, Tumor Suppressor Protein p53, Genotoxicity, Mutagens, DNA Damage

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c9243c6dbb2a4d056266f56a3e6873
http://hdl.handle.net/1887/3216873