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المؤلفون: Hong-Min Liu, Ya-Hong Wu, Yihui Song, Min Zhao, Bin Yu
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 750-762 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: PMSF, phenylmethanesulfonyl fluoride, LS, LEOPARD syndrome, Mutant, IC50, half maximal inhibitory concentration, Protein tyrosine phosphatase, HTS, high-throughput screening, chemistry.chemical_compound, 0302 clinical medicine, DiFMUP, 6,8-difluoro-4-methylumbelliferyl phosphate, General Pharmacology, Toxicology and Pharmaceutics, AML, acute myelogenous leukemia, Tm, melting temperature, 0303 health sciences, LB, lysogeny broth, SDS-PAGE, sodium dodecyl sulphate polyacyrlamide gel electrophoresis, High-throughput screening, R2, coefficient of determination, S/B, signal over background, STAT, signal transducer and activator of transcription, SHP2, Src homology phosphotyrosyl phosphatase 2, Biochemistry, 030220 oncology & carcinogenesis, Original Article, BTLA, B and T lymphocyte attenuator, PTP, protein tyrosine phosphatase, SH2, Src homology 2, Proto-oncogene tyrosine-protein kinase Src, Thermal shift assay, Allosteric regulation, Phosphatase, JAK, janus kinase, AKT, protein kinase B, SHP2-WT, wild type Src homology phosphotyrosyl phosphatase 2, SHP2-PTP, protein tyrosine phosphatase domain of Src homology phosphotyrosyl phosphatase 2, 03 medical and health sciences, PI3K, phosphatidylinositol 3 kinase, NS, Noonan syndrome, RAS, rat sarcoma, FI, fluorescence intensity, NPC, no protein control, 030304 developmental biology, ΔTm, melting temperature change, DiFMU, 6,8-difluoro-4-methylumbelliferyl hydroxid, ALK, anaplastic lymphoma kinase, lcsh:RM1-950, HEPES, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, MEK, extracellular regulated protein kinase kinases, JMML, juvenile myelomonocytic leukaemia, Enzyme assay, PD-1, programmed death 1, p-IRS1, phosphorylated insulin receptor substrate 1, Bis-tris, bis-(2-hydroxyethyl)amino-tris(hydroxymethyl)methane, OD, optical density, lcsh:Therapeutics. Pharmacology, chemistry, DTT, dithiothreitol, SHP2, Allosteric inhibitors, Bioisostere, LOC, ligand only control, SD, standard deviation, MAPK, mitogen-activated protein kinase
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المصدر: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 6125-6139 (2021)مصطلحات موضوعية: SHP2, Src homology 2 domain-containing phosphatase 2, CTLA-4, cytotoxic T lymphocyte-associated antigen 4, NSML, Noonan syndrome with multiple lentigines, Allosteric regulation, Phosphatase, Biophysics, Protein Data Bank (RCSB PDB), Protein tyrosine phosphatase, FRET, Förster resonance energy transfer, SH2 domain, Biochemistry, PD-1, programmed cell death protein 1, RMSF, root mean square fluctuation, RMSD, root mean square deviation, SAXS, small angle X-ray scattering, PMF, potential of mean force, Settore CHIM/02, Structural Biology, NS, Noonan syndrome, Genetics, Protein flexibility, pY, phosphorylated tyrosine, Binding site, PDB, protein data bank, ComputingMethodologies_COMPUTERGRAPHICS, JMML, juvenile myelomonocytic leukemia, biology, Chemistry, Wild type, Active site, SHP2 regulatory mechanism, REMD, replica exchange molecular dynamics, MD, molecular dynamics, SIRPalpha, signal regulatory protein alpha, Computer Science Applications, Inter-domain dynamics, Replica exchange molecular dynamics simulations, biology.protein, SASA, solvent accessible surface area, RTK, receptor tyrosine kinase, BTLA, B and T lymphocyte attenuator, PTP, protein tyrosine phosphatase, TP248.13-248.65, SH2, Src homology 2, Biotechnology, Research Article
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المؤلفون: Allison, Callum M, Shumon, Syed, Joshi, Abhijit, Quaegebeur, Annelies, Sinclair, Georges, Surash, Surash
مصطلحات موضوعية: NF-1 = neurofibromatosis-1, CNS = central nervous system, GFAP = glial fibrillary acidic protein, GTR = gross-total resection, LL = lower limb, MAPK = mitogen-activated protein kinase, MINST = malignant intracerebral nerve sheath tumor, MPNST = malignant peripheral nerve sheath tumor, MRI = magnetic resonance imaging, NS = Noonan syndrome, TERT = telomerase reverse transcriptase, UL = upper limb, WHO = World Health Organization, frontal lobe, intraparenchymal, malignant intracerebral nerve sheath tumor, malignant peripheral nerve sheath tumor, malignant schwannoma