المؤلفون: Alex G. Waterson, H. Alex Brown, Anna L. Blobaum, Nathan R. Kett, Sarah A. Scott, Craig W. Lindsley

المصدر: Bioorganic & Medicinal Chemistry Letters. 28:3670-3673

مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, 03 medical and health sciences, In vivo, Drug Discovery, Phospholipase D, Animals, Humans, Protein Isoforms, Spiro Compounds, Enzyme Inhibitors, Molecular Biology, Chemistry, Organic Chemistry, Phosphodiesterase, Stereoisomerism, Highly selective, Combinatorial chemistry, Small molecule, Rats, HEK293 Cells, 030104 developmental biology, Free fraction, Molecular Medicine, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb5c7d794e3c5e9dce68aabf4f47e61
https://doi.org/10.1016/j.bmcl.2018.10.033

المؤلفون: Zhijian Zhao, Nathan R. Kett, Sujata Sharma, James C. Barrow, Robert F. Smith, Jeffrey W. Schubert, Nancy A. Sachs, Scott E. Wolkenberg, Ronald G. Robinson, Jeffrey Y. Melamed, Michael S. Poslusney, James Mulhearn, Pete H. Hutson, Scott T. Harrison, Dawn L. Hall, John M. Sanders, Timothy J. Allison, Sangita B. Patel

المصدر: ACS Medicinal Chemistry Letters. 6:318-323

مصطلحات موضوعية: chemistry.chemical_classification, Catechol, Catechol-O-methyl transferase, biology, Tolcapone, Chemistry, Stereochemistry, Organic Chemistry, Biochemistry, Cocrystal, Cofactor, chemistry.chemical_compound, Enzyme, Drug Discovery, biology.protein, medicine, Entacapone, Toxicity profile, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0ee80fe9b95ccf26d22c6a22811b6f
https://doi.org/10.1021/ml500502d

المؤلفون: Peter Chase, Thomas M. Bridges, Nathan R. Kett, Colleen M. Niswender, Patrick R. Gentry, Peter Hodder, Michael R. Wood, Masaya Kokubo, J. Scott Daniels, P. Jeffrey Conn, Hyekyung P. Cho, Emery Smith, Craig W. Lindsley, Joel M. Harp

المصدر: Journal of Medicinal Chemistry. 56:9351-9355

مصطلحات موضوعية: Allosteric modulator, biology, Stereochemistry, Chemistry, Drug discovery, Allosteric regulation, Pharmacology, biology.organism_classification, Drug Discovery, Muscarinic acetylcholine receptor, Molecular Medicine, Structure–activity relationship, Cricetulus, Receptor, IC50

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bdd4f50af0afaa3a7b9041ab569889f9
https://doi.org/10.1021/jm4013246

المؤلفون: Matthew J. Cato, Peter J. Manley, Christopher J. Dinsmore, Jixin Wang, B. Wesley Trotter, M. Brad Nolt, Bing Li, Robert H. Spencer, Mark T. Bilodeau, Gary L. Stump, Scott E. Wolkenberg, Rebecca B. White, Kausik K. Nanda, Laszlo Kiss, George D. Hartman, Craig W. Lindsley, Christopher P. Regan, Stefanie A. Kane, Zhicai Wu, Suzie Yeh, Joseph J. Lynch, Nathan R. Kett

المصدر: Bioorganicmedicinal chemistry letters. 27(4)

مصطلحات موضوعية: 0301 basic medicine, Pyridines, Clinical Biochemistry, Pharmaceutical Science, 030204 cardiovascular system & hematology, Pharmacology, Selective inhibition, Biochemistry, 03 medical and health sciences, Kv1.5 Potassium Channel, Structure-Activity Relationship, 0302 clinical medicine, Pharmacokinetics, In vivo, Drug Discovery, medicine, Humans, Molecular Biology, Proarrhythmia, Chemistry, Drug discovery, Organic Chemistry, Atrial fibrillation, medicine.disease, 030104 developmental biology, Delayed rectifier, Molecular Medicine, Selectivity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c28d78944ff68aea790d3850958003ea
https://pubmed.ncbi.nlm.nih.gov/28131713

المؤلفون: Colleen M. Niswender, Michael R. Wood, P.J. Conn, Christian Sevel, Ryan D. Morrison, Craig W. Lindsley, Thomas M. Bridges, Thomas J. Utley, Douglas J. Sheffler, Nathan R. Kett, J. S. Daniels, Michael S. Poslusney

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:6923-6928

مصطلحات موضوعية: Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Stereoisomerism, Biochemistry, chemistry.chemical_compound, Amide, Drug Discovery, Radioligand, Molecular Medicine, Structure–activity relationship, Selectivity, Molecular Biology, Acetylcholine receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4bb5cea6985279f87de6884870073fab
https://doi.org/10.1016/j.bmcl.2012.09.011

المؤلفون: Eric Delpire, Ryan D. Morrison, Kwangho Kim, Nathan R. Kett, J. Scott Daniels, Alex G. Waterson, Aleksandra Baranczak, Craig W. Lindsley, C. David Weaver

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:4532-4535

مصطلحات موضوعية: Molecular Structure, Symporters, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Antagonist, Pharmaceutical Science, Transporter, Biochemistry, Article, Pyridazines, Structure-Activity Relationship, Thiazoles, Drug Discovery, Symporter, Molecular Medicine, Structure–activity relationship, Cotransporter, Selectivity, Molecular Biology, Ion channel, G protein-coupled receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f45d187b9fc0bb00c7fcbaddfb2cea
https://doi.org/10.1016/j.bmcl.2012.05.126

المؤلفون: Michael D. Leitl, Darrell A. Henze, B. Wesley Trotter, Kimberly Della Penna, Ahren Iver Green, Mark T. Bilodeau, Zhicai Wu, Christopher S. Burgey, Wei Lemaire, Stefanie A. Kane, Craig M. Potteiger, Reshma Desai, Mark O. Urban, Suzie Yeh, Rebecca B. White, Nathan R. Kett, James Z. Deng, George D. Hartman, John C. Hartnett, Kausik K. Nanda

المصدر: Bioorganic & Medicinal Chemistry Letters. 21:2354-2358

مصطلحات موضوعية: Agonist, Imidazopyridine, Cannabinoid receptor, Pyridines, medicine.drug_class, medicine.medical_treatment, Freund's Adjuvant, Clinical Biochemistry, Analgesic, Pharmaceutical Science, Pharmacology, Biochemistry, Receptor, Cannabinoid, CB2, Receptor, Cannabinoid, CB1, In vivo, Drug Discovery, medicine, Animals, Humans, Receptor, Molecular Biology, Analgesics, Chemistry, Organic Chemistry, In vitro, Rats, Disease Models, Animal, Hyperalgesia, Molecular Medicine, lipids (amino acids, peptides, and proteins), Cannabinoid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14244f428a1317fe2d743c1692b389db
https://doi.org/10.1016/j.bmcl.2011.02.082

المؤلفون: Jin Hua, J. Christopher Culberson, David C. Heimbrook, B. Wesley Trotter, Steven M. Stirdivant, Annette S. Kim, Dawn L. Hall, Christopher J. Dinsmore, Maria Kornienko, C. Blair Zartman, Steven N. Gallicchio, Theresa M. Williams, Ian M. Bell, Samuel L. Graham, Lloyd Waxman, John C. Reid, Nathan R. Kett, Paul L. Darke, Ahern Janet, Sanjeev Munshi, Lawrence C. Kuo, Robert A. Drakas, Amy G. Quigley

المصدر: Biochemistry. 44:9430-9440

مصطلحات موضوعية: Molecular Sequence Data, Borohydrides, Biology, Mitogen-activated protein kinase kinase, Crystallography, X-Ray, Biochemistry, Tropomyosin receptor kinase C, Cell Line, Receptor, IGF Type 1, Structure-Activity Relationship, Humans, Pyrroles, Amino Acid Sequence, Phosphorylation, Protein Kinase Inhibitors, Protein kinase B, Schiff Bases, Insulin-like growth factor 1 receptor, Aldehydes, Binding Sites, Cyclin-dependent kinase 4, Cyclin-dependent kinase 2, Molecular biology, Peptide Fragments, Receptor, Insulin, Protein Structure, Tertiary, Enzyme Activation, Insulin receptor, biology.protein, Cyclin-dependent kinase 9

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee3bcffd91b9d3914757d323f0c95ae
https://doi.org/10.1021/bi0500628

المؤلفون: Nathan R. Kett, Edward K. Hawkins, Carmelo J. Rizzo, Plamen P. Christov

المصدر: Tetrahedron Letters. 54:4289-4291

مصطلحات موضوعية: Nitroaldol reaction, Tertiary amine, Stereochemistry, Chemistry, Organic Chemistry, Diastereomer, Periodate, Biochemistry, Article, Adduct, chemistry.chemical_compound, Nucleophilic aromatic substitution, Dihydroxylation, Drug Discovery, Organic chemistry, Enantiomer

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f031f9e1456af965ce2bcd5a94bb18
https://doi.org/10.1016/j.tetlet.2013.06.004

المؤلفون: Patrick R, Gentry, Masaya, Kokubo, Thomas M, Bridges, Nathan R, Kett, Joel M, Harp, Hyekyung P, Cho, Emery, Smith, Peter, Chase, Peter S, Hodder, Colleen M, Niswender, J Scott, Daniels, P Jeffrey, Conn, Michael R, Wood, Craig W, Lindsley

المصدر: Journal of medicinal chemistry. 56(22)

مصطلحات موضوعية: Male, Indoles, Receptor, Muscarinic M5, Drug Evaluation, Preclinical, Imidazoles, Brain, CHO Cells, Article, Rats, Substrate Specificity, Structure-Activity Relationship, Cricetulus, Allosteric Regulation, Cricetinae, Drug Discovery, Animals, Humans

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::69b22d8208e44f6d33167513c08e8d89
https://pubmed.ncbi.nlm.nih.gov/24164599

المؤلفون: Michael S, Poslusney, Christian, Sevel, Thomas J, Utley, Thomas M, Bridges, Ryan D, Morrison, Nathan R, Kett, Douglas J, Sheffler, Colleen M, Niswender, J S, Daniels, P J, Conn, Craig W, Lindsley, Michael R, Wood

المصدر: Bioorganicmedicinal chemistry letters. 22(22)

مصطلحات موضوعية: Receptor, Muscarinic M1, Stereoisomerism, CHO Cells, Amides, Binding, Competitive, Acetylcholine, Piperazines, Article, Structure-Activity Relationship, Cricetulus, Cricetinae, Stilbenes, Animals, Humans

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::cf2b84b0f0518c7b3beb9a6261fe370e
https://pubmed.ncbi.nlm.nih.gov/23062550

المؤلفون: Anthony L. Gotter, B. Wesley Trotter, Martin Henault, Amy E. Zartman, Cindra L. Condra, Rino Stocco, Mark T. Bilodeau, Christine Fandozzi, Duane R. Reiss, Georgia B. McGaughey, Laura S. Lubbers, George D. Hartman, Victor N. Uebele, Nathan R. Kett, John J. Renger, Blake A. Rowe, Jeffrey Y. Melamed

المصدر: Bioorganicmedicinal chemistry letters. 20(15)

مصطلحات موضوعية: Central Nervous System, Receptors, Neuropeptide, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Quinolones, Biochemistry, Iodine Radioisotopes, Structure-Activity Relationship, In vivo, Drug Discovery, Neuropeptide S, Structure–activity relationship, Animals, Humans, Receptor, Molecular Biology, Neuropeptide S receptor, G protein-coupled receptor, Chemistry, Organic Chemistry, Antagonist, Amides, Rats, Blood-Brain Barrier, Molecular Medicine, Wakefulness, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f90e870c1a89cb2504715678c9d259
https://pubmed.ncbi.nlm.nih.gov/20510609

المؤلفون: Charles J. Mcintyre, Nathan R. Kett, Jixin Wang, Douglas C. Beshore, Nigel J. Liverton, Kausik K. Nanda, George D. Hartman, B. Wesley Trotter, Christopher P. Regan, Christopher J. Dinsmore, Laszlo Kiss, Kenneth D. Anderson, Stefanie A. Kane, Rebecca B. White, Rena Zhang, Joseph J. Lynch, Gary L. Stump, Robert H. Spencer

المصدر: Journal of medicinal chemistry. 49(24)

مصطلحات موضوعية: Patch-Clamp Techniques, Stereochemistry, medicine.medical_treatment, Administration, Oral, Biological Availability, Antiarrhythmic agent, Pharmacology, complex mixtures, Chemical synthesis, chemistry.chemical_compound, Kv1.5 Potassium Channel, Structure-Activity Relationship, In vivo, Oral administration, Drug Discovery, Atrial Fibrillation, Nitriles, medicine, Potency, Animals, Humans, Isoquinoline, Chemistry, Heart, Stereoisomerism, Isoquinolines, Potassium channel, Bioavailability, Rats, Electrophysiology, Molecular Medicine, Anti-Arrhythmia Agents

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec258d42b08624c9020f97db78af8ed
https://pubmed.ncbi.nlm.nih.gov/17125248