المؤلفون: Emily I. Sparkes, Rachel A. Kettles, Chisom S. Egedeuzu, Natalie L. Stephenson, Stephanie A. Caslin, S. Yasin Tabatabaei Dakhili, Lu Shin Wong

المصدر: Biomolecules, Vol 10, Iss 9, p 1209 (2020)

مصطلحات موضوعية: silicatein, biocatalysis, biosilification, organosilicon, organosiloxane, hexahistidine tag, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2218-273X/10/9/1209; https://doaj.org/toc/2218-273X

URL الوصول: https://doaj.org/article/490a315e87ae4b82b8065adec2bc2654

المؤلفون: Natalie L. Stephenson, Johanna M. Avis

المصدر: FEBS Open Bio, Vol 5, Iss 1, Pp 625-633 (2015)

مصطلحات موضوعية: Notch, Negative regulatory region, Heterodimerization domain, HD domain, Atomic force microscopy, Molecular dynamics simulations, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2211-5463

URL الوصول: https://doaj.org/article/bbe65295cefc4552a0ebedf9141e41eb

المؤلفون: John Brognard, Owen J. Sansom, Tony Hunter, Crispin J. Miller, Ewelina Testoni, Matthew Collier, Ross Overman, Isabelle Green, Chris Phillips, Hannah K. Pollard, Claire Brassington, Jon A. Read, Lorena A. Puto, Phil Chapman, Susan Mason, Karen Blyth, Yaoyong Li, Eleanor W. Trotter, Hayeon Baik, Natalie L. Stephenson, Anna A. Marusiak

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0722c76c95b7bbc4901db1e2b3ae68
https://doi.org/10.1158/0008-5472.22409912

المؤلفون: Ewelina Testoni, Natalie L Stephenson, Pedro Torres‐Ayuso, Anna A Marusiak, Eleanor W Trotter, Andrew Hudson, Cassandra L Hodgkinson, Christopher J Morrow, Caroline Dive, John Brognard

المصدر: EMBO Molecular Medicine, Vol 8, Iss 2, Pp 105-116 (2016)

مصطلحات موضوعية: ABL1 mutations, dasatinib, imatinib, non‐small cell lung cancer, Medicine (General), R5-920, Genetics, QH426-470

Relation: https://doi.org/10.15252/emmm.201505456; https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684; https://doaj.org/article/09b706bec30d4b42952219ab90a03b7c

الاتاحة: https://doi.org/10.15252/emmm.201505456
https://doaj.org/article/09b706bec30d4b42952219ab90a03b7c

المؤلفون: Alexander Jones, John Brognard, Yimin Yang, Gema Lordén, Alexandra C. Newton, Natalie L. Stephenson, Julia A. Callender

المصدر: Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 24

مصطلحات موضوعية: 0301 basic medicine, Aging, Neurodegenerative, Inbred C57BL, Alzheimer's Disease, Mice, 0302 clinical medicine, Catalytic Domain, Chlorocebus aethiops, enzyme mutation, 2.1 Biological and endogenous factors, Phosphorylation, PKC, Aetiology, Multidisciplinary, Chemistry, Brain, Cell biology, Protein destabilization, PNAS Plus, Gain of Function Mutation, Second messenger system, COS Cells, Signal transduction, Alzheimer’s disease, signal transduction, Signal Transduction, Protein Kinase C-alpha, Allosteric regulation, Down-Regulation, Catalysis, Cell Line, 03 medical and health sciences, Alzheimer Disease, Acquired Cognitive Impairment, Animals, Humans, Protein kinase A, Protein kinase C, Diacylglycerol kinase, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Brain Disorders, Mice, Inbred C57BL, Enzyme Activation, 030104 developmental biology, Protein kinase domain, Mutation, Calcium, Dementia, CRISPR-Cas Systems, 030217 neurology & neurosurgery, protein kinase C

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18276fc3e965284a0d17e12beae5ed5
https://escholarship.org/uc/item/3js1d9tn

المؤلفون: Cynthia Li, Christopher Wirth, John Brognard, Matthew Howell, Gitta Katona, S Furney, Natalie L. Stephenson, Eleanor W. Trotter, Andrew M Hudson, Patrycja Bieniasz-Krzywiec, Crispin J. Miller, Adam Fletcher

المصدر: Sci Signal

مصطلحات موضوعية: 0301 basic medicine, MAP Kinase Signaling System, MAP Kinase Kinase 7, Biology, Molecular Dynamics Simulation, Biochemistry, Article, law.invention, 03 medical and health sciences, law, Loss of Function Mutation, Stomach Neoplasms, Cell Line, Tumor, Humans, Kinome, Genes, Tumor Suppressor, Amino Acid Sequence, Kinase activity, Molecular Biology, Gene, Sequence Homology, Amino Acid, Kinase, Cell Biology, Genomics, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Protein kinase domain, Cancer cell, Cancer research, Suppressor, Functional genomics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab9ac2252ba0709b0016d5a7e4819f68
https://pubmed.ncbi.nlm.nih.gov/29666306

المؤلفون: Alexander M. Jones, Natalie L. Stephenson, Alexandra C. Newton, Yimin Yang, John Brognard, Julia Callender

المصدر: The FASEB Journal. 32

مصطلحات موضوعية: Gain of function, Downregulation and upregulation, Mechanism (biology), Chemistry, Genetics, Protein kinase A, Molecular Biology, Biochemistry, Biotechnology, Cell biology, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5c89f7fb7d497b20ffa82746db595ab0
https://doi.org/10.1096/fasebj.2018.32.1_supplement.662.7

المؤلفون: Natalie L. Stephenson, Andrew M Hudson, John Brognard, Crispin J. Miller, Christopher Wirth, Shameem Fawdar

المصدر: Pharmacogenomics. 16:1149-1160

مصطلحات موضوعية: Pharmacology, Poor prognosis, Lung Neoplasms, In silico, Smoking, Computational Biology, Genomics, Disease, Biology, Bioinformatics, medicine.disease, Databases, Genetic, Mutation, Genetics, medicine, Humans, Molecular Medicine, Lung tumor, Lung cancer, Cancer death

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa44d783d1f99bbf60b980fa5663c43
https://doi.org/10.2217/pgs.15.60

المؤلفون: Andrew M. Hudson, Natalie L. Stephenson, Cynthia Li, Eleanor Trotter, Adam J. Fletcher, Gitta Katona, Patrycja Bieniasz-Krzywiec, Matthew Howell, Chris Wirth, Simon Furney, Crispin J. Miller, John Brognard

مصطلحات موضوعية: Protein kinase domain, Pan cancer, law, Kinase, Cancer genome, Suppressor, Genomics, Kinome, Motif (music), Computational biology, Biology, law.invention

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1fa9cdde5a1fa64f5311a868fd3df9f
https://doi.org/10.1101/254813

المؤلفون: John Brognard, Anna A. Marusiak, Bohdan Waszkowycz, Franziska Hanke, Natalie L. Stephenson, Shameem Fawdar, Eleanor W. Trotter, Crispin J. Miller, Sara Ientile, Yaoyong Li, Zoe C. Edwards

المصدر: Proceedings of the National Academy of Sciences. 110:12426-12431

مصطلحات موضوعية: Lung Neoplasms, Cell Survival, MAP Kinase Signaling System, Somatic cell, Disease, Biology, medicine.disease_cause, Bioinformatics, medicine, Humans, Receptor, Fibroblast Growth Factor, Type 4, Lung cancer, p21-activated kinases, Cell Proliferation, Mutation, Multidisciplinary, business.industry, Kinase, Cancer, Biological Sciences, MAP Kinase Kinase Kinases, medicine.disease, p21-Activated Kinases, Personalized medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ce1123fb8b84512a6bbc0645e72a1e
https://doi.org/10.1073/pnas.1305207110

المؤلفون: Ewelina Testoni, Matthew Collier, Isabelle Green, Christopher R. Phillips, Claire Brassington, Yaoyong Li, Phil Chapman, Ross Overman, Crispin J. Miller, Hannah Pollard, Karen Blyth, Lorena A. Puto, Eleanor W. Trotter, Susan M. Mason, Anna A. Marusiak, Tony Hunter, Owen J. Sansom, John Brognard, Hayeon Baik, Jon Read, Natalie L. Stephenson

المصدر: Cancer research. 76(3)

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Carcinogenesis, MAP Kinase Signaling System, p38 mitogen-activated protein kinases, Mice, Nude, Biology, medicine.disease_cause, Article, MAP2K7, 03 medical and health sciences, Mice, CDKN2B, medicine, Animals, Humans, Mutation, Mice, Inbred BALB C, MAP kinase kinase kinase, Kinase, MAP Kinase Kinase Kinases, Molecular biology, Xenograft Model Antitumor Assays, 030104 developmental biology, Oncology, Colonic Neoplasms, Cancer research, Female, Signal transduction, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b269b8d8e2babc7c88b71cafcfdf84be
https://pubmed.ncbi.nlm.nih.gov/26637668

المؤلفون: Ciro Zanca, Natalie L. Stephenson, Andrew M Hudson, Christopher Wirth, Corina E. Antal, Frank B. Furnari, John Brognard, Tony Hunter, Lisa L. Gallegos, Alexandra C. Newton, Eleanor W. Trotter, Crispin J. Miller, Emily Kang

مصطلحات موضوعية: Models, Molecular, Mice, Nude, Biology, medicine.disease_cause, Isozyme, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, Neoplasms, medicine, Fluorescence Resonance Energy Transfer, Animals, Humans, Genes, Tumor Suppressor, Gene, Protein kinase C, Loss function, Protein Kinase C, 030304 developmental biology, 0303 health sciences, Mutation, Kinase, Biochemistry, Genetics and Molecular Biology(all), Cancer, medicine.disease, Molecular biology, 3. Good health, Protein Structure, Tertiary, Isoenzymes, 030220 oncology & carcinogenesis, Phosphorylation, Heterografts, Neoplasm Transplantation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db9fe00af8d8a5d6eb7c5ce29de4738c
https://europepmc.org/articles/PMC4313737/

المؤلفون: Zoe C. Edwards, Natalie L. Stephenson, Andrew M Hudson, Roger S. Lo, Xiangju Kong, Anna A. Marusiak, Eleanor W. Trotter, Richard Marais, Wolfgang Breitwieser, Willy Hugo, Shameem Fawdar, John Brognard, Michael Gartside, Nicholas K. Hayward, Maria Romina Girotti

المصدر: Nature Communications
Nature communications, vol 5, iss 1

مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, MAPK/ERK pathway, Indoles, Lineage (genetic), Cell Survival, MAP Kinase Signaling System, Drug Resistance, General Physics and Astronomy, Drug resistance, Biology, Bioinformatics, Article, General Biochemistry, Genetics and Molecular Biology, Cell Line, Mice, Downregulation and upregulation, medicine, Animals, Humans, In patient, Phosphorylation, Protein Kinase Inhibitors, Cancer, Mitogen-Activated Protein Kinase Kinases, Sulfonamides, Multidisciplinary, Animal, Kinase, Melanoma, General Chemistry, MAP Kinase Kinase Kinases, medicine.disease, Up-Regulation, 3. Good health, Enzyme Activation, Disease Models, Animal, Vemurafenib, Drug Resistance, Neoplasm, Cell culture, Disease Models, Mutation, Cancer research, Neoplasm

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81dc8509c49aae5d265e541c9dfeb3e3
https://doi.org/10.1038/ncomms4901

المؤلفون: Tony Hunter, John Brognard, Natalie L. Stephenson, Alexandra C. Newton, Eleanor W. Trotter, Corina E. Antal, Emily Kang

المصدر: The FASEB Journal. 28

مصطلحات موضوعية: Kinase, Context (language use), Biology, Biochemistry, Isozyme, Diacylglycerol binding, Protein kinase domain, Genetics, Cancer research, Molecular Biology, Protein kinase C, Biotechnology, C2 domain, C1 domain

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::94233bc4ab52b598c2f34bc91a5380f7
https://doi.org/10.1096/fasebj.28.1_supplement.1055.2

المؤلفون: Johanna M. Avis, Natalie L. Stephenson

مصطلحات موضوعية: Models, Molecular, Protein domain, Blotting, Western, Notch signaling pathway, ADAM17 Protein, Molecular Dynamics Simulation, Regulatory Sequences, Nucleic Acid, Cleavage (embryo), Ligands, Microscopy, Atomic Force, Protein structure, Humans, Amino Acid Sequence, Receptor, Notch2, Binding site, Protein Unfolding, Multidisciplinary, Binding Sites, Chemistry, ADAM Proteins, Protein Structure, Tertiary, Biochemistry, PNAS Plus, Proteolysis, Biophysics, Nucleic Acid Conformation, HD domain, Protein Binding, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2a82b9528a61786b7b907c2e30b471a
https://europepmc.org/articles/PMC3478610/

المؤلفون: Corina E. Antal, Lisa L. Gallegos, Eleanor W. Trotter, Crispin J. Miller, John Brognard, Frank B. Furnari, Tony Hunter, Alexandra C. Newton, Ciro Zanca, Emily Kang, Christopher Wirth, Natalie L. Stephenson, Andrew M Hudson

المصدر: Cancer Research. 75:125-125

مصطلحات موضوعية: Genetics, Cancer Research, Mutation, business.industry, Cancer, medicine.disease_cause, medicine.disease, law.invention, Oncology, Genome editing, law, Cancer research, Suppressor, Medicine, Tumor growth, Haploinsufficiency, business, Protein kinase C, Loss function

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ab21937a26fdeff43043da8c04558059
https://doi.org/10.1158/1538-7445.am2015-125

المؤلفون: Emily Kang, Eleanor W. Trotter, John Brognard, Corina E. Antal, Natalie L. Stephenson, Tony Hunter, Alexandra C. Newton

المصدر: Cancer Research. 74:5270-5270

مصطلحات موضوعية: Genetics, Cancer Research, business.industry, Kinase, Cancer, Context (language use), medicine.disease, Isozyme, Diacylglycerol binding, Oncology, Protein kinase domain, Cancer research, Medicine, business, Protein kinase C, C1 domain

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::049a7235d154a98e813925d29528ede9
https://doi.org/10.1158/1538-7445.am2014-5270