نتائج البحث - "Morishima, Yoshihiro"

1

Academic Journal

Mapping interactions of calmodulin and neuronal NO synthase by crosslinking and mass spectrometry

المؤلفون: Felker, Dana, Lee, Kanghyun, Pospiech, Thomas H., Morishima, Yoshihiro, Zhang, Haoming, Lau, Miranda, Southworth, Daniel R., Osawa, Yoichi

المساهمون: National Institute of Environmental Health Sciences, Medical School, University of Michigan, National Institutes of Health, National Institute of General Medical Sciences

المصدر: Journal of Biological Chemistry ; volume 300, issue 1, page 105464 ; ISSN 0021-9258

الاتاحة: http://dx.doi.org/10.1016/j.jbc.2023.105464
https://api.elsevier.com/content/article/PII:S0021925823024924?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0021925823024924?httpAccept=text/plain

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2

Academic Journal

Dynamic cycling with a unique Hsp90/Hsp70-dependent chaperone machinery and GAPDH is needed for heme insertion and activation of neuronal NO synthase

المؤلفون: Morishima, Yoshihiro, Lau, Miranda, Pratt, William B., Osawa, Yoichi

المساهمون: Medical School, University of Michigan, National Institutes of Health

المصدر: Journal of Biological Chemistry ; volume 299, issue 2, page 102856 ; ISSN 0021-9258

الاتاحة: http://dx.doi.org/10.1016/j.jbc.2022.102856
https://api.elsevier.com/content/article/PII:S0021925822012996?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0021925822012996?httpAccept=text/plain

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3

Academic Journal

A model in which heat shock protein 90 targets protein-folding clefts: Rationale for a new approach to neuroprotective treatment of protein folding diseases

المؤلفون: Pratt, William B, Morishima, Yoshihiro, Gestwicki, Jason E, Lieberman, Andrew P, Osawa, Yoichi

المصدر: Experimental Biology and Medicine. 239(11)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Acquired Cognitive Impairment, Neurodegenerative, Alzheimer's Disease, Brain Disorders, Dementia, Orphan Drug, Rare Diseases, Aging, Huntington's Disease, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Neurosciences, 2.1 Biological and endogenous factors, Aetiology, Neurological, HSP90 Heat-Shock Proteins, Humans, Huntingtin Protein, Nerve Tissue Proteins, Neuroprotective Agents, Protein Folding, Proteolysis, Proteostasis Deficiencies, Receptors, Neurotransmitter, Ubiquitination, alpha-Synuclein, tau Proteins, Proteostasis, neurodegeneration, heat shock protein 90, heat shock protein 70, ubiquitination, carboxyl-terminus of Hsc70-interacting protein, Medical and Health Sciences, Biochemistry & Molecular Biology, Biological sciences, Biomedical and clinical sciences, Engineering

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/40h7w77c

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4

Academic Journal

Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation.

المؤلفون: Wang, Adrienne, Miyata, Yoshinari, Klinedinst, Susan, Peng, Hwei-Ming, Chua, Jason, Komiyama, Tomoko, Li, Xiaokai, Morishima, Yoshihiro, Merry, Diane, Pratt, William, Osawa, Yoichi, Collins, Catherine, Lieberman, Andrew, Gestwicki, Jason

المصدر: Nature Chemical Biology. 9(2)

مصطلحات موضوعية: Animals, Dose-Response Relationship, Drug, Doxorubicin, Drosophila, Female, HEK293 Cells, HSP70 Heat-Shock Proteins, HeLa Cells, Humans, Inhibitory Concentration 50, Models, Chemical, Molecular Chaperones, Muscular Disorders, Atrophic, Neurotoxins, PC12 Cells, Peptides, Protein Structure, Tertiary, Proteins, Pyridines, Rats, Receptors, Androgen, Thiazoles, Ubiquitination

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/4tn0f2fc
https://escholarship.org/content/qt4tn0f2fc/qt4tn0f2fc.pdf

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5

Academic Journal

Activation of Heat Shock Protein 70 as a Potential Therapeutic Strategy for the Treatment of Protein Folding Disease

المؤلفون: Davis, Amanda, Zhang, Haoming, Lau, Miranda, Chakraborty, Sumita, Morishima, Yoshihiro, Lieberman, Andrew, Osawa, Yoichi

المساهمون: National Institutes of Health

المصدر: The FASEB Journal ; volume 33, issue S1 ; ISSN 0892-6638 1530-6860

الاتاحة: http://dx.doi.org/10.1096/fasebj.2019.33.1_supplement.501.15

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6

Academic Journal

Cryo-EM Structural Analysis of Neuronal Nitric Oxide Synthase

المؤلفون: Pospiech, Thomas H., Morishima, Yoshihiro, Osawa, Yoichi, Southworth, Daniel R.

المصدر: Biophysical Journal ; volume 116, issue 3, page 187a-188a ; ISSN 0006-3495

الاتاحة: http://dx.doi.org/10.1016/j.bpj.2018.11.1040
https://api.elsevier.com/content/article/PII:S0006349518323051?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0006349518323051?httpAccept=text/plain

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7

Academic Journal

Mapping protein-protein interactions in homodimeric CYP102A1 by crosslinking and mass spectrometry

المؤلفون: Felker, Dana, Zhang, Haoming, Bo, Zhiyuan, Lau, Miranda, Morishima, Yoshihiro, Schnell, Santiago, Osawa, Yoichi

المساهمون: NINDS, NIEHS, NIGMS

المصدر: Biophysical Chemistry ; volume 274, page 106590 ; ISSN 0301-4622

الاتاحة: http://dx.doi.org/10.1016/j.bpc.2021.106590
https://api.elsevier.com/content/article/PII:S0301462221000727?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0301462221000727?httpAccept=text/plain

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8

Academic Journal

Architecture of the Nitric-oxide Synthase Holoenzyme Reveals Large Conformational Changes and a Calmodulin-driven Release of the FMN Domain

المؤلفون: Yokom, Adam L., Morishima, Yoshihiro, Lau, Miranda, Su, Min, Glukhova, Alisa, Osawa, Yoichi, Southworth, Daniel R.

المساهمون: National Institutes of Health

المصدر: Journal of Biological Chemistry ; volume 289, issue 24, page 16855-16865 ; ISSN 0021-9258

الاتاحة: http://dx.doi.org/10.1074/jbc.m114.564005
https://api.elsevier.com/content/article/PII:S002192582040657X?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S002192582040657X?httpAccept=text/plain
https://syndication.highwire.org/content/doi/10.1074/jbc.M114.564005

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9

Periodical

High-throughput screening identifies a novel small-molecule modulator of Hsp70 that selectively enhances ubiquitination and degradation of misfolded neuronal NO synthase

المؤلفون: Garcia, Anthony M., Davis, Amanda K., Martinez-Ramos, Cristian, Morishima, Yoshihiro, Lau, Miranda, Xu, Emily, Sunil, Arya, Zhang, Haoming, Alt, Andrew, Lieberman, Andrew P., Osawa, Yoichi

المصدر: Molecular Pharmacology; February 2025, Vol. 107 Issue: 2

10

Academic Journal

Destabilization of the Epidermal Growth Factor Receptor (EGFR) by a Peptide That Inhibits EGFR Binding to Heat Shock Protein 90 and Receptor Dimerization

المؤلفون: Ahsan, Aarif, Ray, Dipankar, Ramanand, Susmita G., Hegde, Ashok, Whitehead, Christopher, Rehemtulla, Alnawaz, Morishima, Yoshihiro, Pratt, William B., Osawa, Yoichi, Lawrence, Theodore S., Nyati, Mukesh K.

المصدر: Journal of Biological Chemistry ; volume 288, issue 37, page 26879-26886 ; ISSN 0021-9258

الاتاحة: http://dx.doi.org/10.1074/jbc.m113.492280
https://api.elsevier.com/content/article/PII:S0021925820490945?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0021925820490945?httpAccept=text/plain
https://syndication.highwire.org/content/doi/10.1074/jbc.M113.492280

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11

Academic Journal

Ubiquitination of Neuronal Nitric Oxide Synthase in the P450 Oxygenase and Calmodulin‐binding Domain

المؤلفون: Clapp, Kelly M, Peng, Hwei-Ming, Jenkins, Gary J, Ford, Michael, Morishima, Yoshihiro, Lau, Miranda, Osawa, Yoichi

المساهمون: National Institutes of Health

المصدر: The FASEB Journal ; volume 26, issue S1 ; ISSN 0892-6638 1530-6860

الاتاحة: http://dx.doi.org/10.1096/fasebj.26.1_supplement.1052.1

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12

Academic Journal

Modulation of Heme/Substrate Binding Cleft of Neuronal Nitric-oxide Synthase (nNOS) Regulates Binding of Hsp90 and Hsp70 Proteins and nNOS Ubiquitination

المؤلفون: Peng, Hwei-Ming, Morishima, Yoshihiro, Pratt, William B., Osawa, Yoichi

المصدر: Journal of Biological Chemistry ; volume 287, issue 2, page 1556-1565 ; ISSN 0021-9258

الاتاحة: http://dx.doi.org/10.1074/jbc.m111.323295
https://api.elsevier.com/content/article/PII:S0021925820533917?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0021925820533917?httpAccept=text/plain
https://syndication.highwire.org/content/doi/10.1074/jbc.M111.323295

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13

Academic Journal

Ubiquitination of Neuronal Nitric-oxide Synthase in the Calmodulin-binding Site Triggers Proteasomal Degradation of the Protein

المؤلفون: Clapp, Kelly M., Peng, Hwei-Ming, Jenkins, Gary J., Ford, Michael J., Morishima, Yoshihiro, Lau, Miranda, Osawa, Yoichi

المصدر: Journal of Biological Chemistry ; volume 287, issue 51, page 42601-42610 ; ISSN 0021-9258

الاتاحة: http://dx.doi.org/10.1074/jbc.m112.412494
https://api.elsevier.com/content/article/PII:S0021925820437536?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0021925820437536?httpAccept=text/plain
https://syndication.highwire.org/content/doi/10.1074/jbc.M112.412494

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14

Academic Journal

Probing the recognition signal for ubiquitination of suicide‐inactivated neuronal nitric oxide synthase with a C331A mutant of the enzyme

المؤلفون: Clapp, Kelly Marie, Peng, Hwei‐Ming, Walker, Vyvyca J., Morishima, Yoshihiro, Lau, Miranda, Osawa, Yoichi

المساهمون: National Institutes of Health

المصدر: The FASEB Journal ; volume 24, issue S1 ; ISSN 0892-6638 1530-6860

الاتاحة: http://dx.doi.org/10.1096/fasebj.24.1_supplement.757.9

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15

Academic Journal

Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage

المؤلفون: Pratt, William B, Morishima, Yoshihiro, Peng, Hwei-Ming, Osawa, Yoichi

المصدر: Experimental Biology and Medicine ; volume 235, issue 3, page 278-289 ; ISSN 1535-3702 1535-3699

الاتاحة: http://dx.doi.org/10.1258/ebm.2009.009250
http://journals.sagepub.com/doi/pdf/10.1258/ebm.2009.009250
http://journals.sagepub.com/doi/full-xml/10.1258/ebm.2009.009250

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16

Academic Journal

C331A Mutant of Neuronal Nitric-oxide Synthase Is Labilized for Hsp70/CHIP (C Terminus of HSC70-interacting Protein)-dependent Ubiquitination

المؤلفون: Clapp, Kelly M., Peng, Hwei-Ming, Morishima, Yoshihiro, Lau, Miranda, Walker, Vyvyca J., Pratt, William B., Osawa, Yoichi

المصدر: Journal of Biological Chemistry ; volume 285, issue 44, page 33642-33651 ; ISSN 0021-9258

الاتاحة: http://dx.doi.org/10.1074/jbc.m110.159178
https://api.elsevier.com/content/article/PII:S0021925820470759?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0021925820470759?httpAccept=text/plain
https://syndication.highwire.org/content/doi/10.1074/jbc.M110.159178

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17

Academic Journal

Inhibition of Hsp70 by Methylene Blue Affects Signaling Protein Function and Ubiquitination and Modulates Polyglutamine Protein Degradation

المؤلفون: Wang, Adrienne M., Morishima, Yoshihiro, Clapp, Kelly M., Peng, Hwei-Ming, Pratt, William B., Gestwicki, Jason E., Osawa, Yoichi, Lieberman, Andrew P.

المصدر: Journal of Biological Chemistry ; volume 285, issue 21, page 15714-15723 ; ISSN 0021-9258

الاتاحة: http://dx.doi.org/10.1074/jbc.m109.098806
https://api.elsevier.com/content/article/PII:S0021925820493810?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0021925820493810?httpAccept=text/plain
https://syndication.highwire.org/content/doi/10.1074/jbc.M109.098806

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18

Academic Journal

CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins

المؤلفون: Morishima, Yoshihiro, Wang, Adrienne M., Yu, Zhigang, Pratt, William B., Osawa, Yoichi, Lieberman, Andrew P.

مصطلحات موضوعية: Article

وصف الملف: text/html

Relation: http://hmg.oxfordjournals.org/cgi/content/short/ddn296v1; http://dx.doi.org/10.1093/hmg/ddn296

الاتاحة: http://hmg.oxfordjournals.org/cgi/content/short/ddn296v1
https://doi.org/10.1093/hmg/ddn296

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19

Academic Journal

Pharmacologic and genetic inhibition of hsp90-dependent trafficking reduces aggregation and promotes degradation of the expanded glutamine androgen receptor without stress protein induction

المؤلفون: Thomas, Monzy, Harrell, Jennifer M., Morishima, Yoshihiro, Peng, Hwei-Ming, Pratt, William B., Lieberman, Andrew P.

مصطلحات موضوعية: ARTICLES

وصف الملف: text/html

Relation: http://hmg.oxfordjournals.org/cgi/content/short/15/11/1876; http://dx.doi.org/10.1093/hmg/ddl110

الاتاحة: http://hmg.oxfordjournals.org/cgi/content/short/15/11/1876
https://doi.org/10.1093/hmg/ddl110

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20

Academic Journal

Regulation of the Dynamics of hsp90 Action on the Glucocorticoid Receptor by Acetylation/Deacetylation of the Chaperone

المؤلفون: Murphy, Patrick J.M., Morishima, Yoshihiro, Kovacs, Jeffrey J., Yao, Tso-Pang, Pratt, William B.

المصدر: Journal of Biological Chemistry ; volume 280, issue 40, page 33792-33799 ; ISSN 0021-9258

الاتاحة: http://dx.doi.org/10.1074/jbc.m506997200
https://api.elsevier.com/content/article/PII:S0021925820789623?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0021925820789623?httpAccept=text/plain
https://syndication.highwire.org/content/doi/10.1074/jbc.M506997200

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