المؤلفون: S. Kaleem Ahmed (1327023), Nicole N. Haese (3826969), Jaden T. Cowan (10578771), Vibha Pathak (172306), Omar Moukha-Chafiq (7271546), Valerie J. Smith (10578774), Kevin J. Rodzinak (2181544), Fahim Ahmad (1467625), Sixue Zhang (1371636), Kiley M. Bonin (10578777), Aaron D. Streblow (10578780), Cassilyn E. Streblow (10516011), Craig N. Kreklywich (7592762), Clayton Morrison (10578783), Sanjay Sarkar (3386969), Nathaniel Moorman (446135), Wes Sander (10578786), Robbie Allen (10578789), Victor DeFilippis (200525), Babu L. Tekwani (1328517), Mousheng Wu (4837155), Alec J. Hirsch (3826948), Jessica L. Smith (834950), Nichole A. Tower (589415), Lynn Rasmussen (589424), Robert Bostwick (9903900), Joseph A. Maddry (10578792), Subramaniam Ananthan (591094), John M Gerdes (10578795), Corinne E. Augelli-Szafran (2651497), Mark J. Suto (2053921), Thomas E. Morrison (7592765), Mark T. Heise (10053165), Daniel N. Streblow (7592771), Ashish K. Pathak (1333083)

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, Moderate efficacy, CC 50, Chikungunya virus, EC 90, 10 μ M, Targeting Chikungunya Virus Replication, vivo CHIKV challenge mouse model, fibroblast cells, titer reduction, compound 8 q, 270 nM, 2.5 log, nsP 3 macrodomain, drug-like properties, Benzoannulene Inhibitors, activity EC 90, CHIKV resistance, 169 μ M, VTR, 4.5 log, dihydroorotate dehydrogenase

Relation: https://figshare.com/articles/journal_contribution/Targeting_Chikungunya_Virus_Replication_by_Benzoannulene_Inhibitors/14394846

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02183.s001

المؤلفون: S. Kaleem Ahmed (1327023), Nicole N. Haese (3826969), Jaden T. Cowan (10578771), Vibha Pathak (172306), Omar Moukha-Chafiq (7271546), Valerie J. Smith (10578774), Kevin J. Rodzinak (2181544), Fahim Ahmad (1467625), Sixue Zhang (1371636), Kiley M. Bonin (10578777), Aaron D. Streblow (10578780), Cassilyn E. Streblow (10516011), Craig N. Kreklywich (7592762), Clayton Morrison (10578783), Sanjay Sarkar (3386969), Nathaniel Moorman (446135), Wes Sander (10578786), Robbie Allen (10578789), Victor DeFilippis (200525), Babu L. Tekwani (1328517), Mousheng Wu (4837155), Alec J. Hirsch (3826948), Jessica L. Smith (834950), Nichole A. Tower (589415), Lynn Rasmussen (589424), Robert Bostwick (9903900), Joseph A. Maddry (10578792), Subramaniam Ananthan (591094), John M Gerdes (10578795), Corinne E. Augelli-Szafran (2651497), Mark J. Suto (2053921), Thomas E. Morrison (7592765), Mark T. Heise (10053165), Daniel N. Streblow (7592771), Ashish K. Pathak (1333083)

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, Moderate efficacy, CC 50, Chikungunya virus, EC 90, 10 μ M, Targeting Chikungunya Virus Replication, vivo CHIKV challenge mouse model, fibroblast cells, titer reduction, compound 8 q, 270 nM, 2.5 log, nsP 3 macrodomain, drug-like properties, Benzoannulene Inhibitors, activity EC 90, CHIKV resistance, 169 μ M, VTR, 4.5 log, dihydroorotate dehydrogenase

Relation: https://figshare.com/articles/dataset/Targeting_Chikungunya_Virus_Replication_by_Benzoannulene_Inhibitors/14394864

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02183.s007

المؤلفون: S. Kaleem Ahmed (1327023), Nicole N. Haese (3826969), Jaden T. Cowan (10578771), Vibha Pathak (172306), Omar Moukha-Chafiq (7271546), Valerie J. Smith (10578774), Kevin J. Rodzinak (2181544), Fahim Ahmad (1467625), Sixue Zhang (1371636), Kiley M. Bonin (10578777), Aaron D. Streblow (10578780), Cassilyn E. Streblow (10516011), Craig N. Kreklywich (7592762), Clayton Morrison (10578783), Sanjay Sarkar (3386969), Nathaniel Moorman (446135), Wes Sander (10578786), Robbie Allen (10578789), Victor DeFilippis (200525), Babu L. Tekwani (1328517), Mousheng Wu (4837155), Alec J. Hirsch (3826948), Jessica L. Smith (834950), Nichole A. Tower (589415), Lynn Rasmussen (589424), Robert Bostwick (9903900), Joseph A. Maddry (10578792), Subramaniam Ananthan (591094), John M Gerdes (10578795), Corinne E. Augelli-Szafran (2651497), Mark J. Suto (2053921), Thomas E. Morrison (7592765), Mark T. Heise (10053165), Daniel N. Streblow (7592771), Ashish K. Pathak (1333083)

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, Moderate efficacy, CC 50, Chikungunya virus, EC 90, 10 μ M, Targeting Chikungunya Virus Replication, vivo CHIKV challenge mouse model, fibroblast cells, titer reduction, compound 8 q, 270 nM, 2.5 log, nsP 3 macrodomain, drug-like properties, Benzoannulene Inhibitors, activity EC 90, CHIKV resistance, 169 μ M, VTR, 4.5 log, dihydroorotate dehydrogenase

Relation: https://figshare.com/articles/dataset/Targeting_Chikungunya_Virus_Replication_by_Benzoannulene_Inhibitors/14394861

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02183.s006

المؤلفون: S. Kaleem Ahmed (1327023), Nicole N. Haese (3826969), Jaden T. Cowan (10578771), Vibha Pathak (172306), Omar Moukha-Chafiq (7271546), Valerie J. Smith (10578774), Kevin J. Rodzinak (2181544), Fahim Ahmad (1467625), Sixue Zhang (1371636), Kiley M. Bonin (10578777), Aaron D. Streblow (10578780), Cassilyn E. Streblow (10516011), Craig N. Kreklywich (7592762), Clayton Morrison (10578783), Sanjay Sarkar (3386969), Nathaniel Moorman (446135), Wes Sander (10578786), Robbie Allen (10578789), Victor DeFilippis (200525), Babu L. Tekwani (1328517), Mousheng Wu (4837155), Alec J. Hirsch (3826948), Jessica L. Smith (834950), Nichole A. Tower (589415), Lynn Rasmussen (589424), Robert Bostwick (9903900), Joseph A. Maddry (10578792), Subramaniam Ananthan (591094), John M Gerdes (10578795), Corinne E. Augelli-Szafran (2651497), Mark J. Suto (2053921), Thomas E. Morrison (7592765), Mark T. Heise (10053165), Daniel N. Streblow (7592771), Ashish K. Pathak (1333083)

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, Moderate efficacy, CC 50, Chikungunya virus, EC 90, 10 μ M, Targeting Chikungunya Virus Replication, vivo CHIKV challenge mouse model, fibroblast cells, titer reduction, compound 8 q, 270 nM, 2.5 log, nsP 3 macrodomain, drug-like properties, Benzoannulene Inhibitors, activity EC 90, CHIKV resistance, 169 μ M, VTR, 4.5 log, dihydroorotate dehydrogenase

Relation: https://figshare.com/articles/dataset/Targeting_Chikungunya_Virus_Replication_by_Benzoannulene_Inhibitors/14394849

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02183.s002

المؤلفون: S. Kaleem Ahmed (1327023), Nicole N. Haese (3826969), Jaden T. Cowan (10578771), Vibha Pathak (172306), Omar Moukha-Chafiq (7271546), Valerie J. Smith (10578774), Kevin J. Rodzinak (2181544), Fahim Ahmad (1467625), Sixue Zhang (1371636), Kiley M. Bonin (10578777), Aaron D. Streblow (10578780), Cassilyn E. Streblow (10516011), Craig N. Kreklywich (7592762), Clayton Morrison (10578783), Sanjay Sarkar (3386969), Nathaniel Moorman (446135), Wes Sander (10578786), Robbie Allen (10578789), Victor DeFilippis (200525), Babu L. Tekwani (1328517), Mousheng Wu (4837155), Alec J. Hirsch (3826948), Jessica L. Smith (834950), Nichole A. Tower (589415), Lynn Rasmussen (589424), Robert Bostwick (9903900), Joseph A. Maddry (10578792), Subramaniam Ananthan (591094), John M Gerdes (10578795), Corinne E. Augelli-Szafran (2651497), Mark J. Suto (2053921), Thomas E. Morrison (7592765), Mark T. Heise (10053165), Daniel N. Streblow (7592771), Ashish K. Pathak (1333083)

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, Moderate efficacy, CC 50, Chikungunya virus, EC 90, 10 μ M, Targeting Chikungunya Virus Replication, vivo CHIKV challenge mouse model, fibroblast cells, titer reduction, compound 8 q, 270 nM, 2.5 log, nsP 3 macrodomain, drug-like properties, Benzoannulene Inhibitors, activity EC 90, CHIKV resistance, 169 μ M, VTR, 4.5 log, dihydroorotate dehydrogenase

Relation: https://figshare.com/articles/dataset/Targeting_Chikungunya_Virus_Replication_by_Benzoannulene_Inhibitors/14394867

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02183.s008

المؤلفون: S. Kaleem Ahmed (1327023), Nicole N. Haese (3826969), Jaden T. Cowan (10578771), Vibha Pathak (172306), Omar Moukha-Chafiq (7271546), Valerie J. Smith (10578774), Kevin J. Rodzinak (2181544), Fahim Ahmad (1467625), Sixue Zhang (1371636), Kiley M. Bonin (10578777), Aaron D. Streblow (10578780), Cassilyn E. Streblow (10516011), Craig N. Kreklywich (7592762), Clayton Morrison (10578783), Sanjay Sarkar (3386969), Nathaniel Moorman (446135), Wes Sander (10578786), Robbie Allen (10578789), Victor DeFilippis (200525), Babu L. Tekwani (1328517), Mousheng Wu (4837155), Alec J. Hirsch (3826948), Jessica L. Smith (834950), Nichole A. Tower (589415), Lynn Rasmussen (589424), Robert Bostwick (9903900), Joseph A. Maddry (10578792), Subramaniam Ananthan (591094), John M Gerdes (10578795), Corinne E. Augelli-Szafran (2651497), Mark J. Suto (2053921), Thomas E. Morrison (7592765), Mark T. Heise (10053165), Daniel N. Streblow (7592771), Ashish K. Pathak (1333083)

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, Moderate efficacy, CC 50, Chikungunya virus, EC 90, 10 μ M, Targeting Chikungunya Virus Replication, vivo CHIKV challenge mouse model, fibroblast cells, titer reduction, compound 8 q, 270 nM, 2.5 log, nsP 3 macrodomain, drug-like properties, Benzoannulene Inhibitors, activity EC 90, CHIKV resistance, 169 μ M, VTR, 4.5 log, dihydroorotate dehydrogenase

Relation: https://figshare.com/articles/dataset/Targeting_Chikungunya_Virus_Replication_by_Benzoannulene_Inhibitors/14394855

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02183.s004

المؤلفون: S. Kaleem Ahmed (1327023), Nicole N. Haese (3826969), Jaden T. Cowan (10578771), Vibha Pathak (172306), Omar Moukha-Chafiq (7271546), Valerie J. Smith (10578774), Kevin J. Rodzinak (2181544), Fahim Ahmad (1467625), Sixue Zhang (1371636), Kiley M. Bonin (10578777), Aaron D. Streblow (10578780), Cassilyn E. Streblow (10516011), Craig N. Kreklywich (7592762), Clayton Morrison (10578783), Sanjay Sarkar (3386969), Nathaniel Moorman (446135), Wes Sander (10578786), Robbie Allen (10578789), Victor DeFilippis (200525), Babu L. Tekwani (1328517), Mousheng Wu (4837155), Alec J. Hirsch (3826948), Jessica L. Smith (834950), Nichole A. Tower (589415), Lynn Rasmussen (589424), Robert Bostwick (9903900), Joseph A. Maddry (10578792), Subramaniam Ananthan (591094), John M Gerdes (10578795), Corinne E. Augelli-Szafran (2651497), Mark J. Suto (2053921), Thomas E. Morrison (7592765), Mark T. Heise (10053165), Daniel N. Streblow (7592771), Ashish K. Pathak (1333083)

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, Moderate efficacy, CC 50, Chikungunya virus, EC 90, 10 μ M, Targeting Chikungunya Virus Replication, vivo CHIKV challenge mouse model, fibroblast cells, titer reduction, compound 8 q, 270 nM, 2.5 log, nsP 3 macrodomain, drug-like properties, Benzoannulene Inhibitors, activity EC 90, CHIKV resistance, 169 μ M, VTR, 4.5 log, dihydroorotate dehydrogenase

Relation: https://figshare.com/articles/dataset/Targeting_Chikungunya_Virus_Replication_by_Benzoannulene_Inhibitors/14394858

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02183.s005

المؤلفون: S. Kaleem Ahmed (1327023), Nicole N. Haese (3826969), Jaden T. Cowan (10578771), Vibha Pathak (172306), Omar Moukha-Chafiq (7271546), Valerie J. Smith (10578774), Kevin J. Rodzinak (2181544), Fahim Ahmad (1467625), Sixue Zhang (1371636), Kiley M. Bonin (10578777), Aaron D. Streblow (10578780), Cassilyn E. Streblow (10516011), Craig N. Kreklywich (7592762), Clayton Morrison (10578783), Sanjay Sarkar (3386969), Nathaniel Moorman (446135), Wes Sander (10578786), Robbie Allen (10578789), Victor DeFilippis (200525), Babu L. Tekwani (1328517), Mousheng Wu (4837155), Alec J. Hirsch (3826948), Jessica L. Smith (834950), Nichole A. Tower (589415), Lynn Rasmussen (589424), Robert Bostwick (9903900), Joseph A. Maddry (10578792), Subramaniam Ananthan (591094), John M Gerdes (10578795), Corinne E. Augelli-Szafran (2651497), Mark J. Suto (2053921), Thomas E. Morrison (7592765), Mark T. Heise (10053165), Daniel N. Streblow (7592771), Ashish K. Pathak (1333083)

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, Moderate efficacy, CC 50, Chikungunya virus, EC 90, 10 μ M, Targeting Chikungunya Virus Replication, vivo CHIKV challenge mouse model, fibroblast cells, titer reduction, compound 8 q, 270 nM, 2.5 log, nsP 3 macrodomain, drug-like properties, Benzoannulene Inhibitors, activity EC 90, CHIKV resistance, 169 μ M, VTR, 4.5 log, dihydroorotate dehydrogenase

Relation: https://figshare.com/articles/dataset/Targeting_Chikungunya_Virus_Replication_by_Benzoannulene_Inhibitors/14394852

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02183.s003

المؤلفون: S. Kaleem Ahmed (1327023), Nicole N. Haese (3826969), Jaden T. Cowan (10578771), Vibha Pathak (172306), Omar Moukha-Chafiq (7271546), Valerie J. Smith (10578774), Kevin J. Rodzinak (2181544), Fahim Ahmad (1467625), Sixue Zhang (1371636), Kiley M. Bonin (10578777), Aaron D. Streblow (10578780), Cassilyn E. Streblow (10516011), Craig N. Kreklywich (7592762), Clayton Morrison (10578783), Sanjay Sarkar (3386969), Nathaniel Moorman (446135), Wes Sander (10578786), Robbie Allen (10578789), Victor DeFilippis (200525), Babu L. Tekwani (1328517), Mousheng Wu (4837155), Alec J. Hirsch (3826948), Jessica L. Smith (834950), Nichole A. Tower (589415), Lynn Rasmussen (589424), Robert Bostwick (9903900), Joseph A. Maddry (10578792), Subramaniam Ananthan (591094), John M Gerdes (10578795), Corinne E. Augelli-Szafran (2651497), Mark J. Suto (2053921), Thomas E. Morrison (7592765), Mark T. Heise (10053165), Daniel N. Streblow (7592771), Ashish K. Pathak (1333083)

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, Moderate efficacy, CC 50, Chikungunya virus, EC 90, 10 μ M, Targeting Chikungunya Virus Replication, vivo CHIKV challenge mouse model, fibroblast cells, titer reduction, compound 8 q, 270 nM, 2.5 log, nsP 3 macrodomain, drug-like properties, Benzoannulene Inhibitors, activity EC 90, CHIKV resistance, 169 μ M, VTR, 4.5 log, dihydroorotate dehydrogenase

Relation: https://figshare.com/articles/dataset/Targeting_Chikungunya_Virus_Replication_by_Benzoannulene_Inhibitors/14394870

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02183.s009