المؤلفون: Thomas Kuhlman

المصدر: eLife, Vol 13 (2024)

مصطلحات موضوعية: SARS-CoV-2, genotype-phenotype relationship, biophysical fitness landscape, mutant spectrum, intrinsically disordered protein, protein evolution, Medicine, Science, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://elifesciences.org/articles/99991; https://doaj.org/toc/2050-084X

URL الوصول: https://doaj.org/article/cf34a73b55034aa892935994176e10e4

المؤلفون: Ai Nguyen, Huaying Zhao, Dulguun Myagmarsuren, Sanjana Srinivasan, Di Wu, Jiji Chen, Grzegorz Piszczek, Peter Schuck

المصدر: eLife, Vol 13 (2024)

مصطلحات موضوعية: SARS-CoV-2, genotype-phenotype relationship, biophysical fitness landscape, mutant spectrum, intrinsically disordered protein, protein evolution, Medicine, Science, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://elifesciences.org/articles/94836; https://doaj.org/toc/2050-084X

URL الوصول: https://doaj.org/article/69a87aec0aa54120ac8389e03fc2cdf5

المؤلفون: Brenda Martínez-González, María Eugenia Soria, Lucía Vázquez-Sirvent, Cristina Ferrer-Orta, Rebeca Lobo-Vega, Pablo Mínguez, Lorena de la Fuente, Carlos Llorens, Beatriz Soriano, Ricardo Ramos, Marta Cortón, Rosario López-Rodríguez, Carlos García-Crespo, Isabel Gallego, Ana Isabel de Ávila, Jordi Gómez, Luis Enjuanes, Llanos Salar-Vidal, Jaime Esteban, Ricardo Fernandez-Roblas, Ignacio Gadea, Carmen Ayuso, Javier Ruíz-Hornillos, Nuria Verdaguer, Esteban Domingo, Celia Perales

المصدر: Microbiology Spectrum, Vol 10, Iss 2 (2022)

مصطلحات موضوعية: COVID-19 severity, mutant spectrum, diversity index, mutation, deletion, nsp12 (polymerase), Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2165-0497

URL الوصول: https://doaj.org/article/6d9736d4a3d14394be76e5f75a5176ca

المؤلفون: Brandão, Paulo E., Hora, Aline S., Silva, Sheila O. S., Taniwaki, Sueli A., Berg, Mikael

المصدر: Genetics and Molecular Biology. January 2020 43(2)

مصطلحات موضوعية: Avian coronavirus, haplotype, mutant spectrum, NGS, evolution

وصف الملف: text/html

URL الوصول: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000400202

المؤلفون: Martínez-González, Brenda, Soria, María Eugenia, Vázquez-Sirvent, Lucía, Ferrer-Orta, Cristina, Lobo-Vega, Rebeca, Mínguez, Pablo, Fuente, Lorena de la, Llorens, Carlos, Soriano, Beatriz, Ramos-Ruiz, Ricardo, Cortón, Marta, López-Rodríguez, Rosario, García-Crespo, Carlos, Gallego, Isabel, Ávila, Ana Isabel de, Gómez, Jordi, Enjuanes Sánchez, Luis, Salar-Vidal, Llanos, Esteban, Jaime, Fernández-Roblas, Ricardo, Gadea, Ignacio, Ayuso, Carmen, Ruíz-Hornillos, Javier, Verdaguer, Núria, Domingo, Esteban, Perales, Celia

المساهمون: Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Consejo Superior de Investigaciones Científicas (España), Fundació La Marató de TV3, Instituto de Salud Carlos III, Comunidad de Madrid, Fundación Ramón Areces, Banco Santander, Ministerio de Sanidad y Consumo (España), Ministerio de Economía y Competitividad (España), Ramos-Ruiz, Ricardo, Enjuanes Sánchez, Luis, Esteban, Jaime, Verdaguer, Núria, Domingo, Esteban, Perales, Celia

مصطلحات موضوعية: COVID-19 severity, Mutant spectrum, Diversity index, Mutation, Deletion, nsp12 (polymerase), Spike, Ultra-deep sequencing

Relation: #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/AEI//BFU2017-91384-EXP; S2018/BAA-4370/PLATESA2; info:eu-repo/grantAgreement/AEI/Programa Estatal de I+D+i Orientada a los Retos de la Sociedad/PID2020-113888RB-I00; Preprint; https://doi.org/10.1101/2022.01.10.475768; Sí; BioRxiv: 10.1101/2022.01.10.475768 (2022); http://hdl.handle.net/10261/257747; http://dx.doi.org/10.13039/501100003329; http://dx.doi.org/10.13039/100010784; http://dx.doi.org/10.13039/100012818; http://dx.doi.org/10.13039/501100003339; http://dx.doi.org/10.13039/501100000780; http://dx.doi.org/10.13039/100008666; http://dx.doi.org/10.13039/100008054; http://dx.doi.org/10.13039/501100004587; http://dx.doi.org/10.13039/501100011033

الاتاحة: http://hdl.handle.net/10261/257747
https://doi.org/10.1101/2022.01.10.475768
https://doi.org/10.13039/501100003329
https://doi.org/10.13039/100010784
https://doi.org/10.13039/100012818
https://doi.org/10.13039/501100003339
https://doi.org/10.13039/501100000780
https://doi.org/10.13039/100008666
https://doi.org/10.13039/100008054
https://doi.org/10.13039/501100004587

المؤلفون: Paulo E. Brandão, Aline S. Hora, Sheila O. S. Silva, Sueli A. Taniwaki, Mikael Berg

المصدر: Genetics and Molecular Biology, Vol 43, Iss 2 (2020)

مصطلحات موضوعية: Avian coronavirus, haplotype, mutant spectrum, NGS, evolution, Genetics, QH426-470

وصف الملف: electronic resource

Relation: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000400202&tlng=en; http://www.scielo.br/pdf/gmb/v43n2/1415-4757-GMB-43-2-e20190064.pdf; https://doaj.org/toc/1678-4685

URL الوصول: https://doaj.org/article/148665dcbc1b4c698421cc8ebab5ad53

المؤلفون: Piegorsch, Walter W., Richwine, Kelly A.

المصدر: Journal of Agricultural, Biological, and Environmental Statistics, 2001 Sep 01. 6(3), 305-325.

URL الوصول: https://www.jstor.org/stable/1400409

المؤلفون: Carlos García-Crespo, María Eugenia Soria, Isabel Gallego, Ana Isabel de Ávila, Brenda Martínez-González, Lucía Vázquez-Sirvent, Jordi Gómez, Carlos Briones, Josep Gregori, Josep Quer, Celia Perales, Esteban Domingo

المصدر: Journal of Clinical Medicine; Volume 9; Issue 11; Pages: 3450

مصطلحات موضوعية: antiviral intervention, consensus sequence, mutant spectrum, residue conservation, viral ligands, virus data banks

وصف الملف: application/pdf

Relation: Gastroenterology & Hepatopancreatobiliary Medicine; https://dx.doi.org/10.3390/jcm9113450

الاتاحة: https://doi.org/10.3390/jcm9113450

المؤلفون: Domingo, Esteban, Ávila, Ana Isabel de, Gallego, Isabel, Sheldon, Julie, Perales, Celia

المساهمون: Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Comunidad de Madrid

مصطلحات موضوعية: Replicative capacity, Quasispecies dynamics, Mechanism of viral resistance, Mutant spectrum, Large population passages, Bottleneck, Events

Relation: Publisher's version; http://dx.doi.org/10.1093/femspd/ftz021; Sí; EISSN 2049-632X 77 (2019); http://hdl.handle.net/10261/254540; http://dx.doi.org/10.13039/100012818; http://dx.doi.org/10.13039/501100003329

الاتاحة: http://hdl.handle.net/10261/254540
https://doi.org/10.1093/femspd/ftz021
https://doi.org/10.13039/100012818
https://doi.org/10.13039/501100003329

المؤلفون: Domingo, Esteban, Martínez-González, Brenda, García-Crespo, Carlos, Somovilla, Pilar, Ávila, Ana Isabel de, Soria, María Eugenia, Durán-Pastor, Antoni, Perales, Celia

المساهمون: Ministerio de Ciencia e Innovación (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Consejo Superior de Investigaciones Científicas (España), Instituto de Salud Carlos III, Fundació La Marató de TV3, Comunidad de Madrid, Fundación Ramón Areces, Fundación Banco Santander, Domingo, Esteban, Perales, Celia

مصطلحات موضوعية: Cancer heterogeneity, Coronavirus, Deletion, Error threshold, Mutant spectrum, Mutation, Prion, Ultra-deep sequencing, Viral disease control, Virus complexity

Relation: #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113888RB-I00/ES/DESORGANIZACION MOLECULAR DURANTE LA MUTAGENESIS LETAL DE SARS-COV-2: AFECTACION DE REGIONES DE RNA ESTRUCTURADAS Y NO ESTRUCTURADAS/; info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI21%2F00139/ES/SECUENCIACION MASIVA DE SARS-COV-2 PARA LA DETECCION DE VARIANTES Y SU ASOCIACIÓN CON LA SEVERIDAD CLINICA DE LA COVID-19/; S2018/BAA-4370/PLATESA2; https://doi.org/10.1128/jvi.01511-23; Sí; Journal of Virology 97(12): e01511-23 (2023); http://hdl.handle.net/10261/353038; http://dx.doi.org/10.13039/501100004837; http://dx.doi.org/10.13039/501100003339; http://dx.doi.org/10.13039/501100000780; http://dx.doi.org/10.13039/100008666; http://dx.doi.org/10.13039/100008049; http://dx.doi.org/10.13039/100008054; http://dx.doi.org/10.13039/501100004587; http://dx.doi.org/10.13039/501100011033; http://dx.doi.org/10.13039/100012818; 2-s2.0-85181253853; https://api.elsevier.com/content/abstract/scopus_id/85181253853

الاتاحة: http://hdl.handle.net/10261/353038
https://doi.org/10.1128/jvi.01511-23
https://doi.org/10.13039/501100004837
https://doi.org/10.13039/501100003339
https://doi.org/10.13039/501100000780
https://doi.org/10.13039/100008666
https://doi.org/10.13039/100008049
https://doi.org/10.13039/100008054
https://doi.org/10.13039/501100004587
https://doi.org/10.13039/501100011033

المؤلفون: Moreno, Elena, Gallego, Isabel, Beach, Nathan M., Domingo, Esteban, Perales, Celia

المساهمون: European Commission, Instituto de Salud Carlos III, Comunidad de Madrid, Ministerio de Economía y Competitividad (España), Centro para el Desarrollo Tecnológico Industrial (España), Fundación Ramón Areces

مصطلحات موضوعية: RNA virus, Quasispecie, Population instability, Mutant spectrum

Relation: Publisher's version; Sí; Journal of Virology 91 (2017); http://hdl.handle.net/10261/166166; http://dx.doi.org/10.13039/501100000780; http://dx.doi.org/10.13039/501100004587; http://dx.doi.org/10.13039/501100003329; http://dx.doi.org/10.13039/100008054; http://dx.doi.org/10.13039/100012818; http://dx.doi.org/10.13039/501100001872

الاتاحة: http://hdl.handle.net/10261/166166
https://doi.org/10.1128/JVI.02505-16
https://doi.org/10.13039/501100000780
https://doi.org/10.13039/501100004587
https://doi.org/10.13039/501100003329
https://doi.org/10.13039/100008054
https://doi.org/10.13039/100012818
https://doi.org/10.13039/501100001872

المؤلفون: Nguyen, Ai, Zhao, Huaying, Myagmarsuren, Dulguun, Srinivasan, Sanjana, Wu, Di, Chen, Jiji, Piszczek, Grzegorz, Schuck, Peter

المساهمون: Schuck, Peter

مصطلحات موضوعية: Medicine, Health and Life Sciences, SARS-CoV-2, viral mutant spectrum, genotype-phenotype relationship, biophysical mutation landscape, nucleocapsid protein

Relation: https://doi.org/10.7910/DVN/PZ6LRK

الاتاحة: https://doi.org/10.7910/DVN/PZ6LRK

المؤلفون: Ojosnegros Martos, Samuel, Beerenwinkel, Niko, Domingo, Esteban

المساهمون: Fundación Ramón Areces, Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (España)

مصطلحات موضوعية: fitness, mutant spectrum, Foot-and-mouth disease virus, Attenuation, Space-structured habitat, Density dependent selection

Relation: Publisher's version; Sí; Communitative and Integrative Biology 3: 333- 336 (2010); http://hdl.handle.net/10261/213358; http://dx.doi.org/10.13039/100008054

الاتاحة: http://hdl.handle.net/10261/213358
https://doi.org/10.13039/100008054

المؤلفون: Sheila Oliveira de Souza Silva, Mikael Berg, Sueli Akemi Taniwaki, Aline S. Hora, Paulo Eduardo Brandão

المصدر: Genetics and Molecular Biology, Volume: 43, Issue: 2, Article number: e20190064, Published: 22 APR 2020
Genetics and Molecular Biology
Genetics and Molecular Biology, Vol 43, Iss 2 (2020)
Genetics and Molecular Biology v.43 n.2 2020
Sociedade Brasileira de Genética (SBG)
instacron:SBG
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

مصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, haplotype, Mutant, QH426-470, Biology, 01 natural sciences, Genome, Virus, DNA sequencing, 03 medical and health sciences, evolution, Genetics, Molecular Biology, Gene, MUTAÇÃO GENÉTICA, Haplotype, Avian coronavirus, Embryonated, Phenotypic trait, mutant spectrum, Pathobiology, 030104 developmental biology, NGS, Animal Genetics, 010606 plant biology & botany

وصف الملف: application/pdf; text/html

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd3ebb527cc90f05fc55b442efa8620
https://pub.epsilon.slu.se/17157/

المؤلفون: Josep Quer, Qian Chen, Ana Isabel de Ávila, Irene Sanchez-Martin, Celia Perales, Isabel Gallego, Inés Palacios-Blanco, Jordi Gómez, María Eugenia Soria, Brenda Martínez-González, Damir Garcia-Cehic, Soumaya Khalfaoui, Josep Gregori, Patricia Martínez-Barragán, Carlos Briones, Esteban Domingo, Juan Ignacio Esteban, Carlos García-Crespo

المساهمون: Eugenia Soria, M. [0000-0003-1755-6382], García Crespo, C. [0000-0001-6561-5389], García Cehic, D. [0000-0002-0009-038X], Briones, C. [0000-0003-2213-8353], Domingo, E. [0000-0002-0573-1676], Martínez González, B. [0000-0002-4482-5181], Perales Viejo, C. B. [0000-0003-1618-1937], Gregori Font, J. [0000-0002-4253-8015], Gómez, J. [0000-0002-7806-1503], Quer, J. [0000-0003-0014-084X], Instituto de Salud Carlos III (ISCIII), Comunidad de Madrid, Ministerio de Economia y Competitividad (MINECO), Fundación Ramón Areces, Banco Santander, Agencia Estatal de Investigación (AEI), Ministerio de Ciencia Innovación y Universidades (MICIU), Miguel Servet program of the Instituto de Salud Carlos III, European Regional Development Fund (ERDF), Centro para el Desarrollo Tecnologico Industrial (CDTI) from the Spanish Ministry of Economy and Business, Unidad de Excelencia Científica María de Maeztu Centro de Astrobiología del Instituto Nacional de Técnica Aeroespacial y CSIC, Comunidad de Madrid [CAM]/FEDER, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Instituto de Salud Carlos III, European Commission, Agencia Estatal de Investigación (España), Ministerio de Economía y Empresa (España)

المصدر: DIGITAL.INTA Repositorio Digital del Instituto Nacional de Técnica Aeroespacial
instname
J Virol
Instituto Nacional de Técnica Aeroespacial (INTA)
Digital.CSIC. Repositorio Institucional del CSIC

مصطلحات موضوعية: Mutation rate, Immunology, Mutant, Population, Cell Culture Techniques, Viral quasispecies, Hepacivirus, adaptation, Virus Replication, Microbiology, Genome, Virus, 03 medical and health sciences, Virology, Cell Line, Tumor, Humans, education, 030304 developmental biology, Genetics, 0303 health sciences, education.field_of_study, biology, 030306 microbiology, mutational waves, RNA virus, mutant spectrum, biology.organism_classification, Phenotype, Adaptation, Physiological, Genetic Diversity and Evolution, sequence space, Insect Science, Mutation, RNA virus evolution

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::365c1db20d15a1a051ce923950f2b9db
http://hdl.handle.net/20.500.12666/417

المؤلفون: Celia Perales, Julie Sheldon, Isabel Gallego, Esteban Domingo, Ana Isabel de Ávila

المساهمون: Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Comunidad de Madrid

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname

مصطلحات موضوعية: Microbiology (medical), Viral pathogenesis, viruses, Events, Adaptation, Biological, Population genetics, Viral quasispecies, Biology, medicine.disease_cause, Genome, Antiviral Agents, Deep sequencing, Bottleneck, 03 medical and health sciences, Darwinian Fitness, Mutant spectrum, Drug Resistance, Viral, medicine, Immunology and Allergy, Animals, Humans, 030304 developmental biology, Genetics, 0303 health sciences, Mutation, Large population passages, General Immunology and Microbiology, Quasispecies dynamics, 030306 microbiology, Replicative capacity, General Medicine, Biological Evolution, Mechanism of viral resistance, Infectious Diseases, Virus Diseases, Host-Pathogen Interactions, Viral disease, Genetic Fitness, Virus Physiological Phenomena

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0a7d83232206f801ff25f3963d7800
http://hdl.handle.net/10261/254540

المؤلفون: Charles M. Rice, Victoria Castro, Pablo Gastaminza, Celia Perales, Adriana Lucía-Sanz, Josep Gregori, Jordi Gómez, Josep Quer, Susanna C. Manrubia, María Eugenia Soria, Juan Ignacio Esteban, Isabel Gallego, Esteban Domingo, Elena Moreno, Nathan M. Beach

المساهمون: European Commission, Instituto de Salud Carlos III, Comunidad de Madrid, Ministerio de Economía y Competitividad (España), Centro para el Desarrollo Tecnológico Industrial (España), Fundación Ramón Areces

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname

مصطلحات موضوعية: DNA Replication, 0301 basic medicine, Carcinoma, Hepatocellular, RNA virus, viruses, Hepatitis C virus, Immunology, Population, Adaptation, Biological, Genome, Viral, Hepacivirus, Viral quasispecies, Biology, Virus Replication, medicine.disease_cause, Microbiology, Virus, Evolution, Molecular, 03 medical and health sciences, Virology, Mutant spectrum, medicine, Humans, education, Quasispecie, Genetics, education.field_of_study, Population instability, biology.organism_classification, Genome Replication and Regulation of Viral Gene Expression, Phenotype, 030104 developmental biology, Cell killing, Liver, Viral replication, Insect Science, Viral evolution, Host-Pathogen Interactions, Mutation, RNA, Viral

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd955d881628c1b71f9eee37e11dfea8
http://hdl.handle.net/10261/166166

المؤلفون: Esteban Domingo, Samuel Ojosnegros, Niko Beerenwinkel

المساهمون: Fundación Ramón Areces, Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (España)

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname

مصطلحات موضوعية: Genetics, Foot-and-mouth disease virus, Ecology, media_common.quotation_subject, Clone (cell biology), Attenuation, Space-structured habitat, RNA, Virulence, Viral quasispecies, Biology, biology.organism_classification, Density dependent selection, Virus, Competition (biology), Article Addendum, Colonization, General Agricultural and Biological Sciences, fitness, mutant spectrum, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::024c9786f5c175a73d4ff0ad5b96ddf0
https://doi.org/10.4161/cib.3.4.11658

المؤلفون: Lázaro, Ester

المصدر: Structural Approaches to Sequence Evolution

مصطلحات موضوعية: Deleterious Mutation, Transfer Number, Error Threshold, Severe Acute Respiratory Syndrome, Article, Mutant Spectrum

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmc_________::b76c555b0fe4f655fc9e3b194045f59e
http://europepmc.org/articles/PMC7123777

المؤلفون: Domingo E, Pariente N, Airaksinen A, Gonzaĺez-Lopez C, Sierra S, Herrera M, Ana Grande-Pérez, Pr, Lowenstein, Sc, Manrubia, Lázaro E, Escarmís C

المصدر: Foot-and-Mouth Disease Virus
Europe PubMed Central
Digital.CSIC. Repositorio Institucional del CSIC
instname

مصطلحات موضوعية: Compensatory Mutation, Mutant Distribution, Foot-and-Mouth Disease Virus, viruses, Mutation, Ribavirin, Error Threshold, Antiviral Strategy, Biological Evolution, Article, Mutant Spectrum

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::53dcf11cb6b7238672bfe1e242d43ff7
http://europepmc.org/articles/PMC7121672