-
1
المؤلفون: Nanette G, Vrijenhoek, Matthias M, Wehr, Steven J, Kunnen, Lukas S, Wijaya, Giulia, Callegaro, Martijn J, Moné, Sylvia E, Escher, Bob, Van de Water
المساهمون: Publica
المصدر: ALTEX : Alternatives to Animal Experimentation
ALTEXمصطلحات موضوعية: Pharmacology, Medical Laboratory Technology, Liver, Liver toxicity, Valproic Acid, Carboxylic Acids, Hepatocytes, TempO-Seq, Toxicogenomics-MAPr, General Medicine, Transcriptome, Risk assessment, Gene network analysis
وصف الملف: application/pdf
-
2
المؤلفون: Paul Jennings, Giada Carta, Johannes P Schimming, Erik H.J. Danen, Marcel Leist, Giulia Callegaro, Nanette G Vrijenhoek, Joost B. Beltman, Anna Forsby, Johannes Delp, Andrew White, Bob van de Water, Sylvia E. Le Dévédec, Huan Yang, Wanda van der Stel, Salihanur Darici
المساهمون: Molecular and Computational Toxicology, AIMMS
المصدر: van der Stel, W, Yang, H, Vrijenhoek, N G, Schimming, J P, Callegaro, G, Carta, G, Darici, S, Delp, J, Forsby, A, White, A, le Dévédec, S, Leist, M, Jennings, P, Beltman, J B, van de Water, B & Danen, E H J 2022, ' Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation ', Archives of Toxicology, vol. 96, no. 1, pp. 259-285 . https://doi.org/10.1007/s00204-021-03160-7
Archives of Toxicology, 96
Archives of Toxicology
Archives of Toxicology, 96(1), 259-285. Springer Verlagمصطلحات موضوعية: Health, Toxicology and Mutagenesis, Mitochondrial toxicity, ETC complex inhibitors, High-content imaging, TempO-Seq, DILI, Oxidative phosphorylation, Toxicology, ETC Complex Inhibitors, Electron Transport, ddc:570, medicine, Gene silencing, Humans, Glycolysis, Viability assay, Electron Transport Complex I, Mitochondrial toxicity, Chemistry, Endoplasmic reticulum, Mitochondrial Toxicity, ETC complex inhibitors, General Medicine, Hep G2 Cells, medicine.disease, Cell biology, Mitochondria, In Vitro Systems, medicine.anatomical_structure, High-Content Imaging, Hepatocyte, Unfolded protein response, Hepatocytes, TempO-Seq, DILI, High-content imaging
وصف الملف: application/pdf
-
3
المؤلفون: Alejandro Aguayo-Orozco, Liliana Capinha, Nazanin Golbamaki, Enrico Mombelli, Matthias Wehr, Bart van der Burg, Daria Goldmann, Nanette G Vrijenhoek, Thomas Exner, Richard Maclennan, Katharina Brotzmann, Ulf Norinder, Oliver Hatley, Alice Limonciel, Thomas Braunbeck, Sylvia Escher, Barbara Zdrazil, Frédéric Y. Bois, Paul Jennings, Emilio Benfenati, Domenico Gadaleta, Jose Castel, Ciarán Fisher, Sankalp Jain, Anthony Long, Rabea Graepel, Laia Tolosa, Andrew White, Bob van de Water, Barbara M.A. van Vugt-Lussenburg, Paul Walker, Annette Bitsch, Olivier Taboureau, Iain Gardner
المساهمون: AIMMS, Molecular and Computational Toxicology, Publica
المصدر: Toxicology in Vitro, 79:105269, 1-16. Elsevier Limited
Escher, S E, Aguayo-Orozco, A, Benfenati, E, Bitsch, A, Braunbeck, T, Brotzmann, K, Bois, F, van der Burg, B, Castel, J, Exner, T, Gadaleta, D, Gardner, I, Goldmann, D, Hatley, O, Golbamaki, N, Graepel, R, Jennings, P, Limonciel, A, Long, A, Maclennan, R, Mombelli, E, Norinder, U, Jain, S, Capinha, L S, Taboureau, O T, Tolosa, L, Vrijenhoek, N G, van Vugt-Lussenburg, B M A, Walker, P, van de Water, B, Wehr, M, White, A, Zdrazil, B & Fisher, C 2022, ' Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action ', Toxicology in Vitro, vol. 79, 105269, pp. 1-16 . https://doi.org/10.1016/j.tiv.2021.105269
Escher, S E, Aguayo-Orozco, A, Benfenati, E, Bitsch, A, Braunbeck, T, Brotzmann, K, Bois, F, van der Burg, B, Castel, J, Exner, T, Gadaleta, D, Gardner, I, Goldmann, D, Hatley, O, Golbamaki, N, Graepel, R, Jennings, P, Limonciel, A, Long, A, Maclennan, R, Mombelli, E, Norinder, U, Jain, S, Capinha, L S, Taboureau, O T, Tolosa, L, Vrijenhoek, N G, van Vugt-Lussenburg, B M A, Walker, P, van de Water, B, Wehr, M, White, A, Zdrazil, B & Fisher, C 2022, ' Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action ', Toxicology in Vitro, vol. 79, 105269 . https://doi.org/10.1016/j.tiv.2021.105269
Toxicology in Vitro
Toxicology In Vitro, 79مصطلحات موضوعية: Test strategy, Mechanistic hazard assessment, Adverse Outcome Pathways, Computer science, In silico, Gene Expression Profiling, Liver steatosis, Carboxylic Acids, General Medicine, Computational biology, Toxicology, AOP-network, Fatty Liver, Differentially expressed genes, Workflow, Action (philosophy), NAM, Read-across, Adverse Outcome Pathway, Animals, Humans, Computer Simulation, Zebrafish
وصف الملف: application/pdf
-
4
المؤلفون: Anja Wilmes, Tobias Strassfeld, Harry Vrieling, Manoj Kumar, Balázs Mihalik, Costanza Rovida, Giorgia Pallocca, Nanette G Vrijenhoek, Ciarán Fisher, Bart van der Burg, Thomas Braunbeck, Xenia Dolde, Alice Krebs, Zofia Janstova, Béla Z. Schmidt, Wiebke Albrecht, Jan G. Hengstler, Tim Brecklinghaus, David A. Fluri, J. J. W. A. Boei, Thomas Exner, Marcel Leist, Tanja Waldmann, Jaffar Kisitu, Anna-Katharina Holzer, Manuel Pastor, Joh Dokler, Andrea Paola Cediel Ulloa, Paul Jennings, Barbara M.A. van Vugt-Lussenburg, Bas ter Braak, Bob van de Water, Anna Forsby, Maja Brajnik, Wolfgang Moritz, Catherine M. Verfaillie, Johannes P Schimming, Rebecca von Hellfeld, Alice Limonciel, Francois Busquet, Julianna Kobolák, Ugis Sarkans, Regina Stöber, Jessica Lundqvist, Andras Dinnyes
المساهمون: Molecular and Computational Toxicology, AIMMS
المصدر: Archives of Toxicology
Archives of Toxicology, 94(7), 2435-2461. Springer Verlag
Archives of Toxicology, 94(7), 2435-2461. SPRINGER HEIDELBERG
Krebs, A, van Vugt-Lussenburg, B M A, Waldmann, T, Albrecht, W, Boei, J, Ter Braak, B, Brajnik, M, Braunbeck, T, Brecklinghaus, T, Busquet, F, Dinnyes, A, Dokler, J, Dolde, X, Exner, T E, Fisher, C, Fluri, D, Forsby, A, Hengstler, J G, Holzer, A-K, Janstova, Z, Jennings, P, Kisitu, J, Kobolak, J, Kumar, M, Limonciel, A, Lundqvist, J, Mihalik, B, Moritz, W, Pallocca, G, Ulloa, A P C, Pastor, M, Rovida, C, Sarkans, U, Schimming, J P, Schmidt, B Z, Stöber, R, Strassfeld, T, van de Water, B, Wilmes, A, van der Burg, B, Verfaillie, C M, von Hellfeld, R, Vrieling, H, Vrijenhoek, N G & Leist, M 2020, ' The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods ', Archives of Toxicology, vol. 94, no. 7, pp. 2435-2461 . https://doi.org/10.1007/s00204-020-02802-6
Archives of Toxicology, 94(7), 2435-2461
Archives of toxicology, 94:2435-2461مصطلحات موضوعية: 0301 basic medicine, Test data generation, Computer science, Health, Toxicology and Mutagenesis, Data validation, HAZARD ASSESSMENT, Toxicology, CELL-CULTURE PRACTICE, Documentation, Policy Making, Cells, Cultured, Zebrafish, media_common, EPITHELIAL-CELLS, General Medicine, data processing, GIVIMP, in vitro toxicology, metadata, nuclear receptor, Test (assessment), Strategy implementation, Europe, Data processing, In Vitro Systems, NEURAL CREST MIGRATION, Life Sciences & Biomedicine, REPRODUCTIVE TOXICITY, Risk Assessment, 03 medical and health sciences, SDG 17 - Partnerships for the Goals, ddc:570, Terminology as Topic, Toxicity Tests, media_common.cataloged_instance, Animals, Humans, European union, Retrospective Studies, In vitro toxicology, Electronic Data Processing, Metadata, Science & Technology, business.industry, 030111 toxicology, Reproducibility of Results, CALUX METHOD, IN-VITRO, Pipeline (software), DRUG DISCOVERY, 030104 developmental biology, Nuclear receptor, DEVELOPMENTAL NEUROTOXICITY DNT, Government Regulation, Software engineering, business, EMBRYONIC STEM-CELLS
وصف الملف: application/pdf; Print-Electronic
-
5
المؤلفون: Rabea Graepel, Sylvia Escher, B. van de Water, Steven Wink, Nanette G Vrijenhoek
المساهمون: Publica
المصدر: Toxicology Letters. 295:S194
مصطلحات موضوعية: Valproic Acid, Liver steatosis, Chemistry, medicine, General Medicine, Stress response pathway, Toxicology, Throughput (business), medicine.drug, Cell biology