المؤلفون: Izabella Góral, Tomasz Wichur, Emilia Sługocka, Justyna Godyń, Natalia Szałaj, Paula Zaręba, Monika Głuch-Lutwin, Barbara Mordyl, Dawid Panek, Anna Więckowska

المصدر: Molecules, Vol 29, Iss 11, p 2616 (2024)

مصطلحات موضوعية: GSK-3β, IKK-β, ROCK-1, anti-inflammatory activity, neuroprotective properties Alzheimer’s disease, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/29/11/2616; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/d794b4a155cb4c9da646e809bc8a5781

المؤلفون: Marek Staszewski, Magdalena Iwan, Tobias Werner, Marek Bajda, Justyna Godyń, Gniewomir Latacz, Agnieszka Korga-Plewko, Joanna Kubik, Natalia Szałaj, Holger Stark, Barbara Malawska, Anna Więckowska, Krzysztof Walczyński

المصدر: Pharmaceuticals; Volume 16; Issue 5; Pages: 675

مصطلحات موضوعية: guanidines, histamine H 3 receptor, antagonist, breast cancer, multi-target directed ligand

وصف الملف: application/pdf

Relation: Medicinal Chemistry; https://dx.doi.org/10.3390/ph16050675

الاتاحة: https://doi.org/10.3390/ph16050675

المؤلفون: Krzysztof Więckowski, Natalia Szałaj, Beata Gryzło, Tomasz Wichur, Izabella Góral, Emilia Sługocka, Joanna Sniecikowska, Gniewomir Latacz, Agata Siwek, Justyna Godyń, Adam Bucki, Marcin Kołaczkowski, Anna Więckowska

المصدر: International Journal of Molecular Sciences; Volume 23; Issue 16; Pages: 9443

مصطلحات موضوعية: Alzheimer’s disease, cholinesterase inhibitors, AChE, BuChE, 5-HT 6 receptor ligands, antioxidant properties, metal-chelating properties, multifunctional ligands

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Pathology, Diagnostics, and Therapeutics; https://dx.doi.org/10.3390/ijms23169443

الاتاحة: https://doi.org/10.3390/ijms23169443

المؤلفون: Natalia Szałaj, Justyna Godyń, Jakub Jończyk, Anna Pasieka, Dawid Panek, Tomasz Wichur, Krzysztof Więckowski, Paula Zaręba, Marek Bajda, Anja Pislar, Barbara Malawska, Raimon Sabate, Anna Więckowska

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1944-1952 (2020)

مصطلحات موضوعية: multifunctional ligands, β-secretase, 5-ht6 receptor antagonists, cholinesterase inhibitors, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/8664353705ab4c3dbfa4416d81bfa9d5

المؤلفون: Monika Stefaniak-Napieralska, Krzysztof Walczynski, Magdalena Iwan, Agnieszka Korga-Plewko, Natalia Szalaj, Anna Wieckowska, Marek Staszewski

مصطلحات موضوعية: Medicinal and biomolecular chemistry not elsewhere classified, 1,5-benzoxazepine, Alzheimer’s disease, anticancer, cholinesterase, histamine, H3 receptor antagonist

Relation: https://figshare.com/articles/figure/Preliminary_studies_of_1_5-benzoxazepine_derivatives_as_potential_histamine_H3_receptor_antagonists/24960525

الاتاحة: https://doi.org/10.25402/fmc.24960525.v1
https://figshare.com/articles/figure/Preliminary_studies_of_1_5-benzoxazepine_derivatives_as_potential_histamine_H3_receptor_antagonists/24960525

المؤلفون: Dawid Panek, Alba Espargaró, Marek Bajda, Anna Pasieka, Barbara Malawska, Anna Więckowska, Raimon Sabaté, Natalia Szałaj

المصدر: ACS Chemical Neuroscience

مصطلحات موضوعية: Molecular model, Physiology, Cognitive Neuroscience, In silico, Tau protein, Protein aggregation, aggregation inhibitors, Biochemistry, tau protein, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, Humans, Computer Simulation, IC50, 030304 developmental biology, 0303 health sciences, Amyloid beta-Peptides, biology, molecular modeling, Chemistry, Biological activity, Cell Biology, General Medicine, Peptide Fragments, In vitro, Kinetics, Docking (molecular), Drug Design, biology.protein, Cholinesterase Inhibitors, β-Amyloid, Alzheimer’s disease, 030217 neurology & neurosurgery, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ba40071bed94f96862fdb551c1c2b4
https://doi.org/10.1021/acschemneuro.1c00235

المؤلفون: Krzysztof, Więckowski, Natalia, Szałaj, Beata, Gryzło, Tomasz, Wichur, Izabella, Góral, Emilia, Sługocka, Joanna, Sniecikowska, Gniewomir, Latacz, Agata, Siwek, Justyna, Godyń, Adam, Bucki, Marcin, Kołaczkowski, Anna, Więckowska

المصدر: International journal of molecular sciences. 23(16)

مصطلحات موضوعية: Serotonin, Structure-Activity Relationship, Amyloid beta-Peptides, Alzheimer Disease, Butyrylcholinesterase, Drug Design, Receptors, Serotonin, Acetylcholinesterase, Humans, Cholinesterase Inhibitors, Ligands, Antioxidants, Chelating Agents

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::6bd4358802443ef327e1978a76a7da5a
https://pubmed.ncbi.nlm.nih.gov/36012707

المؤلفون: Natalia Szałaj, Andrea Benediktsdottir, Dominika Rusin, Anders Karlén, Sherry L. Mowbray, Anna Więckowska

مصطلحات موضوعية: Pharmacology, Bacteria, Bacterial Proteins, Organic Chemistry, Drug Discovery, Serine Endopeptidases, Membrane Proteins, General Medicine, Anti-Bacterial Agents

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dce85782c3d59e4bbb184325456d7b9b
https://ruj.uj.edu.pl/xmlui/handle/item/297175

المؤلفون: Michalina Hebda, Marek Bajda, Anna Więckowska, Natalia Szałaj, Anna Pasieka, Dawid Panek, Justyna Godyń, Tomasz Wichur, Damijan Knez, Stanislav Gobec, Barbara Malawska

المصدر: Molecules; Volume 21; Issue 4; Pages: 410

مصطلحات موضوعية: cholinesterase inhibitors, molecular modelling, β-amyloid aggregation inhibitors, Alzheimer’s disease, multi-target-directed ligands (MTDL), PAMPA-BBB assay

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Medicinal Chemistry; https://dx.doi.org/10.3390/molecules21040410

الاتاحة: https://doi.org/10.3390/molecules21040410

المؤلفون: Anna Pasieka, Rongbiao Pi, Dawid Panek, Stanislav Gobec, José A. Dias, Georg Höfner, Damijan Knez, Fabien Chantegreil, Eva Mezeiova, Jan Korabecny, Gniewomir Latacz, Natalia Szałaj, Junfeng Lu, Julia Tabor, Anna Więckowska, Justyna Godyń, Xavier Brazzolotto, Barbara Malawska, Jakub Jończyk, Klaus T. Wanner

مصطلحات موضوعية: GABA Plasma Membrane Transport Proteins, Inhibitory postsynaptic potential, 01 natural sciences, Aminobutyric acid, 03 medical and health sciences, Structure-Activity Relationship, Alzheimer Disease, Drug Discovery, medicine, Humans, Cognitive decline, Butyrylcholinesterase, 030304 developmental biology, Pharmacology, chemistry.chemical_classification, 0303 health sciences, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Transporter, General Medicine, Ligand (biochemistry), 0104 chemical sciences, Enzyme, Neuroprotective Agents, Biochemistry, Mechanism of action, Cholinesterase Inhibitors, medicine.symptom

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e39bc9a2e8bc84e7a2828e9131be3c
https://ruj.uj.edu.pl/xmlui/handle/item/274015

المؤلفون: Natalia, Szałaj, Justyna, Godyń, Jakub, Jończyk, Anna, Pasieka, Dawid, Panek, Tomasz, Wichur, Krzysztof, Więckowski, Paula, Zaręba, Marek, Bajda, Anja, Pislar, Barbara, Malawska, Raimon, Sabate, Anna, Więckowska

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record

مصطلحات موضوعية: Models, Molecular, Amyloid beta-Peptides, cholinesterase inhibitors, 5-HT6 receptor antagonists, Multifunctional ligands, tau Proteins, Ligands, Protein Aggregates, Structure-Activity Relationship, Alzheimer Disease, Drug Design, Receptors, Serotonin, Escherichia coli, Fluorescence Resonance Energy Transfer, Cholinesterases, Humans, β-secretase, Cholinesterase Inhibitors, Research Article, Research Paper

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::42a15e91c6c4c4598f6f76b83b7e9d77
https://pubmed.ncbi.nlm.nih.gov/33092411

المؤلفون: Anders Karlén, Máté Erdélyi, Charles Hedgecock, Andrea Benediktsdottir, Gustav Olanders, Peter Brandt, Edouard Zamaratski, Sherry L. Mowbray, Lu Lu, Sha Cao, Diarmaid Hughes, Natalia Szałaj

المصدر: European Journal of Medicinal Chemistry. 157:1346-1360

مصطلحات موضوعية: Macrocyclic Compounds, Serine Proteinase Inhibitors, Antineoplastic Agents, 010402 general chemistry, medicine.disease_cause, 01 natural sciences, Lipopeptides, Structure-Activity Relationship, Drug Discovery, Escherichia coli, medicine, Humans, Cytotoxicity, Peptide sequence, Cell Proliferation, Pharmacology, chemistry.chemical_classification, Signal peptidase, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Serine Endopeptidases, Organic Chemistry, Membrane Proteins, Esters, Hep G2 Cells, General Medicine, Antimicrobial, Boronic Acids, Combinatorial chemistry, Anti-Bacterial Agents, 0104 chemical sciences, Enzyme, chemistry, Drug Screening Assays, Antitumor, Antibacterial activity, Linker

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1842e832737a92e7de3e08d2315ca3
https://doi.org/10.1016/j.ejmech.2018.08.086

المؤلفون: José Marco-Contelles, Mourad Chioua, Eva Ramos, Gniewomir Latacz, Izabella Góral, Águeda González-Rodríguez, Oscar M. Bautista-Aguilera, Víctor Farré Alins, Natalia Szałaj, Adam Bucki, Francisco López-Muñoz, Alejandro Romero, Anna Więckowska, Javier Egea, Katarzyna Kieć-Kononowicz

المساهمون: Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-IP), Instituto Teófilo Hernando de I+D del Medicamento (ITH), Neurotransmisión y Neuroprotección Farmacológica Teófilo Hernando (BIO M-026)

المصدر: Biblos-e Archivo. Repositorio Institucional de la UAM
instname
ACS Chemical Neuroscience

مصطلحات موضوعية: Physiology, Monoamine oxidase, Cognitive Neuroscience, In silico, Cytotoxicity, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Cytochrome P450 enzymes, ADME-tox, Viability assay, 030304 developmental biology, 0303 health sciences, ASS234, CYP3A4, Chemistry, PF9601N, Cell Biology, General Medicine, MAO inhibitors, Alzheimer's disease, Farmacia, In vitro, Contilisant, Multitarget directed ligands, Metabolism, Cell culture, Microsome, Alzheimer’s disease, 030217 neurology & neurosurgery, Research Article

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa85a307aedfd9889b82ebe41f34bc9
https://ruj.uj.edu.pl/xmlui/handle/item/264594

المؤلفون: Krzysztof Walczyński, Ondrej Soukup, Jakub Jończyk, Barbara Filipek, Natalia Malikowska-Racia, Barbara Malawska, Krzysztof Lodarski, Jan Korabecny, Justyna Godyń, Michalina Hebda, Paula Zaręba, Natalia Szałaj, Kinga Sałat, Jana Janockova, Marek Bajda, Marek Staszewski

مصطلحات موضوعية: Male, Models, Molecular, Scopolamine, In Vitro Techniques, Ligands, 01 natural sciences, Biochemistry, Piperazines, chemistry.chemical_compound, Histamine receptor, Mice, Structure-Activity Relationship, In vivo, Alzheimer Disease, Drug Discovery, Animals, Receptors, Histamine H3, Molecular Biology, Butyrylcholinesterase, Molecular Structure, 010405 organic chemistry, Organic Chemistry, In vitro toxicology, Computational Biology, Acetylcholinesterase, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Piperazine, Disease Models, Animal, chemistry, Amnesia, Cholinesterase Inhibitors, Histamine H3 receptor, Adjuvants, Anesthesia

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12992da3790fbecd0bfcf3e14e3538c1
https://ruj.uj.edu.pl/xmlui/handle/item/146477

المؤلفون: Katarzyna Dudek, Marek Bajda, Natalia Szałaj, Stanislav Gobec, Barbara Malawska, Boris Brus

المصدر: Archiv der Pharmazie. 348:556-563

مصطلحات موضوعية: chemistry.chemical_classification, medicine.drug_class, Stereochemistry, Pharmaceutical Science, Isoindoline, Acetylcholinesterase, chemistry.chemical_compound, Enzyme, chemistry, Acetylcholinesterase inhibitor, Drug Discovery, medicine, Moiety, Pharmacophore, Binding site, Lead compound

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d0883e2b6b5079fd28f7e7c83eac00cf
https://doi.org/10.1002/ardp.201500117

المؤلفون: Per E. Andrén, Douglas L. Huseby, Lu Lu, Diarmaid Hughes, Natalia Szałaj, Sha Cao, Anders Karlén, Sherry L. Mowbray, Annette K. Roos, Maria Cristina De Rosa, Edouard Zamaratski, Johan Gising, Peter Brandt, Henrik Wadensten, Lena Lenhammar, Rolf Larsson

المصدر: Bioorganic & Medicinal Chemistry.

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Type I signal peptidase, Cell Survival, Cell- och molekylärbiologi, Clinical Biochemistry, Pharmaceutical Science, medicine.disease_cause, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Solid-phase peptide synthesis, Drug Discovery, medicine, Escherichia coli, Structure–activity relationship, HATU, Humans, Cytotoxicity, Molecular Biology, Medicine(all), Oligopeptide, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Serine Endopeptidases, Membrane Proteins, Hep G2 Cells, Antimicrobial, In vitro, 030104 developmental biology, Drug Design, EDANS, Molecular Medicine, Antibacterials, Oligopeptides, Cell and Molecular Biology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4ee0934c8337bec0e9ec618dd9920c

المؤلفون: Marek Bajda, Justyna Godyń, Michalina Hebda, Barbara Malawska, Natalia Szałaj, Anna Pasieka, Damijan Knez, Anna Więckowska, Stanislav Gobec, Dawid Panek, Tomasz Wichur

المصدر: Molecules, Vol 21, Iss 4, p 410 (2016)
Molecules; Volume 21; Issue 4; Pages: 410
Molecules
Molecules, vol. 21, no. 4, 410, 2016.

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, cholinesterase inhibitors, Pharmaceutical Science, zaviralci acetilholinesteraze, Isoindoles, Ligands, 01 natural sciences, Analytical Chemistry, chemistry.chemical_compound, Drug Discovery, udc:615.2:616.894, Butyrylcholinesterase, biology, Chemistry, Alzheimerjeva bolezen, Acetylcholinesterase, molecular modelling, Acetylcholinesterase inhibitor, Biochemistry, Chemistry (miscellaneous), Blood-Brain Barrier, tarčna zdravila, Molecular Medicine, Alzheimer’s disease, PAMPA-BBB assay, Amyloid beta, medicine.drug_class, β-amyloid aggregation inhibitors, multi-target-directed ligands (MTDL), Protein Aggregation, Pathological, Article, lcsh:QD241-441, 03 medical and health sciences, Structure-Activity Relationship, lcsh:Organic chemistry, Alzheimer Disease, medicine, Humans, Physical and Theoretical Chemistry, Binding site, IC50, Cholinesterase, Amyloid beta-Peptides, Binding Sites, 010405 organic chemistry, Organic Chemistry, In vitro, molekularno modeliranje, 0104 chemical sciences, 030104 developmental biology, biology.protein, razvoj zdravil

وصف الملف: application/pdf; text/url

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a798a9999a34171838112f3e795b0c2
http://www.mdpi.com/1420-3049/21/4/410

المؤلفون: Youssef Dgachi, Lhassane Ismaili, Damijan Knez, Mohamed Benchekroun, Hélène Martin, Natalia Szalaj, Sarah Wehle, Oscar M Bautista-Aguilera, Vincent Luzet, Alexandre Bonnet, Barbara Malawska, Stanislav Gobec, Mourad Chioua, Michael Decker, Fakher Chabchoub, José Marco-Contelles

مصطلحات موضوعية: Uncategorised value

Relation: 10779/uos.23433968.v1; https://figshare.com/articles/journal_contribution/Synthesis_and_biological_assessment_of_racemic_benzochromenopyrimidinimines_as_antioxidant_cholinesterase_and_A_1-42_aggregation_inhibitors_for_Alzheimer_s_disease_therapy/23433968

الاتاحة: https://figshare.com/articles/journal_contribution/Synthesis_and_biological_assessment_of_racemic_benzochromenopyrimidinimines_as_antioxidant_cholinesterase_and_A_1-42_aggregation_inhibitors_for_Alzheimer_s_disease_therapy/23433968

المؤلفون: Fakher Chabchoub, Oscar M. Bautista-Aguilera, Sarah Wehle, Damijan Knez, José Marco-Contelles, Michael Decker, Natalia Szałaj, Mohamed Benchekroun, Alexandre Bonnet, Mourad Chioua, Hélène Martin, Vincent Luzet, Youssef Dgachi, Stanislav Gobec, Barbara Malawska, Lhassane Ismaili

مصطلحات موضوعية: Antioxidant, medicine.drug_class, medicine.medical_treatment, Pharmacology, Ligands, 01 natural sciences, Biochemistry, Antioxidants, chemistry.chemical_compound, Disease therapy, Equivalent, Alzheimer Disease, Drug Discovery, Medicine, Cholinesterases, Humans, General Pharmacology, Toxicology and Pharmaceutics, IC50, Cholinesterase, Amyloid beta-Peptides, Binding Sites, biology, 010405 organic chemistry, business.industry, Organic Chemistry, Peptide Fragments, 0104 chemical sciences, Protein Structure, Tertiary, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, chemistry, Acetylcholinesterase inhibitor, biology.protein, Molecular Medicine, Trolox, Cholinesterase Inhibitors, Imines, business, Primary screening

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eb535b9d098c9a08ae1d321ada7d0e0
https://ruj.uj.edu.pl/xmlui/handle/item/108382

المؤلفون: Katarzyna Kieć-Kononowicz, Barbara Malawska, Dorota Łażewska, Caitlin Moore, Marek Bajda, Anna Więckowska, Jakub Jończyk, Natalia Szałaj, Kamil Kuder, Dawid Panek

مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Inhibitory postsynaptic potential, Ligands, 01 natural sciences, Biochemistry, 03 medical and health sciences, Structure-Activity Relationship, Piperidines, Catalytic Domain, Drug Discovery, Inverse agonist, Humans, Receptors, Histamine H3, Amines, Molecular Biology, IC50, Butyrylcholinesterase, Cholinesterase, chemistry.chemical_classification, Binding Sites, biology, Chemistry, Organic Chemistry, Antagonist, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Kinetics, 030104 developmental biology, Enzyme, biology.protein, Acetylcholinesterase, Molecular Medicine, Cholinesterase Inhibitors, Histamine H3 receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd40657759fb986ec5ff5ed10c6efa94
https://ruj.uj.edu.pl/xmlui/handle/item/107161