المؤلفون: Mortier, Jérémie, Prévost, Julien, Sydow, Dominique, Teuchert, Sabine, Omieczynski, Christian, Bermudez, Marcel, Frédérick, Raphaël, Wolber, Gerhard

المساهمون: UCL - SSS/LDRI - Louvain Drug Research Institute

المصدر: Scientific Reports, Vol. 7, p. 13616 [1-9] (2017)

Relation: boreal:195088; http://hdl.handle.net/2078.1/195088; info:pmid/29051526; urn:ISSN:2045-2322; urn:EISSN:2045-2322

الاتاحة: http://hdl.handle.net/2078.1/195088
https://doi.org/10.1038/s41598-017-13366-4

المؤلفون: Mortier, Jérémie, Prévost, Julien, Sydow, Dominique, Teuchert, Sabine, Omieczynski, Christian, Bermudez, Marcel, Frédérick, Raphaël, Wolber, Gerhard

المساهمون: UCL - SSS/LDRI - Louvain Drug Research Institute

المصدر: Scientific Reports, Vol. 7, p. 13616 [1-9] (2017)

Relation: boreal:195088; http://hdl.handle.net/2078.1/195088; info:pmid/29051526; urn:ISSN:2045-2322; urn:EISSN:2045-2322

الاتاحة: http://hdl.handle.net/2078.1/195088
https://doi.org/10.1038/s41598-017-13366-4

المؤلفون: Meinguet, Céline, Bruyère, Céline, Frédérick, Raphaël, Mathieu, Véronique, Vancraeynest, Christelle, Pochet, Lionel, Laloy, Julie, Mortier, Jérémie, Wolber, Gerhard, Kiss, Robert, Masereel, Bernard, Wouters, Johan

المساهمون: UCL - SSS/LDRI - Louvain Drug Research Institute

المصدر: European Journal of Medicinal Chemistry, Vol. 94, no. 1, p. 45-55 (2015)

مصطلحات موضوعية: Antiproliferative activity, 7 (2 hydroxyethoxy) 2,9 bis (2 hydroxyethyl) 1 methyl beta carbolin 2 ium bromide, 7 (benzyloxy) 2 ethyl 1 methyl 9 propyl beta carbolin 2 ium bromide, 7 (benzyloxy) 2 isobutyl 1 methyl 9 propyl beta carbolin 2 ium bromide, 7 (benzyloxy) 2 isopentyl 1 methyl 9 propyl beta carbolin 2 ium bromide, 7 (isopentyloxy) 1 methyl 2,9 dipropyl beta carbolin 2 ium bromide, 9 [2 (1h tetrazol 5 yl)ethyl] 2 isopentyl 7 (isopentyloxy) 1 methyl beta carbolin 2 ium bromide, Antineoplastic agent, Harmine, Unclassified drug, Comparative molecular field analysis, Article, Blood brain barrier, Cancer cell line, Controlled study, Drug absorption, Drug design, Drug penetration, Drug solubility, Drug synthesis, Cytostatic activity, Glioma cell line, Human, Human cell, In vitro study, Intestine absorption, Lipophilicity, PH, Quantitative structure activity relation, Harmine derivatives

Relation: boreal:165298; http://hdl.handle.net/2078.1/165298; info:pmid/25747498; urn:ISSN:0223-5234; urn:EISSN:1768-3254

الاتاحة: http://hdl.handle.net/2078.1/165298
https://doi.org/10.1016/j.ejmech.2015.02.044

المؤلفون: Mortier, Jérémie, Frédérick, Raphaël, Ganeff, Corinne, Remouchamps, Caroline, Talaga, Patrice, Pochet, Lionel, Wouters, Johan, Piette, Jacques, Dejardin, Emmanuel, Masereel, Bernard

المساهمون: UCL - SSS/LDRI - Louvain Drug Research Institute

المصدر: Biochemical Pharmacology, Vol. 79, no. 10, p. 1462-1472 (2010)

مصطلحات موضوعية: Alternative pathway, 5 (3 methoxyphenyl) 3 phenyl 1h pyrazolo[4,3 c]isoquinoline derivative, I kappa B, I kappa B kinase alpha, Immunoglobulin enhancer binding protein, Interleukin 6, Isoquinoline derivative, Lymphotoxin beta receptor, Pyrazolo[4,3 c]isoquinoline derivative, Staurosporine, Transforming growth factor beta activated kinase 1, Molecular modeling, Tumor necrosis factor alpha, Unclassified drug, Amino acid sequence, Article, Conformational transition, Controlled study, Drug potency, Drug screening, Drug structure, Enzyme active site, NF-κB inducing kinase, Enzyme inhibition, HeLa cell, Human, Human cell, IC 50, Molecular docking, Priority journal

Relation: boreal:162918; http://hdl.handle.net/2078.1/162918; urn:ISSN:0006-2952; urn:EISSN:1873-2968

الاتاحة: http://hdl.handle.net/2078.1/162918
https://doi.org/10.1016/j.bcp.2010.01.007

المؤلفون: Mortier, Jérémie, Masereel, Bernard, Remouchamps, Caroline, Ganeff, Corinne, Piette, Jacques, Frédérick, Raphaël

المساهمون: UCL - SSS/LDRI - Louvain Drug Research Institute

المصدر: Bioorganic & Medicinal Chemistry Letters : the tetrahedron journal for research at the interface of chemistry and biology, Vol. 20, no. 15, p. 4515-4520 (2010)

مصطلحات موضوعية: NF-κB inducing kinase, Protein serine threonine kinase inhibitor, Staurosporine, Unclassified drug, NF kappa B kinase, NF-kappa B kinase, Protein kinase inhibitor, Protein serine threonine kinase, Recombinant protein, Article, Competitive inhibition, NIK, Concentration (parameters), Drug structure, Enzyme inhibition, High throughput screening, IC 50, Model, Molecular docking, Molecular dynamics, Binding site, Chemistry, Virtual screening, Computer simulation, Drug antagonism, Genetics, Human, Metabolism, Rheumatoid arthritis, Arthritis

Relation: boreal:162919; http://hdl.handle.net/2078.1/162919; urn:ISSN:0960-894X; urn:EISSN:1464-3405

الاتاحة: http://hdl.handle.net/2078.1/162919
https://doi.org/10.1016/j.bmcl.2010.06.027

المؤلفون: Mortier, Jérémie, Masereel, Bernard, Remouchamps, Caroline, Ganeff, Corinne, Piette, Jacques, Frédérick, Raphaël

المساهمون: UCL - SSS/LDRI - Louvain Drug Research Institute

المصدر: Bioorganic & Medicinal Chemistry Letters : the tetrahedron journal for research at the interface of chemistry and biology, Vol. 20, no. 15, p. 4515-4520 (2010)

مصطلحات موضوعية: NF-κB inducing kinase, Protein serine threonine kinase inhibitor, Staurosporine, Unclassified drug, NF kappa B kinase, NF-kappa B kinase, Protein kinase inhibitor, Protein serine threonine kinase, Recombinant protein, Article, Competitive inhibition, NIK, Concentration (parameters), Drug structure, Enzyme inhibition, High throughput screening, IC 50, Model, Molecular docking, Molecular dynamics, Binding site, Chemistry, Virtual screening, Computer simulation, Drug antagonism, Genetics, Human, Metabolism, Rheumatoid arthritis, Arthritis

Relation: boreal:162919; http://hdl.handle.net/2078.1/162919; urn:ISSN:0960-894X; urn:EISSN:1464-3405

الاتاحة: http://hdl.handle.net/2078.1/162919
https://doi.org/10.1016/j.bmcl.2010.06.027

المؤلفون: Mortier, Jérémie, Frédérick, Raphaël, Ganeff, Corinne, Remouchamps, Caroline, Talaga, Patrice, Pochet, Lionel, Wouters, Johan, Piette, Jacques, Dejardin, Emmanuel, Masereel, Bernard

المساهمون: UCL - SSS/LDRI - Louvain Drug Research Institute

المصدر: Biochemical Pharmacology, Vol. 79, no. 10, p. 1462-1472 (2010)

مصطلحات موضوعية: Alternative pathway, 5 (3 methoxyphenyl) 3 phenyl 1h pyrazolo[4,3 c]isoquinoline derivative, I kappa B, I kappa B kinase alpha, Immunoglobulin enhancer binding protein, Interleukin 6, Isoquinoline derivative, Lymphotoxin beta receptor, Pyrazolo[4,3 c]isoquinoline derivative, Staurosporine, Transforming growth factor beta activated kinase 1, Molecular modeling, Tumor necrosis factor alpha, Unclassified drug, Amino acid sequence, Article, Conformational transition, Controlled study, Drug potency, Drug screening, Drug structure, Enzyme active site, NF-κB inducing kinase, Enzyme inhibition, HeLa cell, Human, Human cell, IC 50, Molecular docking, Priority journal

Relation: boreal:162918; http://hdl.handle.net/2078.1/162918; urn:ISSN:0006-2952; urn:EISSN:1873-2968

الاتاحة: http://hdl.handle.net/2078.1/162918
https://doi.org/10.1016/j.bcp.2010.01.007

المؤلفون: Mortier, Jérémie

المساهمون: FUNDP - MED_Département de Pharmacie, FUNDP - -, Masereel, Bernard, Dogne, Jean-Michel, Wouters, Johan, Lambert, Catherine, Winum, Jean-Yves, Kiss, Robert

مصطلحات موضوعية: NF-kappaB alternative pathway activation, NF-kappaB inducing kinase (NIK), Rheumatoid arthritis, TGF-beta activated kinase (TAK1), Isoquinolinedione, Pyzazoloisoquinoline, Virtual screening, Docking, Homology modelling, Inflammation

Relation: boreal:32329; http://hdl.handle.net/2078.2/32329

الاتاحة: http://hdl.handle.net/2078.2/32329