المؤلفون: Sarah E. Conduit, Wayne Pearce, Amandeep Bhamra, Benoit Bilanges, Laura Bozal-Basterra, Lazaros C. Foukas, Mathias Cobbaut, Sandra D. Castillo, Mohammad Amin Danesh, Mahreen Adil, Arkaitz Carracedo, Mariona Graupera, Neil Q. McDonald, Peter J. Parker, Pedro R. Cutillas, Silvia Surinova, Bart Vanhaesebroeck

المصدر: Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/73d0a1177d1d4ad6bd109cda96644ef1

المؤلفون: Elena R. Rhymes, Andrew P. Tosolini, Alexander D. Fellows, William Mahy, Neil Q. McDonald, Giampietro Schiavo

المصدر: Cell Death and Disease, Vol 13, Iss 7, Pp 1-11 (2022)

مصطلحات موضوعية: Cytology, QH573-671

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-4889

URL الوصول: https://doaj.org/article/0fdffd993fc54602a801ffc8fbe72a71

المؤلفون: Mathias Cobbaut, Peter J Parker, Neil Q McDonald

مصطلحات موضوعية: Biochemistry & Proteomics, Cell Membrane, Protein Kinase C, apkc, atypical pkc, cell polarity, phospholipids, Parker CC2140, McDonald CC2068, 03 Chemical Sciences, 06 Biological Sciences, 11 Medical and Health Sciences, Biochemistry & Molecular Biology, 3101 Biochemistry and cell biology

Relation: https://figshare.com/articles/journal_contribution/Into_the_fold_advances_in_understanding_aPKC_membrane_dynamics_/24935904

الاتاحة: https://doi.org/10.25418/crick.24935904.v1
https://figshare.com/articles/journal_contribution/Into_the_fold_advances_in_understanding_aPKC_membrane_dynamics_/24935904

المؤلفون: Silvia Martini, Khalil Davis, Rupert Faraway, Lisa Elze, Nicola Lockwood, Andrew Jones, Xiao Xie, Neil Q. McDonald, David J. Mann, Alan Armstrong, Jernej Ule, Peter J. Parker

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/d5e625f8ebda47a580e2c0dff47b3aba

المؤلفون: Lingtian Zhang (8776091), Marialuisa Moccia (750013), David C. Briggs (8776097), Jaideep B. Bharate (1724008), Naga Rajiv Lakkaniga (8776094), Phillip Knowles (12007131), Wei Yan (4327), Phuc Tran (12007134), Anupreet Kharbanda (12007137), Xiuqi Wang (6247901), Yuet-Kin Leung (565316), Brendan Frett (1321818), Massimo Santoro (141869), Neil Q. McDonald (8776103), Francesca Carlomagno (103407), Hong-yu Li (1321812)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Neuroscience, Pharmacology, Biotechnology, Developmental Biology, Cancer, Infectious Diseases, Virology, Chemical Sciences not elsewhere classified, trisubstituted pyrimidine derivatives, attractive therapeutic target, showing potent inhibition, ret phosphorylation indicated, 20 , wt <, ret inhibition, potent inhibitors, unique pose, several fda, ret revealed, resistant mutant, ray structure, gatekeeper mutant, frequently reported, driven lc, driven cancers, biological activity, bifurcates beneath

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_N_Trisubstituted_Pyrimidine_Derivatives_as_Type_I_RET_and_RET_Gatekeeper_Mutant_Inhibitors_with_a_Novel_Kinase_Binding_Pose/19076526

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01280.s001

المؤلفون: Ben D. Bax, Dmitry Sutormin, Neil Q. McDonald, Glenn A. Burley, Tatyana Shelkovnikova

المصدر: International Journal of Molecular Sciences; Volume 23; Issue 19; Pages: 11541

مصطلحات موضوعية: topoisomerases, inhibitors, gene editing, etoposide, camptothecin, CRISPR/Cas9

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Pathology, Diagnostics, and Therapeutics; https://dx.doi.org/10.3390/ijms231911541

الاتاحة: https://doi.org/10.3390/ijms231911541

المؤلفون: Morgan Jones, Fabienne Beuron, Aaron Borg, Andrea Nans, Christopher P. Earl, David C. Briggs, Ambrosius P. Snijders, Maureen Bowles, Edward P. Morris, Mark Linch, Neil Q. McDonald

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/92077ba79c5f4633a25574477d6776b9

المؤلفون: Silvia Martini (140395), Khalil Davis (9528593), Rupert Faraway (7587098), Lisa Elze (11760539), Nicola Lockwood (780367), Andrew Jones (18254), Xiao Xie (133080), Neil Q McDonald (8118887), David J Mann (11026422), Alan Armstrong (1676839), Jernej Ule (115588), Peter J Parker (8117240)

مصطلحات موضوعية: Uncategorized, Parker FC001130, McDonald FC001115, Ule - sec, Nurse FC001121, LM-ack, PRT-ack, PC-ack

Relation: https://figshare.com/articles/journal_contribution/A_genetically-encoded_crosslinker_screen_identifies_SERBP1_as_a_PKC_substrate_influencing_translation_and_cell_division/17086373

الاتاحة: https://doi.org/10.25418/crick.17086373.v1

المؤلفون: Takashi Nakaoku, Takashi Kohno, Mitsugu Araki, Seiji Niho, Rakhee Chauhan, Phillip P. Knowles, Katsuya Tsuchihara, Shingo Matsumoto, Yoko Shimada, Sachiyo Mimaki, Genichiro Ishii, Hitoshi Ichikawa, Satoru Nagatoishi, Kouhei Tsumoto, Yasushi Okuno, Kiyotaka Yoh, Neil Q. McDonald, Koichi Goto

المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/5dda588c6b064bfcbe3ac0b3c008bd63

المؤلفون: Iván Plaza-Menacho, Karin Barnouin, Rachael Barry, Annabel Borg, Mariam Orme, Rakhee Chauhan, Stephane Mouilleron, Rubén J. Martínez-Torres, Pascal Meier, Neil Q. McDonald

المصدر: Cell Reports, Vol 17, Iss 12, Pp 3319-3332 (2016)

مصطلحات موضوعية: receptor tyrosine kinase, RTK, structure-function, phosphorylation, dual-specificity, signaling, oncogene, Drosophila, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124716316345; https://doaj.org/toc/2211-1247

URL الوصول: https://doaj.org/article/d79f670d6e0b48388c49a0287b96fbce

المؤلفون: Lingtian Zhang, Marialuisa Moccia, David C. Briggs, Jaideep B. Bharate, Naga Rajiv Lakkaniga, Phillip Knowles, Wei Yan, Phuc Tran, Anupreet Kharbanda, Xiuqi Wang, Yuet-Kin Leung, Brendan Frett, Massimo Santoro, Neil Q. McDonald, Francesca Carlomagno, Hong-yu Li

المساهمون: Zhang, Lingtian, Moccia, Marialuisa, Briggs, David C, Bharate, Jaideep B, Lakkaniga, Naga Rajiv, Knowles, Phillip, Yan, Wei, Tran, Phuc, Kharbanda, Anupreet, Wang, Xiuqi, Leung, Yuet-Kin, Frett, Brendan, Santoro, Massimo, Mcdonald, Neil Q, Carlomagno, Francesca, Li, Hong-Yu

المصدر: Journal of Medicinal Chemistry. 65:1536-1551

مصطلحات موضوعية: Wound Healing, Lung Neoplasms, Proto-Oncogene Proteins c-ret, Adenocarcinoma of Lung, Apoptosis, Structure-Activity Relationship, Pyrimidines, Mutation, Drug Discovery, Tumor Cells, Cultured, Humans, Molecular Medicine, Protein Kinase Inhibitors, Cell Proliferation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de99c59f8ad8a17aa62c446b5f5bf21
https://doi.org/10.1021/acs.jmedchem.1c01280

المؤلفون: Mathias Cobbaut, Neil Q. McDonald, Peter J. Parker

مصطلحات موضوعية: Chemical Biology & High Throughput, Signalling & Oncogenes, Cell Cycle & Chromosomes, Cell Biology, Biochemistry & Proteomics, Molecular Biology, Biochemistry, Structural Biology & Biophysics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23dcc25c99c56933bfed6e899cdc29bd
https://doi.org/10.1101/2023.01.03.522491

المؤلفون: Kerry M. Goodman, Svend Kjær, Fabienne Beuron, Phillip P. Knowles, Agata Nawrotek, Emily M. Burns, Andrew G. Purkiss, Roger George, Massimo Santoro, Edward P. Morris, Neil Q. McDonald

المصدر: Cell Reports, Vol 8, Iss 6, Pp 1894-1904 (2014)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124714007165; https://doaj.org/toc/2211-1247

URL الوصول: https://doaj.org/article/e0fc25a58f5a44f0a8e9b565c5efa8fc

المؤلفون: Khalil Davis, David J. Mann, Ulrike S. Eggert, John D. Scott, Steven Lynham, Victoria Crossland, Xiaoping Yang, Tanya N. Soliman, Peter J. Parker, Alan Armstrong, Neil Q. McDonald, Lisa Watson, Joanna R. Kelly, Nicola Lockwood

المصدر: Biochemical Journal

مصطلحات موضوعية: Mutant, Aurora B kinase, Protein Kinase C-epsilon, Spindle Apparatus, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Chemical Biology, aurora kinases, Compartment (development), Aurora Kinase B, Humans, Phosphorylation, Molecular Biology, Protein kinase C, Research Articles, 14-3-3, 030304 developmental biology, C2 domain, Cytokinesis, 0303 health sciences, Gene knockdown, Chemistry, Cell Biology, abscission checkpoint, Signaling, Cell biology, Midbody, HEK293 Cells, 14-3-3 Proteins, midbody, 030220 oncology & carcinogenesis, Cell Cycle, Growth & Proliferation, protein kinase C, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d85219ff82fd92ec0f42d125307988a
http://europepmc.org/articles/PMC8238520

المؤلفون: Lisa Watson, Peter J. Parker, Mark Linch, Mathias Cobbaut, Tanya N. Soliman, Véronique Calleja, Jacqueline J. T. Marshall, Silvia Martini, Neil Q. McDonald, Probir Chakravarty, Sophie J. Brown

المصدر: Nature Reviews Cancer. 21:51-63

مصطلحات موضوعية: Gene isoform, Stromal cell, Kinase, Applied Mathematics, General Mathematics, Cancer, Context (language use), Biology, medicine.disease, Immune checkpoint, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Bystander effect, medicine, Neuroscience, Protein kinase C

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::32e1bf02f9b40a301e52c6f1cd0a444b
https://doi.org/10.1038/s41568-020-00310-4

المؤلفون: Sara Al Rawi, Lorna Simpson, Neil Q. McDonald, Veronika Chernuha, Orly Elpeleg, Massimo Zeviani, Roger A. Barker, Ronen Spiegel, Heike Laman

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7eb544a08a24170b08f6719d9c28e8ef
https://doi.org/10.1101/2021.12.22.473884

المؤلفون: Christopher Earl, Ambrosius P. Snijders, Maureen Bowles, Fabienne Beuron, Aaron J. Borg, Morgan Jones, David Briggs, Andrea Nans, Mark Linch, Neil Q. McDonald, Edward P. Morris

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Xeroderma pigmentosum, Protein Conformation, Science, General Physics and Astronomy, Diseases, macromolecular substances, bcs, medicine.disease_cause, Biochemistry, Article, General Biochemistry, Genetics and Molecular Biology, Structure-Activity Relationship, 03 medical and health sciences, Endonuclease, chemistry.chemical_compound, 0302 clinical medicine, Protein Domains, medicine, Humans, Binding site, lcsh:Science, Xeroderma Pigmentosum, Nuclease, Mutation, Binding Sites, Multidisciplinary, biology, Chemistry, Cryoelectron Microscopy, DNA, General Chemistry, Endonucleases, medicine.disease, 3. Good health, Cell biology, DNA-Binding Proteins, Fanconi Anemia, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, lcsh:Q, Protein Multimerization, ERCC1, Nucleotide excision repair

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ae87f15b00e7dd7bc8b620dae28c70
https://doaj.org/article/92077ba79c5f4633a25574477d6776b9

المؤلفون: Thane A. Campbell, James W. Dear, Annya Bruce, Bethany Mills, Tashfeen Walton, Emma Scholefield, Adam Marshall, Neil Q. McDonald, Thomas H. Craven, Timothy S. Walsh, Duncan Humphries, Ahsan R. Akram, Kevin Dhaliwal, David E. Newby, Christopher Haslett, Joanne Mair, Adam T. Hill

المصدر: Craven, T H, Walton, T, Akram, A R, Scholefield, E, Mcdonald, N, Marshall, A D L, Humphries, D C, Mills, B, Campbell, T A, Bruce, A, Mair, J, Dear, J W, Newby, D E, Hill, A T, Walsh, T S, Haslett, C & Dhaliwal, K 2021, ' Activated neutrophil fluorescent imaging technique for human lungs ', Scientific Reports, vol. 11, no. 1 . https://doi.org/10.1038/s41598-020-80083-w
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

مصطلحات موضوعية: 0301 basic medicine, Male, Pathology, medicine.medical_specialty, Neutrophils, Science, Inflammation, Cellular imaging, Article, Neutrophil Activation, 03 medical and health sciences, 0302 clinical medicine, In vivo, Endomicroscopy, medicine, Animals, Humans, Lung, Respiratory tract diseases, Multidisciplinary, Pancreatic Elastase, business.industry, Pinocytosis, Elastase, In vitro, Bronchiectasis, 030104 developmental biology, Spectrometry, Fluorescence, 030228 respiratory system, Medicine, Molecular imaging, medicine.symptom, business, Ex vivo

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856a21122b702775030cfd15054a6b98
https://www.pure.ed.ac.uk/ws/files/191779842/s41598_020_80083_w_1_.pdf

المؤلفون: Francesca M. Houghton, Andrea Nans, Christopher Earl, Neil Q. McDonald, Svend Kjaer, Pauline B. McIntosh, David Briggs, Phillip P. Knowles, Andrew Purkiss, Sarah E. Adams, Agata Nawrotek, Kerry M. Goodman, Aaron J. Borg, Annabel Borg

المصدر: Structure(London, England:1993)

مصطلحات موضوعية: Models, Molecular, Glial Cell Line-Derived Neurotrophic Factor Receptors, co-receptor, Co-receptor, glycosylation, Protein Conformation, GDNF family ligands, Crystallography, X-Ray, Article, Receptor tyrosine kinase, 03 medical and health sciences, Protein Domains, Structural Biology, Glial cell line-derived neurotrophic factor, Animals, ligand recognition, Glial Cell Line-Derived Neurotrophic Factor, Receptor, cystine knot, Molecular Biology, Zebrafish, X-ray crystallography, 030304 developmental biology, 0303 health sciences, biology, Chemistry, Cryoelectron Microscopy, Proto-Oncogene Proteins c-ret, 030302 biochemistry & molecular biology, Cystine knot, Zebrafish Proteins, Cadherins, biology.organism_classification, Cell biology, Cytoplasm, Multiprotein Complexes, receptor tyrosine kinase, biology.protein, cryo-EM, RET, Function (biology), Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4a4294b6a753737fb2a4f8fea66864
https://doi.org/10.1016/j.str.2020.12.012

المؤلفون: Peter J, Parker, Sophie J, Brown, Veronique, Calleja, Probir, Chakravarty, Mathias, Cobbaut, Mark, Linch, Jacqueline J T, Marshall, Silvia, Martini, Neil Q, McDonald, Tanya, Soliman, Lisa, Watson

المصدر: Nature reviews. Cancer. 21(1)

مصطلحات موضوعية: Isoenzymes, Neoplasms, Mutation, Tumor Microenvironment, Animals, Humans, Phosphorylation, Promoter Regions, Genetic, Protein Kinase C

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::410d4d3047c3f5feee1b3390ee9d6c72
https://pubmed.ncbi.nlm.nih.gov/33177705