المؤلفون: Hiroshi Nagabukuro, Sean M. Smith, Richard A. Berger, Melissa Costa, Nam Fung Kar, Bart Harper, Karen H. Dingley, Gino Salituro, Liping Wang, Jerry Di Salvo, Scott D. Edmondson, Bing Li, Xiaofang Li, Cheng Zhu, Christopher Moyes, Stephen D. Goble, Sookhee Ha, Mary Struthers, Jeffrey J. Hale, Amanda L. Hurley, Randy R. Miller

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:1094-1098

مصطلحات موضوعية: medicine.medical_specialty, Clinical Biochemistry, Pharmaceutical Science, Adrenergic beta-3 Receptor Agonists, Pharmacology, 030226 pharmacology & pharmacy, 01 natural sciences, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Drug Discovery, medicine, Potency, Structure–activity relationship, Benzamide, Receptor, Molecular Biology, biology, Organic Chemistry, medicine.disease, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Piperazine, Endocrinology, Overactive bladder, chemistry, Norepinephrine transporter, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a81656be92fb37eb8138200c6f4a9e90
https://doi.org/10.1016/j.bmcl.2016.12.033

المؤلفون: Cheng Zhu, Mary Struthers, Jerry Di Salvo, Bing Li, Jeffrey J. Hale, Ann E. Weber, Xiaofang Li, Randy R. Miller, Scott D. Edmondson, Melissa Costa, Nam Fung Kar, Sookhee Ha, Karen H. Dingley, Amanda L. Hurley, Gino Salituro

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:55-59

مصطلحات موضوعية: Agonist, Stereochemistry, medicine.drug_class, Clinical Biochemistry, hERG, Pharmaceutical Science, Adrenergic beta-3 Receptor Agonists, 01 natural sciences, Biochemistry, Pyrrolidine, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Humans, Structure–activity relationship, Benzamide, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Chemistry, Drug discovery, Organic Chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Receptors, Adrenergic, beta-3, Benzamides, biology.protein, Molecular Medicine, Bioisostere

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e27d3b6f5e7b1c5dde05b81dd6b0cf4
https://doi.org/10.1016/j.bmcl.2015.11.030

المؤلفون: Beata Zamlynny, Stuart A. Green, Karen H. Dingley, Liping Wang, Ann E. Weber, Katherine L. Villa, Amanda L. Hurley, Dong-Ming Shen, Gregori J. Morriello, Scott D. Edmondson, Sookhee Ha, Anthony Sanfiz, Dorothy Levorse, Nam Fung Kar, Beatrice Sacre-Salem, Hiroshi Nagabukuro, Nina Jochnowitz, Aileen Fitzmaurice, Gino Salituro, Tara L. Frenkl, Jerry Di Salvo, Richard G. Ball, Loise Gichuru, James D. Ormes, Cheng Zhu, Christopher Moyes, Stephen D. Goble, Randy R. Miller, Mary Struthers, Bart Harper, Shruty Mistry, Andra S. Stevenson, Richard A. Berger

المصدر: Journal of medicinal chemistry. 59(2)

مصطلحات موضوعية: 0301 basic medicine, Agonist, Models, Molecular, Pyrrolidines, medicine.drug_class, Urinary Bladder, Urination, Adrenergic beta-3 Receptor Agonists, CHO Cells, Pyrimidinones, Pharmacology, Lipidoses, Rats, Sprague-Dawley, 03 medical and health sciences, Structure-Activity Relationship, Cricetulus, X-Ray Diffraction, Cricetinae, Drug Discovery, Receptors, Adrenergic, beta, medicine, Structure–activity relationship, Animals, Humans, Receptor, Phospholipidosis, Serotonin Plasma Membrane Transport Proteins, Drug discovery, Chemistry, Urinary Bladder, Overactive, medicine.disease, Rats, 030104 developmental biology, Overactive bladder, Toxicity, Microsomes, Liver, Molecular Medicine, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f522169161222843c23eb180bd9c7b46
https://pubmed.ncbi.nlm.nih.gov/26709102

المؤلفون: Anka G. Ehrhardt, Karen H. Dingley, Nam Fung Kar, Harold B. Wood, Gary G. Chicchi, Ping Liu, Timothy J. Kowalski, Cheng Zhu, Viktor Hornak, Joe Lamberson, Morgan Woods, Jenna L. Terebetski, Margaret van Heek, Joie Garfunkle, Christopher Moyes, Michael W. Miller, Zhiyong Hu, Byron G. DuBois, Andrea Woods, Ravi P. Nargund, Joyce Powell, Gino Salituro, Jianmei Pang, Louis-Charles Campeau, Yuping Zhu, David N. Hunter, Scott D. Edmondson, Toru Seo, Fez Ujjainwalla, Ling Kang, Andrew Stamford

مصطلحات موضوعية: Type ii diabetes, GPR119, Orally active, In vivo, Chemistry, Organic Chemistry, Drug Discovery, Potency, Gpr119 agonist, Pharmacology, Biochemistry, Combinatorial chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75fe1104d7a92c070c3421cd8c4ffa1f
https://europepmc.org/articles/PMC4538435/

المؤلفون: Edmondson, Scott D., Cheng Zhu, Nam Fung Kar, Di Salvo, Jerry, Hiroshi Nagabukuro, Sacre-Salem, Beatrice, Dingley, Karen, Berger, Richard, Goble, Stephen D., Morriello, Gregori, Harper, Bart, Moyes, Christopher R., Dong-Ming Shen, Liping Wang, Ball, Richard, Fitzmaurice, Aileen, Frenkl, Tara, Gichuru, Loise N., Sookhee Ha, Hurley, Amanda L.

المصدر: Journal of Medicinal Chemistry; Jan2016, Vol. 59 Issue 2, p609-623, 15p