المؤلفون: Tao Zhang, Gaia Scalabrino, Neil Frankish, Helen Sheridan

المصدر: Molecules, Vol 23, Iss 7, p 1503 (2018)

مصطلحات موضوعية: bioactive indanes, PH46A, enantioselective, biocatalysis, hydrolases, phase-transfer catalyst (PTC), Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1420-3049/23/7/1503; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/a062af63ac834a068ede4903a7476de8

المؤلفون: Helen Sheridan, Neil Frankish, Tom McCabe, Vilmar Bandero, Tao Zhang

المصدر: Acta Crystallographica Section E, Vol 69, Iss 8, Pp o1306-o1307 (2013)

مصطلحات موضوعية: Crystallography, QD901-999

وصف الملف: electronic resource

Relation: http://scripts.iucr.org/cgi-bin/paper?S1600536813018990; https://doaj.org/toc/1600-5368

URL الوصول: https://doaj.org/article/46aa7007292d448d8c48b6bf7fcf883b

المؤلفون: Tao Zhang, Tom McCabe, Bartosz Marzec, Neil Frankish, Helen Sheridan

المصدر: Acta Crystallographica Section E, Vol 68, Iss 4, Pp o958-o958 (2012)

مصطلحات موضوعية: Crystallography, QD901-999

وصف الملف: electronic resource

Relation: http://scripts.iucr.org/cgi-bin/paper?S160053681200606X; https://doaj.org/toc/1600-5368

URL الوصول: https://doaj.org/article/ed1889bbc38b47db8a28d0d049a14bfb

المؤلفون: Anthony Linden, Christopher S. Frampton, Tao Zhang, Gaia A. Scalabrino, Neil Frankish, Helen Sheridan, A Tao Zhang, B Gaia A, B Neil Frankishc, Helen Sheridanc

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://bura.brunel.ac.uk/bitstream/2438/8347/2/Fulltext.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.656.4111; http://bura.brunel.ac.uk/bitstream/2438/8347/2/Fulltext.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.656.4111
http://bura.brunel.ac.uk/bitstream/2438/8347/2/Fulltext.pdf

المؤلفون: Helen Sheridan, Brendan McHale, Neil Frankish

المصدر: The Journal of Pharmacy and Pharmacology

مصطلحات موضوعية: 0301 basic medicine, colitis, Anti-Inflammatory Agents, Indane, Pharmaceutical Science, Dermatitis, Contact, Jurkat cells, Inflammatory bowel disease, Molecular and Clinical Pharmacology, Oxazolone, Jurkat Cells, Mice, bi‐indanes, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, inflammatory bowel disease, medicine, Animals, Humans, Hypersensitivity, Delayed, Colitis, Inflammation, Pharmacology, Mice, Inbred BALB C, Dextran Sulfate, Diastereomer, Interleukin, Stereoisomerism, Inflammatory Bowel Diseases, medicine.disease, Disease Models, Animal, 030104 developmental biology, delayed‐type hypersensitivity, chemistry, 030220 oncology & carcinogenesis, Indans, Immunology, Female, Enantiomer, Research Paper

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ddf1f6ded764395dc5ce216eff7f96
https://doi.org/10.1111/jphp.12846

المؤلفون: Gaia Scalabrino, Tao Zhang, Neil Frankish, Helen Sheridan

المساهمون: The Wellcome Trust UK

المصدر: Articles

مصطلحات موضوعية: Bioactive indane, PH46A, PH46, Metabolism, PH132, LC-MS, Biosynthesis, 010405 organic chemistry, Metabolite, 010401 analytical chemistry, Primary metabolite, Life Sciences, Pharmacology, 01 natural sciences, 0104 chemical sciences, Hydroxylation, chemistry.chemical_compound, chemistry, Pharmacokinetics, In vivo, Microsome, Glucuronide

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c56e8b356535fa2ffaa1501fb9af22
https://arrow.tudublin.ie/schfsehart/347

المؤلفون: Tao Zhang, Neil Frankish, Gaia Scalabrino, Helen Sheridan

المساهمون: The Wellcome Trust UK

المصدر: Articles
Molecules, Vol 23, Iss 7, p 1503 (2018)
Molecules
Volume 23
Issue 7
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

مصطلحات موضوعية: Ketone, Alkylation, biocatalysis, Cinchona Alkaloids, Anti-Inflammatory Agents, Pharmaceutical Science, Chemistry Techniques, Synthetic, hydrolases, 010402 general chemistry, Proof of Concept Study, 01 natural sciences, Article, Analytical Chemistry, Stereocenter, lcsh:QD241-441, chemistry.chemical_compound, lcsh:Organic chemistry, Drug Discovery, Hydrolase, Physical and Theoretical Chemistry, Bioactive indanes, Enantiomeric excess, Cinchonidine, chemistry.chemical_classification, Molecular Structure, Quinine, 010405 organic chemistry, Chemistry, Organic Chemistry, Enantioselective synthesis, Life Sciences, Stereoisomerism, PH46A, Ketones, Combinatorial chemistry, 3. Good health, 0104 chemical sciences, Kinetics, Chemistry (miscellaneous), Biocatalysis, Indans, Molecular Medicine, Enantiomer, enantioselective, phase-transfer catalyst (PTC), bioactive indanes

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8321de6e0a3de3eb6da690a11d1d8b89
https://arrow.tudublin.ie/context/schfsehart/article/1385/viewcontent/Molecules_Proof_of_Concept_Study_for_enantioselective_PH46.pdf

المؤلفون: Tom McCabe, Neil Frankish, Tao Zhang, Vilmar Bandero, Helen Sheridan

المساهمون: Trinity College Dublin, Trinity College Postgraduate Research Studentships

المصدر: Articles
Acta Crystallographica Section E, Vol 69, Iss 8, Pp o1306-o1307 (2013)
Acta Crystallographica Section E: Structure Reports

مصطلحات موضوعية: chemistry.chemical_classification, 2-(Diphenylmethylidene)-2, Double bond, Hydrogen bond, General Chemistry, 3-dihydro1H-inden-1-one, Dihedral angle, Condensed Matter Physics, Ring (chemistry), Organic Papers, Crystal, lcsh:Chemistry, X-ray, chemistry.chemical_compound, Crystallography, Chemistry, chemistry, lcsh:QD1-999, General Materials Science, Benzene

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04fc4da7f06a63c11f6af5bc99965c1
https://arrow.tudublin.ie/context/schfsehart/article/1391/viewcontent/2__Diphenyl_methylidene__2_3_dihydro_1H_inden_1_one_ACE_2013.pdf

المؤلفون: Tao Zhang, Helen Sheridan, Jacintha O'Sullivan, Abdulilah Ece, Neil Frankish, Kit Chan, Aoife Cannon

المساهمون: The Wellcome Trust, Enterprise Ireland, Trino Therapeutics Ltd and Trinity College Dublin Postgraduate Scholarship, Eczacılık Fakültesi

المصدر: Articles
The Journal of Pharmacy and Pharmacology

مصطلحات موضوعية: THP-1 Cells, colitis, medicine.medical_treatment, Lipoxygenase, Anti-Inflammatory Agents, Pharmaceutical Science, 01 natural sciences, Molecular and Clinical Pharmacology, chemistry.chemical_compound, Mice, Cytotoxicity, chemistry.chemical_classification, 0303 health sciences, biology, Molecular Structure, Life Sciences, Colitis, Indanes, 3. Good health, Cytokine, Biochemistry, indanes, Indans, Cytokines, cytokine profiling, Research Paper, medicine.drug_class, Indane, Biological Availability, Nitric Oxide, Anti-inflammatory, Nitric oxide, 03 medical and health sciences, Structure-Activity Relationship, In vivo, inflammatory bowel disease, nitric oxide, Cell Line, Tumor, medicine, Animals, Humans, 030304 developmental biology, Pharmacology, 010405 organic chemistry, Inflammatory Bowel Disease, Inflammatory Bowel Diseases, lipoxygenase, 0104 chemical sciences, Enzyme, chemistry, Drug Design, Cytokine Profiling, biology.protein

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f3cb33dbe0a6a98231021ba571ba1a
https://arrow.tudublin.ie/context/schfsehart/article/1383/viewcontent/JPP_Bioactive_indanes_insight_into_the_bioactivity_of_indane_dimers_related_to_the_lead_anti_inflammatory_molecule_PH46A..pdf

المؤلفون: Graham Robert Cumming, Tao Zhang, Gaia Scalabrino, Neil Frankish, Helen Sheridan

المساهمون: The Wellcome Trust UK, Enterprise Ireland

المصدر: Articles
Organic Process Research & Development

مصطلحات موضوعية: chemistry.chemical_classification, Ketone, stereoselective, 010405 organic chemistry, Chemistry, Stereochemistry, phase transfer catalyst (PTC), Dimer, Organic Chemistry, Diastereomer, Indane, Life Sciences, PH46A, Alkylation, 010402 general chemistry, 01 natural sciences, Article, 0104 chemical sciences, chemistry.chemical_compound, Stereoselectivity, Physical and Theoretical Chemistry, Enantiomer, Bioactive indanes, diastereoselective reduction, Phase-transfer catalyst

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0669bc0ac98d37ed288454551f69c71e
https://arrow.tudublin.ie/context/schfsehart/article/1386/viewcontent/OPRD_Investigation_of_the_Stereoselective_Synthesis_of_the_Indane_Dimer.pdf

المؤلفون: Neil Frankish, Tao Zhang, Helen Sheridan, Gaia Scalabrino

المصدر: Journal of Pharmaceutical and Biomedical Analysis
Articles

مصطلحات موضوعية: Male, chemical, Serial dilution, Clinical Biochemistry, Cmax, Anti-Inflammatory Agents, Dog plasma, Pharmaceutical Science, Administration, Oral, 01 natural sciences, Article, Analytical Chemistry, Matrix (chemical analysis), Rats, Sprague-Dawley, Dogs, Pharmacokinetics, LC–MS/MS, Liquid chromatography–mass spectrometry, Oral administration, In vivo, Tandem Mass Spectrometry, Drug Discovery, Validation, Animals, Spectroscopy, ComputingMethodologies_COMPUTERGRAPHICS, Chromatography, Dose-Response Relationship, Drug, 010405 organic chemistry, Chemistry, Safety pharmacology, 010401 analytical chemistry, Reproducibility of Results, PH46A, Pharmacy and Pharmaceutical Sciences, studies, 3. Good health, 0104 chemical sciences, Rats, Indans, Rat plasma, pharmacology, toxicology, Chromatography, Liquid

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee13613e339bd9e60c15576d7d2f923b
https://pubmed.ncbi.nlm.nih.gov/31835124

المؤلفون: Krzysztof J. Paluch, Anne Marie Healy, Tao Zhang, Helen Sheridan, Neil Frankish, Gaia Scalabrino

المساهمون: The Wellcome Trust UK

المصدر: Journal of Molecular Structure
Articles

مصطلحات موضوعية: Stereochemistry, Crystal structure, Nuclear magnetic resonance crystallography, XRPD, Article, Analytical Chemistry, X-ray, Inorganic Chemistry, Chemical separation, Molecule, Spectroscopy, 2S)-2-Benzyl-2, Chemistry, (1S, Organic Chemistry, Diastereomer, Life Sciences, (1S,2S)-2-Benzyl-2,3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol, NMR, 3. Good health, 3-dihydro-2-(1H-inden- 2-yl)-1H-inden-1-ol, Single enantiomer, Enantiomer, Powder diffraction

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::215cb79206801a318378e42321be7263

المؤلفون: Imran Nazir, M. Hafizur Rahman, Neil Frankish, Zunaira Alvi, Jandirk Sendker, Nisar ur Rahman, Tao Zhang, Helen Sheridan

المصدر: Articles

مصطلحات موضوعية: medicine.drug_class, streptozotocin-nicotinamide, Pharmaceutical Science, 030209 endocrinology & metabolism, Fagonia cretica L, 01 natural sciences, Analytical Chemistry, Glibenclamide, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Diabetes mellitus, Fagonia cretica, Drug Discovery, Medicine, Ingestion, Isorhamnetin, Pharmacology, chemistry.chemical_classification, Alpha-glucosidase inhibitor, Traditional medicine, biology, business.industry, antidiabetic, Organic Chemistry, Glycoside, Life Sciences, alpha-glucosidase inhibitor, Streptozotocin, medicine.disease, biology.organism_classification, Traditional Medicine, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Complementary and alternative medicine, chemistry, Molecular Medicine, business, Zygophyllaceae, flavonoid glycoside, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b03bddbf2a1190e77379d6fbb7c443c2
https://pubmed.ncbi.nlm.nih.gov/28388787

المؤلفون: Imran Nazir, Nisar ur Rahman, Zunaira Alvi, M. Hafizur Rahman, Jandirk Sendker, Tao Zhang, Neil Frankish, Helen Sheridan

المصدر: Articles

مصطلحات موضوعية: streptozotocin-nicotinamide, α-glucosidase inhibitor, Pharmaceutical Science, Fagonia cretica L, traditional medicine, Streptozocin, Analytical Chemistry, Diabetes Mellitus, Experimental, flavonoid glycosides, Tandem Mass Spectrometry, Drug Discovery, Medicine and Health Sciences, Hydroxybenzoates, Animals, Hypoglycemic Agents, Pakistan, Glycosides, Rats, Wistar, Pharmacology, Plants, Medicinal, antidiabetic, Plant Extracts, Organic Chemistry, Life Sciences, Complementary and alternative medicine, Molecular Medicine, Female, Medicine, Traditional, Zygophyllaceae, Chromatography, Liquid

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d436f52884631d0e1db6ab3764491c8
https://pubmed.ncbi.nlm.nih.gov/28476067

المؤلفون: Egle Passante, Neil Frankish

المصدر: Inflammation Research. 58:737-745

مصطلحات موضوعية: Allergy, Research groups, Immunology, chemical and pharmacologic phenomena, Inflammation, Basophil, Models, Biological, Cell Line, medicine, Animals, Mast Cells, Pharmacology, business.industry, hemic and immune systems, Mast cell, medicine.disease, Phenotype, Basophils, Rats, medicine.anatomical_structure, Cell culture, medicine.symptom, Line (text file), Peptides, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21bd763ba9d607c46e6257d5f07d1d72
https://doi.org/10.1007/s00011-009-0074-y

المؤلفون: Neil Frankish, Carsten Ehrhardt, Egle Passante, Helen Sheridan

المصدر: Inflammation Research. 58:611-618

مصطلحات موضوعية: Lipopolysaccharides, Ketotifen, Cell type, Immunology, Lipopolysaccharide Receptors, Immunoglobulin E, Cell Degranulation, Cell Line, chemistry.chemical_compound, medicine, Animals, Mast Cells, Receptor, Calcimycin, Pharmacology, Interleukin-13, Ionophores, biology, Tumor Necrosis Factor-alpha, Toll-Like Receptors, Degranulation, hemic and immune systems, Mast cell, Rats, Cell biology, medicine.anatomical_structure, chemistry, Cell culture, biology.protein, Cytokines, lipids (amino acids, peptides, and proteins), Histamine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b145a109de16df7e2ab1de748087d15c
https://doi.org/10.1007/s00011-009-0028-4

المؤلفون: Michael Jordan, Helen Sheridan, C. Cogan, O. Nolan, S. Butterly, John J. Walsh, Neil Frankish

المصدر: Bioorganic & Medicinal Chemistry. 16:248-254

مصطلحات موضوعية: Stereochemistry, medicine.drug_class, Muscle Relaxation, Guinea Pigs, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Ileum, Drug Discovery, medicine, Animals, Structure–activity relationship, Mast Cells, Amines, Rats, Wistar, Molecular Biology, Organic Chemistry, Muscle, Smooth, Biological activity, In vitro, Rats, chemistry, Indans, Molecular Medicine, Liberation, Female, Amine gas treating, Histamine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28396964d9198f81baa8ea1251c37c16
https://doi.org/10.1016/j.bmc.2007.09.041

المؤلفون: Neil Frankish, John M. Clancy, Ana Luísa Simplício, Helen Sheridan, John J. Walsh, John F. Gilmer

المصدر: Journal of Chromatography A. 1045:233-238

مصطلحات موضوعية: Chromatography, Chemistry, Indenone, Osmolar Concentration, Organic Chemistry, Temperature, Analytical chemistry, Electrophoresis, Capillary, Context (language use), General Medicine, Hydrogen-Ion Concentration, Biochemistry, Decomposition, Analytical Chemistry, Dissociation constant, Elimination reaction, chemistry.chemical_compound, Capillary electrophoresis, Ionic strength, Indans, Amines, Selectivity, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b194fb441c10162fbe964e78c2638b
https://doi.org/10.1016/j.chroma.2004.06.031

المؤلفون: Helen Sheridan, Neil Frankish

المصدر: Journal of medicinal chemistry. 55(11)

مصطلحات موضوعية: Colon, Indane, Pharmacology, Inflammatory bowel disease, chemistry.chemical_compound, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, Weight Loss, medicine, Structure–activity relationship, Animals, Serum amyloid A, Colitis, Intestinal Mucosa, Mice, Knockout, Mice, Inbred BALB C, Serum Amyloid A Protein, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Stereoisomerism, medicine.disease, Bioavailability, Interleukin-10, Disease Models, Animal, Biochemistry, Acute Disease, Chronic Disease, Indans, Prednisolone, Molecular Medicine, Female, Gastrointestinal Hemorrhage, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a12796fa5e72f8ccbcb5616818fe3c8
https://pubmed.ncbi.nlm.nih.gov/22663546

المؤلفون: Helen Sheridan, Gaia Scalabrino, Tao Zhang, Christopher S. Frampton, Neil Frankish

المصدر: Articles

مصطلحات موضوعية: Models, Molecular, 1'H-[2, Stereochemistry, Indane, Anti-Inflammatory Agents, Crystal structure, 3-dihydro-1H, Methyl benzoate, Crystallography, X-Ray, Benzoates, General Biochemistry, Genetics and Molecular Biology, Ion, X-ray, chemistry.chemical_compound, 2'-biinden]-2-yl]methyl}benzoate, Molecular Structure, Absolute configuration, Atom (order theory), Hydrogen Bonding, General Medicine, Crystallography, absolute configuration, chemistry, Indenes, 2S)-1-hydroxy-2, (1S)-1-Phenylethanaminium 4-{[(1S, Indans, Flack parameter, Pharmacophore

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::778de845ce652b6f9740bfc48fa665b9
http://bura.brunel.ac.uk/handle/2438/8347