المؤلفون: Robert M. Cox, Josef D. Wolf, Nicole A. Lieberman, Carolin M. Lieber, Hae-Ji Kang, Zachary M. Sticher, Jeong-Joong Yoon, Meghan K. Andrews, Mugunthan Govindarajan, Rebecca E. Krueger, Elizabeth B. Sobolik, Michael G. Natchus, Andrew T. Gewirtz, Rik L. deSwart, Alexander A. Kolykhalov, Khan Hekmatyar, Kaori Sakamoto, Alexander L. Greninger, Richard K. Plemper

المصدر: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/c318e8440b28489e92886789df7a2812

المؤلفون: Robert M Cox, Julien Sourimant, Mugunthan Govindarajan, Michael G Natchus, Richard K Plemper

المصدر: PLoS Pathogens, Vol 17, Iss 2, p e1009371 (2021)

مصطلحات موضوعية: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

URL الوصول: https://doaj.org/article/92949f42620c4f69984e9de22c19a941

المؤلفون: Robert M. Cox (8029568), Julien Sourimant (8307855), Mugunthan Govindarajan (6704285), Michael G. Natchus (1884760), Richard K. Plemper (221041)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, label-free biolayer interferometry, phosphodiester bond formation, L protein polyribonucleotidyl trans., mononegavirus L polymerase proteins, measles virus polymerase, ERDRP -0519, RNA synthesis activity Morbilliviruses, resistance profiling-informed ligan., CDV, MeV RdRP complexes, morbillivirus RNA-dependent RNA-pol.

Relation: https://figshare.com/articles/journal_contribution/Substitutions_in_the_RdRP_catalytic_site_inhibit_RNA_synthesis_in_the_primer_extension_assay_/14098445

الاتاحة: https://doi.org/10.1371/journal.ppat.1009371.s008

المؤلفون: Robert M. Cox (8029568), Julien Sourimant (8307855), Mugunthan Govindarajan (6704285), Michael G. Natchus (1884760), Richard K. Plemper (221041)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, label-free biolayer interferometry, phosphodiester bond formation, L protein polyribonucleotidyl trans., mononegavirus L polymerase proteins, measles virus polymerase, ERDRP -0519, RNA synthesis activity Morbilliviruses, resistance profiling-informed ligan., CDV, MeV RdRP complexes, morbillivirus RNA-dependent RNA-pol.

Relation: https://figshare.com/articles/journal_contribution/Peptides_in_MeV_L_identified_as_candidate_targets_for_ERDRP-0519_binding_through_photo-affinity_mapping_with_ERDRP-0519_sub_az_sub_/14098451

الاتاحة: https://doi.org/10.1371/journal.ppat.1009371.s010

المؤلفون: Robert M. Cox (8029568), Julien Sourimant (8307855), Mugunthan Govindarajan (6704285), Michael G. Natchus (1884760), Richard K. Plemper (221041)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, label-free biolayer interferometry, phosphodiester bond formation, L protein polyribonucleotidyl trans., mononegavirus L polymerase proteins, measles virus polymerase, ERDRP -0519, RNA synthesis activity Morbilliviruses, resistance profiling-informed ligan., CDV, MeV RdRP complexes, morbillivirus RNA-dependent RNA-pol.

Relation: https://figshare.com/articles/journal_contribution/Synergy_between_ERDRP-0519_and_GHP-88309_/14098433

الاتاحة: https://doi.org/10.1371/journal.ppat.1009371.s004

المؤلفون: Robert M. Cox (8029568), Julien Sourimant (8307855), Mugunthan Govindarajan (6704285), Michael G. Natchus (1884760), Richard K. Plemper (221041)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, label-free biolayer interferometry, phosphodiester bond formation, L protein polyribonucleotidyl trans., mononegavirus L polymerase proteins, measles virus polymerase, ERDRP -0519, RNA synthesis activity Morbilliviruses, resistance profiling-informed ligan., CDV, MeV RdRP complexes, morbillivirus RNA-dependent RNA-pol.

Relation: https://figshare.com/articles/journal_contribution/Experimental_repeats_of_target_binding_affinity_of_ERDRP-0519_to_MeV_P-L_sub_1708_sub_complexes_harboring_different_resistance_mutations_/14098439

الاتاحة: https://doi.org/10.1371/journal.ppat.1009371.s006

المؤلفون: Robert M. Cox (8029568), Julien Sourimant (8307855), Mugunthan Govindarajan (6704285), Michael G. Natchus (1884760), Richard K. Plemper (221041)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, label-free biolayer interferometry, phosphodiester bond formation, L protein polyribonucleotidyl trans., mononegavirus L polymerase proteins, measles virus polymerase, ERDRP -0519, RNA synthesis activity Morbilliviruses, resistance profiling-informed ligan., CDV, MeV RdRP complexes, morbillivirus RNA-dependent RNA-pol.

Relation: https://figshare.com/articles/journal_contribution/Cross-species_conservation_of_morbillivirus_L_residues_involved_in_ERDRP-519_drug_resistance_/14098430

الاتاحة: https://doi.org/10.1371/journal.ppat.1009371.s003

المؤلفون: Robert M. Cox (8029568), Julien Sourimant (8307855), Mugunthan Govindarajan (6704285), Michael G. Natchus (1884760), Richard K. Plemper (221041)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, label-free biolayer interferometry, phosphodiester bond formation, L protein polyribonucleotidyl trans., mononegavirus L polymerase proteins, measles virus polymerase, ERDRP -0519, RNA synthesis activity Morbilliviruses, resistance profiling-informed ligan., CDV, MeV RdRP complexes, morbillivirus RNA-dependent RNA-pol.

Relation: https://figshare.com/articles/journal_contribution/S2_Fig_-/14098427

الاتاحة: https://doi.org/10.1371/journal.ppat.1009371.s002

المؤلفون: Robert M. Cox (8029568), Julien Sourimant (8307855), Mugunthan Govindarajan (6704285), Michael G. Natchus (1884760), Richard K. Plemper (221041)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, label-free biolayer interferometry, phosphodiester bond formation, L protein polyribonucleotidyl trans., mononegavirus L polymerase proteins, measles virus polymerase, ERDRP -0519, RNA synthesis activity Morbilliviruses, resistance profiling-informed ligan., CDV, MeV RdRP complexes, morbillivirus RNA-dependent RNA-pol.

Relation: https://figshare.com/articles/journal_contribution/Multiple_sequence_alignment_of_different_mononegavirus_L_proteins_/14098424

الاتاحة: https://doi.org/10.1371/journal.ppat.1009371.s001

المؤلفون: Robert M. Cox (8029568), Julien Sourimant (8307855), Mugunthan Govindarajan (6704285), Michael G. Natchus (1884760), Richard K. Plemper (221041)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, label-free biolayer interferometry, phosphodiester bond formation, L protein polyribonucleotidyl trans., mononegavirus L polymerase proteins, measles virus polymerase, ERDRP -0519, RNA synthesis activity Morbilliviruses, resistance profiling-informed ligan., CDV, MeV RdRP complexes, morbillivirus RNA-dependent RNA-pol.

Relation: https://figshare.com/articles/journal_contribution/Experimental_repeats_of_target_binding_affinity_of_ERDRP-0519_/14098436

الاتاحة: https://doi.org/10.1371/journal.ppat.1009371.s005

المؤلفون: Robert M. Cox (8029568), Julien Sourimant (8307855), Mugunthan Govindarajan (6704285), Michael G. Natchus (1884760), Richard K. Plemper (221041)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, label-free biolayer interferometry, phosphodiester bond formation, L protein polyribonucleotidyl trans., mononegavirus L polymerase proteins, measles virus polymerase, ERDRP -0519, RNA synthesis activity Morbilliviruses, resistance profiling-informed ligan., CDV, MeV RdRP complexes, morbillivirus RNA-dependent RNA-pol.

Relation: https://figshare.com/articles/journal_contribution/Steady-state_analyses_of_BLI_binding_saturation_shown_in_Fig_2_/14098442

الاتاحة: https://doi.org/10.1371/journal.ppat.1009371.s007

المؤلفون: Robert M. Cox (8029568), Julien Sourimant (8307855), Mugunthan Govindarajan (6704285), Michael G. Natchus (1884760), Richard K. Plemper (221041)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, label-free biolayer interferometry, phosphodiester bond formation, L protein polyribonucleotidyl trans., mononegavirus L polymerase proteins, measles virus polymerase, ERDRP -0519, RNA synthesis activity Morbilliviruses, resistance profiling-informed ligan., CDV, MeV RdRP complexes, morbillivirus RNA-dependent RNA-pol.

Relation: https://figshare.com/articles/journal_contribution/Conformational_rearrangements_of_the_priming_and_intrusion_loops_into_initiation_conformation_eliminates_ERDRP-0519_binding_pocket_/14098463

الاتاحة: https://doi.org/10.1371/journal.ppat.1009371.s014

المؤلفون: Robert M. Cox (8029568), Julien Sourimant (8307855), Mugunthan Govindarajan (6704285), Michael G. Natchus (1884760), Richard K. Plemper (221041)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, label-free biolayer interferometry, phosphodiester bond formation, L protein polyribonucleotidyl trans., mononegavirus L polymerase proteins, measles virus polymerase, ERDRP -0519, RNA synthesis activity Morbilliviruses, resistance profiling-informed ligan., CDV, MeV RdRP complexes, morbillivirus RNA-dependent RNA-pol.

Relation: https://figshare.com/articles/journal_contribution/_i_In_silico_i_docking_attempts_of_ERDRP-0519_into_PIV-5_RSV_and_VSV_L_polymerases_which_are_all_not_inhibited_by_the_compound_/14098460

الاتاحة: https://doi.org/10.1371/journal.ppat.1009371.s013

المؤلفون: Robert M. Cox (8029568), Julien Sourimant (8307855), Mugunthan Govindarajan (6704285), Michael G. Natchus (1884760), Richard K. Plemper (221041)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, label-free biolayer interferometry, phosphodiester bond formation, L protein polyribonucleotidyl trans., mononegavirus L polymerase proteins, measles virus polymerase, ERDRP -0519, RNA synthesis activity Morbilliviruses, resistance profiling-informed ligan., CDV, MeV RdRP complexes, morbillivirus RNA-dependent RNA-pol.

Relation: https://figshare.com/articles/journal_contribution/ERDRP-0519_sub_az_sub_inhibits_MeV_RdRP_activity_in_the_i_in_vitro_i_RdRP_assay_/14098448

الاتاحة: https://doi.org/10.1371/journal.ppat.1009371.s009

المؤلفون: Robert M. Cox (8029568), Julien Sourimant (8307855), Mugunthan Govindarajan (6704285), Michael G. Natchus (1884760), Richard K. Plemper (221041)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, label-free biolayer interferometry, phosphodiester bond formation, L protein polyribonucleotidyl trans., mononegavirus L polymerase proteins, measles virus polymerase, ERDRP -0519, RNA synthesis activity Morbilliviruses, resistance profiling-informed ligan., CDV, MeV RdRP complexes, morbillivirus RNA-dependent RNA-pol.

Relation: https://figshare.com/articles/journal_contribution/Synthetic_evolution_of_the_ERDRP-0519_chemotype_does_not_alter_the_pharmacophore_/14098454

الاتاحة: https://doi.org/10.1371/journal.ppat.1009371.s011

المؤلفون: Robert M. Cox (8029568), Julien Sourimant (8307855), Mugunthan Govindarajan (6704285), Michael G. Natchus (1884760), Richard K. Plemper (221041)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, label-free biolayer interferometry, phosphodiester bond formation, L protein polyribonucleotidyl trans., mononegavirus L polymerase proteins, measles virus polymerase, ERDRP -0519, RNA synthesis activity Morbilliviruses, resistance profiling-informed ligan., CDV, MeV RdRP complexes, morbillivirus RNA-dependent RNA-pol.

Relation: https://figshare.com/articles/journal_contribution/Conservation_of_morbillivirus_L_residues_surrounding_the_predicted_ERDRP-519_binding_pocket_/14098457

الاتاحة: https://doi.org/10.1371/journal.ppat.1009371.s012

المؤلفون: Robert M. Cox (8029568), Julien Sourimant (8307855), Mugunthan Govindarajan (6704285), Michael G. Natchus (1884760), Richard K. Plemper (221041)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, label-free biolayer interferometry, phosphodiester bond formation, L protein polyribonucleotidyl trans., mononegavirus L polymerase proteins, measles virus polymerase, ERDRP -0519, RNA synthesis activity Morbilliviruses, resistance profiling-informed ligan., CDV, MeV RdRP complexes, morbillivirus RNA-dependent RNA-pol.

Relation: https://figshare.com/articles/journal_contribution/Chemical_synthesis_strategy_of_ERDRP-0519_sub_az_sub_/14098466

الاتاحة: https://doi.org/10.1371/journal.ppat.1009371.s015

المؤلفون: Robert M. Cox (8029568), Julien Sourimant (8307855), Mugunthan Govindarajan (6704285), Michael G. Natchus (1884760), Richard K. Plemper (221041)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, label-free biolayer interferometry, phosphodiester bond formation, L protein polyribonucleotidyl trans., mononegavirus L polymerase proteins, measles virus polymerase, ERDRP -0519, RNA synthesis activity Morbilliviruses, resistance profiling-informed ligan., CDV, MeV RdRP complexes, morbillivirus RNA-dependent RNA-pol.

Relation: https://figshare.com/articles/journal_contribution/Mass_spectrometry_analysis_of_recombinant_P-L_complex_preparations_/14098469

الاتاحة: https://doi.org/10.1371/journal.ppat.1009371.s016

المؤلفون: Robert M. Cox (8029568), Julien Sourimant (8307855), Mugunthan Govindarajan (6704285), Michael G. Natchus (1884760), Richard K. Plemper (221041)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, label-free biolayer interferometry, phosphodiester bond formation, L protein polyribonucleotidyl trans., mononegavirus L polymerase proteins, measles virus polymerase, ERDRP -0519, RNA synthesis activity Morbilliviruses, resistance profiling-informed ligan., CDV, MeV RdRP complexes, morbillivirus RNA-dependent RNA-pol.

Relation: https://figshare.com/articles/journal_contribution/Source_and_biological_repeats_from_Fig_2A_/14098475

الاتاحة: https://doi.org/10.1371/journal.ppat.1009371.s018

المؤلفون: Robert M. Cox (8029568), Julien Sourimant (8307855), Mugunthan Govindarajan (6704285), Michael G. Natchus (1884760), Richard K. Plemper (221041)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, label-free biolayer interferometry, phosphodiester bond formation, L protein polyribonucleotidyl trans., mononegavirus L polymerase proteins, measles virus polymerase, ERDRP -0519, RNA synthesis activity Morbilliviruses, resistance profiling-informed ligan., CDV, MeV RdRP complexes, morbillivirus RNA-dependent RNA-pol.

Relation: https://figshare.com/articles/journal_contribution/ERDRP-0519_analogs_used_for_development_of_the_3D-QSAR_model_/14098472

الاتاحة: https://doi.org/10.1371/journal.ppat.1009371.s017