المؤلفون: Mark S. Tichenor (2468158), John J. M. Wiener (2984025), Navin L. Rao (6454055), Charlotte Pooley Deckhut (10526589), J. Kent Barbay (2540770), Kevin D. Kreutter (8580129), Genesis M. Bacani (1455166), Jianmei Wei (2428387), Leon Chang (1464883), Heather E. Murrey (1266897), Weixue Wang (1307655), Kay Ahn (1523929), Michael Huber (274369), Elizabeth Rex (10526592), Kevin J. Coe (156425), JieJun Wu (10526595), Mark Seierstad (1464892), Scott D. Bembenek (2245663), Kristi A. Leonard (2692219), Alec D. Lebsack (2222389), Jennifer D. Venable (2658031), James P. Edwards (2428411)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Biotechnology, Ecology, Immunology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, covalent bond formation, cytoplasmic tyrosine kinase, Compound 27, Selective Covalent Inhibitor, vivo BTK occupancy, noncatalytic cysteine residue, rat collagen-induced arthritis model

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_a_Potent_and_Selective_Covalent_Inhibitor_of_Bruton_s_Tyrosine_Kinase_with_Oral_Anti-Inflammatory_Activity/14374155

الاتاحة: https://doi.org/10.1021/acsmedchemlett.1c00044.s001

المؤلفون: Stephane Becart (4012106), Karen B. Whittington (10004970), Amanda Prislovsky (197782), Navin L. Rao (6454055), Edward F. Rosloniec (8098397)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Physiology, Biotechnology, Ecology, Immunology, Developmental Biology, Cancer, Chemical Sciences not elsewhere classified, HLA-DR binding affinity, RA, HLA-DR 1, citrullinated proteins, self-reactive cell receptor, T cell response, arthritis-associated HLA-DR alleles, P 4 position, type II collagen, DR 4-restricted T cell responses, clonal T cell populations, MHC-II, peptide binding affinity, binding affinity, novel T cell epitope, T cell responses, T cell receptor recognition, T cells

Relation: https://figshare.com/articles/figure/Measurement_of_peptide_binding_to_DRB1_01_01_/13609470

الاتاحة: https://doi.org/10.1371/journal.pone.0245541.g001

المؤلفون: Stephane Becart (4012106), Karen B. Whittington (10004970), Amanda Prislovsky (197782), Navin L. Rao (6454055), Edward F. Rosloniec (8098397)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Physiology, Biotechnology, Ecology, Immunology, Developmental Biology, Cancer, Chemical Sciences not elsewhere classified, HLA-DR binding affinity, RA, HLA-DR 1, citrullinated proteins, self-reactive cell receptor, T cell response, arthritis-associated HLA-DR alleles, P 4 position, type II collagen, DR 4-restricted T cell responses, clonal T cell populations, MHC-II, peptide binding affinity, binding affinity, novel T cell epitope, T cell responses, T cell receptor recognition, T cells

Relation: https://figshare.com/articles/figure/Measurement_of_peptide_binding_to_DRB1_04_01_/13609473

الاتاحة: https://doi.org/10.1371/journal.pone.0245541.g002

المؤلفون: Stephane Becart (4012106), Karen B. Whittington (10004970), Amanda Prislovsky (197782), Navin L. Rao (6454055), Edward F. Rosloniec (8098397)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Physiology, Biotechnology, Ecology, Immunology, Developmental Biology, Cancer, Chemical Sciences not elsewhere classified, HLA-DR binding affinity, RA, HLA-DR 1, citrullinated proteins, self-reactive cell receptor, T cell response, arthritis-associated HLA-DR alleles, P 4 position, type II collagen, DR 4-restricted T cell responses, clonal T cell populations, MHC-II, peptide binding affinity, binding affinity, novel T cell epitope, T cell responses, T cell receptor recognition, T cells

Relation: https://figshare.com/articles/figure/Immunogenicity_and_antigenicity_of_WT_and_Cit-peptides_in_DRB1_01_01_and_DRB1_04_01_humanized_mice_/13609479

الاتاحة: https://doi.org/10.1371/journal.pone.0245541.g004

المؤلفون: Stephane Becart (4012106), Karen B. Whittington (10004970), Amanda Prislovsky (197782), Navin L. Rao (6454055), Edward F. Rosloniec (8098397)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Physiology, Biotechnology, Ecology, Immunology, Developmental Biology, Cancer, Chemical Sciences not elsewhere classified, HLA-DR binding affinity, RA, HLA-DR 1, citrullinated proteins, self-reactive cell receptor, T cell response, arthritis-associated HLA-DR alleles, P 4 position, type II collagen, DR 4-restricted T cell responses, clonal T cell populations, MHC-II, peptide binding affinity, binding affinity, novel T cell epitope, T cell responses, T cell receptor recognition, T cells

Relation: https://figshare.com/articles/figure/Relative_affinity_of_WT_and_Cit-peptide_binding_to_DRB1_01_01_and_DRB1_04_01_/13609476

الاتاحة: https://doi.org/10.1371/journal.pone.0245541.g003

المؤلفون: Stephane Becart (4012106), Karen B. Whittington (10004970), Amanda Prislovsky (197782), Navin L. Rao (6454055), Edward F. Rosloniec (8098397)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Physiology, Biotechnology, Ecology, Immunology, Developmental Biology, Cancer, Chemical Sciences not elsewhere classified, HLA-DR binding affinity, RA, HLA-DR 1, citrullinated proteins, self-reactive cell receptor, T cell response, arthritis-associated HLA-DR alleles, P 4 position, type II collagen, DR 4-restricted T cell responses, clonal T cell populations, MHC-II, peptide binding affinity, binding affinity, novel T cell epitope, T cell responses, T cell receptor recognition, T cells

Relation: https://figshare.com/articles/dataset/Summary_of_DR_binding_T_cell_proliferation_and_cytokine_production_as_stimulated_by_WT_or_Cit_antigenic_peptide_/13609497

الاتاحة: https://doi.org/10.1371/journal.pone.0245541.t002

المؤلفون: Stephane Becart (4012106), Karen B. Whittington (10004970), Amanda Prislovsky (197782), Navin L. Rao (6454055), Edward F. Rosloniec (8098397)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Physiology, Biotechnology, Ecology, Immunology, Developmental Biology, Cancer, Chemical Sciences not elsewhere classified, HLA-DR binding affinity, RA, HLA-DR 1, citrullinated proteins, self-reactive cell receptor, T cell response, arthritis-associated HLA-DR alleles, P 4 position, type II collagen, DR 4-restricted T cell responses, clonal T cell populations, MHC-II, peptide binding affinity, binding affinity, novel T cell epitope, T cell responses, T cell receptor recognition, T cells

Relation: https://figshare.com/articles/figure/Induction_of_autoimmune_arthritis_in_HLA-DR1_mice_with_WT_CII_and_Cit-CII_/13609491

الاتاحة: https://doi.org/10.1371/journal.pone.0245541.g008

المؤلفون: Stephane Becart (4012106), Karen B. Whittington (10004970), Amanda Prislovsky (197782), Navin L. Rao (6454055), Edward F. Rosloniec (8098397)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Physiology, Biotechnology, Ecology, Immunology, Developmental Biology, Cancer, Chemical Sciences not elsewhere classified, HLA-DR binding affinity, RA, HLA-DR 1, citrullinated proteins, self-reactive cell receptor, T cell response, arthritis-associated HLA-DR alleles, P 4 position, type II collagen, DR 4-restricted T cell responses, clonal T cell populations, MHC-II, peptide binding affinity, binding affinity, novel T cell epitope, T cell responses, T cell receptor recognition, T cells

Relation: https://figshare.com/articles/figure/Cytokine_production_by_T_cells_stimulated_with_WT_or_Cit-peptides_/13609482

الاتاحة: https://doi.org/10.1371/journal.pone.0245541.g005

المؤلفون: Stephane Becart (4012106), Karen B. Whittington (10004970), Amanda Prislovsky (197782), Navin L. Rao (6454055), Edward F. Rosloniec (8098397)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Physiology, Biotechnology, Ecology, Immunology, Developmental Biology, Cancer, Chemical Sciences not elsewhere classified, HLA-DR binding affinity, RA, HLA-DR 1, citrullinated proteins, self-reactive cell receptor, T cell response, arthritis-associated HLA-DR alleles, P 4 position, type II collagen, DR 4-restricted T cell responses, clonal T cell populations, MHC-II, peptide binding affinity, binding affinity, novel T cell epitope, T cell responses, T cell receptor recognition, T cells

Relation: https://figshare.com/articles/figure/Measurement_of_PAD4-meidated_citrullination_of_CII_/13609488

الاتاحة: https://doi.org/10.1371/journal.pone.0245541.g007

المؤلفون: Stephane Becart (4012106), Karen B. Whittington (10004970), Amanda Prislovsky (197782), Navin L. Rao (6454055), Edward F. Rosloniec (8098397)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Physiology, Biotechnology, Ecology, Immunology, Developmental Biology, Cancer, Chemical Sciences not elsewhere classified, HLA-DR binding affinity, RA, HLA-DR 1, citrullinated proteins, self-reactive cell receptor, T cell response, arthritis-associated HLA-DR alleles, P 4 position, type II collagen, DR 4-restricted T cell responses, clonal T cell populations, MHC-II, peptide binding affinity, binding affinity, novel T cell epitope, T cell responses, T cell receptor recognition, T cells

Relation: https://figshare.com/articles/dataset/Sequences_of_peptides_tested_for_their_ability_to_bind_to_HLA-DR1_and_DR4_and_to_induce_a_CD4_T_cell_response_in_mice_expressing_these_HLA-DR_allotypes_/13609494

الاتاحة: https://doi.org/10.1371/journal.pone.0245541.t001

المؤلفون: Stephane Becart (4012106), Karen B. Whittington (10004970), Amanda Prislovsky (197782), Navin L. Rao (6454055), Edward F. Rosloniec (8098397)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Physiology, Biotechnology, Ecology, Immunology, Developmental Biology, Cancer, Chemical Sciences not elsewhere classified, HLA-DR binding affinity, RA, HLA-DR 1, citrullinated proteins, self-reactive cell receptor, T cell response, arthritis-associated HLA-DR alleles, P 4 position, type II collagen, DR 4-restricted T cell responses, clonal T cell populations, MHC-II, peptide binding affinity, binding affinity, novel T cell epitope, T cell responses, T cell receptor recognition, T cells

Relation: https://figshare.com/articles/figure/T_cell_receptor_cross_recognition_of_WT_and_Cit-peptides_/13609485

الاتاحة: https://doi.org/10.1371/journal.pone.0245541.g006