المؤلفون: Younho Lee (5409854), Hyunkyung Kim (2902602), Haelee Kim (5738474), Ha Yeon Cho (10756372), Jun-Goo Jee (627412), Kyung-Ah Seo (10743561), Jung Beom Son (2474797), Eunhwa Ko (531562), Hwan Geun Choi (750017), Nam Doo Kim (77751), Ikyon Kim (1478845)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Cancer, Infectious Diseases, Plant Biology, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, X-ray crystal structure analysis, apical dual-specificity protein kinase, pyrimidine -5-carbonitrile Scaffold, 7 H, MPS 1 inhibitor, Monopolar Spindle 1 Inhibitor Tripl., TNBC cell proliferation, breast-cancer subtype, Monopolar spindle 1 kinase, vivo evaluation, relapse rates

Relation: https://figshare.com/articles/journal_contribution/X_ray_Crystal_Structure-Guided_Design_and_Optimization_of_7_i_H_i_Pyrrolo_2_3_i_d_i_pyrimidine-5-carbonitrile_Scaffold_as_a_Potent_and_Orally_Active_Monopolar_Spindle_1_Inhibitor/14534565

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00542.s005

المؤلفون: Younho Lee (5409854), Hyunkyung Kim (2902602), Haelee Kim (5738474), Ha Yeon Cho (10756372), Jun-Goo Jee (627412), Kyung-Ah Seo (10743561), Jung Beom Son (2474797), Eunhwa Ko (531562), Hwan Geun Choi (750017), Nam Doo Kim (77751), Ikyon Kim (1478845)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Cancer, Infectious Diseases, Plant Biology, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, X-ray crystal structure analysis, apical dual-specificity protein kinase, pyrimidine -5-carbonitrile Scaffold, 7 H, MPS 1 inhibitor, Monopolar Spindle 1 Inhibitor Tripl., TNBC cell proliferation, breast-cancer subtype, Monopolar spindle 1 kinase, vivo evaluation, relapse rates

Relation: https://figshare.com/articles/journal_contribution/X_ray_Crystal_Structure-Guided_Design_and_Optimization_of_7_i_H_i_Pyrrolo_2_3_i_d_i_pyrimidine-5-carbonitrile_Scaffold_as_a_Potent_and_Orally_Active_Monopolar_Spindle_1_Inhibitor/14534553

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00542.s001

المؤلفون: Younho Lee (5409854), Hyunkyung Kim (2902602), Haelee Kim (5738474), Ha Yeon Cho (10756372), Jun-Goo Jee (627412), Kyung-Ah Seo (10743561), Jung Beom Son (2474797), Eunhwa Ko (531562), Hwan Geun Choi (750017), Nam Doo Kim (77751), Ikyon Kim (1478845)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Cancer, Infectious Diseases, Plant Biology, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, X-ray crystal structure analysis, apical dual-specificity protein kinase, pyrimidine -5-carbonitrile Scaffold, 7 H, MPS 1 inhibitor, Monopolar Spindle 1 Inhibitor Tripl., TNBC cell proliferation, breast-cancer subtype, Monopolar spindle 1 kinase, vivo evaluation, relapse rates

Relation: https://figshare.com/articles/dataset/X_ray_Crystal_Structure-Guided_Design_and_Optimization_of_7_i_H_i_Pyrrolo_2_3_i_d_i_pyrimidine-5-carbonitrile_Scaffold_as_a_Potent_and_Orally_Active_Monopolar_Spindle_1_Inhibitor/14534559

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00542.s003

المؤلفون: Younho Lee (5409854), Hyunkyung Kim (2902602), Haelee Kim (5738474), Ha Yeon Cho (10756372), Jun-Goo Jee (627412), Kyung-Ah Seo (10743561), Jung Beom Son (2474797), Eunhwa Ko (531562), Hwan Geun Choi (750017), Nam Doo Kim (77751), Ikyon Kim (1478845)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Cancer, Infectious Diseases, Plant Biology, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, X-ray crystal structure analysis, apical dual-specificity protein kinase, pyrimidine -5-carbonitrile Scaffold, 7 H, MPS 1 inhibitor, Monopolar Spindle 1 Inhibitor Tripl., TNBC cell proliferation, breast-cancer subtype, Monopolar spindle 1 kinase, vivo evaluation, relapse rates

Relation: https://figshare.com/articles/dataset/X_ray_Crystal_Structure-Guided_Design_and_Optimization_of_7_i_H_i_Pyrrolo_2_3_i_d_i_pyrimidine-5-carbonitrile_Scaffold_as_a_Potent_and_Orally_Active_Monopolar_Spindle_1_Inhibitor/14534556

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00542.s002

المؤلفون: Younho Lee (5409854), Hyunkyung Kim (2902602), Haelee Kim (5738474), Ha Yeon Cho (10756372), Jun-Goo Jee (627412), Kyung-Ah Seo (10743561), Jung Beom Son (2474797), Eunhwa Ko (531562), Hwan Geun Choi (750017), Nam Doo Kim (77751), Ikyon Kim (1478845)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Cancer, Infectious Diseases, Plant Biology, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, X-ray crystal structure analysis, apical dual-specificity protein kinase, pyrimidine -5-carbonitrile Scaffold, 7 H, MPS 1 inhibitor, Monopolar Spindle 1 Inhibitor Tripl., TNBC cell proliferation, breast-cancer subtype, Monopolar spindle 1 kinase, vivo evaluation, relapse rates

Relation: https://figshare.com/articles/dataset/X_ray_Crystal_Structure-Guided_Design_and_Optimization_of_7_i_H_i_Pyrrolo_2_3_i_d_i_pyrimidine-5-carbonitrile_Scaffold_as_a_Potent_and_Orally_Active_Monopolar_Spindle_1_Inhibitor/14534562

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00542.s004