المؤلفون: Chua TC, Rao A, Morris DL, Chan DL

المصدر: Cancer Management and Research, Vol 2012, Iss default, Pp 413-422 (2012)

مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: http://www.dovepress.com/intraperitoneal-chemotherapy-in-ovarian-cancer-a-review-of-tolerance-a-a11599; https://doaj.org/toc/1179-1322

URL الوصول: https://doaj.org/article/797e6f4b62134e51830aee339b15d2ab

المؤلفون: Hanscombe, KB, Morris, DL, Noble, JA, Dilthey, AT, Tombleson, P, Kaufman, KM, Comeau, M, Langefeld, CD, Alarcon-Riquelme, ME, Gaffney, PM, Jacob, CO, Sivils, KL, Tsao, BP, Alarcon, GS, Brown, EE, Croker, J, Edberg, J, Gilkeson, G, James, JA, Kamen, DL, Kelly, JA, McCune, J, Merri, JT, Petri, M, Ramsey-Goldman, R, Reveille, JD, Salmon, JE, Scofield, H, Utset, T, Wallace, DJ, Weisman, MH, Kimberly, RP, Harley, JB, Lewis, CM, Criswell, LA, Vyse, TJ

المصدر: Human molecular genetics. 27(21):3813-3824

مصطلحات موضوعية: Medicin och hälsovetenskap, Klinisk medicin, Reumatologi och inflammation, Autoimmunitet och inflammation, Medicinska och farmaceutiska grundvetenskaper, Medicinsk genetik

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:139748488

المؤلفون: Hauberg, ME, Zhang, W, Giambartolomei, C, Franzen, O, Morris, DL, Vyse, TJ, Ruusalepp, A, Sklar, P, Schadt, EE, Bjorkegren, JLM, Roussos, P

المصدر: American journal of human genetics. 100(6):885-894

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:135905744

المؤلفون: Fernando, MMA, Freudenberg, J, Lee, A, Morris, DL, Boteva, L, Rhodes, B, Gonzalez-Escribano, MF, Lopez-Nevot, MA, Navarra, SV, Gregersen, PK, Martin, J, Vyse, TJ

المصدر: Annals of the rheumatic diseases. 71(5):777-784

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:124378369

المؤلفون: Morris, DL, Taylor, KE, Fernando, MMA, Nititham, J, Alarcon-Riquelme, ME, Barcellos, LF, Behrens, TW, Cotsapas, C, Gaffney, PM, Graham, RR, Pons-Estel, BA, Gregersen, PK, Harley, JB, Hauser, SL, Hom, G, Langefeld, CD, Noble, JA, Rioux, JD, Seldin, MF, Criswel, LA, Vyse, TJ

المصدر: American journal of human genetics. 91(5):778-793

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:125586248

المؤلفون: Morris, DL, Montgomery, SM, Galloway, ML, Pounder, RE, Wakefield, AJ

المصدر: Gut. 49(2):199-202

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:1960559

المؤلفون: Gavan, SP, Bruce, IN, Payne, K, Bruce, I, Lunt, M, Peek, N, Geifman, N, Armitt, G, Doherty, P, Prattley, J, Azadbakht, N, Papazian, A, Le Sueur, H, Farrelly, C, Richardson, C, Shabbir, Z, Hewitt, L, McHugh, N, Gordon, C, Reynolds, J, Young, S, Jayne, D, Farewell, V, Su, L, Pickering, M, Lightstone, E, Gilmore, A, Botto, M, Vyse, T, Morris, DL, D'Cruz, D, Vital, E, Wittmann, M, Emery, P, Beresford, M, Hedrich, C, Midgley, A, Gritzfeld, J, Ehrenstein, M, Isenberg, D, Parvaz, M, Dunnage, J, Batchelor, J, Holland, E, Upsall, P, Youssef, H, McCann, L, Mediwake, R, Bharadwaj, A, Kapur, D, Chee-Seng Yee, P, Griffiths, B, Yusuf, A, Zoma, A, Vermaak, E, Carlucci, F, Watts, R, Gordon, P, Shaffu, S, Wijeyekoon, J, McLaren, Z, Ahmad, Y, Batley, M, Gompels, L, Sheeran, T, Yi Yong, C, Jeffery, R, Hamdulay, S, Rahmeh, F, Young Min, S, Rhodes, B, De Lord, D, Lanyon, P, Chan, A, Teh, LS, Marks, J, Hutchinson, D, Regan, M, Haigh, R, Stratton, R, Rhys-Dillon, C, Akil, M, Mewar, D, Skeoch, S, Erb, N, O'Riordan, E, Bartram, S, Gayed, M, Dasgupta, B, Gunwardena, H, Pyne, D, Kaul, A, Mahindrakar, M, Raj Sood, B, Gullick, N, Edwards, C, Robson, JC, King, J

المصدر: Value in Health (2022) (In press).

وصف الملف: text

Relation: https://discovery.ucl.ac.uk/id/eprint/10155147/1/1-s2.0-S1098301522020976-main.pdf; https://discovery.ucl.ac.uk/id/eprint/10155147/

الاتاحة: https://discovery.ucl.ac.uk/id/eprint/10155147/1/1-s2.0-S1098301522020976-main.pdf
https://discovery.ucl.ac.uk/id/eprint/10155147/

المؤلفون: Pilonis, ND, Killcoyne, S, Tan, WK, O'Donovan, M, Malhotra, S, Tripathi, M, Miremadi, A, Debiram-Beecham, I, Evans, T, Phillips, R, Morris, DL, Vickery, C, Harrison, J, di Pietro, M, Ortiz-Fernandez-Sordo, J, Haidry, R, Kerridge, A, Sasieni, PD, Fitzgerald, RC

وصف الملف: 270 - 278

Relation: LANCET ONCOLOGY; Nastazja Dagny Pilonis, Sarah Killcoyne, W Keith Tan, Maria O'Donovan, Shalini Malhotra, Monika Tripathi, Ahmad Miremadi, Irene Debiram-Beecham, Tara Evans, Rosemary Phillips, Danielle L Morris, Craig Vickery, Jon Harrison, Massimiliano di Pietro, Jacobo Ortiz-Fernandez-Sordo, Rehan Haidry, Abigail Kerridge, Peter D Sasieni, Rebecca C Fitzgerald, Use of a Cytosponge biomarker panel to prioritise endoscopic Barrett's oesophagus surveillance: a cross-sectional study followed by a real-world prospective pilot, The Lancet Oncology, Volume 23, Issue 2, 2022, Pages 270-278, ISSN 1470-2045, https://doi.org/10.1016/S1470-2045(21)00667-7. (https://www.sciencedirect.com/science/article/pii/S1470204521006677) Abstract: Summary Background Endoscopic surveillance is recommended for patients with Barrett's oesophagus because, although the progression risk is low, endoscopic intervention is highly effective for high-grade dysplasia and cancer. However, repeated endoscopy has associated harms and access has been limited during the COVID-19 pandemic. We aimed to evaluate the role of a non-endoscopic device (Cytosponge) coupled with laboratory biomarkers and clinical factors to prioritise endoscopy for Barrett's oesophagus. Methods We first conducted a retrospective, multicentre, cross-sectional study in patients older than 18 years who were having endoscopic surveillance for Barrett's oesophagus (with intestinal metaplasia confirmed by TFF3 and a minimum Barrett's segment length of 1 cm [circumferential or tongues by the Prague C and M criteria]). All patients had received the Cytosponge and confirmatory endoscopy during the BEST2 (ISRCTN12730505) and BEST3 (ISRCTN68382401) clinical trials, from July 7, 2011, to April 1, 2019 (UK Clinical Research Network Study Portfolio 9461). Participants were divided into training (n=557) and validation (n=334) cohorts to identify optimal risk groups. The biomarkers evaluated were overexpression of p53, cellular atypia, and 17 clinical demographic variables. Endoscopic biopsy diagnosis of high-grade dysplasia or cancer was the primary endpoint. Clinical feasibility of a decision tree for Cytosponge triage was evaluated in a real-world prospective cohort from Aug 27, 2020 (DELTA; ISRCTN91655550; n=223), in response to COVID-19 and the need to provide an alternative to endoscopic surveillance. Findings The prevalence of high-grade dysplasia or cancer determined by the current gold standard of endoscopic biopsy was 17% (92 of 557 patients) in the training cohort and 10% (35 of 344) in the validation cohort. From the new biomarker analysis, three risk groups were identified: high risk, defined as atypia or p53 overexpression or both on Cytosponge; moderate risk, defined by the presence of a clinical risk factor (age, sex, and segment length); and low risk, defined as Cytosponge-negative and no clinical risk factors. The risk of high-grade dysplasia or intramucosal cancer in the high-risk group was 52% (68 of 132 patients) in the training cohort and 41% (31 of 75) in the validation cohort, compared with 2% (five of 210) and 1% (two of 185) in the low-risk group, respectively. In the real-world setting, Cytosponge results prospectively identified 39 (17%) of 223 patients as high risk (atypia or p53 overexpression, or both) requiring endoscopy, among whom the positive predictive value was 31% (12 of 39 patients) for high-grade dysplasia or intramucosal cancer and 44% (17 of 39) for any grade of dysplasia. Interpretation Cytosponge atypia, p53 overexpression, and clinical risk factors (age, sex, and segment length) could be used to prioritise patients for endoscopy. Further investigation could validate their use in clinical practice and lead to a substantial reduction in endoscopy procedures compared with current surveillance pathways. Funding Medical Research Council, Cancer Research UK, Innovate UK.; https://qmro.qmul.ac.uk/xmlui/handle/123456789/96828

الاتاحة: https://qmro.qmul.ac.uk/xmlui/handle/123456789/96828
https://doi.org/10.1016/S1470-2045(21)00667-7

المؤلفون: Robinson, JI, Md Yusof, MY, Davies, V, Wild, D, Morgan, M, Taylor, JC, El-Sherbiny, Y, Morris, DL, Liu, L, Rawstron, AC, Buch, MH, Plant, D, Cordell, HJ, Isaacs, JD, Bruce, IN, Emery, P, Barton, A, Vyse, TJ, Barrett, JH, Vital, EM, Morgan, AW, MATURA Consortia, MASTERPLANS Consortia

وصف الملف: text

Relation: https://eprints.whiterose.ac.uk/193664/6/PIIS2352396422005254.pdf; Robinson, JI orcid.org/0000-0001-5425-7520 , Md Yusof, MY orcid.org/0000-0003-3131-9121 , Davies, V et al. (20 more authors) (2022) Comprehensive genetic and functional analyses of Fc gamma receptors influence on response to rituximab therapy for autoimmunity. eBioMedicine, 86. 104343. ISSN 2352-3964

الاتاحة: https://eprints.whiterose.ac.uk/193664/
https://eprints.whiterose.ac.uk/193664/6/PIIS2352396422005254.pdf

المؤلفون: Morris, DL, Fernando, MMA, Taylor, KE, Chung, SA, Nititham, J, Alarcón-Riquelme, ME, Barcellos, LF, Behrens, TW, Cotsapas, C, Gaffney, PM, Graham, RR, Pons-Estel, BA, Gregersen, PK, Harley, JB, Hauser, SL, Hom, G, Langefeld, CD, Noble, JA, Rioux, JD, Seldin, MF, Vyse, TJ, Criswell, LA

المصدر: Genes & Immunity. 15(4)

مصطلحات موضوعية: Biological Sciences, Biomedical and Clinical Sciences, Genetics, Immunology, Women's Health, Autoimmune Disease, Lupus, 2.1 Biological and endogenous factors, Inflammatory and immune system, Autoantibodies, Europe, Female, HLA-DRB1 Chains, Humans, Lupus Erythematosus, Systemic, Male, Models, Genetic, Sub-phenotype analysis, MHC, meta-analysis, genetics, systemic lupus erythematosus, Europeans, Systemic Lupus Erythematosus Genetics Consortium

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/4m87f4kh
https://escholarship.org/content/qt4m87f4kh/qt4m87f4kh.pdf

المؤلفون: Hauser, Stephen, Fernando, MMA, Freudenberg, J, Lee, A, Morris, DL, Boteva, L, Rhodes, B, Gonzalez-Escribano, MF, Lopez-Nevot, MA, Navarra, SV, Gregersen, PK

URL الوصول: https://escholarship.org/uc/item/2xr7d06x

المؤلفون: Phillips, BE, Kelly, BM, Lilja, M, Ponce-Gonzalez, JG, Brogan, RJ, Morris, DL, Gustafsson, T, Kraus, WE, Atherton, PJ, Vollaard, NBJ, Rooyackers, O, Timmons, JA

المصدر: Frontiers in endocrinology. 8:229

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:136581150

المؤلفون: Langefeld, CD, Ainsworth, HC, Graham, DSC, Kelly, JA, Comeau, ME, Marion, MC, Howard, TD, Ramos, PS, Croker, JA, Morris, DL, Sandling, JK, Almlof, JC, Acevedo-Vasquez, EM, Alarcon, GS, Babini, AM, Baca, V, Bengtsson, AA, Berbotto, GA, Bijl, M, Brown, EE, Brunner, HI, Cardiel, MH, Catoggio, L, Cervera, R, Cucho-Venegas, JM, Dahlqvist, SR, D'Alfonso, S, Silva, BM, Figueroa, ID, Doria, A, Edberg, JC, Endreffy, E, Esquivel-Valerio, JA, Fortin, PR, Freedman, BI, Frostegard, J, Garcia, MA, de la Torre, IG, Gilkeson, GS, Gladman, DD, Gunnarsson, I, Guthridge, JM, Huggins, JL, James, JA, Kallenberg, CGM, Kamen, DL, Karp, DR, Kaufman, KM, Kottyan, LC, Kovacs, L, Laustrup, H, Lauwerys, BR, Li, QZ, Maradiaga-Cecena, MA, Martin, J, McCune, JM, McWilliams, DR, Merrill, JT, Miranda, P, Moctezuma, JF, Nath, SK, Niewold, TB, Orozco, L, Ortego-Centeno, N, Petri, M, Pineau, CA, Pons-Estel, BA, Pope, J, Raj, P, Ramsey-Goldman, R, Reveille, JD, Russell, LP, Sabio, JM, Aguilar-Salinas, CA, Scherbarth, HR, Scorza, R, Seldin, MF, Sjowall, C, Svenungsson, E, Thompson, SD, Toloza, SMA, Truedsson, L, Tusie-Luna, T, Vasconcelos, C, Vila, LM, Wallace, DJ, Weisman, MH, Wither, JE, Bhangale, T, Oksenberg, JR, Rioux, JD, Gregersen, PK, Syvanen, AC, Ronnblom, L, Criswell, LA, Jacob, CO, Sivils, KL, Tsao, BP, Schanberg, LE, Behrens, TW, Silverman, ED, Alarcon-Riquelme, ME, Kimberly, RP, Harley, JB, Wakeland, EK, Graham, RR, Gaffney, PM, Vyse, TJ

المصدر: Nature communications. 8:16021

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:136276015

المؤلفون: Kamitaki, N, Sekar, A, Handsaker, RE, de Rivera, H, Tooley, K, Morris, DL, Taylor, KE, Whelan, CW, Tombleson, P, Loohuis, LMO, Schizophrenia Working Group of the Psychiatric Genomics Consorti, Boehnke, M, Kimberly, RP, Kaufman, KM, Harley, JB, Langefeld, CD, Seidman, CE, Pato, MT, Pato, CN, Ophoff, RA, Graham, RR, Criswell, LA, Vyse, TJ, McCarroll, SA

المصدر: Nature , 582 pp. 577-581. (2020)

وصف الملف: text

Relation: https://discovery.ucl.ac.uk/id/eprint/10116953/1/Complement%20genes%20contribute%20sex-biased%20vulnerability%20in%20diverse%20disorders.pdf; https://discovery.ucl.ac.uk/id/eprint/10116953/

الاتاحة: https://discovery.ucl.ac.uk/id/eprint/10116953/1/Complement%20genes%20contribute%20sex-biased%20vulnerability%20in%20diverse%20disorders.pdf
https://discovery.ucl.ac.uk/id/eprint/10116953/

المؤلفون: Christodoulou, K, Farooqi, AR, Shaw, KT, Sargeant, IR, Morris, DL

المصدر: Endoscopy ; page A24.1-A24

الاتاحة: http://dx.doi.org/10.1136/gutjnl-2018-bsgabstracts.45
https://syndication.highwire.org/content/doi/10.1136/gutjnl-2018-BSGAbstracts.45

المؤلفون: Huang, Y, Alzahrani, NA, Fisher, OM, Chua, TC, Kozman, MA, Liauw, W, Arrowaili, A, Valle, SJ, Morris, DL

مصطلحات موضوعية: Clinical sciences, Appendix, Consistency, Cytoreductive surgery, Peritoneal metastases, Tumour characteristics

Relation: American Journal of Surgery; Huang, Y; Alzahrani, NA; Fisher, OM; Chua, TC; Kozman, MA; Liauw, W; Arrowaili, A; Valle, SJ; Morris, DL, Intraoperative macroscopic tumour consistency is associated with overall survival after cytoreductive surgery and intraperitoneal chemotherapy for appendiceal adenocarcinoma with peritoneal metastases: A retrospective observational study, American Journal of Surgery, 2019, 217 (4), pp. 704-712; http://hdl.handle.net/10072/387229

الاتاحة: http://hdl.handle.net/10072/387229
https://doi.org/10.1016/j.amjsurg.2018.12.037

المؤلفون: Lewis, MJ, McAndrew, MB, Wheeler, C, Workman, N, Agashe, P, Koopmann, J, Uddin, E, Morris, DL, Zou, L, Stark, R, Anson, J, Cope, AP, Vyse, TJ

مصطلحات موضوعية: Systemic lupus erythematosus, Autoantibodies, Autoimmunity, Personalised medicine, Diagnostic assay, Protein microarray

وصف الملف: 1 - 12

Relation: JOURNAL OF AUTOIMMUNITY; http://qmro.qmul.ac.uk/xmlui/handle/123456789/39555

الاتاحة: http://qmro.qmul.ac.uk/xmlui/handle/123456789/39555
https://doi.org/10.1016/j.jaut.2018.02.009

المؤلفون: Pullabhatla, V, Roberts, AL, Lewis, MJ, Mauro, D, Morris, DL, Odhams, CA, Tombleson, P, Liljedahl, U, Vyse, S, Simpson, MA, Sauer, S, de Rinaldis, E, Syvanen, A-C, Vyse, TJ

وصف الملف: 421 - 429

Relation: HUMAN MOLECULAR GENETICS; https://academic.oup.com/hmg/article/27/3/421/4644524; http://qmro.qmul.ac.uk/xmlui/handle/123456789/32326

الاتاحة: http://qmro.qmul.ac.uk/xmlui/handle/123456789/32326
https://doi.org/10.1093/hmg/ddx407
https://academic.oup.com/hmg/article/27/3/421/4644524

المؤلفون: Odhams CA, Cortini A, Chen L, Roberts AL, Vinuela A, Buil A, Small KS, Dermitzakis ET, Morris DL, Vyse TJ, Cunninghame Graham DS

المصدر: Human Molecular Genetics, 1 March 2017

وصف الملف: application/pdf

Relation: https://eprints.ncl.ac.uk/267506; https://eprints.ncl.ac.uk/fulltext.aspx?url=267506/7EDE980F-6130-4C80-A49F-3FB1EA078940.pdf&pub_id=267506

الاتاحة: https://eprints.ncl.ac.uk/267506

المؤلفون: Pillai, K, Akhter, J, Mekkawy, A, Chua, TC, Morris, DL

المصدر: urn:ISSN:1449-1907 ; International Journal of Medical Sciences, 14, 1, 18-28

مصطلحات موضوعية: 32 Biomedical and Clinical Sciences, Lung, Cystic Fibrosis, Rare Diseases, Glucose, Humans, Lipids, Mucin 5AC, Mucin-2, Mucin-5B, Mucins, Mucus, N-Acetylneuraminic Acid, Peritoneal Neoplasms, Pseudomyxoma Peritonei, Sulfhydryl Compounds, Viscosity, chemical, hardness, mucin, physical, anzsrc-for: 32 Biomedical and Clinical Sciences, anzsrc-for: 11 Medical and Health Sciences

Relation: http://hdl.handle.net/1959.4/unsworks_53328; https://doi.org/10.7150/ijms.16422

الاتاحة: http://hdl.handle.net/1959.4/unsworks_53328
https://doi.org/10.7150/ijms.16422