يعرض 1 - 20 نتائج من 1,326 نتيجة بحث عن '"Neutrophil Engraftment"', وقت الاستعلام: 0.56s تنقيح النتائج
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    Academic Journal

    المصدر: Kammersgaard , M B , Kielsen , K , Nielsen , C H , Ifversen , M , Bohr , A H & Müller , K 2023 , ' Plasma Levels of MRP-8/14 Associate With Neutrophil Recovery, Bacterial Bloodstream Infections, and Engraftment Syndrome Following Pediatric Allogeneic Hematopoietic Stem Cell Transplantation ' , Transplantation and Cellular Therapy , vol. 29 , no. 4 , pp. 242.e1-242.e9 . https://doi.org/10.1016/j.jtct.2022.12.019

    وصف الملف: application/pdf

    الاتاحة: https://curis.ku.dk/portal/da/publications/plasma-levels-of-mrp814-associate-with-neutrophil-recovery-bacterial-bloodstream-infections-and-engraftment-syndrome-following-pediatric-allogeneic-hematopoietic-stem-cell-transplantation(25f93a67-432b-431c-867d-eb405fd43759).html
    https://doi.org/10.1016/j.jtct.2022.12.019
    https://curis.ku.dk/ws/files/388872131/1_s2.0_S266663672201867X_main.pdf

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    Academic Journal

    المساهمون: La Rocca, Ursula, Perrone, Maria P, Piciocchi, Alfonso, Barberi, Walter, Gesuiti, Paola, Laurenti, Luca, Cinti, Paola, Gozzer, Maria, Bafti, Manhaz Shafii, Carmini, Daniela, Cinelli, Nadia, Cavallari, Claudio, Giovannetti, Gianluca, Ricci, Roberto, Girelli, Gabriella, Foà, Robin, Martelli, Maurizio, Coluzzi, Serelina, Iori, Anna P

    مصطلحات موضوعية: Background: In the setting of mismatched-hematopoietic stem cells transplantation, the detection of antibodies directed against donor-specific HLA allele(s) or antigen(s) (DSA) represents a barrier for engraftment. It is thus necessary to plan an immunosuppressive strategy, or to select an alternative donor. This prospective study aimed at evaluating the efficacy of our strategy for testing DSAs and the efficacy of the desensitization strategy (DS) employed between November 2017 and November 2020. Materials and methods: The anti-HLA antibody search was performed using the Luminex bead assays (Lifecode ID and LSA I/II-Immucor) and expressed as mean fluorescence intensity (MFI >1,000 positive). If the patient had DSAs and no alternative donors, a DS was employed with rituximab (day -15), 2 single volume plasmaphereses (PP, days -9 and -8), intravenous immunoglobulins (day -7) and infusion of HLA selected platelets, if persistent DSAs were directed against class I HLA. DS was scheduled with or without PP, according to the DSA MFI (>1,000 or <5,000) and FCXM (flow cytometry crossmatch). Results: Twenty-two out of 126 patients (17.46%) showed anti-HLA antibodies, 5 of them DSAs (3.97% of total), 3 patients underwent DS obtaining engraftment. Female gender (p=0.033) and a history of previous pregnancies or miscarriages (p=0.009) showed a statistically significant impact on alloimmunization. Factors associated with a delayed neutrophil engraftment were patient's female gender (p=0.039), stem cell source (p=0.025), and a high HSCT-specific comorbidity index (p=0.028). None of the analyzed variables, including the DSA detection, influenced engraftment. Conclusions: Our study confirms the importance to test DSAs in mismatched-hematopoietic stem cells transplantation The DS used proved successful in removing DSAs. Prospective multicenter studies are needed to better define and validate consensus strategies on DSA management in HSCT

    Relation: info:eu-repo/semantics/altIdentifier/pmid/37847211; info:eu-repo/semantics/altIdentifier/wos/WOS:001227816800008; firstpage:1; lastpage:10; numberofpages:10; journal:BLOOD TRANSFUSION; https://hdl.handle.net/11573/1691221

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    المصدر: European Journal of Haematology. 108:61-72

    وصف الملف: application/pdf

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    المساهمون: Recherche clinique appliquée à l'hématologie ((EA_3518)), Université Paris Diderot - Paris 7 (UPD7), Centre Scientifique de Monaco (CSM), Agence de la biomédecine [Saint-Denis la Plaine], IRCCS San Raffaele Scientific Institute [Milan, Italie], Etablissement français du sang - Normandie (EFS), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Etablissement Français du Sang Nouvelle Aquitaine [Bordeaux] (EFS Bordeaux Nouvelle Aquitaine), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Etablissement Français du Sang Ile de France (EFS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Henry Mondor, Etablissement français du sang [Poitiers] (EFS), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Etablissement français du sang- Rhône-Alpes [Lyon], Etablissement Français du Sang [Grenoble] (EFS), Etablissement français du sang [Bourgogne-Franche-Comté] (EFS BFC), Etablissement français du sang [Rennes] (EFS Bretagne), Hôpital Robert Debré Paris, Hôpital Robert Debré, Hôpital de la Timone [CHU - APHM] (TIMONE), Universidade de São Paulo = University of São Paulo (USP), CHU Clermont-Ferrand, Service d'Hématologie [CHRU Nancy], Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)

    المصدر: Bone Marrow Transplantation
    Bone Marrow Transplantation, 2021, 56 (10), pp.2497-2509. ⟨10.1038/s41409-021-01313-x⟩

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    المصدر: Chinese Medical Journal, Vol 134, Iss 10, Pp 1199-1208 (2021)
    Chinese Medical Journal

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    المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
    Scientific Reports

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    المصدر: Annals of Hematology. 100(3):743-752

    وصف الملف: application/pdf

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    المصدر: Transfusion. 61:1202-1214