المؤلفون: Joseph D. Houck, Timothy L. Macdonald, Yugesh Kharel, James E. East, Saundra D. Field, Andrew J. Kennedy, Morgan L. Moyer, Kevin R. Lynch, Thomas P. Mathews

المصدر: Journal of Medicinal Chemistry. 54:3524-3548

مصطلحات موضوعية: Models, Molecular, Chemistry, Pharmaceutical, Amidines, Antineoplastic Agents, Article, Amidine, chemistry.chemical_compound, Sphingosine, Cell Line, Tumor, Drug Discovery, medicine, Humans, Sphingosine-1-phosphate, Enzyme Inhibitors, Leukemia, biology, U937 cell, Gene Expression Regulation, Leukemic, Kinase, Cancer, U937 Cells, medicine.disease, Kinetics, Phosphotransferases (Alcohol Group Acceptor), SPHK2, Models, Chemical, chemistry, Biochemistry, Sphingosine kinase 1, Drug Design, biology.protein, Molecular Medicine, Lysophospholipids

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cd6baf3fc66c36c987c285d398789fd
https://doi.org/10.1021/jm2001053

المؤلفون: Morgan L. Moyer, Amanda M. Gellett, Yugesh Kharel, Thomas P. Mathews, Timothy L. Macdonald, Perry C. Kennedy, Kevin R. Lynch, Jose L. Tomsig

المصدر: The Biochemical journal. 440(3)

مصطلحات موضوعية: MAPK/ERK pathway, Pyrrolidines, Cell Survival, Sphingosine kinase, Amidines, Poly (ADP-Ribose) Polymerase-1, Biology, Biochemistry, Article, Cell Line, chemistry.chemical_compound, Mice, Epidermal growth factor, Sphingosine, Animals, Humans, Sphingosine-1-phosphate, Phosphorylation, Receptor, Extracellular Signal-Regulated MAP Kinases, Molecular Biology, Protein kinase B, Sphingolipids, Kinase, Caspase 3, Stereoisomerism, Cell Biology, Cell biology, Rats, Mice, Inbred C57BL, Phosphotransferases (Alcohol Group Acceptor), chemistry, Lysophospholipids, Poly(ADP-ribose) Polymerases, Proto-Oncogene Proteins c-akt

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93303db13dfd67a12770cbba63d71445
https://pubmed.ncbi.nlm.nih.gov/21848514

المؤلفون: Yugesh Kharel, Amanda M. Gellett, Jose L. Tomsig, Perry C. Kennedy, Morgan L. Moyer, Kevin R. Lynch

المصدر: Biochemical Journal; Dec2011, Vol. 440 Issue 3, p345-353, 9p

مصطلحات موضوعية: SPHINGOSINE, ENZYME inhibitors, PHOSPHATES, CELL migration, CELLULAR signal transduction, G protein-coupled receptor kinases, LABORATORY mice, EPIDERMAL growth factor