المؤلفون: Xiawei Dang (8992400), Sidney B. Williams (11306623), Sriram Devanathan (474812), Antonietta Franco (760360), Lijun Fu (120480), Peter R. Bernstein (2004739), Daniel Walters (391478), Gerald W. Dorn (7327829)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Neuroscience, Physiology, Science Policy, Chemical Sciences not elsewhere classified, MFN, analogue, Neuronal Activity Mitochondrial fra., plasma, activation, cycloalkyl linker groups, 380 side chains, Small molecule mitofusin activators, single-crystal X-ray diffraction st., first-in-class mitofusin activator, neuron pharmacodynamic effects, 5 B, system bioavailability, murine ALS phenotypes

Relation: https://figshare.com/articles/journal_contribution/Pharmacophore-Based_Design_of_Phenyl-_hydroxycyclohexyl_Cycloalkyl-Carboxamide_Mitofusin_Activators_with_Improved_Neuronal_Activity/15772747

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00163.s001

المؤلفون: Xiawei Dang (8992400), Sidney B. Williams (11306623), Sriram Devanathan (474812), Antonietta Franco (760360), Lijun Fu (120480), Peter R. Bernstein (2004739), Daniel Walters (391478), Gerald W. Dorn (7327829)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Neuroscience, Physiology, Science Policy, Chemical Sciences not elsewhere classified, MFN, analogue, Neuronal Activity Mitochondrial fra., plasma, activation, cycloalkyl linker groups, 380 side chains, Small molecule mitofusin activators, single-crystal X-ray diffraction st., first-in-class mitofusin activator, neuron pharmacodynamic effects, 5 B, system bioavailability, murine ALS phenotypes

Relation: https://figshare.com/articles/dataset/Pharmacophore-Based_Design_of_Phenyl-_hydroxycyclohexyl_Cycloalkyl-Carboxamide_Mitofusin_Activators_with_Improved_Neuronal_Activity/15772759

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00163.s002

المؤلفون: Xiawei Dang (8992400), Sidney B. Williams (11306623), Sriram Devanathan (474812), Antonietta Franco (760360), Lijun Fu (120480), Peter R. Bernstein (2004739), Daniel Walters (391478), Gerald W. Dorn (7327829)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Neuroscience, Physiology, Science Policy, Chemical Sciences not elsewhere classified, MFN, analogue, Neuronal Activity Mitochondrial fra., plasma, activation, cycloalkyl linker groups, 380 side chains, Small molecule mitofusin activators, single-crystal X-ray diffraction st., first-in-class mitofusin activator, neuron pharmacodynamic effects, 5 B, system bioavailability, murine ALS phenotypes

Relation: https://figshare.com/articles/dataset/Pharmacophore-Based_Design_of_Phenyl-_hydroxycyclohexyl_Cycloalkyl-Carboxamide_Mitofusin_Activators_with_Improved_Neuronal_Activity/15772777

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00163.s003

المؤلفون: Xiawei Dang (8992400), Sidney B. Williams (11306623), Sriram Devanathan (474812), Antonietta Franco (760360), Lijun Fu (120480), Peter R. Bernstein (2004739), Daniel Walters (391478), Gerald W. Dorn (7327829)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Neuroscience, Physiology, Science Policy, Chemical Sciences not elsewhere classified, MFN, analogue, Neuronal Activity Mitochondrial fra., plasma, activation, cycloalkyl linker groups, 380 side chains, Small molecule mitofusin activators, single-crystal X-ray diffraction st., first-in-class mitofusin activator, neuron pharmacodynamic effects, 5 B, system bioavailability, murine ALS phenotypes

Relation: https://figshare.com/articles/dataset/Pharmacophore-Based_Design_of_Phenyl-_hydroxycyclohexyl_Cycloalkyl-Carboxamide_Mitofusin_Activators_with_Improved_Neuronal_Activity/15772780

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00163.s004