المؤلفون: Jmaeff, Sean, Sidorova, Yulia, Nedev, Hinyu, Saarma, Mart, Saragovi, H. Uri

المساهمون: Institute of Biotechnology

مصطلحات موضوعية: receptor tyrosine kinase, signal transduction, small molecule, ligand-binding protein, retinal degeneration, structure?function, biased agonist, naphthoquinone, neuroprotection, RET receptor, retinitis pigmentosa, NEUROTROPHIC FACTOR, NEURONAL SURVIVAL, GDNF, GFR-ALPHA-1, EXPRESSION, RHODOPSIN, MECHANISM, BINDING, MICE, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

Relation: DThis work was supported by grants from the Canada Institutes of Health Research and the Canadian Consortium on Neurodegeneration and Aging and by Optic Nerve Trauma Grant W81XWH1910853 from the U.S. Department of Defense (to H. U. S.). Patents have been filed by McGill University on behalf of the authors, covering agents reported in this work.; Jmaeff , S , Sidorova , Y , Nedev , H , Saarma , M & Saragovi , H U 2020 , ' Small-molecule agonists of the RET receptor tyrosine kinase activate biased trophic signals that are influenced by the presence of GFRa1 co-receptors ' , Journal of Biological Chemistry , vol. 295 , no. 19 , pp. 6532-6542 . https://doi.org/10.1074/jbc.RA119.011802; ORCID: /0000-0001-5543-7160/work/82132942; http://hdl.handle.net/10138/327047; 2efcee09-4ba1-4fbe-8908-700ab2892dc0; 000537685000023

الاتاحة: http://hdl.handle.net/10138/327047

المؤلفون: Jmaeff, Sean, Sidorova, Yulia, Lippiatt, Hayley, Barcelona, Pablo F., Nedev, Hinyu, Saragovi, Lucia M., Hancock, Mark A., Saarma, Mart, Saragovi, H. Uri

المساهمون: Institute of Biotechnology

مصطلحات موضوعية: NEUROTROPHIC FACTOR GDNF, TYROSINE KINASE, RAT MODEL, FAMILY, TRKA, GROWTH, DEGENERATION, NEUROPATHY, MECHANISM, NEURTURIN, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

Relation: This work was supported by the Sean Murphy Award given to S.J., grants from the Canadian Institutes of Health Research (Pharmacology) and from the US Department of Defense [Optic Nerve Trauma W81XWH1910853] to H.U.S., a grant from the Finnish Academy [N1325555] to Y.S., and the Lundbeck Foundation and the Sigrid Juselius Foundation to M.S. The McGill SPR-MS Facility was supported by the Canada Foundation for Innovation [CFI Grant 228340] for the BIACORE T200 SPR infrastructure.; Jmaeff , S , Sidorova , Y , Lippiatt , H , Barcelona , P F , Nedev , H , Saragovi , L M , Hancock , M A , Saarma , M & Saragovi , H U 2020 , ' Small-Molecule Ligands that Bind the RET Receptor Activate Neuroprotective Signals Independent of but Modulated by Coreceptor GFR alpha 1 ' , Molecular pharmacology : an international journal , vol. 98 , no. 1 , pp. 1-12 . https://doi.org/10.1124/mol.119.118950; ORCID: /0000-0001-5543-7160/work/83843658; http://hdl.handle.net/10138/332075; 70f7c297-e01c-429f-8678-5edc970c950e; 000571818000001

الاتاحة: http://hdl.handle.net/10138/332075

المؤلفون: Jmaeff, Sean, Sidorova, Yulia, Nedev, Hinyu, Saarma, Mart, Saragovi, H. Uri

المساهمون: Gouvernement du Canada | CIHR | Institute of Neurosciences, Mental Health and Addiction, Canadian Consortium on Neurodegeneration, U.S. Department of Defense

المصدر: Journal of Biological Chemistry ; volume 295, issue 19, page 6532-6542 ; ISSN 0021-9258

الاتاحة: http://dx.doi.org/10.1074/jbc.ra119.011802
https://api.elsevier.com/content/article/PII:S0021925817485140?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0021925817485140?httpAccept=text/plain
https://syndication.highwire.org/content/doi/10.1074/jbc.RA119.011802

المؤلفون: Barcelona, Pablo F., Galan, Alba, Nedev, Hinyu, Jian, Yifan, Sarunic, Marinko V., Saragovi, H. Uri

المساهمون: Liu, Guei-Sheung, CIHR Pharmacology, Foundation Fighting Blindness

المصدر: PLOS ONE ; volume 13, issue 6, page e0199079 ; ISSN 1932-6203

الاتاحة: http://dx.doi.org/10.1371/journal.pone.0199079
http://dx.plos.org/10.1371/journal.pone.0199079

المؤلفون: Bai, Yujing, Dergham, Pauline, Nedev, Hinyu, Xu, Jing, Galan, Alba, Rivera, Jose Carlos, ZhiHua, Shi, Mehta, Hrishikesh M., Woo, Sang B., Sarunic, Marinko V., Neet, Kenneth E., Saragovi, H. Uri

المصدر: Journal of Biological Chemistry ; volume 285, issue 50, page 39392-39400 ; ISSN 0021-9258

الاتاحة: http://dx.doi.org/10.1074/jbc.m110.147801
https://api.elsevier.com/content/article/PII:S0021925820606366?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0021925820606366?httpAccept=text/plain
https://syndication.highwire.org/content/doi/10.1074/jbc.M110.147801

المؤلفون: Kojic, Liliana D., Wiseman, Sam M., Ghaidi, Fariba, Joshi, Bharat, Nedev, Hinyu, Saragovi, H. Uri, Nabi, Ivan R.

المساهمون: Bauer, Joseph Alan

المصدر: PLoS ONE ; volume 3, issue 10, page e3597 ; ISSN 1932-6203

الاتاحة: http://dx.doi.org/10.1371/journal.pone.0003597
http://dx.plos.org/10.1371/journal.pone.0003597

المؤلفون: Jmaeff, Sean, Sidorova, Yulia, Lippiatt, Hayley, Barcelona, Pablo F., Nedev, Hinyu, Saragovi, Lucia M., Hancock, Mark A., Saarma, Mart, Saragovi, H. Uri

المساهمون: Institute of Biotechnology

مصطلحات موضوعية: NEUROTROPHIC FACTOR GDNF, TYROSINE KINASE, RAT MODEL, FAMILY, TRKA, GROWTH, DEGENERATION, NEUROPATHY, MECHANISM, NEURTURIN, 1182 Biochemistry, cell and molecular biology, info, socio

Relation: http://hdl.handle.net/10138/332075

الاتاحة: http://hdl.handle.net/10138/332075

المؤلفون: Ettinger, Keren, Lecht, Shimon, Arien-Zakay, Hadar, Cohen, Gadi, Aga-Mizrachi, Shlomit, Yanay, Nurit, Saragovi, H. Uri, Nedev, Hinyu, Marcinkiewicz, Cezary, Nevo, Yoram, Lazarovici, Philip

المساهمون: David R. Bloom Center of Pharmacy, Dr. Adolf and Klara Brettler Center for Research in Molecular Pharmacology and Therapeutics, Alex Grass Center for Drug Design and Synthesis of Novel Therapeutics, NIH NCI

المصدر: Cellular Signalling ; volume 24, issue 12, page 2378-2388 ; ISSN 0898-6568

الاتاحة: http://dx.doi.org/10.1016/j.cellsig.2012.08.008
https://api.elsevier.com/content/article/PII:S089865681200229X?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S089865681200229X?httpAccept=text/plain

المؤلفون: Jmaeff, Sean, Sidorova, Yulia, Lippiatt, Hayley, Barcelona, Pablo F., Nedev, Hinyu, Saragovi, Lucia M., Hancock, Mark A., Saarma, Mart, Saragovi, H. Uri

المصدر: Molecular Pharmacology; 2020, Vol. 98 Issue: 1 p1-12, 12p

المؤلفون: Savić, Radoslav, Azzam, Tony, Eisenberg, Adi, Nedev, Hinyu, Rosenberg, Lawrence, Maysinger, Dusica

المصدر: Biomaterials ; volume 30, issue 21, page 3597-3604 ; ISSN 0142-9612

الاتاحة: http://dx.doi.org/10.1016/j.biomaterials.2009.03.028
https://api.elsevier.com/content/article/PII:S0142961209002877?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0142961209002877?httpAccept=text/plain

المؤلفون: Guillemard, Veronique, Nedev, Hinyu N., Berezov, Alan, Murali, Ramachandran, Saragovi, H. Uri

المصدر: DNA and Cell Biology ; volume 24, issue 6, page 351-358 ; ISSN 1044-5498 1557-7430

الاتاحة: http://dx.doi.org/10.1089/dna.2005.24.351
http://www.liebertpub.com/doi/pdf/10.1089/dna.2005.24.351

المؤلفون: Jmaeff, Sean, Sidorova, Yulia, Lippiatt, Hayley, Barcelona, Pablo Federico, Nedev, Hinyu, Saragovi, Lucia M., Hancock, Mark A., Saarma, Mart, Saragovi, H. Uri

مصطلحات موضوعية: GFR α 1, RET Receptor Activate Neuroprotective, https://purl.org/becyt/ford/1.6, https://purl.org/becyt/ford/1

وصف الملف: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/url/https://molpharm.aspetjournals.org/content/98/1/1; http://hdl.handle.net/11336/158914; Jmaeff, Sean; Sidorova, Yulia; Lippiatt, Hayley; Barcelona, Pablo Federico; Nedev, Hinyu; et al.; Small-Molecule Ligands that bind the RET receptor activate neuroprotective signals independent of but modulated by coreceptor GFR α 1; American Society for Pharmacology and Experimental Therapeutics; Molecular Pharmacology; 98; 1; 8-2020; 1-12; CONICET Digital; CONICET

الاتاحة: http://hdl.handle.net/11336/158914

المؤلفون: Galan, Alba, Barcelona, Pablo Federico, Nedev, Hinyu, Sarunic, Marinko V., Jian, Yifan, Saragovi, H. Uri

مصطلحات موضوعية: ANTAGONIST, DIABETIC RETINOPATHY, P75 RECEPTOR, SUBCONJUNCTIVAL, TARGET, https://purl.org/becyt/ford/3.1, https://purl.org/becyt/ford/3

وصف الملف: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/28570737; http://hdl.handle.net/11336/48639; Galan, Alba; Barcelona, Pablo Federico; Nedev, Hinyu; Sarunic, Marinko V.; Jian, Yifan; et al.; Subconjunctival delivery of p75NTR antagonists reduces the inflammatory, vascular, and neurodegenerative pathologies of diabetic retinopathy; Association for Research in Vision and Ophthalmology; Investigative Ophthalmology & Visual Science; 58; 7; 6-2017; 2852-2862; CONICET Digital; CONICET

الاتاحة: http://hdl.handle.net/11336/48639

المؤلفون: Nedev, Hinyu, Nabarisoa, Hanitra, Haertle, Tomasz

المصدر: Tetrahedron Letters ; volume 34, issue 26, page 4201-4204 ; ISSN 0040-4039

الاتاحة: http://dx.doi.org/10.1016/s0040-4039(00)60527-0
https://api.elsevier.com/content/article/PII:S0040403900605270?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0040403900605270?httpAccept=text/plain

المؤلفون: Nedev, Hinyu N.¹, Klaiman, Guy², LeBlanc, Andrea^2,3, Saragovi, H. Uri^1,3,4 Uri.Saragovi@McGill.ca

المصدر: Biochemical & Biophysical Research Communications. Oct2005, Vol. 336 Issue 2, p397-400. 4p.

مصطلحات موضوعية: *ORGANIC compounds, *HYDROGEN-ion concentration, *CARBON compounds, *KETONES

المؤلفون: Minchev, Stoyan, Nedev, Hinyu, Enchev, Venelin

المصدر: Liebigs Annalen der Chemie ; volume 1987, issue 4, page 375-376 ; ISSN 0170-2041

الاتاحة: http://dx.doi.org/10.1002/jlac.198719870337
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjlac.198719870337
https://onlinelibrary.wiley.com/doi/full/10.1002/jlac.198719870337

المؤلفون: Minchev Stoyan, Aleksiev Boris V., Stoyanov Neiko M., Nedev Hinyu N.

Time: 1081, 1084

وصف الملف: electronic

Relation: https://kramerius.lib.cas.cz/view/uuid:c7bf4fb0-be79-11e2-9ddd-001e65b2b442

الاتاحة: https://kramerius.lib.cas.cz/view/uuid:c7bf4fb0-be79-11e2-9ddd-001e65b2b442
https://doi.org/10.1135/cccc19921081

المؤلفون: Yujing Bai¹, Dergham, Pauline¹, Nedev, Hinyu¹, Jing Xu², Galan, Alba¹, Rivera, Jose Carlos³, Shi ZhiHua¹, Mehta, Hrishikesh M.⁴, Wooll, Sang B.⁴, Sarunic, Marinko V.², Neet, Kenneth E.⁴, Saragovi, H. Uri^1,5,6,7 uri.saragovi@mcgill.ca

المصدر: Journal of Biological Chemistry. 12/10/2010, Vol. 285 Issue 50, p39392-39400. 9p.

مصطلحات موضوعية: *RETINA, *RETINAL ganglion cells, *RETINAL degeneration, *GLAUCOMA, *OPTIC nerve