المؤلفون: Ipsen

المصدر: A Phase 2 Study to Assess the Efficacy and Safety of 2 Dosage Regimens of Oral Fidrisertib (IPN60130) for the Treatment of Fibrodysplasia Ossificans Progressiva in Male and Female Paediatric and Adult Participants.

Other URLs: https://vivli.org/members/ourmembers/

المصدر: An International Observational Registry Study to Further Describe Long-term Safety and Effectiveness of Palovarotene in Patients With Fibrodysplasia Ossificans Progressiva (FOP)

Other URLs: https://vivli.org/members/ourmembers/

المصدر: Rollover Study; Multicentre, Phase III, Open-label Study to Further Evaluate the Safety and Efficacy of Palovarotene Capsules in Male and Female Participants Aged ≥14 Years With Fibrodysplasia Ossificans Progressiva (FOP) Who Have Completed Study PVO-1A-301 or PVO-1A-202/PVO-1A-204 and May Benefit From Palovarotene Therapy.

Other URLs: https://vivli.org/members/ourmembers/

المصدر: A Phase 2/3, Global, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Two-Part Study With Open-Label Extension (OLE) to Assess the Efficacy and Safety of Andecaliximab in Participants With Fibrodysplasia Ossificans Progressiva (FOP)
Lounev V, Groppe JC, Brewer N, Wentworth KL, Smith V, Xu M, Schomburg L, Bhargava P, Al Mukaddam M, Hsiao EC, Shore EM, Pignolo RJ, Kaplan FS. Matrix metalloproteinase-9 deficiency confers resilience in fibrodysplasia ossificans progressiva in a man and mice. J Bone Miner Res. 2024 May 2;39(4):382-398. doi: 10.1093/jbmr/zjae029.
Wein MN, Yang Y. Actionable disease insights from bedside-to-bench investigation in fibrodysplasia ossificans progressiva. J Bone Miner Res. 2024 May 2;39(4):375-376. doi: 10.1093/jbmr/zjae044. No abstract available.

المصدر: A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of INCB000928 in Participants With Fibrodysplasia Ossificans Progressiva

Other URLs: https://www.incyte.com/our-company/compliance-and-transparency

المؤلفون: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

المصدر: An Observational Study of IL1 Inhibition for Blocking ACVR1-Induced Flare Activity and Heterotopic Ossification in Fibrodysplasia Ossificans Progressiva (FOP)
Haviv R, Zeitlin L, Moshe V, Ziv A, Rabinowicz N, De Benedetti F, Prencipe G, Matteo V, De Cunto CL, Hsiao EC, Uziel Y. Long-term use of interleukin-1 inhibitors reduce flare activity in patients with fibrodysplasia ossificans progressiva. Rheumatology (Oxford). 2024 Sep 1;63(9):2597-2604. doi: 10.1093/rheumatology/keae255.
Haviv R, Moshe V, De Benedetti F, Prencipe G, Rabinowicz N, Uziel Y. Is fibrodysplasia ossificans progressiva an interleukin-1 driven auto-inflammatory syndrome? Pediatr Rheumatol Online J. 2019 Dec 21;17(1):84. doi: 10.1186/s12969-019-0386-6.

المصدر: Phase 3 Randomized, Placebo-Controlled Study to Assess Safety, Tolerability, and Efficacy of Garetosmab in Patients With Fibrodysplasia Ossificans Progressiva

Other URLs: https://vivli.org/

المؤلفون: Diolintzi, Anastasia, Pervin, Mst, Hsiao, Edward

المصدر: Biomolecules. 14(3)

مصطلحات موضوعية: cytokines, fibrodysplasia ossificans progressiva (FOP), heterotopic ossification, immune activation, inflammation, macrophages, Humans, Myositis Ossificans, Ossification, Heterotopic, Cell Differentiation, Signal Transduction, Inflammation

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/872585rr
https://escholarship.org/content/qt872585rr/qt872585rr.pdf

المصدر: A Phase 2, Open-Label Extension, Efficacy and Safety Study of a Retinoic Acid Receptor Gamma (RARγ) Specific Agonist (Palovarotene) in the Treatment of Preosseous Flare-ups in Subjects With Fibrodysplasia Ossificans Progressiva (FOP)
Shimono K, Tung WE, Macolino C, Chi AH, Didizian JH, Mundy C, Chandraratna RA, Mishina Y, Enomoto-Iwamoto M, Pacifici M, Iwamoto M. Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-gamma agonists. Nat Med. 2011 Apr;17(4):454-60. doi: 10.1038/nm.2334. Epub 2011 Apr 3. Erratum In: Nat Med. 2012 Oct;18(10):1592.

المؤلفون: Royal National Orthopaedic Hospital NHS Trust, Klinikum Garmisch-Patenkirchen, University of Oxford, Brigham and Women's Hospital, AstraZeneca, Innovative Medicines Initiative

المساهمون: Elisabeth MW Eekhoff, Coordinating Principal Investigator

المصدر: Saracatinib Trial TO Prevent FOP
Smilde BJ, Stockklausner C, Keen R, Whittaker A, Bullock AN, von Delft A, van Schoor NM, Yu PB, Eekhoff EMW. Protocol paper: a multi-center, double-blinded, randomized, 6-month, placebo-controlled study followed by 12-month open label extension to evaluate the safety and efficacy of Saracatinib in Fibrodysplasia Ossificans Progressiva (STOPFOP). BMC Musculoskelet Disord. 2022 Jun 1;23(1):519. doi: 10.1186/s12891-022-05471-x.

المساهمون: Matthias Mäurer, Principal Investigator

المصدر: Comparative Analysis of Radiotherapeutic and Medical Procedures for the Prophylaxis of Heterotopic Ossifications in the Context of Total Hip Arthroplasty

المؤلفون: Bowen Lai, Heng Jiang, Yuan Gao, Xuhui Zhou

المصدر: EFORT Open Reviews, Vol 9, Iss 7, Pp 589-599 (2024)

مصطلحات موضوعية: myositis ossificans, fibrodysplasia ossificans progressiva, heterotopic ossification, bibliometric analysis, research hotspot and trends, Orthopedic surgery, RD701-811

وصف الملف: electronic resource

Relation: https://eor.bioscientifica.com/view/journals/eor/9/7/EOR-23-0207.xml; https://doaj.org/toc/2058-5241

URL الوصول: https://doaj.org/article/4f4943360cc141359a9e807c241924f4

المصدر: A Phase 3, Efficacy and Safety Study of Oral Palovarotene for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP)
Shimono K, Tung WE, Macolino C, Chi AH, Didizian JH, Mundy C, Chandraratna RA, Mishina Y, Enomoto-Iwamoto M, Pacifici M, Iwamoto M. Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-gamma agonists. Nat Med. 2011 Apr;17(4):454-60. doi: 10.1038/nm.2334. Epub 2011 Apr 3. Erratum In: Nat Med. 2012 Oct;18(10):1592.

المصدر: Clinical Characteristics and Mortality in Patients With Fibrodysplasia Ossificans Progressiva (FOP): A Non-Interventional US National Retrospective Cohort

المؤلفون: Karolina Korta, Marta Bieńko, Magdalena Marchaj, Mateusz Bieńko, Anna Putra, Tomasz Król, Michalina Toborek, Natalia Niedziela, Maria Maciąg, Karolina Bednarz

المصدر: Quality in Sport, Vol 28 (2024)

مصطلحات موضوعية: Quadriceps contusion, platelet-rich plasma, musculoskeletal injury, contact sports, myositis ossificans, regenerative therapies, Sports, GV557-1198.995, Sports medicine, RC1200-1245

وصف الملف: electronic resource

Relation: https://apcz.umk.pl/QS/article/view/55120; https://doaj.org/toc/2450-3118

URL الوصول: https://doaj.org/article/4e0fd038dbb7435da63a78d3db769b29

المؤلفون: Amir Jalal Abbasi, Mohammad Mehdi Taheri, Amirali Asadi, Rashin Bahrami, Nariman Nikparto

المصدر: Oral and Maxillofacial Surgery Cases, Vol 10, Iss 3, Pp 100361- (2024)

مصطلحات موضوعية: Myositis ossificans traumatica, Masseter, Medial pterygoid, Lateral pterygoid, Temporalis, Trauma, Surgery, RD1-811

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2214541924000178; https://doaj.org/toc/2214-5419

URL الوصول: https://doaj.org/article/959c91a530b24fa990ab1d15cfb63aee

المؤلفون: R.L. Vishnu, Prashant Kumar, Revathi Radhakrishnan

المصدر: Journal of Orthopaedic Reports, Vol 3, Iss 3, Pp 100306- (2024)

مصطلحات موضوعية: Bony mass, Myositis ossificans, Adductor longus, Idiopathic, Orthopedic surgery, RD701-811

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2773157X24000018; https://doaj.org/toc/2773-157X

URL الوصول: https://doaj.org/article/f19b0f7596f84e85bf7b0bc27340aae5

المؤلفون: Jacobsen, Kim L, Wiebe, Valerie, Davidson, Autumn P, Murphy, Brian G, Pool, Jr Roy R

مصطلحات موضوعية: Animals, Myositis Ossificans, Ossification, Heterotopic, Hydrotherapy, Quality of Life, Male, Enrofloxacin, Savannah cat, enrofloxacin, feline, fibrodysplasia ossificans progressiva, heterotopic ossification, hydrotherapy, Veterinary Sciences, Other Agricultural and Veterinary Sciences

URL الوصول: https://escholarship.org/uc/item/7r75g37k

المؤلفون: Yu, Xiaobing, Ton, Amy N, Niu, Zejun, Morales, Blanca M, Chen, Jiadong, Braz, Joao, Lai, Michael H, Barruet, Emilie, Liu, Hongju, Cheung, Kin, Ali, Syed, Chan, Tea, Bigay, Katherine, Ho, Jennifer, Nikolli, Ina, Hansberry, Steven, Wentworth, Kelly, Kriegstein, Arnold, Basbaum, Allan, Hsiao, Edward C

المصدر: Pain. 164(1)

مصطلحات موضوعية: Humans, Myositis Ossificans, Neuralgia, Ossification, Heterotopic, Activin Receptors, Type I, Mutation, Sensory Receptor Cells, Gain of Function Mutation, Neurodegenerative, Pain Research, Chronic Pain, Peripheral Neuropathy, Rare Diseases, Stem Cell Research, Neurosciences, Stem Cell Research - Induced Pluripotent Stem Cell - Human, Stem Cell Research - Induced Pluripotent Stem Cell, 2.1 Biological and endogenous factors, Aetiology, Neurological, Musculoskeletal, Medical and Health Sciences, Psychology and Cognitive Sciences, Anesthesiology

URL الوصول: https://escholarship.org/uc/item/9f01g2c9

المؤلفون: Heba Almutairi, MD, Ranim Y. Nasr, MBBS, Rana Ajabnoor, MD

المصدر: Radiology Case Reports, Vol 19, Iss 5, Pp 1893-1899 (2024)

مصطلحات موضوعية: Myositis ossificans, Chest wall mass, Muscle injury, Ossification, Medical physics. Medical radiology. Nuclear medicine, R895-920

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S193004332400089X; https://doaj.org/toc/1930-0433

URL الوصول: https://doaj.org/article/5d34095bd5ce4704972988952dbeaf54