المؤلفون: Yuemin Bian, Xiang-Qun Xie

المصدر: Cells; Volume 11; Issue 5; Pages: 915

مصطلحات موضوعية: drug discovery, generative modeling, recurrent neural network, deep-learning molecule generation model (DeepMGM), cannabinoid receptor 2 (CB2), negative allosteric modulator (NAM)

وصف الملف: application/pdf

Relation: Cell Signaling; https://dx.doi.org/10.3390/cells11050915

الاتاحة: https://doi.org/10.3390/cells11050915

المؤلفون: Kimberly M. Holter, Alex D. Lekander, Christina M. LaValley, Elizabeth G. Bedingham, Bethany E. Pierce, L. Paul Sands, Craig W. Lindsley, Carrie K. Jones, Robert W. Gould

المصدر: Frontiers in Neuroscience, Vol 15 (2021)

مصطلحات موضوعية: electroencephalography (EEG), cognition, metabotropic glutamate receptor 5 (mGlu5), negative allosteric modulator (NAM), MK-801, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnins.2021.700822/full; https://doaj.org/toc/1662-453X

URL الوصول: https://doaj.org/article/0a0ae44e0f6442668ba0e76ba53e03d1

المؤلفون: Sarah Beggiato, Miriam Melis, Beatrice Gianibbi, Valeria Serra, Valeria Sogos, Rafaela Mostallino, Bernhard Bettler, Claudia Mugnaini, Fabrizio Manetti, Federico Corelli, Luca Ferraro, M. Paola Castelli, Alessandra Porcu

مصطلحات موضوعية: 0301 basic medicine, Allosteric modulator, GABAB receptors, G protein, Protein subunit, Allosteric modulators, Allosteric regulation, GABAB receptor, NO, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, GTPγS binding, GABA(B) receptors, Binding site, Bioluminescence resonance energy transfer (BRET), G protein-coupled receptor, Pharmacology, Negative allosteric modulator (NAM), Chemistry, 030104 developmental biology, Biophysics, Phosphorylation, GABAB receptors, Allosteric modulators, Negative allosteric modulator (NAM), GTPγS binding, Bioluminescence resonance energy transfer (BRET), 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceae48a91725d2420490e6bd0ee6705a
http://hdl.handle.net/11392/2459141

المؤلفون: Kimberly M, Holter, Alex D, Lekander, Christina M, LaValley, Elizabeth G, Bedingham, Bethany E, Pierce, L Paul, Sands, Craig W, Lindsley, Carrie K, Jones, Robert W, Gould

المصدر: Frontiers in Neuroscience

مصطلحات موضوعية: cognition, metabotropic glutamate receptor 5 (mGlu5), MK-801, electroencephalography (EEG), negative allosteric modulator (NAM), Neuroscience, Original Research

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::80c35bada9f89ce2ecb66ac6bb120494
https://pubmed.ncbi.nlm.nih.gov/34276300

المؤلفون: Porcu, Alessandra, Mostallino, Rafaela, Serra, Valeria, Melis, Miriam, Sogos, Valeria, Beggiato, Sarah, Ferraro, Luca, Manetti, Fabrizio, Gianibbi, Beatrice, Bettler, Bernhard, Corelli, Federico, Mugnaini, Claudia, Castelli, M. Paola

المساهمون: Porcu, Alessandra, Mostallino, Rafaela, Serra, Valeria, Melis, Miriam, Sogos, Valeria, Beggiato, Sarah, Ferraro, Luca, Manetti, Fabrizio, Gianibbi, Beatrice, Bettler, Bernhard, Corelli, Federico, Mugnaini, Claudia, Castelli, M. Paola

مصطلحات موضوعية: GABAB receptors, Allosteric modulators, Negative allosteric modulator (NAM), GTPγS binding, Bioluminescence resonance energy transfer (BRET)

وصف الملف: ELETTRONICO

Relation: info:eu-repo/semantics/altIdentifier/pmid/33798546; info:eu-repo/semantics/altIdentifier/wos/WOS:000663078500002; volume:189; numberofpages:15; journal:NEUROPHARMACOLOGY; https://hdl.handle.net/11365/1141414; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85104124556; https://www.sciencedirect.com/science/article/pii/S0028390821000915

الاتاحة: https://hdl.handle.net/11365/1141414
https://doi.org/10.1016/j.neuropharm.2021.108537
https://www.sciencedirect.com/science/article/pii/S0028390821000915

المؤلفون: Margherita Brindisi, Giuseppe Campiani, Simone Brogi, Stefania Butini

المساهمون: Brogi, Simone, Campiani, Giuseppe, Brindisi, Margherita, Butini, Stefania

المصدر: ACS Medicinal Chemistry Letters. 10:228-236

مصطلحات موضوعية: business.industry, Organic Chemistry, Allosteric regulation, Central nervous system, Glutamate receptor, ionotropic glutamate receptors (iGluRs), negative allosteric modulator (NAM), Allosteric modulation, CNS-related disorders, positive allosteric modulator (PAM), Biochemistry, medicine.anatomical_structure, Drug Discovery, Medicine, business, Neuroscience, Ionotropic effect

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340bce8a1459da09271d9413d231fa3c
https://doi.org/10.1021/acsmedchemlett.8b00450

المؤلفون: Henderson, Brandon J., González-Cestari, Tatiana F., Yi, Bitna, Pavlovicz, Ryan E., Boyd, R. Thomas, Li, Chenglong, Bergmeier, Stephen C., McKay, Dennis B.

المصدر: ACS Chemical Neuroscience, 3(9), 682-692, (2012-09)

مصطلحات موضوعية: Negative allosteric modulator (NAM), neuronal nicotinic acetylcholine receptors (nAChRs), α4β2, site-directed mutagenesis, structure−activity relationships, nicotine

Relation: https://doi.org/10.1021/cn300035f; https://www.ncbi.nlm.nih.gov/pmc/PMC3447398; eprintid:35434

الاتاحة: https://doi.org/10.1021/cn300035f
https://www.ncbi.nlm.nih.gov/pmc/PMC3447398

المؤلفون: Kimberly M. Holter (11063892), Alex D. Lekander (11063895), Christina M. LaValley (11063898), Elizabeth G. Bedingham (11063901), Bethany E. Pierce (11063904), L. Paul Sands (3830362), Craig W. Lindsley (203380), Carrie K. Jones (1326210), Robert W. Gould (1634869)

مصطلحات موضوعية: Neuroscience, Biological Engineering, Developmental Biology, Stem Cells, Artificial Intelligence and Image Processing, Endocrinology, Radiology and Organ Imaging, Autonomic Nervous System, Cellular Nervous System, Central Nervous System, Sensory Systems, Clinical Nursing: Tertiary (Rehabilitative), Decision Making, Rehabilitation Engineering, Biomedical Engineering not elsewhere classified, Signal Processing, Neurogenetics, Image Processing, electroencephalography (EEG), cognition, metabotropic glutamate receptor 5 (mGlu5), negative allosteric modulator (NAM), MK-801

Relation: https://figshare.com/articles/dataset/Data_Sheet_1_Partial_mGlu5_Negative_Allosteric_Modulator_M-5MPEP_Demonstrates_Antidepressant-Like_Effects_on_Sleep_Without_Affecting_Cognition_or_Quantitative_EEG_PDF/14897904

الاتاحة: https://doi.org/10.3389/fnins.2021.700822.s001

المؤلفون: Luis Mart?nez, Raquel

المساهمون: Mart?nez-Cu? Pesini, Carmen, Universidad de Cantabria

مصطلحات موضوعية: Rat?n Ts65Dn, Subunidad ?5 del receptor GABA, Down syndrome, GABA receptors a5 subunit, S?ndrome de Down, Negative Allosteric Modulator (NAM), Ts65Dn mouse, Modulador Alost?rico Negativo (NAM), Tratamiento cr?nico

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______2473::6e6e82169c5b35f1db6caafd0ad227ab
http://hdl.handle.net/10902/7661

المؤلفون: Luis Martínez, Raquel

المساهمون: Martínez-Cué, Carmen, Universidad de Cantabria

المصدر: UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)

مصطلحات موضوعية: Down syndrome, GABA receptors a5 subunit, Síndrome de Down, Modulador Alostérico Negativo (NAM), Subunidad α5 del receptor GABA, Negative Allosteric Modulator (NAM), Ts65Dn mouse, Ratón Ts65Dn, Tratamiento crónico

URL الوصول: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::6e6e82169c5b35f1db6caafd0ad227ab
http://hdl.handle.net/10902/7661