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المؤلفون: Francesca Pieropan, Filippo Calzolari, Andrea Rivera, Kasum Azim, Gareth Williams, Arthur M. Butt
المصدر: Biomedicine & Pharmacotherapy, Vol 145, Iss, Pp 112436-(2022)
Biomedicine & Pharmacotherapyمصطلحات موضوعية: Myelin, Mice, Myelin Sheath, NSC, Neural stem cell, Systems Biology, OPC, Oligodendrocyte progenitor cell, High-Throughput Nucleotide Sequencing, LINCS, The Library of Integrated Network-based Cellular Signatures, Cell Differentiation, General Medicine, CNS, Central Nervous System, Oligodendroglia, medicine.anatomical_structure, Oligodendrogenesis, NFOL, Newly formed oligodendrocyte, OL, Oligodendrocyte, Signal Transduction, Subventricular zone, Optic nerve, In silico, Systems biology, Morpholines, SVZ, subventricular zone, Context (language use), RM1-950, Biology, Article, medicine, Pharmacogenomics, The Library of Integrated Network-Based Cellular Signatures/LINCS, Animals, H-LY29, High concentration of LY294002, Computer Simulation, PI3K/AKT/mTOR pathway, L-LY29, Low concentration of LY294002, Pharmacology, PI3K/Akt, TCN, Triciribine, Dose-Response Relationship, Drug, Regeneration (biology), Multiple sclerosis, medicine.disease, Oligodendrocyte, iNSCs, iPSC-derived NSCs, TAPs, Transiently amplifying progenitors, Mice, Inbred C57BL, MS, Multiple Sclerosis, iPCS, induced Pluripotent Stem Cell, Chromones, Pharmacogenetics, Therapeutics. Pharmacology, MOL, Myelinating oligodendrocyte, Neuroscience
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المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: PEI, polyethylenimine, Protein-Arginine N-Methyltransferases, PRMT1, Cellular differentiation, Biochemistry, Mice, Neural Stem Cells, neural stemness, RA, retinoic acid, deubiquitination, primNSC, primitive neural stem cell, cancer cell, Mice, Knockout, Hep G2 Cells, Cell cycle, Neural stem cell, Cell biology, Neoplasm Proteins, ChIP, chromatin immunoprecipitation, MDN1, Midasin, rRNA, ribosomal RNA, ribosome, mESC, mouse embryonic stem cell, Neoplastic Stem Cells, Research Article, Proteasome Endopeptidase Complex, RT-qPCR, reverse transcriptase–quantitative polymerase chain reaction, neural stem cell (NSC), Biology, Downregulation and upregulation, WCL, whole cell lysate, Animals, Humans, IF, immunofluorescence, Progenitor cell, NPC, neural progenitor cell, Molecular Biology, Cell Biology, Embryonic stem cell, Repressor Proteins, cell differentiation, proteasome, Proteasome, A549 Cells, Cancer cell, USP7, tumorigenicity, NSC, neural stem cell, PRMT, protein arginine methyltransferase, Ribosomes
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المؤلفون: Nan Du, Bingqiang He, Hui Li, Ting Yang, Chunshuai Sun, Honghua Song, Yongjun Wang, Yingjie Wang
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, cell migration, eAS, embryonic rat astrocytes, IPTG, isopropyl-b-D-thiogalactopyranoside, Biochemistry, neuroinflammation, TLRs, Toll-like receptors, MIF, macrophage migration inhibitory factor, NODs, oligomerization domain proteins, Cell Movement, cytokine, GFAP, glial fibrillary acid protein, ANOVA, analysis of variance, Cells, Cultured, DAMPs, damage-associated molecular pattern molecules, immunosuppression, MIF, Cell migration, ELISA, enzyme-linked immunosorbent assay, gAS, adult gecko astrocytes, Neural stem cell, Cell biology, medicine.anatomical_structure, rAS, adult rat astrocytes, DMEM, Dulbecco's modified eagle's medium, medicine.symptom, Q-PCR, quantitative real-time polymerase chain reaction, Inflammation Mediators, Astrocyte, Research Article, Central nervous system, PBS, phosphate-buffered saline, Inflammation, Biology, Proinflammatory cytokine, 03 medical and health sciences, SCI, spinal cord injury, astrocyte, IPA, Ingenuity Pathway Analysis Software, medicine, Animals, Proto-Oncogene Proteins c-vav, Molecular Biology, Macrophage Migration-Inhibitory Factors, Neuroinflammation, Cell Proliferation, 030102 biochemistry & molecular biology, spinal cord, Reptiles, Cell Biology, Rats, reptile, 030104 developmental biology, Vav1, Astrocytes, Macrophage migration inhibitory factor, NSC, neural stem cell, 4-IPP, 4-iodo-6-phenylpyrimidine, MAPK, mitogen-activated protein kinase, Biomarkers
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المؤلفون: Nihal Altan-Bonnet, Hayley S. McLoughlin, Michael Schlame, Kirill Gorshkov, Wei Zheng, Ruth D. Azaria, Kimberly Lai, Yang Xu, Thaddeus J. Kunkel, Miriam Waghalter, Mark L. Schultz, Andrew P. Lieberman, Judith Storch, Maciej Jeziorek, Radek Dobrowolski, Bruce Nguyen Tran, Olga Ilnytska
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, LC3, microtubule-associated proteins 1A/1B light chain 3, AML, amitriptyline, Niemann–Pick type C disease, BMP, bis(monoacylglycerol)phosphate, PG, phosphatidylglycerol, Biochemistry, ASM, acid sphingomyelinase, NPC1, Niemann–Pick type C1, DHA, docosahexaenoyl, PC, phosphatidylcholine, Purkinje Cells, chemistry.chemical_compound, Neural Stem Cells, hemic and lymphatic diseases, Sequestosome-1 Protein, Cardiolipin, Homeostasis, acid sphingomyelinase, Late endosome, LBPA, lysobisphosphatidic acid, SREBP2, sterol regulatory element binding protein 2, Intracellular Signaling Peptides and Proteins, Niemann-Pick Disease, Type C, Phosphatidylglycerols, AP, autophagosome, MVB, multivesicular bodies, Cell biology, Cholesterol, Sphingomyelin Phosphodiesterase, medicine.anatomical_structure, PM, plasma membrane, Monoglycerides, lipids (amino acids, peptides, and proteins), Acid sphingomyelinase, Sphingomyelin, Cholesterol storage, Research Article, AC, acid ceramidase, BafA1, Bafilomycin A1, medicine.drug, autophagy, iPSC, induced pluripotent stem cell, CL, cardiolipin, Mice, Transgenic, Endosomes, Models, Biological, PI, phosphatidylinositol, ER, endoplasmic reticulum, 03 medical and health sciences, FBS, fetal bovine serum, Niemann-Pick C1 Protein, Lysosome, PUFA, polyunsaturated fatty acid, medicine, Animals, Humans, Molecular Biology, SM, sphingomyelin, 030102 biochemistry & molecular biology, Autophagy, ILV, intralumenal vesicle, Cell Biology, Fibroblasts, SMPD1, gene encoding acid sphingomyelinase, Mice, Inbred C57BL, 030104 developmental biology, LAMP1, lysosomal-associated membrane protein, chemistry, Mutation, LY, lysosome, lysobisphosphatidic acid, LE, late endosome, NSC, neural stem cell, Lysophospholipids, NPC1, PFO, perfringolysin O, Lysosomes, EACC, ethyl (2-(5-nitrothiophene-2-carboxamido) thiophene-3-carbonyl) carbamate, HeLa Cells
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المؤلفون: Itsuki Ajioka
المصدر: Regenerative Therapy
Regenerative Therapy, Vol 3, Iss C, Pp 63-67 (2016)مصطلحات موضوعية: 0301 basic medicine, Central nervous system, Biomedical Engineering, MSC, mesenchymal stem cell, V–SVZ, ventricular–subventricular zone, Review Article, Cell cycle, CNS, central nervous system, VZ, ventricular zone, Biomaterials, 03 medical and health sciences, 0302 clinical medicine, Cortex (anatomy), medicine, Regeneration, lcsh:QH573-671, lcsh:R5-920, lcsh:Cytology, OB, olfactory bulb, Regeneration (biology), ES, embryonic stem, Biomaterial, Cerebral cortex, Functional recovery, 030104 developmental biology, medicine.anatomical_structure, MZ, marginal zone, NSC, neural stem cell, lcsh:Medicine (General), Psychology, Neuroscience, 030217 neurology & neurosurgery, Developmental Biology
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المؤلفون: Elaine L, Ferguson, Sameza, Naseer, Lydia C, Powell, Joseph, Hardwicke, Fraser I, Young, Bangfu, Zhu, Qian, Liu, Bing, Song, David W, Thomas
المصدر: Stem Cell Research
مصطلحات موضوعية: DMF, N,N-dimethyl formamide, Cell Culture Techniques, PLGA, poly(lactic-co-glycolic acid), DMSO, dimethyl sulfoxide, Biodegradable polymers, Article, Olig2, oligodendrocyte transcription factor, MAP2, microtubule-associated protein 2, MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, SCI, spinal cord injury, DNA, deoxyribonucleic acid, FPLC, fast protein liquid chromatography, Neural Stem Cells, PBS, phosphate buffered saline, Dextrins, TUNEL, terminal deoxynucleotidyl transferase (TdT) dUTP nick-end labelling, Humans, DMAP, 4-dimethylaminopyridine, Controlled release, EDC, 1-ethyl-3-(3-dimethylaminopropyl carbodiimide hydrochloride), mNSC, mouse neural stem cell, Cell Proliferation, EMEM, eagle's minimum essential media, EGF, epidermal growth factor, bFGF, basic fibroblast growth factor (FGF-2), GFAP, glial fibrillary acidic protein, Cell Differentiation, CLSM, confocal laser scanning microscopy, GPC, gel permeation chromatography, BCA, bicinchoninic acid, HAMC, hyaluronan and methyl cellulose, Fibroblast Growth Factor 2, sulfo-NHS, N-hydroxysulfosuccinimide, FCS, fetal calf serum, GF, growth factor, NSC, neural stem cell, Polymer therapeutics, Growth factors, Hep2, human epidermoid carcinoma
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المؤلفون: Christopher J. Hindley, Anna Philpott
المصدر: Biochemical Journal
مصطلحات موضوعية: Prox1, Prospero-related homeobox 1, HLH, helix–loop–helix, Neurogenesis, Embryonic Development, Review Article, Sox3, Sry-type high mobility group box, Biology, CNS, central nervous system, Nervous System, Biochemistry, Rb, retinoblastoma susceptibility gene, bHLH, basic helix–loop–helix, 03 medical and health sciences, 0302 clinical medicine, Hes, hairy and enhancer of split, Cyclin-dependent kinase, TGF-β, transforming growth factor-β, Animals, Humans, development, Molecular Biology, CDKi, CDK inhibitor, Ascl1, achaete-scute homologue 1, CDK, cyclin-dependent kinase, 030304 developmental biology, Cyclin, 0303 health sciences, Ngn2, neurogenin 2, Kinase, Fox, forkhead box, Cell Cycle, Embryogenesis, Cell Differentiation, differentiation, Cell Biology, cyclin-dependent kinase (CDK), Cell cycle, Phenotype, Developing nervous system, Control cell, Cell biology, biology.protein, NSC, neural stem cell, DP, dimerization partner, Id, inhibitor of DNA binding, 030217 neurology & neurosurgery
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المؤلفون: Martina Nardini, Giacomo P. Comi, Federica Rizzo, Sabrina Salani, Irene Faravelli, Stefania Corti, Francesca Magri, Giulietta Riboldi, Chiara Zanetta, Monica Nizzardo, Nereo Bresolin, Marianna Falcone, Chiara Simone, Chiara Donadoni
المصدر: Experimental Cell Research
مصطلحات موضوعية: Polydendrocytes, NSC, Neural Stem Cell, Induced Pluripotent Stem Cells, Transplantation, Heterologous, Biology, Mice, SOX2, Neurosphere, Animals, Humans, ESC, Embryonic Stem Cell, Induced pluripotent stem cell, Cells, Cultured, Neural stem cells, Homeodomain Proteins, Neurons, Induced stem cells, Multipotent Stem Cells, SOXB1 Transcription Factors, Reprogramming, Cell Biology, Nanog Homeobox Protein, Cell Dedifferentiation, DNA Methylation, iPSC, induced Pluripotent Stem Cell, Neural stem cell, Cell biology, Neuroepithelial cell, Astrocytes, Cell Transdifferentiation, Stem cell, Octamer Transcription Factor-3, Research Article
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المؤلفون: Jennifer M. Bain, Lisamarie Moore, Ji Meng Loh, Steven W. Levison
المصدر: ASN NEURO
ASN Neuro, Vol 6 (2013)مصطلحات موضوعية: NCS, newborn calf serum, PRP, PDGF-responsive precursor, Neocortex, Bone Morphogenetic Protein 4, DMEM, Dulbecco’s modified Eagle’s medium, PDGF, platelet-derived growth factor, SHH, sonic hedgehog, Rats, Sprague-Dawley, neural stem cell, Neural Stem Cells, BMP-4, bone morphogenetic protein 4, Lateral Ventricles, rat, Cells, Cultured, Neurons, Platelet-Derived Growth Factor, education.field_of_study, General Neuroscience, Neurogenesis, Cell Differentiation, Proto-Oncogene Proteins c-sis, Neural stem cell, DIV, days in vitro, Cell biology, Oligodendroglia, medicine.anatomical_structure, embryonic structures, Fibroblast Growth Factor 2, Astrocyte, Research Article, Population, Subventricular zone, SVZ, subventricular zone, Biology, ERK, extracellular-signal-regulated kinase, S2, S5, lcsh:RC321-571, O-2A, oligodendrocyte-type 2 astrocyte, astrocyte, Neurosphere, medicine, Animals, Cell Lineage, Rats, Wistar, education, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, EGF, epidermal growth factor, T3, triiodothyronine, Epidermal Growth Factor, GFAP, glial fibrillary acidic protein, OPC, oligodendrocyte progenitor cell, central nervous system, Oligodendrocyte, neuron, Rats, FGF, fibroblast growth factor, nervous system, Animals, Newborn, Astrocytes, PSA-NCAM, polysialated neural cell adhesion molecule, SD, Sprague–Dawley, Neurology (clinical), Neuron, NSC, neural stem cell, PFA, paraformaldehyde, PDGFR, PDGF receptor, Neuroscience, oligodendrocyte, MAPK, mitogen-activated protein kinase
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المصدر: ASN NEURO
ASN Neuro, Vol 5 (2013)
Scopus-Elsevierمصطلحات موضوعية: PAC1, PACAP (pituitary adenylate cyclase-activating polypeptide) ligand/type 1 receptor, Cellular differentiation, PACAP, pituitary adenylate cyclase-activating polypeptide, DMEM, Dulbecco’s modified Eagle’s medium, astrocytic differentiation, CREB, cAMP-responsive element binding protein, GFAP, glial fibrillary acid protein, IL-6, interleukin-6, ADAM, a disintegrin and metalloprotease, Sulfonamides, Glial fibrillary acidic protein, Receptors, Notch, dbcAMP, dibutyryl-cAMP, General Neuroscience, Neurogenesis, CAT, chloramphenicol acetyltransferase, Cell Differentiation, glial transcriptional control, Cell biology, Up-Regulation, STAT, signal transducer and activator of transcription, Protein Transport, protein kinase A (PKA), GAPDH, glyceraldehyde-3-phosphate dehydrogenase, Signal transduction, JAK, Janus kinase, NICD, Notch1 intracellular domain, Signal Transduction, Subcellular Fractions, Research Article, Transcriptional Activation, S1, Notch signaling pathway, RBPJκ, recombinant binding protein for immunoglobulin κ region, Biology, Astrocytoma, Transfection, CNS, central nervous system, S5, lcsh:RC321-571, Adjuvants, Immunologic, Cell Line, Tumor, Glial Fibrillary Acidic Protein, Animals, Protein kinase A, glia cell, Transcription factor, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Protein Kinase Inhibitors, RT–qPCR, reverse transcription–quantitative PCR, Notch1, RBPJ, Colforsin, Intracellular Membranes, CRE, cAMP-response element, Isoquinolines, Molecular biology, cAMP signaling, Rats, Bucladesine, Astrocytes, biology.protein, NPC, neuronal progenitor cell, PKA, protein kinase A, Neurology (clinical), NSC, neural stem cell
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المصدر: Bioscience Reports, Vol 33, Iss 2, p e00032 (2013)
Bioscience Reportsمصطلحات موضوعية: ESC, embryonic stem cell, Swine, Cellular differentiation, CD34, lcsh:Life, lcsh:QR1-502, MSC, mesenchymal stem cell, Biochemistry, DMEM, Dulbecco’s modified Eagle’s medium, lcsh:Microbiology, PVA, poly(vinyl alcohol), bFGF, basic fibroblast growth factor, Adipocytes, Oct4, octamer-binding transcription factor 4, RA, retinoic acid, TGFβ, transforming growth factor β, mesenchymal stem cell, Neurons, reverse transcription–PCR, qRT-PCR, quantitative real-time PCR, Cell Differentiation, differentiation, Flow Cytometry, Neural stem cell, Cell biology, medicine.anatomical_structure, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, PPARG, peroxisome-proliferator-activated receptor γ, FBS, foetal bovine serum, Stem cell, Homeobox protein NANOG, S1, PB, parthenogenetic blastocyst, Biophysics, RT–PCR, reverse transcription–PCR, Bone Marrow Cells, Biology, octamer-binding transcription factor 4, PI, propidium iodide, MAP2, microtubule-associated protein 2, Fetus, COC, cumulus–oocyte complex, medicine, Animals, Molecular Biology, IVM, in vitro maturation, porcine bone marrow, Cell Proliferation, EGF, epidermal growth factor, Original Paper, Mesenchymal stem cell, Mesenchymal Stem Cells, Cell Biology, Nestin, lcsh:QH501-531, Immunology, Bone marrow, NSC, neural stem cell, pMSC, porcine MSC
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المؤلفون: Makoto Yanagisawa, Robert K. Yu, Saori Yoshimura
المصدر: ASN NEURO
ASN Neuro, Vol 3 (2011)مصطلحات موضوعية: Immunocytochemistry, neural stem cell (NSC), Biology, glycosphingolipid (GSL), S2, SSEA-1, stage-specific embryonic antigen-1. Abbreviations for gangliosides follow Svennerholm's nomenclature system (Svennerholm, 1963), lcsh:RC321-571, Mice, neurosphere, bFGF, basic fibroblast growth factor, Glycolipid, Neural Stem Cells, Gangliosides, Neurosphere, Animals, Humans, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Cells, Cultured, Embryonic Stem Cells, reproductive and urinary physiology, Ganglioside, ganglioside, stage-specific embryonic antigen-1 (SSEA-1), General Neuroscience, Embryo, Mammalian, Embryonic stem cell, Neural stem cell, In vitro, nervous system diseases, Cell biology, nervous system, Biochemistry, LAMP-1, lysosome-associated membrane protein-1, biology.protein, lipids (amino acids, peptides, and proteins), Neurology (clinical), NSC, neural stem cell, biological phenomena, cell phenomena, and immunity, Antibody, Biomarkers, Research Article, GSL, glycosphingolipid
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المؤلفون: Robert K. Yu, Makoto Yanagisawa, Toshio Ariga
المصدر: ASN NEURO
مصطلحات موضوعية: Alzheimer’s disease (AD), DMEM, Dulbecco’s modified Eagle’s medium, neural stem cell, Mice, bFGF, basic fibroblast growth factor, Neural Stem Cells, Cytotoxic T cell, NEC, neuroepithelial cell, Senile plaques, amyloid β-peptide (Aβ), biotin-Ctxb, biotin-conjugated cholera toxin B subunit, Cells, Cultured, glycosphingolipid, General Neuroscience, apoptosis, Neural stem cell, Neuroepithelial cell, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, CCD, charge-coupled device, lipids (amino acids, peptides, and proteins), Research Article, FITC-Aβ-(1–40), FITC-conjugated Aβ-(1–40), Programmed cell death, RT–PCR, reverse transcription–PCR, G(M1) Ganglioside, Biology, S3, AD, Alzheimer’s disease, ERK, extracellular-signal-regulated kinase, IACUC, Institutional Animal Care and Use Committee, MAP2, microtubule-associated protein 2, N2-DMEM/F12, N2-supplemented DMEM/Ham’s Nutrient Mixture F12, Alzheimer Disease, Neurosphere, Aβ, amyloid β-peptide, Animals, Humans, Cell Lineage, Protein kinase A, Cell Proliferation, Amyloid beta-Peptides, Cell growth, Molecular biology, digestive system diseases, TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling, Peptide Fragments, IL, interleukin, GM1 ganglioside, Neurology (clinical), NSC, neural stem cell, MAPK, mitogen-activated protein kinase, Biomarkers
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المؤلفون: David Oxley, Maria L. Arbonés, Pamela A. Lochhead, Anne L. Ashford, Maria Jose Barallobre, Juan Arranz, Sonia Najas, Jean M. Delabar, Simon J. Cook
المساهمون: Generalitat de Catalunya, Biotechnology and Biological Sciences Research Council (UK), Jérôme Lejeune Foundation, Ministerio de Economía y Competitividad (España), Association for International Cancer Research
المصدر: EBioMedicine, Vol 2, Iss 2, Pp 120-134 (2015)
EBioMedicine
Digital.CSIC. Repositorio Institucional del CSIC
instnameمصطلحات موضوعية: Telencephalon, Trisomy 21, DYRK1A, Gene Dosage, DYRK kinases, Intellectual disability, lcsh:Medicine, Trisomy, Mice, IP, intermediate progenitor, Neural Stem Cells, Cyclin D1, Original Research Article, health care economics and organizations, RG, radial glia, Cerebral Cortex, lcsh:R5-920, Neurogenesis, Neurodevelopmental disorders, General Medicine, Protein-Tyrosine Kinases, Neural stem cell, DS, Down syndrome, Cerebral cortex development, medicine.anatomical_structure, Cerebral cortex, lcsh:Medicine (General), education, Subventricular zone, SVZ, subventricular zone, Mice, Transgenic, Biology, Protein Serine-Threonine Kinases, General Biochemistry, Genetics and Molecular Biology, VZ, ventricular zone, medicine, Animals, Humans, lcsh:R, G1 Phase, Embryonic stem cell, Mice, Inbred C57BL, Disease Models, Animal, Immunology, Neuron, NSC, neural stem cell, Down Syndrome, Cell cycle regulation, Neuroscience