المؤلفون: Andrej Emanuel Cotman (5203904), Martina Durcik (8648943), Davide Benedetto Tiz (10499510), Federica Fulgheri (10499513), Daniela Secci (1456555), Maša Sterle (10499516), Štefan Možina (7827599), Žiga Skok (9526072), Nace Zidar (1550383), Anamarija Zega (145577), Janez Ilaš (1550377), Lucija Peterlin Mašič (14420614), Tihomir Tomašič (1550395), Diarmaid Hughes (55014), Douglas L. Huseby (5082230), Sha Cao (194620), Linnéa Garoff (14420617), Talía Berruga Fernández (14420620), Paraskevi Giachou (14420623), Lisa Crone (14420626), Ivailo Simoff (13298093), Richard Svensson (1294284), Bryndis Birnir (113570), Sergiy V. Korol (13999896), Zhe Jin (43692), Francisca Vicente (484392), Maria C. Ramos (9616038), Mercedes de la Cruz (484390), Björn Glinghammar (14420629), Lena Lenhammar (4004096), Sara R. Henderson (14420632), Julia E. A. Mundy (7140383), Anthony Maxwell (9506), Clare E. M. Stevenson (9526084), David M. Lawson (357139), Guido V. Janssen (14420635), Geert Jan Sterk (3832357), Danijel Kikelj (1550389)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Pharmacology, Cancer, Infectious Diseases, Space Science, Chemical Sciences not elsewhere classified, plasma free fraction, ion channel liabilities, fold decreased inhibition, escherichia coli gyrb24, dna gyrase inhibitor, human topoisomerase iiα, fold improved inhibition, aeruginosa gyrb24 revealed, 27 , 1 , topoisomerase iv, >)-< b, retained anti, resistant bacteria, pseudomonas aeruginosa, promising activity, priority list, potent activity, optimization steps, negative activity, mitochondrial toxicity

Relation: https://figshare.com/articles/journal_contribution/Discovery_and_Hit-to-Lead_Optimization_of_Benzothiazole_Scaffold-Based_DNA_Gyrase_Inhibitors_with_Potent_Activity_against_Acinetobacter_baumannii_and_Pseudomonas_aeruginosa/21893086

الاتاحة: https://doi.org/10.1021/acs.jmedchem.2c01597.s001

المؤلفون: Andrej Emanuel Cotman (5203904), Thomas Guérin (10499507), Ivana Kovačević (2015827), Davide Benedetto Tiz (10499510), Martina Durcik (8648943), Federica Fulgheri (10499513), Štefan Možina (7827599), Daniela Secci (1456555), Maša Sterle (10499516), Janez Ilaš (1550377), Anamarija Zega (145577), Nace Zidar (1550383), Lucija Peterlin Mašič (1562221), Tihomir Tomašič (1550395), Frédéric R. Leroux (10499519), Gilles Hanquet (2538175), Danijel Kikelj (1550389)

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Immunology, Mental Health, Space Science, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, building blocks, Practical Synthesis, Application, Halogen-Doped Pyrrole Building Blocks, usefulness, DNA gyrase B, 50 mg, conversion, showcase, access, halogen-substituted pyrrole buildin., chemical motifs, material, 1 g scale, nanomolar inhibitors, target compounds

Relation: https://figshare.com/articles/journal_contribution/Practical_Synthesis_and_Application_of_Halogen-Doped_Pyrrole_Building_Blocks/14341466

الاتاحة: https://doi.org/10.1021/acsomega.1c00331.s004

المؤلفون: Andrej Emanuel Cotman (5203904), Thomas Guérin (10499507), Ivana Kovačević (2015827), Davide Benedetto Tiz (10499510), Martina Durcik (8648943), Federica Fulgheri (10499513), Štefan Možina (7827599), Daniela Secci (1456555), Maša Sterle (10499516), Janez Ilaš (1550377), Anamarija Zega (145577), Nace Zidar (1550383), Lucija Peterlin Mašič (1562221), Tihomir Tomašič (1550395), Frédéric R. Leroux (10499519), Gilles Hanquet (2538175), Danijel Kikelj (1550389)

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Immunology, Mental Health, Space Science, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, building blocks, Practical Synthesis, Application, Halogen-Doped Pyrrole Building Blocks, usefulness, DNA gyrase B, 50 mg, conversion, showcase, access, halogen-substituted pyrrole buildin., chemical motifs, material, 1 g scale, nanomolar inhibitors, target compounds

Relation: https://figshare.com/articles/journal_contribution/Practical_Synthesis_and_Application_of_Halogen-Doped_Pyrrole_Building_Blocks/14341457

الاتاحة: https://doi.org/10.1021/acsomega.1c00331.s001

المؤلفون: Andrej Emanuel Cotman (5203904), Martina Durcik (8648943), Davide Benedetto Tiz (10499510), Federica Fulgheri (10499513), Daniela Secci (1456555), Maša Sterle (10499516), Štefan Možina (7827599), Žiga Skok (9526072), Nace Zidar (1550383), Anamarija Zega (145577), Janez Ilaš (1550377), Lucija Peterlin Mašič (14420614), Tihomir Tomašič (1550395), Diarmaid Hughes (55014), Douglas L. Huseby (5082230), Sha Cao (194620), Linnéa Garoff (14420617), Talía Berruga Fernández (14420620), Paraskevi Giachou (14420623), Lisa Crone (14420626), Ivailo Simoff (13298093), Richard Svensson (1294284), Bryndis Birnir (113570), Sergiy V. Korol (13999896), Zhe Jin (43692), Francisca Vicente (484392), Maria C. Ramos (9616038), Mercedes de la Cruz (484390), Björn Glinghammar (14420629), Lena Lenhammar (4004096), Sara R. Henderson (14420632), Julia E. A. Mundy (7140383), Anthony Maxwell (9506), Clare E. M. Stevenson (9526084), David M. Lawson (357139), Guido V. Janssen (14420635), Geert Jan Sterk (3832357), Danijel Kikelj (1550389)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Pharmacology, Cancer, Infectious Diseases, Space Science, Chemical Sciences not elsewhere classified, plasma free fraction, ion channel liabilities, fold decreased inhibition, escherichia coli gyrb24, dna gyrase inhibitor, human topoisomerase iiα, fold improved inhibition, aeruginosa gyrb24 revealed, 27 , 1 , topoisomerase iv, >)-< b, retained anti, resistant bacteria, pseudomonas aeruginosa, promising activity, priority list, potent activity, optimization steps, negative activity, mitochondrial toxicity

Relation: https://figshare.com/articles/dataset/Discovery_and_Hit-to-Lead_Optimization_of_Benzothiazole_Scaffold-Based_DNA_Gyrase_Inhibitors_with_Potent_Activity_against_Acinetobacter_baumannii_and_Pseudomonas_aeruginosa/21893089

الاتاحة: https://doi.org/10.1021/acs.jmedchem.2c01597.s002

المؤلفون: Andrej Emanuel Cotman (5203904), Thomas Guérin (10499507), Ivana Kovačević (2015827), Davide Benedetto Tiz (10499510), Martina Durcik (8648943), Federica Fulgheri (10499513), Štefan Možina (7827599), Daniela Secci (1456555), Maša Sterle (10499516), Janez Ilaš (1550377), Anamarija Zega (145577), Nace Zidar (1550383), Lucija Peterlin Mašič (1562221), Tihomir Tomašič (1550395), Frédéric R. Leroux (10499519), Gilles Hanquet (2538175), Danijel Kikelj (1550389)

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Immunology, Mental Health, Space Science, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, building blocks, Practical Synthesis, Application, Halogen-Doped Pyrrole Building Blocks, usefulness, DNA gyrase B, 50 mg, conversion, showcase, access, halogen-substituted pyrrole buildin., chemical motifs, material, 1 g scale, nanomolar inhibitors, target compounds

Relation: https://figshare.com/articles/dataset/Practical_Synthesis_and_Application_of_Halogen-Doped_Pyrrole_Building_Blocks/14341460

الاتاحة: https://doi.org/10.1021/acsomega.1c00331.s002

المؤلفون: Andrej Emanuel Cotman (5203904), Thomas Guérin (10499507), Ivana Kovačević (2015827), Davide Benedetto Tiz (10499510), Martina Durcik (8648943), Federica Fulgheri (10499513), Štefan Možina (7827599), Daniela Secci (1456555), Maša Sterle (10499516), Janez Ilaš (1550377), Anamarija Zega (145577), Nace Zidar (1550383), Lucija Peterlin Mašič (1562221), Tihomir Tomašič (1550395), Frédéric R. Leroux (10499519), Gilles Hanquet (2538175), Danijel Kikelj (1550389)

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Immunology, Mental Health, Space Science, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, building blocks, Practical Synthesis, Application, Halogen-Doped Pyrrole Building Blocks, usefulness, DNA gyrase B, 50 mg, conversion, showcase, access, halogen-substituted pyrrole buildin., chemical motifs, material, 1 g scale, nanomolar inhibitors, target compounds

Relation: https://figshare.com/articles/dataset/Practical_Synthesis_and_Application_of_Halogen-Doped_Pyrrole_Building_Blocks/14341463

الاتاحة: https://doi.org/10.1021/acsomega.1c00331.s003