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1Academic Journal
المؤلفون: Rebecca CS Edgar, Ghizal Siddiqui, Katheryn Hjerrild, Tess R Malcolm, Natalie B Vinh, Chaille T Webb, Clare Holmes, Christopher A MacRaild, Hope C Chernih, Willy W Suen, Natalie A Counihan, Darren J Creek, Peter J Scammells, Sheena McGowan, Tania F de Koning-Ward
المصدر: eLife, Vol 11 (2022)
مصطلحات موضوعية: P. falciparum, hemoglobin digestion, aminopeptidase, drug target, Medicine, Science, Biology (General), QH301-705.5
وصف الملف: electronic resource
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المؤلفون: Rebecca CS Edgar, Ghizal Siddiqui, Katheryn Hjerrild, Tess R Malcolm, Natalie B Vinh, Chaille T Webb, Clare Holmes, Christopher A MacRaild, Hope C Chernih, Willy W Suen, Natalie A Counihan, Darren J Creek, Peter J Scammells, Sheena McGowan, Tania F de Koning-Ward
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3
المؤلفون: Petar P.S. Calic, Natalie B. Vinh, Chaille T. Webb, Tess R. Malcolm, Anna Ngo, Kym Lowes, Nyssa Drinkwater, Sheena McGowan, Peter J. Scammells
المصدر: European Journal of Medicinal Chemistry. 248:115051
مصطلحات موضوعية: Pharmacology, Organic Chemistry, Drug Discovery, General Medicine
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المؤلفون: Luke S. Schembri, Susan A. Charman, Sheena McGowan, Georgina S. Butler, Christopher M. Overall, Jisook Lee, Wei Yang, Nyssa Drinkwater, Peter M. Grin, Peter J. Scammells, Natalie B. Vinh, Komagal Kannan Sivaraman, Michelle Gazdik
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: Male, Angiogenesis, CD13 Antigens, 01 natural sciences, Aminopeptidase, Mice, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Animals, Humans, Enzyme Inhibitors, Cytotoxicity, Benzamide, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Binding Sites, Hydroxamic acid, biology, Plasmodium falciparum, biology.organism_classification, In vitro, Protein Structure, Tertiary, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, chemistry, Biochemistry, Molecular Medicine, hormones, hormone substitutes, and hormone antagonists, Protein Binding
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المؤلفون: Natalie B. Vinh, Peter J. Scammells, Khadija Mohamed, Sheena McGowan, Nyssa Drinkwater, Wioletta Rut, Komagal Kannan Sivaraman, Rebecca S. Bamert, Marcin Drag
المصدر: Biochemical Journal. 473:3189-3204
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Protein Conformation, Proteolysis, Plasmodium falciparum, Drug resistance, Biology, Crystallography, X-Ray, Aminopeptidases, Biochemistry, Aminopeptidase, Substrate Specificity, 03 medical and health sciences, Escherichia coli, medicine, Animals, Protease inhibitor (pharmacology), Molecular Biology, chemistry.chemical_classification, 030102 biochemistry & molecular biology, medicine.diagnostic_test, Cell Biology, medicine.disease, biology.organism_classification, Amino acid, 030104 developmental biology, Enzyme, chemistry, Dimerization, Malaria
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6Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases
المؤلفون: Sandra Duffy, Peter J. Scammells, Peter M. Grin, Tess R. Malcolm, Georgina S. Butler, Vicky M. Avery, Leonardo Lucantoni, Christopher M. Overall, Sheena McGowan, Natalie B. Vinh, Nyssa Drinkwater, Michael Kassiou
المصدر: Journal of medicinal chemistry. 62(2)
مصطلحات موضوعية: Plasmodium, Cell Survival, Plasmodium vivax, Drug Resistance, Protozoan Proteins, Hydroxamic Acids, 01 natural sciences, Aminopeptidases, 03 medical and health sciences, chemistry.chemical_compound, Antimalarials, Structure-Activity Relationship, Catalytic Domain, parasitic diseases, Drug Discovery, Structure–activity relationship, Humans, Protease Inhibitors, Binding site, 030304 developmental biology, Metalloexopeptidase, chemistry.chemical_classification, 0303 health sciences, Hydroxamic acid, Binding Sites, biology, Chemistry, Plasmodium falciparum, biology.organism_classification, 3. Good health, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Enzyme, HEK293 Cells, Biochemistry, Molecular Medicine, Hemoglobin
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7
المؤلفون: Henry Krum, David K. Chalmers, Renae M. Ryan, Jamie S. Simpson, Peter J. Scammells, Shane M. Devine, Bing Hui Wang, Natalie B. Vinh, Lenka Munoz
المصدر: ChemistryOpen
مصطلحات موضوعية: chemistry.chemical_classification, MAPK/ERK pathway, Stereochemistry, Ligand binding assay, fibrosis, cardiac remodelling, structure–activity relationships (SAR), molecular docking, General Chemistry, Full Papers, Biology, chemistry.chemical_compound, Enzyme, medicine.anatomical_structure, chemistry, Docking (molecular), Thiophene, medicine, Phosphorylation, p38α mitogen-activated protein kinase (MAPK), Fibroblast, Protein kinase A
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المؤلفون: Chiara Ruggeri, Sasdekumar Loganathan, Vicky M. Avery, Peter J. Scammells, Nyssa Drinkwater, Rebecca S. Bamert, Andrew K. Powell, Susan A. Charman, Sheena McGowan, John P. Holleran, Natalie B. Vinh, Alessandro Paiardini, Shailesh N. Mistry
مصطلحات موضوعية: 0301 basic medicine, Dual inhibition, Models, Molecular, aminopeptidase inhibitors, hydroxamic acid, malaria, plasmodium falciparum, zinc-binding group, aminopeptidases, antimalarials, hek293 cells, humans, hydroxamic acids, malaria, falciparum, models, molecular, protease inhibitors, protozoan proteins, structure-activity relationship, zinc, drug discovery3003 pharmaceutical science, organic chemistry, pharmacology, medicine.medical_treatment, Plasmodium falciparum, Protozoan Proteins, Biology, Hydroxamic Acids, 01 natural sciences, Aminopeptidases, 03 medical and health sciences, chemistry.chemical_compound, models, Antimalarials, Structure-Activity Relationship, falciparum, Resistant strain, Drug Discovery, medicine, Structure–activity relationship, Humans, Protease Inhibitors, molecular, Malaria, Falciparum, Hydroxamic acid, Protease, 010405 organic chemistry, HEK 293 cells, General Medicine, medicine.disease, biology.organism_classification, 3. Good health, 0104 chemical sciences, Zinc, 030104 developmental biology, HEK293 Cells, Biochemistry, chemistry, P. falciparum, Malaria, Aminopeptidase inhibitors, hydroxamic acid, zinc-binding group, Malaria
وصف الملف: PDF; application/pdf
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المصدر: Journal of Computer-Aided Molecular Design. 26:409-423
مصطلحات موضوعية: Models, Molecular, Virtual screening, Chemistry, Stereochemistry, Aryl, Protonation, Ligands, Tautomer, Computer Science Applications, Mitogen-Activated Protein Kinase 14, chemistry.chemical_compound, ROC Curve, Docking (molecular), Catalytic Domain, Drug Discovery, Target protein, Physical and Theoretical Chemistry, Binding site, Decoy, Protein Binding
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المؤلفون: Manuela Jörg, J. Robert Lane, Ben Capuano, Natalie B. Vinh, Peter J. Scammells, Patrick M. Sexton, Shailesh N. Mistry, Arthur Christopoulos, Herman Lim
مصطلحات موضوعية: 0301 basic medicine, Allosteric modulator, Intrinsic activity, Pyridones, Allosteric regulation, CHO Cells, Pharmacology, Muscarinic Agonists, 03 medical and health sciences, Radioligand Assay, Structure-Activity Relationship, Cricetulus, Allosteric Regulation, Alzheimer Disease, Cricetinae, Drug Discovery, Muscarinic acetylcholine receptor, medicine, Structure–activity relationship, Animals, Humans, Receptor, Dose-Response Relationship, Drug, Chemistry, Receptor, Muscarinic M1, Cooperative binding, Acetylcholine, 3. Good health, 030104 developmental biology, Quinolines, Schizophrenia, Molecular Medicine, Cognition Disorders, medicine.drug
وصف الملف: application/pdf
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